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1. Full Text Liver X receptors in lipid metabolism: Opportunities for drug discovery
by Hong, Cynthia and Tontonoz, Peter
Nature reviews. Drug discovery, ISSN 1474-1776, 2014, Volume 13, Issue 6, pp. 433 - 444
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Intestines - drug effects | Intestinal Mucosa - metabolism | Drugs, Investigational - pharmacology | Humans | Drugs, Investigational - therapeutic use | Orphan Nuclear Receptors - metabolism | Brain - metabolism | Drugs, Investigational - chemistry | Protein Isoforms - metabolism | Liver - drug effects | Alzheimer Disease - prevention & control | Liver X Receptors | Drug Design | Neurons - metabolism | Hypolipidemic Agents - chemistry | Drug Evaluation, Preclinical | Neurons - drug effects | Hypolipidemic Agents - adverse effects | Nerve Tissue Proteins - antagonists & inhibitors | Molecular Targeted Therapy - adverse effects | Atherosclerosis - drug therapy | Liver - metabolism | Alzheimer Disease - drug therapy | Nootropic Agents - therapeutic use | Clinical Trials as Topic | Hypolipidemic Agents - pharmacology | Nootropic Agents - adverse effects | Nootropic Agents - chemistry | Drug Discovery | Atherosclerosis - metabolism | Brain - drug effects | Nerve Tissue Proteins - metabolism | Orphan Nuclear Receptors - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Alzheimer Disease - metabolism | Lipid Metabolism - drug effects | Hypolipidemic Agents - therapeutic use | Atherosclerosis - prevention & control | Nootropic Agents - pharmacology | Protein Isoforms - antagonists & inhibitors | Care and treatment | Research | Drug discovery | Patient outcomes | Risk factors | Atherosclerosis | Index Medicus
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2. Full Text The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells
by Fares, Mohamed-Bilal and Ait-Bouziad, Nadine and Dikiy, Igor and Mbefo, Martial K and Jovičić, Ana and Kiely, Aoife and Holton, Janice L and Lee, Seung-Jae and Gitler, Aaron D and Eliezer, David and Lashuel, Hilal A
Human molecular genetics, ISSN 0964-6906, 2014, Volume 23, Issue 17, pp. 4491 - 4509
Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Neurons - pathology | Humans | alpha-Synuclein - ultrastructure | Saccharomyces cerevisiae - drug effects | Protein Transport - drug effects | Brain - metabolism | Saccharomyces cerevisiae - metabolism | Cell Nucleus - metabolism | Protein Binding - drug effects | Sodium Dodecyl Sulfate - pharmacology | Cell Membrane - metabolism | Neurons - metabolism | alpha-Synuclein - genetics | Phosphorylation - drug effects | Buffers | Inclusion Bodies - metabolism | Neurons - drug effects | Protein Aggregation, Pathological - genetics | Cell Membrane - drug effects | Neuroblastoma - pathology | Protein Aggregates - drug effects | Cell Line | Parkinson Disease - pathology | Protein Structure, Secondary | Subcellular Fractions - drug effects | Cells, Cultured | Inclusion Bodies - drug effects | Mitochondria - metabolism | alpha-Synuclein - secretion | Mitochondria - drug effects | Parkinson Disease - genetics | Mutation - genetics | Subcellular Fractions - metabolism | alpha-Synuclein - chemistry | Brain - drug effects | Unilamellar Liposomes - metabolism | Nuclear Envelope - metabolism | Nuclear Envelope - drug effects | Cell Differentiation - drug effects | Brain - pathology | Cell Nucleus - drug effects | Index Medicus
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3. Full Text Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid‑β Aggregation and To Exert Anticholinesterase and Antioxidant Effects
by Nepovimova, Eugenie and Uliassi, Elisa and Korabecny, Jan and Peña-Altamira, Luis Emiliano and Samez, Sarah and Pesaresi, Alessandro and Garcia, Gregory E and Bartolini, Manuela and Andrisano, Vincenza and Bergamini, Christian and Fato, Romana and Lamba, Doriano and Roberti, Marinella and Kuca, Kamil and Monti, Barbara and Bolognesi, Maria Laura
Journal of medicinal chemistry, ISSN 0022-2623, 10/2014, Volume 57, Issue 20, pp. 8576 - 8589
Drug Evaluation, Preclinical - methods | Chemistry Techniques, Synthetic | Quinones - chemistry | Antioxidants - chemistry | Rats, Wistar | Humans | Cholinesterase Inhibitors - chemistry | Models, Molecular | Crystallography, X-Ray | Acetylcholinesterase - chemistry | Antioxidants - pharmacology | Molecular Targeted Therapy | Blood-Brain Barrier - drug effects | Hep G2 Cells - drug effects | Animals | Cholinesterase Inhibitors - pharmacology | Amyloid beta-Peptides - metabolism | Drug Design | Inhibitory Concentration 50 | Oxidative Stress - drug effects | Neurons - drug effects | Acetylcholinesterase - metabolism | Tacrine - chemistry | Index Medicus
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4. Full Text Effects of Particle Size and Surface Modification on Cellular Uptake and Biodistribution of Polymeric Nanoparticles for Drug Delivery
by Kulkarni, Sneha A and Feng, Si-Shen
Pharmaceutical research, ISSN 0724-8741, 10/2013, Volume 30, Issue 10, pp. 2512 - 2522
Biochemistry, general | Biomedical Engineering | biodegradable polymers: blood–brain barrier (BBB) | pharmaceutical nanotechnology | Biomedicine | Pharmacy | Medical Law | chemotherapeutic engineering | Pharmacology/Toxicology | gastrointestinal barrier (GI barrier) | biodegradable polymers: blood-brain barrier (BBB) | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Nanoparticles - chemistry | Humans | Vitamin E - analogs & derivatives | Male | Polyethylene Glycols - chemistry | Chromatography, High Pressure Liquid | Drug Carriers - chemistry | Polystyrenes - chemistry | Tissue Distribution | Surface Properties | Madin Darby Canine Kidney Cells | Vitamin E - chemistry | Caco-2 Cells | Fluorescent Dyes - chemistry | Vitamin E - pharmacokinetics | Administration, Oral | Polyethylene Glycols - pharmacokinetics | Rats | Rats, Sprague-Dawley | Gastrointestinal Tract - metabolism | Blood-Brain Barrier - metabolism | Endocytosis - physiology | Particle Size | Animals | Dogs | Drug Carriers - pharmacokinetics | Polystyrenes - pharmacokinetics | Drug Delivery Systems - methods | Drugs | Drug delivery systems | Vehicles | Biodegradable materials | Chemotherapy | Blood-brain barrier | Nanotechnology | Index Medicus
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5. Full Text Cyclic RGD conjugated poly(ethylene glycol)- co-poly(lactic acid) micelle enhances paclitaxel anti-glioblastoma effect
by Zhan, Changyou and Gu, Bing and Xie, Cao and Li, Jin and Liu, Yu and Lu, Weiyue
Journal of controlled release, ISSN 0168-3659, 2010, Volume 143, Issue 1, pp. 136 - 142
c(RGDyK) | PEG-PLA micelle | Glioblastoma | Paclitaxel | C(RGDyK) | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Injections, Intravenous | Humans | Brain Neoplasms - pathology | Biological Availability | Polyethylene Glycols - chemistry | Paclitaxel - pharmacokinetics | Brain Neoplasms - metabolism | Integrin alphaVbeta3 - metabolism | Peptides, Cyclic - chemistry | Peptides, Cyclic - metabolism | Drug Carriers | Dose-Response Relationship, Drug | Paclitaxel - chemistry | Antineoplastic Agents, Phytogenic - administration & dosage | Micelles | Drug Compounding | Inhibitory Concentration 50 | Glioblastoma - metabolism | Paclitaxel - administration & dosage | Antineoplastic Agents, Phytogenic - pharmacokinetics | Lactates - chemistry | Cell Survival - drug effects | Antineoplastic Agents, Phytogenic - chemistry | Technology, Pharmaceutical - methods | Brain Neoplasms - drug therapy | Chemistry, Pharmaceutical | Particle Size | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Mice, Nude | Glioblastoma - pathology | Cell Line, Tumor | Mice | Glioblastoma - drug therapy | Drugs | Ethylene glycol | Polyethylene | Cell research | Drug delivery systems | Peptides | Gliomas | Analysis | Lactic acid | Integrins | Vehicles | Index Medicus
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6. Full Text Exosomes as drug delivery vehicles for Parkinson's disease therapy
by Haney, Matthew J and Klyachko, Natalia L and Zhao, Yuling and Gupta, Richa and Plotnikova, Evgeniya G and He, Zhijian and Patel, Tejash and Piroyan, Aleksandr and Sokolsky, Marina and Kabanov, Alexander V and Batrakova, Elena V
Journal of controlled release, ISSN 0168-3659, 06/2015, Volume 207, pp. 18 - 30
Oxidative stress | Neuroinflammation | Parkinson's disease | Catalase | Exosomes | Blood–brain barrier | Blood-brain barrier | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Antioxidants - chemistry | Antioxidants - metabolism | Oxidopamine | Anti-Inflammatory Agents - metabolism | PC12 Cells | Neuroprotective Agents - metabolism | Drug Carriers | Brain - metabolism | Nanoparticles | Parkinsonian Disorders - metabolism | Parkinsonian Disorders - drug therapy | Antiparkinson Agents - chemistry | Anti-Inflammatory Agents - administration & dosage | Female | Neurons - metabolism | Neuroprotective Agents - administration & dosage | Nanomedicine | Disease Models, Animal | Neuroprotective Agents - chemistry | Mice, Inbred C57BL | Solubility | Rats | Technology, Pharmaceutical - methods | Parkinsonian Disorders - chemically induced | Administration, Intranasal | Chemistry, Pharmaceutical | Brain - drug effects | Catalase - metabolism | Catalase - administration & dosage | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - administration & dosage | RAW 264.7 Cells | Antiparkinson Agents - administration & dosage | Mice | Kinetics | Oxidative Stress - drug effects | Antiparkinson Agents - metabolism | Catalase - chemistry | Drugs | Drug delivery systems | Proteases | Analysis | Antiparkinsonian agents | Vehicles | Index Medicus | blood-brain barrier | neuroinflammation | exosomes | catalase | oxidative stress | Parkinson’s disease
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7. Full Text The endocannabinoid system and the brain
by Mechoulam, Raphael and Parker, Linda A
Annual review of psychology, ISSN 0066-4308, 2013, Volume 64, Issue 1, pp. 21 - 47
cannabidiol | reward | anxiety | memory | cognition | neurogenesis | δ9-tetrahydrocannabinol (THC) | depression | cannabinoid receptors | 2-arachidonoyl glycerol (2-AG) | anandamide | Drug addiction | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Psychopathology. Psychiatry | Addictive behaviors | Biological and medical sciences | Medical sciences | Memory - drug effects | Endocannabinoids - pharmacology | Learning - drug effects | Humans | Cannabinoids - chemistry | Depressive Disorder - drug therapy | Cognition - drug effects | Cannabinoids - pharmacology | Brain - drug effects | Dose-Response Relationship, Drug | Receptors, Cannabinoid - drug effects | Cannabis - chemistry | Animals | Neurogenesis - drug effects | Anxiety Disorders - drug therapy | Dronabinol - chemistry | Reward | Dronabinol - pharmacology | Psychological aspects | Nerves, Peripheral | Cannabinoids | Research | Drug receptors | Psychotropic drugs | Brain | Nervous system | Mental depression | Cognition & reasoning | Drug dosages | Index Medicus
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