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1. Full Text Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system
by Kohler, Betsy A and Ward, Elizabeth and McCarthy, Bridget J and Schymura, Maria J and Ries, Lynn A. G and Eheman, Christie and Jemal, Ahmedin and Anderson, Robert N and Ajani, Umed A and Edwards, Brenda K
Journal of the National Cancer Institute, ISSN 0027-8874, 05/2011, Volume 103, Issue 9, pp. 714 - 736
Background The American Cancer Society, the Centers for Disease Control and Prevention (CDC), the National Cancer Institute, and the North American Association... 
BREAST-CANCER | UNITED-STATES | LUNG-CANCER | INCIDENCE RATES | RISK-FACTORS | RECENT TRENDS | ADULT GLIOMA | ONCOLOGY | PROSTATE-CANCER | SERVICES TASK-FORCE | ALLERGIC CONDITIONS | United States - epidemiology | SEER Program | Age Distribution | Early Detection of Cancer | Humans | Neoplasms - mortality | Male | Neoplasms - prevention & control | Survival Rate | Mortality - trends | Neoplasms - diagnosis | Incidence | Nervous System Neoplasms - epidemiology | Confounding Factors (Epidemiology) | Neoplasms - ethnology | Sex Distribution | Adult | Female | Registries | Child | Continental Population Groups - statistics & numerical data | Neoplasms - epidemiology | Brain Neoplasms - epidemiology | Population Dynamics | Women | Care and treatment | Demographic aspects | Brain cancer | Diagnosis | Research | Medical statistics | Health aspects | Brain | Nervous system | Trends | Mortality | Cancer | Tumors | Index Medicus | Special
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2. Full Text Preclinical comparison of osimertinib with other EGFR-TKIs in EGFR-mutant NSCLC brain metastases models, and early evidence of clinical brain metastases activity
by Ballard, Peter and Yates, James W.T and Yang, Zhenfan and Kim, Dong-Wan and Yang, James Chih-Hsin and Cantarini, Mireille and Pickup, Kathryn and Jordan, Angela and Hickey, Mike and Grist, Matthew and Box, Matthew and Johnström, Peter and Varnäs, Katarina and Malmquist, Jonas and Thress, Kenneth S and Jänne, Pasi A and Cross, Darren
Clinical Cancer Research, ISSN 1078-0432, 10/2016, Volume 22, Issue 20, pp. 5130 - 5140
Purpose: Approximately one-third of patients with non-small cell lung cancer (NSCLC) harboring tumors with EGFR-tyrosine kinase inhibitor (TKI)-sensitizing... 
CELL LUNG-CANCER | GEFITINIB | ONCOLOGY | BARRIER | DISEASE | TYROSINE KINASE INHIBITOR | RECEPTOR | UNBOUND BRAIN | ERLOTINIB | PET | CHEMOTHERAPY | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Humans | Middle Aged | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Male | Brain Neoplasms - secondary | Madin Darby Canine Kidney Cells | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Piperazines - pharmacokinetics | Drug Evaluation, Preclinical | Acrylamides - pharmacology | Caco-2 Cells | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Protein Kinase Inhibitors - pharmacokinetics | Carcinoma, Non-Small-Cell Lung - genetics | Rats | Pyrimidines - pharmacology | Brain Neoplasms - drug therapy | Mice, SCID | Blood-Brain Barrier - drug effects | Piperazines - pharmacology | Disease Progression | Brain Neoplasms - prevention & control | Xenograft Model Antitumor Assays | Animals | Dogs | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Biological Transport - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Quinazolines - pharmacology | Index Medicus
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3. Full Text Peptide density targets and impedes triple negative breast cancer metastasis
by Liu, Daxing and Guo, Peng and McCarthy, Craig and Wang, Biran and Tao, Yu and Auguste, Debra
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2612 - 11
The C-X-C chemokine receptor type 4 (CXCR4, CD184) pathway is a key regulator of cancer metastasis. Existing therapeutics that block CXCR4 signaling are... 
MIGRATION | D-AMINO ACIDS | CELLS | IN-VITRO | PROTEIN | RECOGNITION | CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | DIMERIZATION | EXPRESSION | CXCR4 RECEPTOR | Luciferases - metabolism | Membrane Microdomains - metabolism | Humans | Lung Neoplasms - metabolism | Polyethylene Glycols - chemistry | Triple Negative Breast Neoplasms - drug therapy | Brain Neoplasms - metabolism | Luciferases - genetics | Antineoplastic Agents - metabolism | Brain Neoplasms - secondary | Peptides - metabolism | Lung Neoplasms - secondary | Triple Negative Breast Neoplasms - pathology | Female | Receptors, CXCR4 - genetics | Antineoplastic Agents - pharmacology | Liver Neoplasms - secondary | Genes, Reporter | Binding, Competitive | Liver Neoplasms - prevention & control | Lung Neoplasms - genetics | Gene Expression | Liver Neoplasms - genetics | Peptides - chemistry | Brain Neoplasms - genetics | Phosphatidylcholines - chemistry | Antineoplastic Agents - chemistry | Peptides - pharmacology | Receptors, CXCR4 - metabolism | Brain Neoplasms - prevention & control | Xenograft Model Antitumor Assays | Liposomes - chemistry | Animals | Triple Negative Breast Neoplasms - genetics | Lung Neoplasms - prevention & control | Membrane Microdomains - drug effects | Mice, Nude | Triple Negative Breast Neoplasms - metabolism | Liver Neoplasms - metabolism | Cell Line, Tumor | Protein Binding | Liposomes - metabolism | Mice | Phosphatidylethanolamines - chemistry | Cell Movement | Binding | Peptides | Gene regulation | Rafts | Lipid rafts | Breast cancer | Metastasis | Gene expression | Density | CXCR4 protein | Molecular chains | Cell adhesion & migration | Metastases | Signaling | CD18 antigen | Dimers | Liposomes | Cell migration | Cancer | Index Medicus
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4. Full Text Role of adjuvant therapy in a population-based cohort of patients with early-stage small-cell lung cancer
by Yang, Chi-Fu Jeffrey and Chan, Derek Y and Speicher, Paul J and Gulack, Brian C and Wang, Xiaofei and Hartwig, Matthew G and Onaitis, Mark W and Tong, Betty C and D'Amico, Thomas A and Berry, Mark F and Harpole, David H
Journal of Clinical Oncology, ISSN 0732-183X, 04/2016, Volume 34, Issue 10, pp. 1057 - 1064
Data on optimal adjuvant therapy after complete resection of small-cell lung cancer (SCLC) are limited, and in particular, there have been no studies... 
Carcinoma, Small Cell - secondary | Lung Neoplasms - drug therapy | Follow-Up Studies | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Pneumonectomy | Secondary Prevention - methods | Brain Neoplasms - secondary | Female | Retrospective Studies | Chemotherapy, Adjuvant | Odds Ratio | Radiotherapy, Adjuvant | Carcinoma, Small Cell - drug therapy | Kaplan-Meier Estimate | Proportional Hazards Models | Treatment Outcome | Cranial Irradiation | Brain Neoplasms - prevention & control | Confounding Factors (Epidemiology) | Carcinoma, Small Cell - prevention & control | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Neoplasm Staging | Index Medicus | Thor11 | Thor3 | Thor4 | ORIGINAL REPORTS | Thor5 | Thor6
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5. Full Text Prophylactic cranial irradiation versus observation in patients with extensive-disease small-cell lung cancer: a multicentre, randomised, open-label, phase 3 trial
by Takahashi, Toshiaki, MD and Yamanaka, Takeharu, Prof and Seto, Takashi, MD and Harada, Hideyuki, MD and Nokihara, Hiroshi, MD and Saka, Hideo, MD and Nishio, Makoto, MD and Kaneda, Hiroyasu, MD and Takayama, Koichi, MD and Ishimoto, Osamu, MD and Takeda, Koji, MD and Yoshioka, Hiroshige, MD and Tachihara, Motoko, MD and Sakai, Hiroshi, MD and Goto, Koichi, MD and Yamamoto, Nobuyuki, Prof
Lancet Oncology, The, ISSN 1470-2045, 2017, Volume 18, Issue 5, pp. 663 - 671
Summary Background Results from a previous phase 3 study suggested that prophylactic cranial irradiation reduces the incidence of symptomatic brain metastases... 
Hematology, Oncology and Palliative Medicine | DIAGNOSIS | METAANALYSIS | THERAPY | COMPLETE REMISSION | CISPLATIN | ONCOLOGY | RISK | ASYMPTOMATIC BRAIN METASTASES | Lung Neoplasms - drug therapy | Brain Neoplasms - diagnostic imaging | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - secondary | Early Termination of Clinical Trials | Brain Neoplasms - secondary | Aged, 80 and over | Medical Futility | Adult | Female | Survival Rate | Cranial Irradiation - adverse effects | Brain Neoplasms - prevention & control | Small Cell Lung Carcinoma - prevention & control | Magnetic Resonance Imaging | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Intention to Treat Analysis | Small Cell Lung Carcinoma - diagnostic imaging | Watchful Waiting | Aged | Platinum Compounds - administration & dosage | Care and treatment | Chemotherapy | Lung cancer | Oncology, Experimental | Radiation | Clinical trials | Metastasis | Research | College teachers | Radiotherapy | Cancer | Analysis | Index Medicus
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6. Full Text Temozolomide treatment can improve overall survival in aggressive pituitary tumors and pituitary carcinomas
by Lasolle, Hélène and Cortet, Christine and Castinetti, Fréderic and Cloix, Lucie and Caron, Philippe and Delemer, Brigitte and Desailloud, Rachel and Jublanc, Christel and Lebrun-Frenay, Christine and Sadoul, Jean-Louis and Taillandier, Luc and Batisse-Lignier, Marie and Bonnet, Fabrice and Bourcigaux, Nathalie and Bresson, Damien and Chabre, Olivier and Chanson, Philippe and Garcia, Cyril and Haissaguerre, Magalie and Reznik, Yves and Borot, Sophie and Villa, Chiara and Vasiljevic, Alexandre and Gaillard, Stephan and Jouanneau, Emmanuel and Assié, Guillaume and Raverot, Gérald
European Journal of Endocrinology, ISSN 0804-4643, 06/2017, Volume 176, Issue 6, pp. 769 - 777
Objectives: Only few retrospective studies have reported an efficacy rate of temozolomide (TMZ) in pituitary tumors (PT), all around 50%. However, the... 
RESISTANT | DIAGNOSIS | MANAGEMENT | THERAPY | PROTEIN | ENDOCRINOLOGY & METABOLISM | MGMT PROMOTER METHYLATION | EXPERIENCE | PRIMARY BRAIN | ADENOMAS | ACTH-Secreting Pituitary Adenoma - drug therapy | ACTH-Secreting Pituitary Adenoma - prevention & control | Follow-Up Studies | Dacarbazine - therapeutic use | Tumor Burden - radiation effects | Humans | Drug Resistance, Neoplasm | Male | Practice Patterns, Physicians | Chemoradiotherapy | Prolactinoma - prevention & control | Prolactinoma - radiotherapy | Neoplasm Recurrence, Local - pathology | Neoplasm Grading | Dacarbazine - analogs & derivatives | Adult | Female | Pituitary Neoplasms - radiotherapy | Retrospective Studies | Carcinoma - pathology | France | Prolactinoma - drug therapy | Pituitary Neoplasms - prevention & control | Prolactinoma - pathology | ACTH-Secreting Pituitary Adenoma - radiotherapy | Carcinoma - drug therapy | Neoplasm Recurrence, Local - prevention & control | Neoplasm Invasiveness | Carcinoma - prevention & control | Pituitary Neoplasms - pathology | Carcinoma - radiotherapy | Antineoplastic Agents, Alkylating - therapeutic use | Pituitary Neoplasms - drug therapy | Tumor Burden - drug effects | Survival Analysis | Neoplasm Recurrence, Local - epidemiology | Temozolomide | ACTH-Secreting Pituitary Adenoma - pathology | Cohort Studies | Carcinoma | Brain tumors | Pituitary | Standardization | Radiation therapy | Survival | Patients | Tumors | Index Medicus
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7. Full Text Adaptation to AI therapy in breast cancer can induce dynamic alterations in ER activity resulting in estrogen-independent metastatic tumors
by Varešlija, Damir and Mcbryan, Jean and Fagan, Ailís and Redmond, Aisling M and Hao, Yuan and Sims, Andrew H and Turnbull, Arran and Dixon, J.M and Gaora, Peadar Ó and Hudson, Lance and Purcell, Siobhan and Hill, Arnold D.K and Young, Leonie S
Clinical Cancer Research, ISSN 1078-0432, 06/2016, Volume 22, Issue 11, pp. 2765 - 2777
Purpose: Acquired resistance to aromatase inhibitor (AI) therapy is a major clinical problem in the treatment of breast cancer. The detailed mechanisms of how... 
ACTIVATION | ONCOLOGY | FULVESTRANT | CONVERSION | AROMATASE INHIBITOR-RESISTANT | PROGESTERONE-RECEPTOR | MUTATIONS | RECEPTOR-ALPHA | PROGRESSION | ENDOCRINE TREATMENT | SRC-1 | Receptors, Estrogen - metabolism | Aromatase Inhibitors - pharmacology | Humans | Transcriptome | Drug Resistance, Neoplasm | Liver Neoplasms - mortality | Brain Neoplasms - metabolism | Breast Neoplasms - metabolism | Brain Neoplasms - secondary | MCF-7 Cells | Antineoplastic Agents, Hormonal - therapeutic use | Female | Brain Neoplasms - mortality | Gene Expression Regulation, Neoplastic - drug effects | Liver Neoplasms - secondary | Aromatase Inhibitors - therapeutic use | Liver Neoplasms - prevention & control | Antineoplastic Agents, Hormonal - pharmacology | Signal Transduction | Kaplan-Meier Estimate | Breast Neoplasms - drug therapy | Brain Neoplasms - prevention & control | Carrier Proteins - metabolism | Breast Neoplasms - pathology | Nuclear Receptor Coactivator 3 - metabolism | Liver Neoplasms - metabolism | Protein Binding | Breast Neoplasms - mortality | Early Growth Response Protein 3 - metabolism | Index Medicus
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8. Full Text Prophylactic Cranial Irradiation in Extensive Small-Cell Lung Cancer
by Slotman, Ben and Faivre-Finn, Corinne and Kramer, Gijs and Rankin, Elaine and Snee, Michael and Hatton, Matthew and Postmus, Pieter and Collette, Laurence and Musat, Elena and Senan, Suresh and EORTC Rad Oncology Grp and Lung Canc Grp and EORTC Radiation Oncology Group and Lung Cancer Group
The New England Journal of Medicine, ISSN 0028-4793, 08/2007, Volume 357, Issue 7, pp. 664 - 672
Symptomatic brain metastases are a major clinical problem in small-cell lung cancer. This trial compared prophylactic cranial irradiation with observation in... 
TRIAL | MEDICINE, GENERAL & INTERNAL | ETOPOSIDE | COMPLETE REMISSION | PHASE-III | METASTASES | NEUROLOGIC DISORDERS | WHOLE-BRAIN RADIOTHERAPY | CONSECUTIVE PATIENTS | CARCINOMA | CHEMOTHERAPY | Carcinoma, Small Cell - secondary | Lung Neoplasms - drug therapy | Lung Neoplasms - mortality | Carcinoma, Small Cell - drug therapy | Humans | Middle Aged | Carcinoma, Small Cell - radiotherapy | Lung Neoplasms - radiotherapy | Lung Neoplasms - pathology | Male | Risk | Combined Modality Therapy | Carcinoma, Small Cell - mortality | Cranial Irradiation | Brain Neoplasms - prevention & control | Disease-Free Survival | Brain Neoplasms - secondary | Survival Analysis | Quality of Life | Adult | Female | Aged | Brain Neoplasms - epidemiology | Cancer survivors | Lung cancer, Small cell | Chemotherapy | Drug therapy | Health aspects | Cancer | Brain | Survival analysis | Medical imaging | Lung cancer | Clinical trials | Radiation therapy | Preventive medicine | Risk factors | Index Medicus | Abridged Index Medicus
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9. Full Text Profound prevention of experimental brain metastases of breast cancer by temozolomide in an MGMT-Dependent manner
by Palmieri, Diane and Duchnowska, Renata and Woditschka, Stephan and Hua, Emily and Qian, Yongzhen and Biernat, Wojciech and Sosinska-Mielcarek, Katarzyna and Gril, Brunilde and Stark, Andreas M and Hewitt, Stephen M and Liewehr, David J and Steinberg, Seth M and Jassem, Jacek and Steeg, Patricia S
Clinical Cancer Research, ISSN 1078-0432, 05/2014, Volume 20, Issue 10, pp. 2727 - 2739
Purpose: Brain metastases of breast cancer cause neurocognitive damage and are incurable. We evaluated a role for temozolomide in the prevention of brain... 
CELL LUNG-CANCER | LAPATINIB | PHASE-II TRIAL | NERVOUS-SYSTEM METASTASES | EFFICACY | ONCOLOGY | IN-VIVO | BARRIER | BLOOD-BRAIN | RADIOTHERAPY | CHEMOTHERAPY | Immunohistochemistry | Humans | DNA Repair Enzymes - genetics | Antineoplastic Agents, Alkylating - pharmacology | Triple Negative Breast Neoplasms - drug therapy | Brain Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Brain Neoplasms - secondary | MCF-7 Cells | RNA Interference | Dacarbazine - pharmacology | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | Dacarbazine - analogs & derivatives | Triple Negative Breast Neoplasms - pathology | Female | Tumor Suppressor Proteins - metabolism | DNA Modification Methylases - metabolism | Drug Administration Schedule | Kaplan-Meier Estimate | Treatment Outcome | Breast Neoplasms - drug therapy | Brain Neoplasms - prevention & control | Xenograft Model Antitumor Assays | DNA Modification Methylases - genetics | Animals | Breast Neoplasms - pathology | Mice, Nude | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | Mice | Index Medicus | temozolomide | breast cancer | metastasis | MGMT | Brain metastasis
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10. Full Text Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
by Ricki J. Colman and Rozalyn M. Anderson and Sterling C. Johnson and Erik K. Kastman and Kristopher J. Kosmatka and T. Mark Beasley and David B. Allison and Christina Cruzen and Heather A. Simmons and Joseph W. Kemnitz and Richard Weindruch
Science, ISSN 0036-8075, 7/2009, Volume 325, Issue 5937, pp. 201 - 204
Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and... 
Animals | Vascular diseases | Life span | Mortality | Humans | Primates | Research facilities | Reports | Diabetes | Cardiovascular diseases | Age | LIFE-SPAN | MACAQUES | DIETARY RESTRICTION | ADULT MALE | MULTIDISCIPLINARY SCIENCES | Body Weight | Caloric Restriction | Cardiovascular Diseases - prevention & control | Male | Neoplasms - prevention & control | Macaca mulatta | Longevity | Incidence | Diabetes Mellitus - prevention & control | Atrophy - epidemiology | Diabetes Mellitus - epidemiology | Atrophy - prevention & control | Aging | Brain - pathology | Cardiovascular Diseases - epidemiology | Glucose - metabolism | Female | Neoplasms - epidemiology | Animal feeding behavior | Rhesus monkey | Disease transmission | Physiological aspects | Calorimetry | Research | Food and nutrition | Methods | Disease prevention | Life expectancy | Diet | Monkeys & apes | Index Medicus
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11. Small Cell Lung Cancer
by Kalemkerian, GP and Akerley, W and Bogner, P and Borghaei, H and Chow, LQM and Downey, RJ and Gandhi, L and Ganti, AKP and Govindan, R and Grecula, JC and Hayman, J and Heist, RS and Horn, L and Jahan, T and Koczywas, M and Loo, BW and Merritt, RE and Moran, CA and Niell, HB and O'Malley, J and Patel, JD and Ready, N and Rudin, CM and Williams, CC and Gregory, K and Hughes, M and National Comprehensive Cancer Network
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, ISSN 1540-1405, 01/2013, Volume 11, Issue 1, pp. 78 - 98
Neuroendocrine tumors account for approximately 20% of lung cancers; most (approximate to 15%) are small cell lung cancer (SCLC). These NCCN Clinical Practice... 
PHASE-III TRIAL | PROPHYLACTIC CRANIAL IRRADIATION | FORTHCOMING 7TH EDITION | MULTICENTER RANDOMIZED-TRIAL | POSITRON-EMISSION-TOMOGRAPHY | COLONY-STIMULATING FACTOR | ONCOLOGY | CISPLATIN PLUS ETOPOSIDE | EATON MYASTHENIC SYNDROME | QUALITY-OF-LIFE | COOPERATIVE-ONCOLOGY-GROUP | Brain Neoplasms - prevention & control | Brain Neoplasms - secondary | Humans | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Lung Neoplasms - therapy | Small Cell Lung Carcinoma - therapy | Brain Neoplasms - radiotherapy | Neoplasm Staging | Radiotherapy | Small Cell Lung Carcinoma - secondary
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12. Full Text Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis
by Gril, Brunilde and Palmieri, Diane and Qian, Yong and Smart, Dee Dee and Ileva, Lilia and Liewehr, David J and Steinberg, Seth M and Steeg, Patricia S
Clinical Cancer Research, ISSN 1078-0432, 01/2011, Volume 17, Issue 1, pp. 142 - 153
Purpose: Brain metastases of breast cancer contribute significantly to patient morbidity and mortality. We have tested pazopanib, a recently approved... 
MELANOMA | THERAPY | ANGIOGENESIS | TRASTUZUMAB | ONCOLOGY | KINASE | GROWTH | CENTRAL-NERVOUS-SYSTEM | MUTATIONS | INHIBITOR | PROGRESSION | Receptor, ErbB-2 - genetics | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Extracellular Signal-Regulated MAP Kinases - metabolism | Breast Neoplasms - metabolism | Brain Neoplasms - secondary | Female | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Disease Models, Animal | Brain Neoplasms - genetics | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Breast Neoplasms - drug therapy | Brain Neoplasms - prevention & control | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - genetics | Signal Transduction - drug effects | Sulfonamides - therapeutic use | Breast Neoplasms - pathology | Mice, Nude | Pyrimidines - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Mutation | Endothelial Cells - drug effects | Index Medicus | Brain | metastases | breast cancer | B-Raf | HER2
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