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1. Full Text Potential therapeutic uses of BDNF in neurological and psychiatric disorders
by Nagahara, Alan H and Tuszynski, Mark H
Nature Reviews Drug Discovery, ISSN 1474-1776, 03/2011, Volume 10, Issue 3, pp. 209 - 219
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TRKB) are actively produced and... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ALZHEIMERS-DISEASE | NEUROTROPHIC FACTOR BDNF | PHARMACOLOGY & PHARMACY | SPINAL-CORD-INJURY | DOPAMINERGIC-NEURONS | DIETARY RESTRICTION | VAL66MET POLYMORPHISM | FACTOR GENE-THERAPY | HUNTINGTONS-DISEASE | NERVE GROWTH-FACTOR | PARKINSONS-DISEASE | Brain-Derived Neurotrophic Factor - genetics | Genetic Therapy | Epigenomics | Spinal Cord Injuries - drug therapy | Humans | Nervous System Diseases - drug therapy | Alzheimer Disease - drug therapy | Metabolic Diseases - drug therapy | Parkinson Disease - drug therapy | Stroke - drug therapy | Amyotrophic Lateral Sclerosis - drug therapy | Brain-Derived Neurotrophic Factor - administration & dosage | Animals | Brain-Derived Neurotrophic Factor - physiology | Mental Disorders - drug therapy | Cognition - physiology | Adult | Brain-Derived Neurotrophic Factor - therapeutic use | Huntington Disease - drug therapy | Physiological aspects | Care and treatment | Cell receptors | Brain-derived neurotrophic factor | Research | Mental illness
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2. Full Text Polypharmacology: Challenges and opportunities in drug discovery
by Anighoro, Andrew and Bajorath, Jürgen and Rastelli, Giulio
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2014, Volume 57, Issue 19, pp. 7874 - 7887
At present , the legendary magic bullet, ie, a drug with high potency and selectivity toward a specific biological target, shares the spotlight with an... 
ANTI-TARGETS | HSP90 | CHEMISTRY, MEDICINAL | PROMISCUITY | PHARMACOLOGY | COMBINATION THERAPIES | KINASE INHIBITORS | PARP INHIBITORS | SYSTEMATIC IDENTIFICATION | CANCER | PREDICTION | Brain Diseases - drug therapy | Humans | Drug Design | Structure-Activity Relationship | Drug Repositioning | Polypharmacology | Drug Therapy, Combination | Neoplasms - drug therapy
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3. Progress in neurotherapeutics and neuropsychopharmacology
by Cummings, Jeffrey L., 1948
Progress in neurotherapeutics and neuropsychopharmacology, ISSN 1748-2321, 2006
Central Nervous System | drug therapy | Mental Disorders | Neuropsychopharmacology | Nervous system | Brain Diseases | drug effects | Neuropharmacology | Clinical Trials | Diseases
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4. Full Text PLGA-based nanoparticles: An overview of biomedical applications
by Danhier, Fabienne and Ansorena, Eduardo and Silva, Joana M and Coco, Régis and Le Breton, Aude and Préat, Véronique
Journal of Controlled Release, ISSN 0168-3659, 07/2012, Volume 161, Issue 2, pp. 505 - 522
Poly(lactic-co-glycolic acid) (PLGA) is one of the most successfully developed biodegradable polymers. Among the different polymers developed to formulate... 
Nanoparticles | Drug delivery | Targeting | Poly(lactic-co-glycolic acid) | HUMAN DENDRITIC CELLS | GENE DELIVERY | DRUG-DELIVERY | NEUROTROPHIC FACTOR | SPINAL-CORD | SEQUENTIAL BMP-2/BMP-7 DELIVERY | BIODEGRADABLE NANOPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | Bacterial Infections - drug therapy | Cardiovascular Diseases - drug therapy | Humans | Polyglycolic Acid - therapeutic use | Drug Delivery Systems | Neoplasms - drug therapy | Brain Diseases - drug therapy | Animals | Vaccination - methods | Inflammation - drug therapy | Nanoparticles - therapeutic use | Nanomedicine - methods | Lactic Acid - therapeutic use | Drugs | Care and treatment | Drug delivery systems | Vehicles | Cancer | Biomedical engineering | Biodegradability | Macromolecules | Vaccination | Inflammation | Hydrophobicity | Drug development | Cancer vaccines | Reviews | nanoparticles | Surface properties | Biocompatibility | polylactide-co-glycolide | Controlled release
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5. Full Text Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases
by Saraiva, Cláudia and Praça, Catarina and Ferreira, Raquel and Ferreira, Lino and Santos, Tiago and Bernardino, Liliana
Journal of Controlled Release, ISSN 0168-3659, 08/2016, Volume 235, pp. 34 - 47
The blood–brain barrier (BBB) is a vital boundary between neural tissue and circulating blood. The BBB's unique and protective features control brain... 
Nanoparticles | Brain repair | Stroke | Parkinson's disease | Alzheimer's disease | Blood–brain barrier | Blood-brain barrier | P-GLYCOPROTEIN FUNCTION | GOLD NANOPARTICLES | ALZHEIMERS-DISEASE | LACTOFERRIN-MODIFIED NANOPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | TANSHINONE IIA NANOPARTICLES | NEURAL STEM-CELLS | POLY(BUTYL CYANOACRYLATE) NANOPARTICLES | IN-VITRO MODEL | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | PARKINSONS-DISEASE | Brain - metabolism | Animals | Biological Transport | Nanoparticles - therapeutic use | Humans | Nanoparticles - administration & dosage | Neurodegenerative Diseases - metabolism | Neurodegenerative Diseases - drug therapy | Drug Delivery Systems | Drugs | Drug delivery systems | Nervous system diseases | Vehicles
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6. Full Text Pharmacological modulation of autophagy: Therapeutic potential and persisting obstacles
by Galluzzi, Lorenzo and Bravo-San Pedro, José Manuel and Levine, Beth and Green, Douglas R and Kroemer, Guido
Nature Reviews Drug Discovery, ISSN 1474-1776, 07/2017, Volume 16, Issue 7, pp. 487 - 511
Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have... 
LIFE-SPAN EXTENSION | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATED PROTEIN-KINASE | BECLIN 1-DEPENDENT AUTOPHAGY | TRAUMATIC BRAIN-INJURY | ATTENUATES RENAL HYPERTROPHY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | FOCAL CEREBRAL-ISCHEMIA | PHARMACOLOGY & PHARMACY | AMYOTROPHIC-LATERAL-SCLEROSIS | INDUCED PULMONARY-HYPERTENSION | MPTP-INDUCED PARKINSONISM | Animals | Neurodegenerative Diseases - physiopathology | Heart Diseases - physiopathology | Humans | Drug Design | Heart Diseases - drug therapy | Molecular Targeted Therapy | Neoplasms - pathology | Neurodegenerative Diseases - drug therapy | Autophagy - drug effects | Neoplasms - drug therapy | Autophagy (Cytology) | Obstacles (Military science) | Research | Analysis | Autophagy
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