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Journal of Inherited Metabolic Disease, ISSN 0141-8955, 4/2008, Volume 31, Issue 2, pp. 230 - 239
Creatine deficiency syndromes, either due to AGAT, GAMT or SLC6A8 deficiencies, lead to a complete absence, or a very strong decrease, of creatine within the... 
Biochemistry, general | Human Genetics | Pediatrics | Internal Medicine | Medicine & Public Health | Metabolic Diseases | GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY | LINKED MENTAL-RETARDATION | ARGININE RESTRICTION | ENERGY HOMEOSTASIS | ENDOCRINOLOGY & METABOLISM | GENETICS & HEREDITY | IN-SITU HYBRIDIZATION | MAGNETIC-RESONANCE | CLINICAL CHARACTERISTICS | RAT-BRAIN | TRANSPORTER GENE SLC6A8 | INBORN ERROR | Glycine - analogs & derivatives | Glycine - metabolism | Prognosis | Guanidinoacetate N-Methyltransferase - genetics | Humans | Brain - enzymology | Amidinotransferases - genetics | Developmental Disabilities - genetics | Intellectual Disability - genetics | Membrane Transport Proteins - deficiency | Amino Acid Metabolism, Inborn Errors - genetics | Developmental Disabilities - enzymology | Membrane Transport Proteins - genetics | Movement Disorders - enzymology | Intellectual Disability - enzymology | Creatine - deficiency | Amidinotransferases - deficiency | Genetic Predisposition to Disease | Language Development Disorders - genetics | Speech Disorders - genetics | Language Development Disorders - enzymology | Phenotype | Animals | Guanidinoacetate N-Methyltransferase - deficiency | Movement Disorders - congenital | Speech Disorders - enzymology | Movement Disorders - genetics | Amino Acid Metabolism, Inborn Errors - enzymology | Creatine | Central nervous system
Journal Article
Cellular and molecular life sciences : CMLS, ISSN 1420-9071, 2008, Volume 66, Issue 1, pp. 27 - 42
The glucokinase (GCK) gene was one of the first candidate genes to be identified as a human “diabetes gene". Subsequently, important advances were made in... 
Biochemistry, general | hepatocyte | insulin | Biomedicine general | Cell Biology | Life Sciences | islet of Langerhans | MODY | Life Sciences, general | Glucokinase | diabetes | glucose metabolism | hexokinase | Glucose metabolism | Hepatocyte | Islet of Langerhans | Diabetes | Insulin | Hexokinase | INSULIN-DEPENDENT INDUCTION | HEPATIC GLYCOGEN-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | YOUNG TYPE-2 MODY-2 | BETA-CELL GLUCOKINASE | CELL BIOLOGY | PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA | GENE-EXPRESSION | REGULATORY PROTEIN | LIVER-X-RECEPTOR | GROWTH-FACTOR-I | Hexokinase - physiology | Liver - enzymology | Insulin - physiology | Islets of Langerhans - enzymology | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Type 2 - enzymology | Gene Expression Regulation | Brain - enzymology | Congenital Hyperinsulinism - enzymology | Congenital Hyperinsulinism - genetics | Homeostasis - physiology | Glucose - metabolism | Mitochondrial Membranes - enzymology | Adaptor Proteins, Signal Transducing - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Hexokinase - genetics | Hexokinase - chemistry | Homeostasis - genetics | Anopheles | Isoenzymes | Analysis | Physiological aspects | Glucose | Gene expression | Dextrose | Proteins | Enzymes | Biochemistry | Molecular biology | Review
Journal Article
Current pharmaceutical design, ISSN 1381-6128, 01/2007, Volume 13, Issue 3, pp. 333 - 346
The matrix metalloproteinase family of enzymes has been a pharmaceutical target for over 20 years. In that time, many drugs have been developed but none have... 
Cardiovascular disease | Inflammation | Topical | Acute therapy | Remodeling | SMOKE-INDUCED EMPHYSEMA | cardiovascular disease | remodeling | topical | ABDOMINAL AORTIC-ANEURYSMS | HEART-FAILURE | BLOOD-BRAIN-BARRIER | RESPIRATORY-DISTRESS-SYNDROME | MUSCLE-CELL-MIGRATION | OBSTRUCTIVE PULMONARY-DISEASE | TISSUE-PLASMINOGEN-ACTIVATOR | inflammation | acute therapy | MACROPHAGE ELASTASE MMP-12 | PHARMACOLOGY & PHARMACY | PREVENTS CARDIAC RUPTURE | Hypertrophy, Left Ventricular - enzymology | Humans | Eye Diseases - enzymology | Protease Inhibitors - pharmacology | Atherosclerosis - enzymology | Drug Design | Hypertrophy, Left Ventricular - drug therapy | Protease Inhibitors - therapeutic use | Vascular Diseases - drug therapy | Extracellular Matrix Proteins - metabolism | Myocardial Infarction - enzymology | Atherosclerosis - drug therapy | Heart Rupture, Post-Infarction - enzymology | Neoplasms - enzymology | Skin Diseases - drug therapy | Stroke - drug therapy | Respiratory Distress Syndrome, Adult - drug therapy | Vascular Diseases - enzymology | Arthritis - enzymology | Neoplasms - drug therapy | Pulmonary Disease, Chronic Obstructive - enzymology | Stroke - enzymology | Animals | Myocardial Infarction - drug therapy | Eye Diseases - drug therapy | Arthritis - drug therapy | Matrix Metalloproteinase Inhibitors | Matrix Metalloproteinases - metabolism | Heart Rupture, Post-Infarction - drug therapy | Respiratory Distress Syndrome, Adult - enzymology | Skin Diseases - enzymology | Pulmonary Disease, Chronic Obstructive - drug therapy
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2001, Volume 21, Issue 19, pp. 7691 - 7704
L-Serine is synthesized from glycolytic intermediate 3-phosphoglycerate and is an indispensable precursor for the synthesis of proteins, membrane lipids,... 
Immunohistochemistry | Brain | L-serine | Olfactory ensheathing glia | Mouse | Development | 3-Phosphoglycerate dehydrogenase | Astrocyte | In situ hybridization | development | 3-phosphoglycerate dehydrogenase | RAT | NEURON REGENERATION | GLUCOSE DEPRIVATION | brain | PRIMARY CULTURES | NEUROSCIENCES | mouse | olfactory ensheathing glia | CEREBELLAR CORTEX | CELL-MIGRATION | AMINO-ACIDS | GLUTAMATE | immunohistochemistry | BASIC-PROTEIN | astrocyte | DEVELOPMENTAL EXPRESSION | in situ hybridization | Antibody Specificity | Brain - embryology | Brain - enzymology | Serine - biosynthesis | Dendrites - ultrastructure | Stem Cells - cytology | Astrocytes - enzymology | Olfactory Bulb - embryology | Microscopy, Immunoelectron | RNA, Messenger - biosynthesis | Neuroglia - cytology | In Situ Hybridization | Organelles - ultrastructure | Stem Cells - enzymology | Gene Expression Regulation, Developmental | Organelles - enzymology | Cell Differentiation - physiology | Carbohydrate Dehydrogenases - genetics | Olfactory Bulb - cytology | Olfactory Bulb - enzymology | Astrocytes - cytology | Brain - cytology | Mice, Inbred C57BL | Neuroglia - enzymology | Synapses - enzymology | Synapses - ultrastructure | Phosphoglycerate Dehydrogenase | Cell Lineage - physiology | Animals | Dendrites - enzymology | Mice | Aging - metabolism | Carbohydrate Dehydrogenases - metabolism
Journal Article
American journal of human genetics, ISSN 0002-9297, 02/2012, Volume 90, Issue 2, pp. 282 - 289
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 9/2006, Volume 103, Issue 39, pp. 14602 - 14607
Allopregnanolone (ALLO) and tetrahydrodeoxycorticosterone (THDOC) are potent positive allosteric modulators of GABA action at receptors. ALLO and THDOC are... 
Brain | Enzymes | Receptors | Messenger RNA | Neurons | Purkinje cells | Pyramidal cells | Neuroglia | Antibodies | Hippocampus | Glutamatergic neurons | 5α-reductase (type I) | GABAergic neurons | 3α-hydroxysteroid dehydrogenase | GABA(A) RECEPTOR FUNCTION | ALLOPREGNANOLONE SYNTHESIS | SOCIAL-ISOLATION | REELIN MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | IN-SITU HYBRIDIZATION | STEROID 5-ALPHA-REDUCTASE | glutamatergic neurons | 3 alpha-hydroxysteroid dehydrogenase | NEUROACTIVE STEROIDS | 5 alpha-reductase (type I) | GAMMA-AMINOBUTYRIC-ACID | RAT-BRAIN | 3-ALPHA-HYDROXYSTEROID DIHYDRODIOL DEHYDROGENASE | Brain - enzymology | Male | Neurons - cytology | Cerebellum - enzymology | RNA, Messenger - metabolism | Cerebral Cortex - cytology | Corpus Striatum - cytology | 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) - genetics | Amygdala - enzymology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Hippocampus - enzymology | Corpus Striatum - enzymology | Olfactory Bulb - cytology | Olfactory Bulb - enzymology | Cerebral Cortex - enzymology | RNA, Messenger - genetics | Thalamus - enzymology | Rats | Amygdala - cytology | Hippocampus - cytology | Desoxycorticosterone - analogs & derivatives | Desoxycorticosterone - biosynthesis | Gene Expression Regulation, Enzymologic | Membrane Proteins | Animals | Pregnanolone - biosynthesis | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) - metabolism | Neurons - enzymology | Cerebellum - cytology | Thalamus - cytology | Mice | GABA | Research | Progesterone | Oxidoreductases | Structure | Steroids | Biological Sciences
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 502, Issue 7471, pp. 372 - 376
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is an enzyme with important regulatory functions in the heart and brain, and its chronic activation can be... 
N-ACETYLGLUCOSAMINE | MYOCYTES | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | CARDIAC-HYPERTROPHY | RECEPTOR | CYTOSOLIC PROTEINS | CARDIOMYOCYTES | MELLITUS | CA2+/CALMODULIN-DEPENDENT PROTEIN-KINASE | INSIGHT | Calcium - metabolism | Humans | Brain - enzymology | Hyperglycemia - complications | Glycosylation - drug effects | Acetylglucosamine - metabolism | Myocytes, Cardiac - enzymology | Diazooxonorleucine - pharmacology | Sarcoplasmic Reticulum - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Arrhythmias, Cardiac - metabolism | Diabetes Complications - metabolism | Rats | Glucose - pharmacology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Myocardium - cytology | Brain - drug effects | Hyperglycemia - metabolism | Myocardium - enzymology | Animals | Arrhythmias, Cardiac - enzymology | Glucose - metabolism | Hyperglycemia - enzymology | Myocytes, Cardiac - metabolism | Arrhythmias, Cardiac - complications | Diabetes Complications - enzymology | Mice | Benzylamines - pharmacology | Enzymes | Medical research | Arrhythmia | Protein biosynthesis | Glycosylation | Research | Risk factors | Complications and side effects | Hyperglycemia | Physiological aspects | Medicine, Experimental | Regulation | Protein kinases | Proteins | Brain | Phosphorylation | Rodents | Cardiomyocytes | Diabetes | Kinases
Journal Article
Journal Article