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International journal of radiation oncology, biology, physics, ISSN 0360-3016, 2013, Volume 85, Issue 2, pp. 293 - 295
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2017, Volume 357, Issue 6349, pp. 409 - 413
The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed... 
CELL LUNG-CANCER | SURVIVAL | COLORECTAL CARCINOMAS | RECEIVING NIVOLUMAB | IMMUNOTHERAPY | MICROSATELLITE INSTABILITY | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | NEOANTIGENS | CHECKPOINT BLOCKADE | LYMPHOCYTES | Neoplastic Syndromes, Hereditary - immunology | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Neoplastic Syndromes, Hereditary - mortality | Young Adult | Colorectal Neoplasms - therapy | Brain Neoplasms - immunology | DNA Mismatch Repair | Aged, 80 and over | Adult | Female | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Biomarkers, Tumor - antagonists & inhibitors | Colorectal Neoplasms - mortality | Antibodies, Monoclonal, Humanized - therapeutic use | Antigens, Neoplasm - immunology | Brain Neoplasms - genetics | Disease-Free Survival | Colorectal Neoplasms - immunology | Cell Cycle Checkpoints - drug effects | Brain Neoplasms - therapy | Neoplastic Syndromes, Hereditary - therapy | T-Lymphocytes - immunology | Aged | Mutation | Programmed Cell Death 1 Receptor - immunology | Colorectal cancer | Genetic aspects | Nucleotide sequencing | Health aspects | DNA repair | Methods | Tumors | DNA sequencing | Yeast | PD-1 protein | Antibodies | Clinical trials | Genomes | Functional analysis | Lymphocytes T | Patients | Survival | Colon cancer | Immune checkpoint | Immunotherapy | Mismatch repair | Pancreatic cancer | Biomarkers | Colon | Solid tumors | Genetic recombination | Repair | Cancer | Apoptosis
Journal Article
by Hendry, Shona and Salgado, Roberto and Gevaert, Thomas and Russell, Prudence A and John, Tom and Thapa, Bibhusal and Christie, Michael and van de Vijver, Koen and Estrada, M V and Gonzalez-Ericsson, Paula I and Sanders, Melinda and Solomon, Benjamin and Solinas, Cinzia and Van den Eynden, Gert G G M and Allory, Yves and Preusser, Matthias and Hainfellner, Johannes and Pruneri, Giancarlo and Vingiani, Andrea and Demaria, Sandra and Symmans, Fraser and Nuciforo, Paolo and Comerma, Laura and Thompson, E A and Lakhani, Sunil and Kim, Seong-Rim and Schnitt, Stuart and Colpaert, Cecile and Sotiriou, Christos and Scherer, Stefan J and Ignatiadis, Michail and Badve, Sunil and Pierce, Robert H and Viale, Giuseppe and Sirtaine, Nicolas and Penault-Llorca, Frederique and Sugie, Tomohagu and Fineberg, Susan and Paik, Soonmyung and Srinivasan, Ashok and Richardson, Andrea and Wang, Yihong and Chmielik, Ewa and Brock, Jane and Johnson, Douglas B and Balko, Justin and Wienert, Stephan and Bossuyt, Veerle and Michiels, Stefan and Ternes, Nils and Burchardi, Nicole and Luen, Stephen J and Savas, Peter and Klauschen, Frederick and Watson, Peter H and Nelson, Brad H and Criscitiello, Carmen and O'Toole, Sandra and Larsimont, Denis and de Wind, Roland and Curigliano, Giuseppe and André, Fabrice and Lacroix-Triki, Magali and van de Vijver, Mark and Rojo, Federico and Floris, Giuseppe and Bedri, Shahinaz and Sparano, Joseph and Rimm, David and Nielsen, Torsten and Kos, Zuzana and Hewitt, Stephen and Singh, Baljit and Farshid, Gelareh and Loibl, Sibylle and Allison, Kimberly H and Tung, Nadine and Adams, Sylvia and Willard-Gallo, Karen and Horlings, Hugo M and Gandhi, Leena and Moreira, Andre and Hirsch, Fred and Dieci, Maria V and Urbanowicz, Maria and Brcic, Iva and Korski, Konstanty and Gaire, Fabien and Koeppen, Hartmut and Lo, Amy and Giltnane, Jennifer and Rebelatto, Marlon C and Steele, Keith E and Zha, Jiping and Emancipator, Kenneth and Juco, Jonathan W and Denkert, Carsten and Reis-Filho, Jorge and Loi, Sherene and Fox, Stephen B
Advances in anatomic pathology, ISSN 1072-4109, 11/2017, Volume 24, Issue 6, pp. 311 - 335
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2000, Volume 165, Issue 11, pp. 6015 - 6019
STAT4 and STAT6 are essential for the development of CD4(+) Th1 and Th2 development, respectively, Tumor immunologists have hypothesized that Th1 cells are... 
RESPONSES | INTERLEUKIN-4 | TH2 CELLS | ACTIVATOR | SUBPOPULATIONS | LYMPHOCYTE | STAT6 | DIFFERENTIATION | IMMUNOLOGY | CLASS-II | SIGNAL TRANSDUCER | Mammary Neoplasms, Experimental - immunology | Bone Marrow Neoplasms - immunology | Bone Marrow Neoplasms - genetics | Mammary Neoplasms, Experimental - genetics | STAT6 Transcription Factor | T-Lymphocytes, Cytotoxic - pathology | CD4-Positive T-Lymphocytes - immunology | Cell Differentiation - genetics | Brain Neoplasms - secondary | Brain Neoplasms - immunology | Lung Neoplasms - secondary | Neoplasm Metastasis - immunology | Cell Division - immunology | Neoplasm Metastasis - prevention & control | Mammary Neoplasms, Experimental - pathology | Trans-Activators - genetics | Liver Neoplasms - secondary | Cell Division - genetics | Liver Neoplasms - prevention & control | Lung Neoplasms - genetics | Bone Marrow Neoplasms - prevention & control | Cytotoxicity, Immunologic - genetics | Mammary Neoplasms, Experimental - prevention & control | Liver Neoplasms - genetics | Brain Neoplasms - genetics | Liver Neoplasms - immunology | Lymphatic Metastasis | Bone Marrow Neoplasms - secondary | Disease Progression | Mice, Knockout | Brain Neoplasms - prevention & control | Cell Differentiation - immunology | Neoplasm Metastasis - genetics | Lung Neoplasms - immunology | Animals | Trans-Activators - deficiency | Lung Neoplasms - prevention & control | Neoplasm Metastasis - pathology | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology
Journal Article
Molecular therapy, ISSN 1525-0016, 2015, Volume 23, Issue 3, pp. 602 - 608
Journal Article
Cancer, ISSN 0008-543X, 2016, Volume 122, Issue 21, pp. 3354 - 3362
Journal Article
BMC cancer, ISSN 1471-2407, 2006, Volume 6, Issue 1, pp. 225 - 225
Background: HER2/neu overexpression is linked to promotion of angiogenesis in breast cancer. We therefore tested the activity of the combination of Trastuzumab... 
PROTEIN | ANGIOGENESIS | ONCOLOGY | NEU ONCOGENE | EPIDERMAL-GROWTH-FACTOR | IN-VIVO | PHASE-II | MONOCLONAL-ANTIBODY | ANTITUMOR-ACTIVITY | FACTOR RECEPTOR | PLUS | Lung Neoplasms - drug therapy | Cyclophosphamide - administration & dosage | Humans | Middle Aged | Neoplasm Proteins - immunology | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Neoplasm Proteins - antagonists & inhibitors | Cyclophosphamide - adverse effects | Bone Neoplasms - blood supply | Leukopenia - chemically induced | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Liver Neoplasms - secondary | Combined Modality Therapy | Lung Neoplasms - therapy | Lymphatic Metastasis | Breast Neoplasms - blood supply | Brain Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Remission Induction | Methotrexate - adverse effects | Breast Neoplasms - genetics | Brain Neoplasms - therapy | Immunization, Passive | Methotrexate - administration & dosage | Trastuzumab | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Bone Neoplasms - therapy | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Brain Neoplasms - blood supply | Liver Neoplasms - therapy | Ventricular Dysfunction, Left - chemically induced | Breast Neoplasms - therapy | Antibodies, Monoclonal, Humanized | Brain Neoplasms - secondary | Lung Neoplasms - secondary | Angiogenesis Inhibitors - therapeutic use | Adult | Female | Bone Neoplasms - drug therapy | Neutropenia - chemically induced | Lung Neoplasms - blood supply | Drug Administration Schedule | Liver Neoplasms - drug therapy | Treatment Outcome | Gene Amplification | Liver Neoplasms - blood supply | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Genes, erbB-2 | Aged
Journal Article
Brain (London, England : 1878), ISSN 1460-2156, 2012, Volume 135, Issue 4, pp. 1042 - 1054
Peptides presented at the cell surface reflect the protein content of the cell; those on HLA class I molecules comprise the critical peptidome elements... 
peptidome | glioblastoma | tumour-infiltrating lymphocytes | tumour antigen | immunotherapy | AVIDITY | IDENTIFICATION | NEUROSCIENCES | CLINICAL NEUROLOGY | GLIOMA-CELL | GROWTH | CHONDROITIN SULFATE PROTEOGLYCAN | SELECTION | EXPRESSION | T-CELLS | PROGRESSION | TENASCIN-C | Oligonucleotide Array Sequence Analysis | Humans | Brain Neoplasms - pathology | Gene Expression Profiling | Glial Fibrillary Acidic Protein - metabolism | RNA, Messenger - metabolism | Antigens, Neoplasm - chemistry | HLA-A Antigens - analysis | Antigens, CD - metabolism | Sequence Analysis, Protein | Brain Neoplasms - immunology | Flow Cytometry | Antigens, Neoplasm - therapeutic use | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Mass Spectrometry | Chromatography, Liquid | Cytokines - metabolism | Antigens, Neoplasm - immunology | Peptides - immunology | Glioblastoma - therapy | HLA-A Antigens - immunology | Glioblastoma - immunology | Glioblastoma - pathology | Brain Neoplasms - therapy | HLA-A Antigens - chemistry | CD8-Positive T-Lymphocytes - immunology | Antigen Presentation - physiology | Peptides - analysis | Receptor-Like Protein Tyrosine Phosphatases, Class 5 - metabolism | Immunogenicity | CD8 antigen | Immunotherapy | Glioblastoma | Data processing | Histocompatibility antigen HLA | Lymphocytes T | Vaccines | Cell surface | Immunological tolerance
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2019, Volume 116, Issue 3, pp. 997 - 1006
Glioblastoma multiforme (GBM) is a highly aggressive malignant brain tumor with fatal outcome. Tumor-associated macrophages and microglia (TAMs) have been... 
Checkpoint inhibition | Anti-CD47 | Immunotherapy | Glioblastoma | Microglia | STEM-CELLS | checkpoint inhibition | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | anti-CD47 | MOUSE | NEUROTOXICITY | glioblastoma | FRACTALKINE RECEPTOR | GENE | RESIDENT MICROGLIA | immunotherapy | INFILTRATING MONOCYTES | microglia | BRAIN | PROGRESSION | Brain Neoplasms - pathology | Neoplasm Proteins - immunology | Monocytes - immunology | CD47 Antigen - immunology | Neoplasms, Experimental - pathology | Signal Transduction - immunology | Brain Neoplasms - immunology | Microglia - immunology | Glioblastoma - genetics | Neoplasms, Experimental - immunology | Monocytes - pathology | Neoplasms, Experimental - genetics | Microglia - pathology | Receptors, Immunologic - immunology | Neoplasm Proteins - genetics | Macrophages - immunology | CD47 Antigen - genetics | Macrophages - pathology | Mice, Transgenic | Signal Transduction - genetics | Animals | Glioblastoma - immunology | Glioblastoma - pathology | Mice, Inbred NOD | Mice | Receptors, Immunologic - genetics | Phagocytosis | Brain | Transcription factors | Animal models | Transcription | Brain cancer | Brain tumors | Central nervous system | Effector cells | Inflammatory response | Macrophages | Blood | Immune system | Yolk | Therapeutic applications | Immunodeficiency | Inflammation | Glioblastoma multiforme | Cells | Yolk sac | Monocytes | Morphology | Disruption | Tumors | Biological Sciences | PNAS Plus
Journal Article
Cancer immunology, immunotherapy, ISSN 1432-0851, 2012, Volume 62, Issue 1, pp. 125 - 135
This study evaluated the safety and immune responses to an autologous dendritic cell vaccine pulsed with class I peptides from tumor-associated antigens (TAA)... 
Cancer vaccine | Immunology | Medicine & Public Health | Glioblastoma | Oncology | Cancer Research | CTL | Epitopes | Cancer stem cells | Dendritic cell immunotherapy | GP100 | MARKER CD133 | IMMUNOLOGY | IDENTIFICATION | CANCER STEM-CELLS | MALIGNANT GLIOMA | CYTOTOXIC T-CELLS | ONCOLOGY | IMMUNOTHERAPY | GENE-EXPRESSION | PCR | ANTIGEN | Antigens, Neoplasm - immunology | Dendritic Cells - immunology | Humans | Middle Aged | Brain Neoplasms - pathology | Histocompatibility Antigens Class I - immunology | Kaplan-Meier Estimate | Neoplastic Stem Cells - immunology | Male | Reverse Transcriptase Polymerase Chain Reaction | Epitopes - immunology | Glioblastoma - therapy | Cancer Vaccines - immunology | Cancer Vaccines - therapeutic use | Brain Neoplasms - immunology | Glioblastoma - immunology | Glioblastoma - pathology | Brain Neoplasms - therapy | Adult | Female | Aged | Brain Neoplasms - mortality | Dendritic Cells - transplantation | Glioblastoma - mortality | Rare earth metals | Care and treatment | Peptides | Dendritic cells | Immunotherapy | Stem cells | Clinical trials | Product development | Vaccines | T cells | Glioblastoma multiforme | Autografts | Brain stem | Brain tumors | Data processing | Leukocytes (mononuclear) | ErbB-2 protein | Survival | Leukapheresis | Glioma | Antigen (tumor-associated) | Interleukin 1 | Histocompatibility antigen HLA | Glycoprotein gp100 | Tumors | Original
Journal Article
Seminars in immunopathology, ISSN 1863-2300, 2011, Volume 34, Issue 1, pp. 43 - 62
The interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles... 
Autoimmunity | Complement receptor 3 | Multiple sclerosis | Stroke | Alzheimer’s disease | Internal Medicine | Macrophages | Blood brain barrier | Inflammatory disease | Microglia | Biomedicine | Immunology | Rheumatoid arthritis | CD11b/CD18 | Atherosclerosis | Plasminogen | Anticoagulant therapy | Alzheimer's disease | ALZHEIMERS-DISEASE | IMMUNOLOGY | PATHOLOGY | GAMMA-C-DOMAIN | BINDING-SITE | CENTRAL-NERVOUS-SYSTEM | MULTIPLE-SCLEROSIS LESIONS | CRYSTAL-STRUCTURE | BLOOD-BRAIN-BARRIER | INTEGRIN ALPHA(M)BETA | PROTEASE-ACTIVATED RECEPTORS | PERIPHERAL ARTERIAL-DISEASE | Colitis - genetics | Humans | Brain Injuries - metabolism | Arthritis, Rheumatoid - metabolism | Bacterial Infections - genetics | Inflammation - metabolism | Blood Coagulation - immunology | Muscular Dystrophy, Duchenne - immunology | Alzheimer Disease - immunology | Fibrinogen - immunology | Thromboplastin - immunology | Pulmonary Fibrosis - immunology | Vascular Diseases - genetics | Brain Injuries - genetics | Thrombin - genetics | Kidney Diseases - immunology | Arthritis, Rheumatoid - genetics | Neoplasms - immunology | Colitis - metabolism | Muscular Dystrophy, Duchenne - genetics | Bacterial Infections - metabolism | Neoplasms - metabolism | Pulmonary Fibrosis - genetics | Spinal Cord Injuries - genetics | Kidney Diseases - genetics | Stroke - genetics | Brain Injuries - immunology | Neoplasms - genetics | Bacterial Infections - immunology | Pulmonary Fibrosis - metabolism | Colitis - immunology | Thrombin - immunology | Stroke - immunology | Kidney Diseases - metabolism | Multiple Sclerosis - metabolism | Vascular Diseases - immunology | Spinal Cord Injuries - metabolism | Multiple Sclerosis - genetics | Inflammation - immunology | Fibrinogen - genetics | Stroke - metabolism | Animals | Thromboplastin - genetics | Alzheimer Disease - metabolism | Fibrinogen - metabolism | Inflammation - genetics | Multiple Sclerosis - immunology | Blood Coagulation - genetics | Spinal Cord Injuries - immunology | Muscular Dystrophy, Duchenne - metabolism | Thrombin - metabolism | Thromboplastin - metabolism | Alzheimer Disease - genetics | Arthritis, Rheumatoid - immunology | Vascular Diseases - metabolism | Nervous system diseases | Bacterial infections | Oncology, Experimental | Thrombin | Inflammation | Anticoagulants (Medicine) | Research | Rheumatoid factor | Fibrin | Fibrinogen | Genetic research | Colitis | Cancer | Traumatic brain injury | Coagulation | Tissue factor | hemostasis | Spinal cord injury | Inflammatory diseases | Kidney | Signal transduction | Duchenne's muscular dystrophy | Neurodegenerative diseases | Therapeutic applications | Thrombosis | Coagulation factors | Infection | Molecular modelling | Fibrosis | Brain injury
Journal Article