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Nature medicine, ISSN 1546-170X, 2010, Volume 16, Issue 12, pp. 1439 - 1443
.... Here we show that cerebral ischemia induces the interaction of nNOS with postsynaptic density protein-95 (PSD-95... 
MEDICINE, RESEARCH & EXPERIMENTAL | BRAIN-INJURY | NITRIC-OXIDE SYNTHASE | PDZ DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBCELLULAR-LOCALIZATION | NEUROTOXICITY | MICE LACKING | NEUROPROTECTION | CELL BIOLOGY | EXCITOTOXICITY | PROTEIN INTERACTIONS | ANTAGONISTS | Disks Large Homolog 4 Protein | Neuroprotective Agents - therapeutic use | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Immunoprecipitation | Oligonucleotides, Antisense - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Brain Ischemia - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Neuroprotective Agents - metabolism | Neuroprotective Agents - pharmacology | Oligonucleotides, Antisense - therapeutic use | Infarction, Middle Cerebral Artery - drug therapy | Membrane Proteins - metabolism | Molecular Structure | Cell Death - drug effects | Brain Ischemia - complications | Oligonucleotides, Antisense - pharmacology | Rats | Stroke - drug therapy | Glutamic Acid | Microscopy, Confocal | Stroke - etiology | Animals | Guanylate Kinases | Analysis of Variance | Cell Death - physiology | Signal Transduction - drug effects | Brain Ischemia - drug therapy | Nitric Oxide Synthase Type I - metabolism | Signal Transduction - physiology | Biological Transport - physiology | Mice | Nitric Oxide Synthase Type I - chemistry | Cerebral ischemia | Care and treatment | Nitric oxide | Physiological aspects | Genetic aspects | Research | Risk factors | Nerve proteins | Enzymes | Stroke | Biomedical research | Cellular biology | Neurons | Pharmacology
Journal Article
Brain Research, ISSN 0006-8993, 2009, Volume 1282, pp. 133 - 141
.... This study evaluated the time course expression regularity of Nrf2, HO-1 and the curcumin's role in cerebral ischemia and its potential mechanism. Methods: Male, Sprague... 
Neurology | Nuclear factor erythroid 2-related factor 2(Nrf2) | Neuroprotection | Cerebral ischemia | Curcumin | OXIDATIVE STRESS | ACTIVATION | MACROPHAGES | NEUROSCIENCES | ANTIOXIDANT DEFENSE | CEREBRAL-ARTERY OCCLUSION | IN-VIVO | NITRIC-OXIDE | NEURONS | KEAP1/NRF2 PATHWAY | HEME OXYGENASE-1 | Infarction, Middle Cerebral Artery - physiopathology | Heme Oxygenase-1 - metabolism | Brain Ischemia - metabolism | RNA, Messenger - analysis | Brain Infarction - pathology | Heme Oxygenase-1 - drug effects | Male | Cytoprotection - physiology | Infarction, Middle Cerebral Artery - metabolism | RNA, Messenger - metabolism | Brain - metabolism | Brain Edema - prevention & control | Brain Infarction - prevention & control | Heme Oxygenase-1 - genetics | Neuroprotective Agents - pharmacology | Time Factors | Up-Regulation - physiology | Cytoprotection - drug effects | NF-E2-Related Factor 2 - genetics | Infarction, Middle Cerebral Artery - drug therapy | Brain Infarction - drug therapy | Disease Models, Animal | Curcumin - therapeutic use | Brain - physiopathology | Brain Edema - pathology | NF-E2-Related Factor 2 - drug effects | Curcumin - pharmacology | Enzyme Inhibitors - pharmacology | Gene Expression Regulation - physiology | Rats | Brain Ischemia - physiopathology | Rats, Sprague-Dawley | Brain - drug effects | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | Animals | Brain Ischemia - drug therapy | NF-E2-Related Factor 2 - metabolism | Brain Edema - drug therapy
Journal Article
Journal Article
Brain Research, ISSN 0006-8993, 12/2017, Volume 1677, pp. 118 - 128
•(−)-Phenserine reduced infarct volume in a rat MCAO model of ischemia/reperfusion injury... 
Glial fibrillary acidic protein (GFAP) | Metallopeptidase-9 (MMP-9) | Stroke | ERK-1/2 signaling pathway | Ischemia/reperfusion injury | Activated-caspase 3 | Brain-derived neurotrophic factor (BDNF) | Amyloid precursor protein (APP) | (−)-Phenserine | Middle cerebral artery occlusion (MCAO) | B-cell lymphoma 2 (Bcl-2) expression | FUNCTIONAL RECOVERY | NEUROTROPHIC FACTOR | FOCAL CEREBRAL-ISCHEMIA | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | MATRIX METALLOPROTEINASES | MESSENGER-RNA | (-)-Phenserine | MATRIX-METALLOPROTEINASE-9 | BRAIN-BARRIER DISRUPTION | TRANSGENIC MICE | Neurons - pathology | Cell Hypoxia - physiology | Apoptosis - drug effects | Humans | Reperfusion Injury - drug therapy | Brain Ischemia - metabolism | Male | Dose-Response Relationship, Drug | Stroke - pathology | Neuroprotective Agents - pharmacology | Neurons - metabolism | Neurons - drug effects | Reperfusion Injury - metabolism | Cell Survival - physiology | Cell Survival - drug effects | Cell Hypoxia - drug effects | Physostigmine - analogs & derivatives | Reperfusion Injury - pathology | Rats | Stroke - drug therapy | Rats, Sprague-Dawley | Physostigmine - pharmacology | Glucose - deficiency | Stroke - metabolism | Animals | Cholinesterase Inhibitors - pharmacology | Brain Ischemia - drug therapy | Brain Ischemia - pathology | Cell Line, Tumor | Apoptosis - physiology | Brain | Neurons | Analysis | Injuries | Apoptosis | Stroke (Disease) | Amyloid beta-protein | Lymphomas | middle cerebral artery occlusion (MCAO) | brain-derived neurotrophic factor (BDNF) | metallopeptidase-9 (MMP-9) | activated-caspase 3 | reperfusion injury | stroke | amyloid precursor protein (APP) | glial fibrillary acidic protein (GFAP) | ischemia | ERK-1 | 2 signaling pathway
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 11, p. e49701
.... However, the mechanisms underlying the protective effects of PF on cerebral ischemia are still under investigation... 
STROKE | ACTIVATION | PATHWAY | NEUROVASCULAR UNIT | MULTIDISCIPLINARY SCIENCES | FOCAL CEREBRAL-ISCHEMIA | INTRACEREBRAL HEMORRHAGE | NITRIC-OXIDE | MECHANISMS | EXPRESSION | NEUROPROTECTION | Microglia - metabolism | Tumor Necrosis Factor-alpha - blood | Tumor Necrosis Factor-alpha - genetics | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | Brain - metabolism | Inflammation - metabolism | Bridged-Ring Compounds - pharmacology | Monoterpenes | Neurons - metabolism | Disease Models, Animal | NF-kappa B - antagonists & inhibitors | bcl-2-Associated X Protein - metabolism | Rats | Brain - drug effects | Signal Transduction - drug effects | Brain Ischemia - drug therapy | Benzoates - pharmacology | Brain - pathology | Bridged-Ring Compounds - administration & dosage | Astrocytes - metabolism | Nitric Oxide Synthase Type II - metabolism | Cerebral Infarction - drug therapy | Brain Ischemia - metabolism | Cytochromes c - genetics | Hippocampus - drug effects | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Interleukin-1beta - blood | Proto-Oncogene Proteins c-bcl-2 - metabolism | Lipoxygenase - metabolism | Cerebral Infarction - metabolism | Inflammation - drug therapy | Neurons - drug effects | bcl-2-Associated X Protein - genetics | Cerebral Infarction - pathology | Astrocytes - drug effects | Glucosides - pharmacology | Microglia - drug effects | Cytochromes c - metabolism | Benzoates - administration & dosage | Gene Expression Regulation - drug effects | Animals | Glucosides - administration & dosage | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Cyclooxygenase 2 - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinases - metabolism | Occlusion | Neuroprotection | Brain | Inflammatory response | Activation | Kinases | Carotid arteries | Signal transduction | Chinese medicine | Ischemia | Neurodegeneration | Cerebral blood flow | Rodents | Tumor necrosis factor-TNF | Inhibition | NF-κB protein | Stroke | Cytokines | Astrocytes | Traditional Chinese medicine | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Pharmacology | Inflammation | Tumor necrosis factor-α | IL-1β | Nitric-oxide synthase | Microglia | Signaling | Brain research | Liquid oxygen | Hypoxia | Brain damage | Cyclooxygenase-2 | Laboratory animals | Apoptosis | Veins & arteries
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