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1. Full Text Acute Traumatic Brain Injury: Mortality in the Elderly
by Herou, Erik and Romner, Bertil and Tomasevic, Gregor
World Neurosurgery, ISSN 1878-8750, 2015, Volume 83, Issue 6, pp. 996 - 1001
Objective Despite recent progress, prognosis for the elderly (defined as aged ≥70 years) afflicted by traumatic brain injury (TBI) is unfavorable and surgical... 
Neurosurgery | Craniotomy | TBI | aSDH | Head injury | Elderly | Trauma | SURGERY | VALIDATION | PROGNOSTIC VALUE | INTRACRANIAL HEMORRHAGE | ANTIPLATELET | CLINICAL NEUROLOGY | REACTION LEVEL SCALE | IMPACT | ADMISSION CHARACTERISTICS | GLASGOW COMA SCALE | OUTCOMES | AGE | Prognosis | Age Factors | Anticoagulants - administration & dosage | Humans | Brain Injuries - complications | Male | Brain Injuries - mortality | Head Injuries, Closed - diagnosis | Warfarin - administration & dosage | Hematoma, Subdural - etiology | Hematoma, Subdural - surgery | Glasgow Coma Scale | Aged, 80 and over | Brain Injuries - surgery | Female | Retrospective Studies | Head Injuries, Closed - complications | Acute Disease | Risk Factors | Treatment Outcome | Brain Injuries - therapy | Head Injuries, Closed - mortality | Head Injuries, Closed - therapy | Sweden - epidemiology | Brain Injuries - diagnosis | Head Injuries, Closed - surgery | Aged | Brain | Mortality | Injuries
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2. Full Text Mortality and Prehospital Blood Pressure in Patients With Major Traumatic Brain Injury: Implications for the Hypotension Threshold
by Spaite, Daniel W and Hu, Chengcheng and Bobrow, Bentley J and Chikani, Vatsal and Sherrill, Duane and Barnhart, Bruce and Gaither, Joshua B and Denninghoff, Kurt R and Viscusi, Chad and Mullins, Terry and Adelson, P. David
JAMA Surgery, ISSN 2168-6254, 04/2017, Volume 152, Issue 4, pp. 360 - 368
IMPORTANCE: Current prehospital traumatic brain injury guidelines use a systolic blood pressure threshold of less than 90 mm Hg for treating hypotension for... 
SURGERY | IMPACT | SEVERITY SCORE TRISS | INTERNATIONAL CLASSIFICATION | 110 MMHG | SEVERE HEAD-INJURY | PATIENTS MULTICENTER COHORT | REDEFINING HYPOTENSION | HYPOXIA | PROGNOSTIC VALUE | INSULTS | Brain Injuries, Traumatic - complications | Hospital Mortality | Humans | Middle Aged | Logistic Models | Male | Young Adult | Brain Injuries, Traumatic - physiopathology | Hypotension - mortality | Hypotension - physiopathology | Adolescent | Aged, 80 and over | Adult | Female | Hypotension - etiology | Aged | Blood Pressure - physiology | Brain Injuries, Traumatic - mortality | Odds Ratio | Child | Emergency Medical Services | Cohort Studies
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3. Full Text Trends in traumatic brain injury mortality in China, 2006–2013: A population-based longitudinal study
by Cheng, Peixia and Yin, Peng and Ning, Peishan and Wang, Lijun and Cheng, Xunjie and Liu, Yunning and Schwebel, David C and Liu, Jiangmei and Qi, Jinlei and Hu, Guoqing and Zhou, Maigeng
PLoS Medicine, ISSN 1549-1277, 07/2017, Volume 14, Issue 7, p. e1002332
Background Traumatic brain injury (TBI) is a significant global public health problem, but has received minimal attention from researchers and policy-makers in... 
SYSTEMATIC ANALYSIS | GLOBAL BURDEN | MEDICINE, GENERAL & INTERNAL | NEW-ZEALAND | DISABILITY | PREVENTION | ROAD TRAFFIC MORTALITY | RISK | OLDER WOMEN | DEATH | EPIDEMIOLOGY | Geography | Age Factors | Humans | Middle Aged | Child, Preschool | Infant | Male | Young Adult | Brain Injuries, Traumatic - epidemiology | Aged, 80 and over | Adult | Female | Accidents, Traffic - trends | Child | Infant, Newborn | Accidental Falls - mortality | Accidental Falls - statistics & numerical data | China - epidemiology | Accidents, Traffic - statistics & numerical data | Adolescent | Sex Factors | Brain Injuries, Traumatic - etiology | Aged | Accidents, Traffic - mortality | Brain Injuries, Traumatic - mortality | Longitudinal Studies | Brain | Complications and side effects | Analysis | Mortality | China | Public health | Risk factors | Injuries | Elderly people | Traumatic brain injury | Sex | Driving | Economic factors | Risk | Rural populations | Population studies | Alcohol | Traffic accidents & safety | Males | Motor vehicles | Epidemiology | Subgroups | Alcohols | Head injuries | Drunkenness | Driving ability | Classification | Children | Trends | Age | Pedestrians | Crashes | Adjustment | Attention | Cultures | Group dynamics | Morbidity | Falls | Enforcement | Census | Passengers | Protective equipment | Correlation analysis | Fatalities | Adults | Females | Elderly | Geriatrics
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4. Full Text Erythropoietin in patients with traumatic brain injury and extracranial injury - A post hoc analysis of the erythropoietin traumatic brain injury trial
by Skrifvars, Markus B and Bailey, Michael and French, Craig and Presneill, Jeffrey and Nichol, Alistair and Little, Lorraine and Duranteau, Jacques and Huet, Olivier and Haddad, Samir and Arabi, Yaseen and McArthur, Colin and Cooper, D. James and Bellomo, Rinaldo and EPO-TBI Investigators and ANZICS Clinical Trials Grp and EPO-TBI investigators and the ANZICS Clinical Trials Group
Journal of Trauma and Acute Care Surgery, ISSN 2163-0755, 09/2017, Volume 83, Issue 3, pp. 449 - 456
BACKGROUND: Erythropoietin (EPO) may reduce mortality after traumatic brain injury (TBI). Secondary brain injury is exacerbated by multiple trauma, and... 
Erythropoietin | traumatic brain injury | multiple trauma | DEFINITION | SURGERY | EFFICACY | RECOMBINANT-HUMAN-ERYTHROPOIETIN | MODEL | INFLAMMATION | HYPOTENSION | DYSFUNCTION | OUTCOMES | CRITICAL CARE MEDICINE | Brain Injuries, Traumatic - drug therapy | Erythropoietin - therapeutic use | Humans | Middle Aged | Adult | Female | Male | Treatment Outcome | Abbreviated Injury Scale | Brain Injuries, Traumatic - mortality | Multiple Trauma | Injury Severity Score
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5. Full Text Erythropoietin to Reduce Mortality in Traumatic Brain Injury: A Post-hoc Dose-effect Analysis
by Gantner, Dashiell C and Bailey, Michael and Presneill, Jeffrey and French, Craig J and Nichol, Alistair and Little, Lorraine and Bellomo, Rinaldo and EPO-TBI Investigators ANZICS Clini and EPO-TBI Investigators and the ANZICS Clinical Trials Group
Annals of Surgery, ISSN 0003-4932, 03/2018, Volume 267, Issue 3, pp. 585 - 589
OBJECTIVE:We aimed to assess whether the dosing regimen of erythropoietin shows a relationship to mortality in critically ill patients with traumatic brain... 
mortality | traumatic brain injury | dose-response relationship | erythropoietin | SURGERY | RECOMBINANT-HUMAN-ERYTHROPOIETIN | GLASGOW OUTCOME SCALE | IMPROVED SURVIVAL | PHARMACODYNAMICS | RANDOMIZED CONTROLLED-TRIAL | EPOETIN-ALPHA | HUMAN ERYTHROPOLETIN | PHARMACOKINETICS | DOUBLE-BLIND | CRITICALLY-ILL PATIENTS
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6. Full Text Association of Out-of-Hospital Hypotension Depth and Duration With Traumatic Brain Injury Mortality
by Spaite, Daniel W., MD and Hu, Chengcheng, PhD and Bobrow, Bentley J., MD and Chikani, Vatsal, MPH and Barnhart, Bruce, RN, CEP and Gaither, Joshua B., MD and Denninghoff, Kurt R., MD and Adelson, P. David, MD and Keim, Samuel M., MD, MS and Viscusi, Chad, MD and Mullins, Terry, MBA and Rice, Amber D., MD, MS and Sherrill, Duane, PhD
Annals of Emergency Medicine, ISSN 0196-0644, 2017, Volume 70, Issue 4, pp. 522 - 530.e1
Study objective Out-of-hospital hypotension has been associated with increased mortality in traumatic brain injury. The association of traumatic brain injury... 
Emergency | PEDIATRIC HEAD-INJURY | MANAGEMENT | EMERGENCY MEDICINE | DATA-BANK | GLASGOW COMA SCALE | HYPOXIA | PROGNOSTIC VALUE | BLOOD-PRESSURE | INSULTS | SEVERITY | RESUSCITATION | Medical colleges | Brain | Emergency medicine | Analysis | Mortality | Injuries
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7. Full Text The Effect of Combined Out-of-Hospital Hypotension and Hypoxia on Mortality in Major Traumatic Brain Injury
by Spaite, Daniel W., MD and Hu, Chengcheng, PhD and Bobrow, Bentley J., MD and Chikani, Vatsal, MPH and Barnhart, Bruce, RN, CEP and Gaither, Joshua B., MD and Denninghoff, Kurt R., MD and Adelson, P. David, MD and Keim, Samuel M., MD, MS and Viscusi, Chad, MD and Mullins, Terry, MBA and Sherrill, Duane, PhD
Annals of Emergency Medicine, ISSN 0196-0644, 2016, Volume 69, Issue 1, pp. 62 - 72
Study objective Survival is significantly reduced by either hypotension or hypoxia during the out-of-hospital management of major traumatic brain injury.... 
Emergency | RAPID-SEQUENCE INTUBATION | IMPACT | MANAGEMENT | EMERGENCY MEDICINE | DATA-BANK | SEVERE HEAD-INJURY | SECONDARY INSULTS | GLASGOW COMA SCALE | HYPOXEMIA | PROGNOSTIC VALUE | CARE | Hypotension - complications | Brain Injuries, Traumatic - complications | Hypotension - mortality | Humans | Middle Aged | Hypoxia - mortality | Adult | Female | Male | Aged | Hypoxia - complications | Brain Injuries, Traumatic - mortality | Medical colleges | Brain | Continuing medical education | Analysis | Mortality | Emergency medicine | Web sites | Injuries
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8. Full Text Chronic impact of traumatic brain injury on outcome and quality of life: A narrative review
by Stocchetti, Nino and Zanier, Elisa R
Critical Care, ISSN 1364-8535, 06/2016, Volume 20, Issue 1, p. 148
Traditionally seen as a sudden, brutal event with short-term impairment, traumatic brain injury (TBI) may cause persistent, sometimes life-long, consequences.... 
Disability | Traumatic brain injury | Rehabilitation | Long-term outcome | Axonal injury | Quality of life | DIFFUSE AXONAL INJURY | HEAD-INJURY | COGNITIVE RECOVERY | ADULT RATS | CONTROLLED CORTICAL IMPACT | NEURONAL DIFFERENTIATION | AMYLOID-BETA | GLIAL PROLIFERATION | PROGRESSIVE ATROPHY | NEUROGENESIS | CRITICAL CARE MEDICINE | Brain Injuries, Traumatic - physiopathology | Brain Injuries, Traumatic - complications | Glasgow Outcome Scale - trends | Humans | Cognition - physiology | Quality of Life - psychology | Patient Outcome Assessment | Brain Injuries, Traumatic - mortality | Glasgow Coma Scale - trends | Brain | Complications and side effects | Care and treatment | Mortality | Research | Risk factors | Injuries | Review
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9. Full Text Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury The POLAR Randomized Clinical Trial
by Cooper, DJ and Nichol, AD and Bailey, M and Bernard, S and Cameron, PA and Pili-Floury, S and Forbes, A and Gantner, D and Higgins, AM and Huet, O and Kasza, J and Murray, L and Newby, L and Presneill, JJ and Rashford, S and Rosenfeld, JV and Stephenson, M and Vallance, S and Varma, D and Webb, SAR and Trapani, T and McArthur, C and POLAR Trial Investigators ANZICS and POLAR Trial Investigators and the ANZICS Clinical Trials Group and for the POLAR Trial Investigators and the ANZICS Clinical Trials Group
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, ISSN 0098-7484, 12/2018, Volume 320, Issue 21, pp. 2211 - 2220
IMPORTANCE After severe traumatic brain injury, induction of prophylactic hypothermia has been suggested to be neuroprotective and improve long-term neurologic... 
MEDICINE, GENERAL & INTERNAL | MANAGEMENT | THERAPEUTIC HYPOTHERMIA | GUIDELINES | MILD HYPOTHERMIA | SALINE | MODERATE HYPOTHERMIA | PATHOPHYSIOLOGY | RESUSCITATION | Brain Injuries, Traumatic - therapy | Hypothermia, Induced - adverse effects | Brain Injuries, Traumatic - complications | Pneumonia - etiology | Hospital Mortality | Humans | Independent Living | Male | Treatment Outcome | Trauma Severity Indices | Rewarming | Intracranial Pressure | Brain Injuries, Traumatic - physiopathology | Nervous System Diseases - prevention & control | Nervous System Diseases - etiology | Adult | Female | Brain Injuries, Traumatic - mortality | Neurology | Brain | Care and treatment | Research | Health aspects | Injuries | Risk factors | Hypothermia | Temperature requirements | Neuroprotection | Traumatic brain injury | Clinical trials | Patients | Clinical outcomes | Bleeding | Randomization | Injury prevention | Head injuries | Emergency medical services | Caring for the Critically Ill Patient | Online First | Original Investigation
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10. Full Text Association of Alcohol With Mortality After Traumatic Brain Injury
by Albrecht, Jennifer S and Afshar, Majid and Stein, Deborah M and Smith, Gordon S
American Journal of Epidemiology, ISSN 0002-9262, 02/2018, Volume 187, Issue 2, pp. 233 - 241
Abstract Although alcohol exposure results in reduced mortality after traumatic brain injury (TBI) in animal models, clinical trials based on proposed... 
alcohol | mortality | traumatic brain injury | MODERATE | SUBSTANCE-ABUSE | HEAD-INJURY | RISK | LEVEL | INTOXICATION | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | ETHANOL | OUTCOMES | SCALE | COMA | Hospital Mortality | Humans | Middle Aged | Logistic Models | Male | Baltimore - epidemiology | Protective Factors | Adult | Female | Aged | Blood Alcohol Content | Retrospective Studies | Brain Injuries, Traumatic - blood | Brain Injuries, Traumatic - mortality | Odds Ratio | Brain | Analysis | Clinical trials | Drinking of alcoholic beverages | Health aspects | Injuries | Risk factors | Original Contributions
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11. Full Text Modern modelling techniques had limited external validity in predicting mortality from traumatic brain injury
by van der Ploeg, Tjeerd, MSc and Nieboer, Daan, MSc and Steyerberg, Ewout W., PhD
Journal of Clinical Epidemiology, ISSN 0895-4356, 2016, Volume 78, pp. 83 - 89
Abstract Background Prediction of medical outcomes may potentially benefit from using modern statistical modeling techniques. We aimed to externally validate... 
Internal Medicine | Modeling techniques | Discrimination | Calibration | Prediction models | External validation | Internal validation | DESIGN | PROGNOSIS | LOGISTIC-REGRESSION | PERFORMANCE | VALIDATION | RISK | SIMULATION | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HEALTH CARE SCIENCES & SERVICES | Models, Theoretical | ROC Curve | Reproducibility of Results | Support Vector Machine | Brain Injuries, Traumatic - mortality | Humans | Brain | Prognosis | Mortality | Analysis | Models | Methods | Injuries | Studies | Trees | Forests | Traumatic brain injury | Neural networks
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