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Pain, ISSN 0304-3959, 2005, Volume 117, Issue 1, pp. 171 - 181
Protein kinase C (PKC) is able to phosphorylate several cellular components that serve as key regulatory components in signal transduction pathways of... 
Nociception | Protein kinase C | Substance P | Phorbol ester | MAP kinase | Mice | Glutamate | phorbol ester | PRIMARY AFFERENT NEURONS | INFLAMMATORY HYPERALGESIA | nociception | VANILLOID RECEPTOR | NECROSIS-FACTOR-ALPHA | RAT SENSORY NEURONS | mice | NEUROSCIENCES | CLINICAL NEUROLOGY | NERVE GROWTH-FACTOR | IN-VITRO | SCIATIC-NERVE | ANESTHESIOLOGY | substance P | UP-REGULATION | protein kinase C | glutamate | Bradykinin - analogs & derivatives | Analgesics - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Capsaicin - pharmacology | Nociceptors - physiology | Tetradecanoylphorbol Acetate - analogs & derivatives | Male | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Pain - chemically induced | Dose-Response Relationship, Drug | Salicylates - pharmacology | Adrenergic beta-Antagonists - pharmacology | Propranolol - pharmacology | Drug Interactions | Pain - enzymology | Time Factors | Pain - drug therapy | Protein Kinase C - metabolism | Sympatholytics - pharmacology | Behavior, Animal - drug effects | Indoles - pharmacology | Bradykinin - pharmacology | Blotting, Western - methods | Protein Kinase C - physiology | Calcitonin Gene-Related Peptide - pharmacology | Dipeptides - pharmacology | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Chelating Agents - pharmacology | Enzyme Activation - drug effects | Antibodies - pharmacology | Pain Measurement - methods | Animals | Egtazic Acid - pharmacology | Ruthenium Red - pharmacology | Dizocilpine Maleate - pharmacology | Excitatory Amino Acid Antagonists | Guanethidine - pharmacology | Nociceptors - drug effects | Methyl aspartate | Nerve growth factor | Cell research | Protein kinases
Journal Article
Pharmacological Research, ISSN 1043-6618, 12/2014, Volume 90, pp. 25 - 35
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2008, Volume 154, Issue 5, pp. 1094 - 1103
Background and purpose: We investigated the mechanisms underlying the pruritogenic response induced by trypsin in mice, to assess the relevance of neurogenic... 
neuropeptides | Trypsin | PAR‐2 | TRPV1 | mast cells | scratching behaviour | PAR-2 | Neuropeptides | Mast cells | Scratching behaviour | PROTEINASE-ACTIVATED RECEPTOR-2 | NAFAMOSTAT MESILATE | HUMAN SKIN | PRURITUS | HUMAN KERATINOCYTES | ITCH | PAIN | IN-VIVO | HISTAMINE H-4 | PHARMACOLOGY & PHARMACY | trypsin | MAST-CELL TRYPTASE | Receptor, PAR-2 - metabolism | Male | Peptide Fragments - pharmacology | Antipruritics - pharmacology | Receptors, Calcitonin Gene-Related Peptide - metabolism | Quinolines - pharmacology | TRPV Cation Channels - metabolism | Receptor, PAR-2 - antagonists & inhibitors | Cromolyn Sodium - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Neurogenic Inflammation - chemically induced | Bradykinin Receptor Antagonists | Dioxoles - pharmacology | Behavior, Animal - drug effects | Pruritus - chemically induced | Disease Models, Animal | Injections, Intradermal | Pyrazoles - pharmacology | Reproducibility of Results | Plant Proteins - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Calcitonin Gene-Related Peptide - pharmacology | Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors | p-Methoxy-N-methylphenethylamine - pharmacology | Celecoxib | Sulfonamides - pharmacology | Cinnamates - pharmacology | Mast Cells - drug effects | Trypsin - administration & dosage | TRPV Cation Channels - genetics | Mice, Knockout | Neurogenic Inflammation - prevention & control | Pruritus - metabolism | Animals | Receptors, Bradykinin - metabolism | Signal Transduction - drug effects | Nerve Fibers, Unmyelinated - metabolism | Anilides - pharmacology | Cyclooxygenase 2 - metabolism | Neurogenic Inflammation - metabolism | Pruritus - prevention & control | Mice | Oligopeptides - pharmacology | Cell Degranulation - drug effects | Index Medicus | Research Papers
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2014, Volume 171, Issue 11, pp. 2751 - 2766
Background and Purpose Cardiovascular risk is higher in men and postmenopausal women compared with premenopausal women. This may be due to sex differences in... 
porcine coronary artery (PCA) | gap junctions | endothelium‐derived hyperpolarization (EDH) | nitric oxide (NO) | intermediate‐conductance calcium‐activated K+ channel (IKca) | connexin (Cx) | bradykinin | hydrogen peroxide (H2O2) | small‐conductance calcium‐activated K+ channel (SKca) | sex differences | endothelium-derived hyperpolarization (EDH) | small-conductance calcium-activated K+ channel (SKc(a)) | MESENTERIC-ARTERIES | CA2+-ACTIVATED K+ CHANNELS | ACTIVATED POTASSIUM CHANNELS | intermediate-conductance calcium-activated K+ channel (IKca) | HYPERPOLARIZING FACTOR | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | PIG CAROTID-ARTERY | HYDROGEN-PEROXIDE | DEPENDENT RELAXATIONS | GENDER-DIFFERENCES | SMALL-CONDUCTANCE | Catalase - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Coronary Vessels - physiology | Glycyrrhetinic Acid - analogs & derivatives | Hydrogen Peroxide - pharmacology | Male | Sex Characteristics | Apamin - pharmacology | Indomethacin - pharmacology | Vasodilation | Connexins - metabolism | Endothelium, Vascular - physiology | Carbenoxolone - pharmacology | Glycyrrhetinic Acid - pharmacology | Animals | Gap Junctions - physiology | Swine | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Female | Bradykinin - pharmacology | Polyethylene Glycols - pharmacology | Pyrazoles - pharmacology | Postmenopausal women | Hydrogen peroxide | Nitric oxide | Arteries | Endothelium | Research Papers | small-conductance calcium-activated K+ channel (SKca)
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2001, Volume 276, Issue 17, pp. 13750 - 13755
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 04/2004, Volume 141, Issue 7, pp. 1175 - 1184
This study characterises some of the mechanisms and mediators involved in the orofacial nociception triggered by injection of formalin into the upper lip of... 
Formalin | bradykinin | prostaglandins | cytokines | noradrenaline | Prostaglandins | Cytokines | Noradrenaline | Bradykinin | THERMAL HYPERALGESIA | CYCLOOXYGENASE-2 | INFLAMMATORY HYPERALGESIA | NECROSIS-FACTOR-ALPHA | B-2 RECEPTOR | NERVE GROWTH-FACTOR | PAIN | formalin | PHARMACOLOGY & PHARMACY | INHIBITOR | UP-REGULATION | ANALGESIC EFFICACY | Bradykinin - analogs & derivatives | Bradykinin B1 Receptor Antagonists | Captopril - pharmacology | Rats, Wistar | Nociceptors - physiology | Male | Cytokines - physiology | Facial Pain - physiopathology | Cytokines - chemistry | Dose-Response Relationship, Drug | Facial Pain - chemically induced | Tyramine - chemistry | Arachidonic Acids - metabolism | Injections, Subcutaneous | Formaldehyde - administration & dosage | Thiazines - pharmacology | Behavior, Animal - drug effects | Interleukin-8 - pharmacology | Biogenic Amines - physiology | Bradykinin - pharmacology | Atenolol - pharmacology | Pyrazoles - pharmacology | Lip - drug effects | Tyramine - physiology | Rats | Behavior, Animal - physiology | Hindlimb - innervation | Receptor, Bradykinin B2 - physiology | Bradykinin B2 Receptor Antagonists | Celecoxib | Sulfonamides - pharmacology | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Drug Synergism | Bradykinin - physiology | Tumor Necrosis Factor-alpha - pharmacology | Prostaglandins - physiology | Animals | Interleukin-6 - pharmacology | Lip - innervation | Receptor, Bradykinin B1 - physiology | Hindlimb - drug effects | Thiazoles - pharmacology | Guanethidine - pharmacology | Nociceptors - drug effects | Facial Pain - drug therapy | Papers
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2009, Volume 29, Issue 41, pp. 13063 - 13073
Journal Article
Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 10/2017, Volume 79, Issue Pt B, pp. 493 - 498
Journal Article
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 09/2004, Volume 44, Issue 3, pp. 302 - 309
The mechanisms involved in the cardioprotector effect of red wine have not yet been completely elucidated but probably an endothelium-dependent vasodilator... 
Antihypertensive | EDHF | Brazilian red wine | Vasodilation | Endothelium | Flavonoids - antagonists & inhibitors | Male | Nitroglycerin - pharmacology | Yohimbine - pharmacology | Glyburide - pharmacology | Charybdotoxin - pharmacology | Oxadiazoles - pharmacology | Phenols - antagonists & inhibitors | Brazil | Polyphenols | Wine - adverse effects | Muscle, Smooth, Vascular - drug effects | Phenols - pharmacology | Administration, Oral | Rats | Atropine - pharmacology | Pressure | Vasoconstriction - drug effects | Indomethacin - pharmacology | Phenols - analysis | Pyrilamine - pharmacology | Perfusion | Vasodilation - drug effects | Quinazolines - pharmacology | Bradykinin - analogs & derivatives | Norepinephrine - pharmacology | Flavonoids - analysis | Rats, Wistar | Nitric Oxide Synthase - antagonists & inhibitors | Mesenteric Arteries - drug effects | Guanylate Cyclase - antagonists & inhibitors | Apamin - pharmacology | Endothelium, Vascular - physiology | Quinoxalines - pharmacology | Hypertension - chemically induced | Potassium Chloride - pharmacology | Hypertension - prevention & control | Clonidine - pharmacology | Blood Pressure - drug effects | Flavonoids - pharmacology | Vasodilation - physiology | Drug Therapy, Combination | Oxadiazoles - chemistry | Quinazolines - chemistry | Bradykinin - pharmacology | Acetylcholine - pharmacology | NG-Nitroarginine Methyl Ester - adverse effects | Alcohol Drinking - adverse effects | Clonidine - antagonists & inhibitors | Animals | Deoxycholic Acid - pharmacology | Acetylcholine - antagonists & inhibitors
Journal Article
Gut, ISSN 0017-5749, 01/2018, Volume 67, Issue 1, pp. 86 - 96
Journal Article