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1. Full Text Sick sinus syndrome and atrial fibrillation in older persons — A view from the sinoatrial nodal myocyte
by Monfredi, O and Boyett, M.R
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 83, pp. 88 - 100
Abstract Sick sinus syndrome remains a highly relevant clinical entity, being responsible for the implantation of the majority of electronic pacemakers... 
Cardiovascular | Pacemaking | Ion channels | Calcium handling | Arrhythmia | Sinoatrial node | Atrial fibrillation | MOLECULAR-MECHANISM | CARDIAC & CARDIOVASCULAR SYSTEMS | PACEMAKER ACTIVITY | CARDIAC-ARRHYTHMIA | ANGIOTENSIN-II | CELL BIOLOGY | SODIUM-CHANNEL MUTATIONS | TARGETED DISRUPTION | HCN CHANNELS | ION-CHANNEL | ELECTRICAL-ACTIVITY | HEART-RATE | Bradycardia - genetics | Heart Atria - pathology | Humans | MicroRNAs - metabolism | NAV1.5 Voltage-Gated Sodium Channel - metabolism | Bradycardia - metabolism | Ion Transport | NAV1.5 Voltage-Gated Sodium Channel - genetics | Atrial Fibrillation - pathology | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism | Receptors, Purinergic P1 - genetics | Gene Expression Regulation | Connexins - genetics | Renin-Angiotensin System - genetics | Atrial Fibrillation - genetics | Aging - pathology | Connexins - metabolism | Heart Atria - metabolism | Sinoatrial Node - pathology | Atrial Fibrillation - metabolism | Myocytes, Cardiac - pathology | Animals | Bradycardia - pathology | Myocytes, Cardiac - metabolism | Sinoatrial Node - metabolism | Aged | MicroRNAs - genetics | Receptors, Purinergic P1 - metabolism | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics | Aging - metabolism | Sick sinus syndrome
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2. Full Text Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: Insights from bifurcation analyses of two mathematical models
by Kurata, Yasutaka and Tsumoto, Kunichika and Hayashi, Kenshi and Hisatome, Ichiro and Tanida, Mamoru and Kuda, Yuhichi and Shibamoto, Toshishige
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2017, Volume 312, Issue 1, pp. H106 - H127
Early afterdepolarization (EAD) is known as a cause of ventricular arrhythmias in long QT syndromes. We theoretically investigated how the rapid (I-Kr) and... 
Long QT syndrome | Early afterdepolarization | Computer simulation | Mathematical model | Bifurcation analysis | early afterdepolarization | CHRONIC HEART-FAILURE | TRIGGERED ACTIVITY | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | long QT syndrome | CARDIAC-ARRHYTHMIAS | LONG-QT SYNDROME | bifurcation analysis | INTRACELLULAR NA+ | L-TYPE CA2 | SINOATRIAL NODE PACEMAKING | BIOLOGICAL PACEMAKER | NA+/CA2+ EXCHANGER | mathematical model | computer simulation | PERIPHERAL VASCULAR DISEASE | CURRENT I-F | Models, Theoretical | Heart Ventricles - cytology | Heart Conduction System - metabolism | Calcium - metabolism | Models, Cardiovascular | Humans | Sodium - metabolism | Delayed Rectifier Potassium Channels - metabolism | Action Potentials | Long QT Syndrome - metabolism | Sodium-Potassium-Exchanging ATPase - metabolism | Bradycardia - metabolism | Membrane Potentials | Sodium-Calcium Exchanger - metabolism | Myocytes, Cardiac - metabolism | Sarcoplasmic Reticulum - metabolism | Calcium Channels, L-Type - metabolism | Physiological aspects | Models | Arrhythmia | Mathematical analysis | Methods | Heart cells
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3. Full Text Primary blast causes mild, moderate, severe and lethal TBI with increasing blast overpressures: Experimental rat injury model
by Mishra, Vikas and Skotak, Maciej and Schuetz, Heather and Heller, Abi and Haorah, James and Chandra, Namas
Scientific Reports, ISSN 2045-2322, 06/2016, Volume 6, Issue 1, p. 26992
Injury severity in blast induced Traumatic Brain Injury (bTBI) increases with blast overpressure (BOP) and impulse in dose-dependent manner. Pure primary blast... 
BARRIER DYSFUNCTION | NERVOUS-SYSTEM | OXIDATIVE STRESS | ACETYL-L-CARNITINE | SHELL SHOCK | TRAUMATIC BRAIN-INJURY | ANESTHETIZED RAT | MULTIDISCIPLINARY SCIENCES | INDUCED NEUROTRAUMA | COMBAT VETERANS | SHOCK-WAVE | Lung Injury - pathology | NADPH Oxidases - metabolism | Blast Injuries - metabolism | Male | Explosions | Nitrosative Stress | Aldehydes - metabolism | Rats, Sprague-Dawley | Tyrosine - analogs & derivatives | Blast Injuries - pathology | Blood-Brain Barrier - metabolism | Blood-Brain Barrier - pathology | Brain - blood supply | Tyrosine - metabolism | Animals | Bradycardia - metabolism | Brain Injuries, Traumatic - metabolism | Brain Injuries, Traumatic - pathology | Bradycardia - pathology | Lung Injury - metabolism | Microvessels - enzymology | Nitric Oxide Synthase Type II - metabolism
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4. Full Text Exercise training reduces resting heart rate via downregulation of the funny channel HCN4
by D'souza, Alicia and Bucchi, Annalisa and Johnsen, Anne Berit and Logantha, Sunil Jit R.J and Monfredi, Oliver and Yanni, Joseph and Prehar, Sukhpal and Hart, George and Cartwright, Elizabeth and Wisloff, Ulrik and Dobryznski, Halina and Difrancesco, Dario and Morris, Gwilym M and Boyett, Mark R
Nature Communications, ISSN 2041-1723, 05/2014, Volume 5, Issue 1, p. 3775
Endurance athletes exhibit sinus bradycardia, that is a slow resting heart rate, associated with a higher incidence of sinus node (pacemaker) disease and... 
ATRIAL | SINUS | MULTIDISCIPLINARY SCIENCES | ATRIOVENTRICULAR NODE | FUNCTIONAL ROLES | FOLLOW-UP | CA2+-ACTIVATED K+ CHANNEL | BRADYCARDIA | EXPRESSION | SINOATRIAL NODE | CLINICAL-SIGNIFICANCE | Up-Regulation | Bradycardia - genetics | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism | Down-Regulation | Heart Rate - genetics | Rats | Repressor Proteins - genetics | MicroRNAs - metabolism | RNA, Messenger - metabolism | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | Animals | Bradycardia - metabolism | Adaptation, Physiological - genetics | Sinoatrial Node - metabolism | Mice | MicroRNAs - genetics | In Vitro Techniques | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics | Physical Conditioning, Animal | Repressor Proteins - metabolism
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5. Full Text Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death
by Marec, Herve Le and Dilly, Keith W and Mohler, Peter J and Guatimosim, Silvia and Kyndt, Florence and Ali, Mervat E and Bennett, Vann and Escande, Denis and duBell, William H and Haurogné, Karine and Rogers, Terry B and Lederer, W. J and Schott, Jean-Jacques and Song, Long-Sheng and Gramolini, Anthony O
Nature, ISSN 0028-0836, 02/2003, Volume 421, Issue 6923, pp. 634 - 639
Mutations in ion channels involved in the generation and termination of action potentials constitute a family of molecular defects that underlie fatal cardiac... 
SODIUM-CALCIUM EXCHANGE | CHANNELS | VENTRICULAR MYOCYTES | SPECTRIN | GENE | MULTIDISCIPLINARY SCIENCES | Bradycardia - genetics | Calcium Channels - metabolism | Humans | Male | Death, Sudden, Cardiac - etiology | Bradycardia - complications | Long QT Syndrome - physiopathology | Action Potentials | Bradycardia - metabolism | Sodium-Calcium Exchanger - metabolism | Myocardium - metabolism | Electrocardiography | Inositol 1,4,5-Trisphosphate Receptors | Female | Calcium Signaling | Heart - physiopathology | Heart Rate | Bradycardia - physiopathology | Long QT Syndrome - classification | Myocardium - pathology | Ankyrins - physiology | Mutation - genetics | Long QT Syndrome - metabolism | Sodium-Potassium-Exchanging ATPase - metabolism | Patch-Clamp Techniques | Phenotype | Animals | Pedigree | Ankyrins - genetics | Long QT Syndrome - genetics | Protein Binding | Heterozygote | Mice | Receptors, Cytoplasmic and Nuclear - metabolism | Cardiovascular disease | Mutation
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6. Full Text The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure
by Schepelmann, M and Yarova, P.L and Lopez-Fernandez, I and Davies, T.S and Brennan, S.C and Edwards, P.J and Aggarwal, A and Graça, J and Rietdorf, K and Matchkov, V and Fenton, R.A and Chang, W and Krssak, M and Stewart, A and Broadley, K.J and Ward, D.T and Price, S.A and Edwards, D.H and Kemp, P.J and Riccardi, D
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 2016, Volume 310, Issue 3, pp. C193 - C204
The extracellular calcium-sensing receptor CaSR is expressed in blood vessels where its role is not completely understood. In this study, we tested the... 
G protein-coupled receptor | CaSR | PULMONARY VEINS | SMALL ARTERIES | PHYSIOLOGY | blood pressure regulation | calcium-sensing receptor | CELL BIOLOGY | ENDOTHELIAL-CELLS | IMAGE-ANALYSIS | NITRIC-OXIDE | GENE-EXPRESSION | SMOOTH-MUSCLE-CELLS | blood vessel tone regulation | CARDIAC FIBROSIS | vascular smooth muscle cells | TRANSGENIC MICE | Bradycardia - genetics | Muscle, Smooth, Vascular - metabolism | Receptors, G-Protein-Coupled - metabolism | Blood Pressure - genetics | Calcium - metabolism | Aorta - metabolism | Mice, 129 Strain | Hypotension - genetics | Muscle, Smooth, Vascular - physiopathology | Dose-Response Relationship, Drug | Vasodilation - genetics | Ventricular Remodeling | Bradycardia - metabolism | Hypotension - physiopathology | Blood Pressure - drug effects | Muscle, Smooth, Vascular - drug effects | Vasoconstriction - genetics | Vasoconstrictor Agents - pharmacology | Heart Rate | Genetic Predisposition to Disease | Vasodilator Agents - pharmacology | Mice, Inbred C57BL | Bradycardia - physiopathology | Mesenteric Arteries - metabolism | Vasoconstriction - drug effects | Mice, Knockout | Phenotype | Animals | Hypotension - metabolism | Receptors, G-Protein-Coupled - deficiency | Calcium Signaling - drug effects | Myocytes, Cardiac - metabolism | Receptors, G-Protein-Coupled - genetics | Vasodilation - drug effects | Calcium Signaling - genetics | Call for Papers
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7. Full Text Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: potential involvement of Na+/Ca2+ exchanger
by Song, JL and Gao, EH and Wang, JF and Zhang, XQ and Chan, TO and Koch, WJ and Shang, XY and Joseph, JI and Peterson, BZ and Feldman, AM and Cheung, JY
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, ISSN 0363-6135, 02/2012, Volume 302, Issue 3, pp. H770 - H781
Song J, Gao E, Wang J, Zhang XQ, Chan TO, Koch WJ, Shang X, Joseph JI, Peterson BZ, Feldman AM, Cheung JY. Constitutive overexpression of phosphomimetic... 
POSTINFARCTION MYOCYTES | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | PHOSPHORYLATION | NA+-CA2+ EXCHANGER | DILATED CARDIOMYOPATHY | intracellular Ca2+ and Na+ regulation | FXYD proteins | NA+-K+-ATPASE | ALTERS CONTRACTILITY | in vivo catheterization | RAT CARDIAC MYOCYTES | RABBIT VENTRICULAR MYOCYTES | TRANSIENTS | PERIPHERAL VASCULAR DISEASE | SODIUM-CALCIUM EXCHANGE | beta-adrenergic responsiveness | Potassium - metabolism | Bradycardia - genetics | Action Potentials - genetics | Calcium - metabolism | Myocardial Contraction - physiology | Male | Sodium-Calcium Exchanger - genetics | Sodium - metabolism | Phosphoproteins - metabolism | Arrhythmias, Cardiac - physiopathology | Bradycardia - metabolism | Sodium-Calcium Exchanger - metabolism | Gene Expression - physiology | Female | Membrane Proteins - metabolism | Receptors, Adrenergic, beta - metabolism | Arrhythmias, Cardiac - genetics | Heart Failure - mortality | Arrhythmias, Cardiac - metabolism | Bradycardia - mortality | Myocytes, Cardiac - cytology | Membrane Proteins - genetics | Calcium Channels, L-Type - physiology | Heart Failure - genetics | Mice, Transgenic | Heart Failure - metabolism | Phosphoproteins - genetics | Mice, Inbred Strains | Action Potentials - physiology | Animals | Myocytes, Cardiac - physiology | Mice | Cardiac Excitation and Contraction | β-adrenergic responsiveness
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8. Full Text Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression
by Molly S. Bray and Chad A. Shaw and Michael W. S. Moore and Rodrigo A. P. Garcia and Melissa M. Zanquetta and David J. Durgan and William J. Jeong and Ju-Yun Tsai and Heiko Bugger and Dongfang Zhang and Andreas Rohrwasser and Julie H. Rennison and Jason R. B. Dyck and Sheldon E. Litwin and Paul E. Hardin and Chi-Wing Chow and Margaret P. Chandler and E. Dale Abel and Martin E. Young
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2008, Volume 294, Issue 2, pp. 1036 - 1047
Virtually every mammalian cell, including cardiomyocytes, possesses an intrinsic circadian clock. The role of this transcriptionally based molecular mechanism... 
Epinephrine | Bradycardia | Carbohydrate | Chronobiology | Fatty acids | OXIDATIVE-PHOSPHORYLATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | PROTEIN | fatty acids | RAT | epinephrine | carbohydrate | BLOOD-PRESSURE | SKELETAL-MUSCLE MITOCHONDRIA | OBESITY | chronobiology | RHYTHMS | ATTENUATION | PERIPHERAL VASCULAR DISEASE | HEART-RATE | DYSFUNCTION | bradycardia | Echocardiography | Oligonucleotide Array Sequence Analysis | Myocardial Contraction - physiology | Circadian Rhythm - genetics | Circadian Rhythm - physiology | Reverse Transcriptase Polymerase Chain Reaction | Telemetry | DNA - genetics | Myocardial Contraction - genetics | Animals | Mitochondria, Heart - physiology | Myocytes, Cardiac - physiology | Perfusion | Gene Expression - physiology | Myocardium - metabolism | Muscle Proteins - metabolism | Electrocardiography | Heart Rate - physiology | DNA - biosynthesis | Signal Transduction - physiology | Mice | In Vitro Techniques
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9. Full Text Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea
by Cerritelli, S and Hirschberg, S and Hill, R and Balthasar, N and Pickering, AE
PLOS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, p. e0153187
Opioids are widely used medicinally as analgesics and abused for hedonic effects, actions that are each complicated by substantial risks such as... 
POMC NEURONS | VAGUS NERVE-STIMULATION | RETICULARIS-VENTRALIS | NUCLEUS-TRACTUS-SOLITARIUS | CARDIAC VAGAL NEURONS | MULTIDISCIPLINARY SCIENCES | AFFERENT MODULATION | IN-VIVO | MEDULLA-OBLONGATA | STRESS-INDUCED ANALGESIA | BETA-ENDORPHIN | Brain Stem - metabolism | Channelrhodopsins | Melanocyte-Stimulating Hormones - pharmacology | Arcuate Nucleus of Hypothalamus - cytology | Male | Brain Stem - cytology | Brain Stem - drug effects | Bradycardia - metabolism | Arcuate Nucleus of Hypothalamus - drug effects | Female | Neurons - metabolism | Neurons - drug effects | Solitary Nucleus - metabolism | Solitary Nucleus - cytology | Arcuate Nucleus of Hypothalamus - metabolism | Mice, Transgenic | Solitary Nucleus - drug effects | Pro-Opiomelanocortin - metabolism | Analgesia | Microscopy, Confocal | Animals | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Analgesics, Opioid - metabolism | Respiratory Insufficiency - metabolism | Bradycardia | Chemotherapy | Usage | Opioids | Research | Health aspects | Risk factors | Cancer | Heart | Neurosciences | Peptides | Arrhythmia | Brain stem | Arcuate nucleus | Central nervous system | Position sensing | Solitary tract nucleus | Proopiomelanocortin | Activation | Mental depression | Experiments | Nuclei | Pain | Analgesics | Rodents | Modulation | Physiology | Heart diseases | Pain perception | Narcotics | Opioid receptors | Neurons | Periaqueductal gray area | Melanocortin | Pharmacology | Metabolism | Vectors (Biology) | Latency | Hypotheses | Naloxone | Nucleus ambiguus | Endorphins | In vivo methods and tests | Respiration
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10. Full Text Proposed mechanisms of relative bradycardia
by Ye, Fan and Winchester, David and Stalvey, Carolyn and Jansen, Michael and Lee, Arthur and Khuddus, Matheen and Mazza, Joseph and Yale, Steven
Medical Hypotheses, ISSN 0306-9877, 10/2018, Volume 119, pp. 63 - 67
Relative bradycardia is the term used to describe the mechanism where there is dissociation between pulse and temperature. This finding is important to... 
MEDICINE, RESEARCH & EXPERIMENTAL | INDUCED SYSTEMIC INFLAMMATION | SMOOTH-MUSCLE | CYCLOSPORINE-A | ROSTRAL VENTROLATERAL MEDULLA | HEART-RATE-VARIABILITY | NITRIC-OXIDE SYNTHASE | IN-VIVO | ENDOTOXIN TOLERANCE | SEPTIC SHOCK | SEPSIS | Models, Theoretical | Tumor Necrosis Factor-alpha - metabolism | Heart Rate | Temperature | Cytokines - metabolism | Bradycardia - diagnosis | Comorbidity | Endothelin-1 - metabolism | Humans | Bradycardia - therapy | NADPH Oxidases - metabolism | Neurotransmitter Agents - metabolism | Pulse | Lipopolysaccharides - metabolism | Treatment Outcome | Inflammation | Sepsis - physiopathology | Immune System | Sinoatrial Node | Autonomic Nervous System | Nitric Oxide - metabolism | Interleukin-6 - metabolism | Medical colleges | Medical research | Bradycardia | Heart beat | College graduates | Medicine, Experimental
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11. Full Text Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons
by Kevin J. Cummings and Kathryn G. Commons and Kenneth C. Fan and Aihua Li and Eugene E. Nattie
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 06/2009, Volume 296, Issue 6, pp. 1783 - 1796
The medullary 5-HT system has potent effects on heart rate and breathing in adults. We asked whether this system mitigates the respiratory instability and... 
Chemoreflex | Neonate | SIDS | Breathing | Hering-breuer | PHYSIOLOGY | UNANESTHETIZED RATS | breathing | CO2 | AWAKE RATS | INFANT-DEATH-SYNDROME | neonate | MEDULLARY RAPHE NEURONS | chemoreflex | CO2 RESPONSE | CONSCIOUS RATS | NEWBORN PIGLETS | NUCLEUS AMBIGUUS | CARDIAC VAGAL NEURONS | Hering-Breuer | SEROTONERGIC NEURONS | Adaptation, Physiological | Neurons - pathology | Age Factors | Apnea - metabolism | Humans | Brain Stem - metabolism | Body Weight - drug effects | Reflex - drug effects | Infant | Apnea - physiopathology | Brain Stem - drug effects | Hypoxia - metabolism | Respiratory Mechanics - drug effects | Heart Rate - drug effects | Serotonin Agents - toxicity | Bradycardia - metabolism | Brain Stem - pathology | Neurons - metabolism | Neurons - drug effects | Infant, Newborn | Hypercapnia - metabolism | Animals, Newborn | Asphyxia - physiopathology | Hypercapnia - physiopathology | Respiration Disorders - chemically induced | Pulmonary Ventilation - drug effects | Respiration Disorders - physiopathology | Bradycardia - physiopathology | Rats | 5,7-Dihydroxytryptamine - toxicity | Respiration Disorders - metabolism | Bradycardia - chemically induced | Animals | Asphyxia - metabolism | Oxygen Consumption - drug effects | Serotonin - metabolism | Sudden Infant Death | Hypoxia - physiopathology | Brain Stem - physiopathology | Energy Metabolism - drug effects | Index Medicus | Neurohumoral Control of Cardiovascular Function
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