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Current Pharmaceutical Design, ISSN 1381-6128, 01/2007, Volume 13, Issue 3, pp. 333 - 346
The matrix metalloproteinase family of enzymes has been a pharmaceutical target for over 20 years. In that time, many drugs have been developed but none have... 
Cardiovascular disease | Inflammation | Topical | Acute therapy | Remodeling | SMOKE-INDUCED EMPHYSEMA | cardiovascular disease | remodeling | topical | ABDOMINAL AORTIC-ANEURYSMS | FOCAL CEREBRAL-ISCHEMIA | BLOOD-BRAIN-BARRIER | RESPIRATORY-DISTRESS-SYNDROME | MUSCLE-CELL-MIGRATION | OBSTRUCTIVE PULMONARY-DISEASE | TISSUE-PLASMINOGEN-ACTIVATOR | inflammation | acute therapy | MACROPHAGE ELASTASE MMP-12 | PHARMACOLOGY & PHARMACY | PREVENTS CARDIAC RUPTURE | Hypertrophy, Left Ventricular - enzymology | Humans | Eye Diseases - enzymology | Protease Inhibitors - pharmacology | Atherosclerosis - enzymology | Drug Design | Hypertrophy, Left Ventricular - drug therapy | Protease Inhibitors - therapeutic use | Vascular Diseases - drug therapy | Extracellular Matrix Proteins - metabolism | Myocardial Infarction - enzymology | Atherosclerosis - drug therapy | Heart Rupture, Post-Infarction - enzymology | Neoplasms - enzymology | Skin Diseases - drug therapy | Stroke - drug therapy | Respiratory Distress Syndrome, Adult - drug therapy | Vascular Diseases - enzymology | Arthritis - enzymology | Neoplasms - drug therapy | Pulmonary Disease, Chronic Obstructive - enzymology | Stroke - enzymology | Animals | Myocardial Infarction - drug therapy | Eye Diseases - drug therapy | Arthritis - drug therapy | Matrix Metalloproteinase Inhibitors | Matrix Metalloproteinases - metabolism | Heart Rupture, Post-Infarction - drug therapy | Respiratory Distress Syndrome, Adult - enzymology | Skin Diseases - enzymology | Pulmonary Disease, Chronic Obstructive - drug therapy
Journal Article
Neurology, ISSN 0028-3878, 05/2016, Volume 86, Issue 21, pp. 1964 - 1974
Journal Article
Stroke, ISSN 0039-2499, 1998, Volume 29, Issue 5, pp. 1020 - 1030
Background and Purpose-Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade the extracellular matrix and are implicated in... 
Antibody inhibition | Endothelium, vascular | Blood-brain barrier | Neutrophils | Leukocytes | Metalloproteinases | Stroke, ischemic | blood-brain barrier | DEGRADING PROTEINASES | NEUTROPHIL | antibody inhibition | TISSUE | VOLUME | metalloproteinases | CLINICAL NEUROLOGY | STROKE | endothelium, vascular | stroke, ischemic | GELATINASE | ENDOTHELIAL-CELLS | leukocytes | PERIPHERAL VASCULAR DISEASE | BRAIN INJURY | SECRETION | neutrophils | Endothelium, Vascular - cytology | Immunohistochemistry | Neutrophils - cytology | Tissue Extracts - chemistry | Brain Injuries - drug therapy | Male | Metalloendopeptidases - metabolism | Collagenases - analysis | Endothelium, Vascular - enzymology | Protease Inhibitors - immunology | Cerebral Infarction - enzymology | Brain Ischemia - enzymology | Gelatinases - analysis | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Time Factors | Tissue Inhibitor of Metalloproteinase-1 - analysis | Tissue Inhibitor of Metalloproteinases - administration & dosage | Tissue Inhibitor of Metalloproteinases - immunology | Gelatinases - metabolism | Protease Inhibitors - administration & dosage | Arterial Occlusive Diseases - physiopathology | Antibodies, Monoclonal - immunology | Cerebral Infarction - pathology | Metalloendopeptidases - analysis | Rats, Inbred SHR | Collagenases - biosynthesis | Neutrophils - enzymology | Electrophoresis, Polyacrylamide Gel | Matrix Metalloproteinase 2 | Brain Injuries - enzymology | Matrix Metalloproteinase 1 | Enzyme Induction | Rats | Cerebral Arteries - physiopathology | Macrophages - cytology | Arterial Occlusive Diseases - enzymology | Sodium Dodecyl Sulfate | Macrophages - enzymology | Matrix Metalloproteinase 3 - biosynthesis | Metalloendopeptidases - biosynthesis | Animals | Cerebral Arteries - pathology | Matrix Metalloproteinase Inhibitors | Collagenases - metabolism | Matrix Metalloproteinase 9
Journal Article
Molecular Neurodegeneration, ISSN 1750-1326, 06/2015, Volume 10, Issue 1, p. 24
Background: Cerebral infarction due to thrombosis leads to the most common type of stroke and a likely cause of age-related cognitive decline and dementia.... 
Cerebral amyloid angiopathy (CAA) | Vascular dementia | Endothelial nitric oxide synthase (eNOS) | Cerebral microinfarction | Cerebral chronic hypoperfusion | Microvessel occlusion | Thrombosis | Cerebral dysfunction | NITRIC-OXIDE SYNTHASE | ALZHEIMERS-DISEASE | MILD HYPOXIA | ISCHEMIC-HEART-DISEASE | BLOOD-FLOW | GENE POLYMORPHISMS | NEUROSCIENCES | MICE LACKING | BETA | AGING BRAIN | Memory Disorders - genetics | Temporal Lobe - blood supply | Cerebral Infarction - genetics | Nitric Oxide Synthase Type III - deficiency | Mice, Neurologic Mutants | Cerebral Infarction - enzymology | RNA, Messenger - biosynthesis | Nerve Tissue Proteins - biosynthesis | Aging | Blood-Brain Barrier - physiology | Hippocampus - enzymology | Nitric Oxide Synthase Type III - physiology | Cerebral Amyloid Angiopathy - genetics | Temporal Lobe - enzymology | Temporal Lobe - pathology | Parietal Lobe - blood supply | Memory Disorders - pathology | Cerebral Infarction - pathology | Cognition Disorders - enzymology | Memory Disorders - enzymology | Hippocampus - blood supply | RNA, Messenger - genetics | Cognition Disorders - pathology | Endothelium, Vascular - physiopathology | Gene Expression Regulation | Cerebrovascular Circulation | Cognition Disorders - genetics | Hippocampus - pathology | Organ Specificity | Nerve Tissue Proteins - genetics | Nitric Oxide Synthase Type III - genetics | Disease Progression | Parietal Lobe - pathology | Cerebral Amyloid Angiopathy - pathology | Animals | Maze Learning | Cerebral Infarction - psychology | Heterozygote | Mice | Parietal Lobe - enzymology | Stroke (Disease) | Immunohistochemistry | Advertising executives | Brain | Nitric oxide | Alzheimer's disease | Blood clot | Endothelium
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2010, Volume 40, Issue 1, pp. 185 - 192
Journal Article
Journal Article
Stroke, ISSN 0039-2499, 12/2008, Volume 39, Issue 12, pp. 3372 - 3377
Background and Purpose-Thrombolysis with tPA is the only FDA-approved therapy for acute ischemic stroke. But its widespread application remains limited by... 
Edema | Neuroprotection | Cerebral ischemia | Hemorrhagic transformation | TPA | MIDDLE CEREBRAL-ARTERY | MICROGLIAL ACTIVATION | edema | tPA | DELAYED MINOCYCLINE | MATRIX-METALLOPROTEINASE | MILD HYPOTHERMIA | AMYOTROPHIC-LATERAL-SCLEROSIS | FOCAL ISCHEMIA | CLINICAL NEUROLOGY | TRAUMATIC BRAIN-INJURY | hemorrhagic transformation | cerebral ischemia | neuroprotection | PERIPHERAL VASCULAR DISEASE | CYTOCHROME-C RELEASE | Neuroprotective Agents - therapeutic use | Recombinant Proteins - therapeutic use | Male | Tissue Plasminogen Activator - therapeutic use | Recombinant Proteins - adverse effects | Cerebral Infarction - prevention & control | Tissue Plasminogen Activator - adverse effects | Cerebral Infarction - enzymology | Brain Ischemia - enzymology | Cerebral Hemorrhage - blood | Intracranial Embolism - enzymology | Fibrinolytic Agents - adverse effects | Brain Ischemia - blood | Reperfusion | Time Factors | Minocycline - therapeutic use | Cerebral Infarction - blood | Fibrinolytic Agents - therapeutic use | Thrombolytic Therapy - methods | Cerebral Hemorrhage - prevention & control | Intracranial Embolism - drug therapy | Minocycline - administration & dosage | Drug Evaluation, Preclinical | Neuroprotective Agents - administration & dosage | Matrix Metalloproteinase 9 - blood | Cerebral Hemorrhage - chemically induced | Rats, Inbred SHR | Intracranial Embolism - blood | Drug Administration Schedule | Rats | Tissue Plasminogen Activator - administration & dosage | Brain Ischemia - etiology | Blood-Brain Barrier - drug effects | Recombinant Proteins - administration & dosage | Animals | Brain Ischemia - drug therapy | Biomarkers | Cerebral Infarction - etiology | Matrix Metalloproteinase Inhibitors | Cerebral Hemorrhage - enzymology | Fibrinolytic Agents - administration & dosage | Thrombolytic Therapy - adverse effects | Intracranial Embolism - complications | Index Medicus
Journal Article
Cardiovascular Research, ISSN 0008-6363, 05/2017, Volume 113, Issue 6, pp. 620 - 632
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4878 - E4886
Journal Article
Journal Article