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Psychiatric genetics, ISSN 0955-8829, 1990
Journal
Seminars in immunopathology, ISSN 1863-2300, 2011, Volume 34, Issue 1, pp. 43 - 62
The interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles in the acute hemostatic cascade... 
Autoimmunity | Complement receptor 3 | Multiple sclerosis | Stroke | Alzheimer’s disease | Internal Medicine | Macrophages | Blood brain barrier | Inflammatory disease | Microglia | Biomedicine | Immunology | Rheumatoid arthritis | CD11b/CD18 | Atherosclerosis | Plasminogen | Anticoagulant therapy | Alzheimer's disease | ALZHEIMERS-DISEASE | IMMUNOLOGY | PATHOLOGY | GAMMA-C-DOMAIN | BINDING-SITE | CENTRAL-NERVOUS-SYSTEM | MULTIPLE-SCLEROSIS LESIONS | CRYSTAL-STRUCTURE | BLOOD-BRAIN-BARRIER | INTEGRIN ALPHA(M)BETA | PROTEASE-ACTIVATED RECEPTORS | PERIPHERAL ARTERIAL-DISEASE | Colitis - genetics | Humans | Brain Injuries - metabolism | Arthritis, Rheumatoid - metabolism | Bacterial Infections - genetics | Inflammation - metabolism | Blood Coagulation - immunology | Muscular Dystrophy, Duchenne - immunology | Alzheimer Disease - immunology | Fibrinogen - immunology | Thromboplastin - immunology | Pulmonary Fibrosis - immunology | Vascular Diseases - genetics | Brain Injuries - genetics | Thrombin - genetics | Kidney Diseases - immunology | Arthritis, Rheumatoid - genetics | Neoplasms - immunology | Colitis - metabolism | Muscular Dystrophy, Duchenne - genetics | Bacterial Infections - metabolism | Neoplasms - metabolism | Pulmonary Fibrosis - genetics | Spinal Cord Injuries - genetics | Kidney Diseases - genetics | Stroke - genetics | Brain Injuries - immunology | Neoplasms - genetics | Bacterial Infections - immunology | Pulmonary Fibrosis - metabolism | Colitis - immunology | Thrombin - immunology | Stroke - immunology | Kidney Diseases - metabolism | Multiple Sclerosis - metabolism | Vascular Diseases - immunology | Spinal Cord Injuries - metabolism | Multiple Sclerosis - genetics | Inflammation - immunology | Fibrinogen - genetics | Stroke - metabolism | Animals | Thromboplastin - genetics | Alzheimer Disease - metabolism | Fibrinogen - metabolism | Inflammation - genetics | Multiple Sclerosis - immunology | Blood Coagulation - genetics | Spinal Cord Injuries - immunology | Muscular Dystrophy, Duchenne - metabolism | Thrombin - metabolism | Thromboplastin - metabolism | Alzheimer Disease - genetics | Arthritis, Rheumatoid - immunology | Vascular Diseases - metabolism | Nervous system diseases | Bacterial infections | Oncology, Experimental | Thrombin | Inflammation | Anticoagulants (Medicine) | Research | Rheumatoid factor | Fibrin | Fibrinogen | Genetic research | Colitis | Cancer | Traumatic brain injury | Coagulation | Tissue factor | hemostasis | Spinal cord injury | Inflammatory diseases | Kidney | Signal transduction | Duchenne's muscular dystrophy | Neurodegenerative diseases | Therapeutic applications | Thrombosis | Coagulation factors | Infection | Molecular modelling | Fibrosis | Brain injury
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 11, p. e50976
Journal Article
Scientific reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, pp. 7519 - 12
.... Furthermore, we employ the context-specific network for the analysis of drug effects with a proximity measure between drug targets and diseases... 
SYSTEM | DATABASE | RENIN | GENE | PATHWAY | MULTIDISCIPLINARY SCIENCES | TISSUE | KEGG | NEBIVOLOL | HYPERTENSION | BLOOD-PRESSURE | Hematologic Diseases - pathology | Liver - pathology | Metabolic Diseases - pathology | Respiratory Tract Diseases - metabolism | Kidney - pathology | Skin - metabolism | Hematologic Diseases - metabolism | Humans | Muscle, Skeletal - metabolism | Respiratory Tract Diseases - drug therapy | Respiratory Tract Diseases - genetics | Brain - metabolism | Musculoskeletal Diseases - pathology | Kidney - metabolism | Liver - drug effects | Muscle, Skeletal - drug effects | Myocardium - metabolism | Nervous System Diseases - metabolism | Nutrition Disorders - pathology | Computational Biology - methods | Kidney - drug effects | Liver - metabolism | Nervous System Diseases - drug therapy | Connective Tissue Diseases - metabolism | Neoplasms - drug therapy | Brain - drug effects | Connective Tissue Diseases - drug therapy | Connective Tissue Diseases - pathology | Lung - drug effects | Brain - pathology | Hematologic Diseases - genetics | Prescription Drugs - pharmacokinetics | Digestive System Diseases - pathology | Neoplasms - metabolism | Cardiovascular Diseases - drug therapy | Drugs, Investigational - pharmacokinetics | Respiratory Tract Diseases - pathology | Hematologic Diseases - drug therapy | Metabolic Diseases - drug therapy | Cardiovascular Diseases - pathology | Nervous System Diseases - genetics | Cardiovascular Diseases - genetics | Musculoskeletal Diseases - genetics | Neoplasms - genetics | Lung - metabolism | Skin - pathology | Nervous System Diseases - pathology | Lung - pathology | Musculoskeletal Diseases - drug therapy | Cardiovascular Diseases - metabolism | Musculoskeletal Diseases - metabolism | Nutrition Disorders - drug therapy | Nutrition Disorders - genetics | Myocardium - pathology | Organ Specificity | Digestive System Diseases - genetics | Algorithms | Digestive System Diseases - drug therapy | Nutrition Disorders - metabolism | Metabolic Diseases - metabolism | Digestive System Diseases - metabolism | Metabolic Diseases - genetics | Connective Tissue Diseases - genetics | Muscle, Skeletal - pathology | Neoplasms - pathology | Skin - drug effects | Drug development
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2018, Volume 115, Issue 28, pp. E6640 - E6649
Endosomes have emerged as a central hub and pathogenic driver of Alzheimer’s disease (AD). The earliest brain cytopathology in neurodegeneration, occurring... 
Histone deacetylase | Trichostatin A | Amyloid beta | ApoE4 | exchanger | Na+/H+ exchanger | CHRISTIANSON SYNDROME | HUMAN BRAIN | trichostatin A | MULTIDISCIPLINARY SCIENCES | SPORADIC ALZHEIMERS-DISEASE | histone deacetylase | SYNAPTIC PLASTICITY | amyloid beta | APOLIPOPROTEIN-E | LYSOSOMAL DYSFUNCTION | DOWN-SYNDROME | A-BETA | GENE-EXPRESSION | PRECURSOR PROTEIN | Microcephaly - genetics | Epigenesis, Genetic | Humans | Astrocytes - pathology | Epilepsy - metabolism | Endosomes - metabolism | Alzheimer Disease - pathology | Intellectual Disability - metabolism | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Ataxia - drug therapy | Genetic Diseases, X-Linked - genetics | Ataxia - genetics | Ataxia - metabolism | Microcephaly - drug therapy | Ataxia - pathology | Ocular Motility Disorders - pathology | Tumor Suppressor Proteins - metabolism | Apolipoprotein E4 - metabolism | Endosomes - genetics | Histone Deacetylases - genetics | Ocular Motility Disorders - metabolism | Intellectual Disability - pathology | Alzheimer Disease - drug therapy | Receptors, LDL - metabolism | Mice, Knockout | Genetic Diseases, X-Linked - pathology | Epilepsy - drug therapy | Histone Deacetylase Inhibitors - pharmacology | Mice | Astrocytes - metabolism | Hydrogen-Ion Concentration | Apolipoprotein E4 - genetics | Ocular Motility Disorders - genetics | Intellectual Disability - genetics | Sodium-Hydrogen Exchangers - metabolism | Genetic Diseases, X-Linked - drug therapy | Microcephaly - pathology | Tumor Suppressor Proteins - genetics | Epilepsy - genetics | Sodium-Hydrogen Exchangers - genetics | Receptors, LDL - genetics | Microcephaly - metabolism | Histone Deacetylases - metabolism | Endosomes - pathology | Genetic Diseases, X-Linked - metabolism | Intellectual Disability - drug therapy | Ocular Motility Disorders - drug therapy | Animals | Alzheimer Disease - metabolism | Alzheimer Disease - genetics | Epilepsy - pathology | Physiological aspects | Epigenetic inheritance | Glycoproteins | Genetic aspects | Observations | Astrocytes | Biological Sciences | PNAS Plus | H+ exchanger | Na+
Journal Article
by Jones, Lesley and Holmans, Peter A and Hamshere, Marian L and Harold, Denise and Moskvina, Valentina and Ivanov, Dobril and Pocklington, Andrew and Abraham, Richard and Hollingworth, Paul and Sims, Rebecca and Gerrish, Amy and Pahwa, Jaspreet Singh and Jones, Nicola and Stretton, Alexandra and Morgan, Angharad R and Lovestone, Simon and Powell, John and Proitsi, Petroula and Lupton, Michelle K and Brayne, Carol and Rubinsztein, David C and Gill, Michael and Lawlor, Brian and Lynch, Aoibhinn and Morgan, Kevin and Brown, Kristelle S and Passmore, Peter A and Craig, David and McGuinness, Bernadette and Todd, Stephen and Holmes, Clive and Mann, David and Smith, A. David and Love, Seth and Kehoe, Patrick G and Mead, Simon and Fox, Nick and Rossor, Martin and Collinge, John and Maier, Wolfgang and Jessen, Frank and Schürmann, Britta and van den Bussche, Hendrik and Heuser, Isabella and Peters, Oliver and Kornhuber, Johannes and Wiltfang, Jens and Dichgans, Martin and Frölich, Lutz and Hampel, Harald and Hüll, Michael and Rujescu, Dan and Goate, Alison M and Kauwe, John S. K and Cruchaga, Carlos and Nowotny, Petra and Morris, John C and Mayo, Kevin and Livingston, Gill and Bass, Nicholas J and Gurling, Hugh and McQuillin, Andrew and Gwilliam, Rhian and Deloukas, Panos and Al-Chalabi, Ammar and Shaw, Christopher E and Singleton, Andrew B and Guerreiro, Rita and Mühleisen, Thomas W and Nöthen, Markus M and Moebus, Susanne and Jöckel, Karl-Heinz and Klopp, Norman and Wichmann, H.-Erich and Rüther, Eckhard and Carrasquillo, Minerva M and Pankratz, V. Shane and Younkin, Steven G and Hardy, John and O'Donovan, Michael C and Owen, Michael J and Williams, Julie
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e13950
Journal Article
Stroke, ISSN 0039-2499, 01/2014, Volume 45, Issue 1, pp. 24 - 36
Journal Article