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International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2012, Volume 83, Issue 3, pp. 878 - 886
Purpose To analyze the long-term survival and tumor control outcomes after stereotactic body radiotherapy (SBRT) for metastases limited in number and extent.... 
Radiology | Hematology, Oncology and Palliative Medicine | Stereotactic body radiotherapy | Breast cancer | Oligometastases | Survival | Metastases | ACR PRACTICE GUIDELINES | PHASE I/II TRIAL | HEPATIC RESECTION | CELL LUNG-CANCER | LIVER METASTASES | ONCOLOGY ASTRO | ONCOLOGY | COLORECTAL-CANCER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | AMERICAN SOCIETY | RADIATION-THERAPY SBRT | TUMOR VOLUME | Bone Neoplasms - mortality | Sarcoma - secondary | Prospective Studies | Follow-Up Studies | Lung Neoplasms - mortality | Humans | Middle Aged | Bone Neoplasms - secondary | Carcinoma, Squamous Cell - surgery | Liver Neoplasms - mortality | Radiosurgery - adverse effects | Brain Neoplasms - surgery | Esophageal Neoplasms - pathology | Brain Neoplasms - secondary | Carcinoma, Squamous Cell - mortality | Lung Neoplasms - secondary | Sarcoma - mortality | Aged, 80 and over | Adult | Female | Brain Neoplasms - mortality | Liver Neoplasms - secondary | Radiosurgery - methods | Colorectal Neoplasms - mortality | Neoplasm Metastasis - radiotherapy | Liver Neoplasms - surgery | Lymphatic Metastasis | Bone Neoplasms - surgery | Adenocarcinoma - secondary | Head and Neck Neoplasms - pathology | Breast Neoplasms - pathology | Sarcoma - surgery | Breast Neoplasms - mortality | Carcinoma, Squamous Cell - secondary | Lung Neoplasms - surgery | Aged | Head and Neck Neoplasms - mortality | Colorectal Neoplasms - pathology | Adenocarcinoma - mortality | Adenocarcinoma - surgery | Radiotherapy | Nuclear radiation | Analysis | Radiation | MULTIVARIATE ANALYSIS | PATIENTS | MAMMARY GLANDS | NEOPLASMS | METASTASES | RADIOLOGY AND NUCLEAR MEDICINE | DEATH | REGRESSION ANALYSIS | RADIOTHERAPY | HAZARDS | SKELETON
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2016, Volume 68, pp. 156 - 162
Abstract Purpose To assess preliminary safety and efficacy results of the anti-programmed cell death ligand-1 (anti-PD-L1) durvalumab in combination with... 
Hematology, Oncology and Palliative Medicine | Immunoradiotherapy | Phase 2 | Phase 1 | Radiotherapy | Anti-PD-L1 | ABSCOPAL | ONCOLOGY | MECHANISMS | PATIENT | RADIATION-THERAPY | Lymphatic Metastasis - radiotherapy | Bone Neoplasms - therapy | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Carcinoma, Transitional Cell - secondary | Radiosurgery | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Carcinoma, Transitional Cell - therapy | Liver Neoplasms - therapy | Eye Neoplasms - therapy | Chemoradiotherapy | Small Cell Lung Carcinoma - secondary | Breast Neoplasms - therapy | Brain Neoplasms - secondary | Neoplasms - therapy | Squamous Cell Carcinoma of Head and Neck | Urinary Bladder Neoplasms - pathology | Aged, 80 and over | Adult | Female | Liver Neoplasms - secondary | Colonic Neoplasms - therapy | Eye Neoplasms - pathology | Head and Neck Neoplasms - therapy | Kaplan-Meier Estimate | Carcinoma, Squamous Cell - therapy | Survival Rate | Lung Neoplasms - therapy | Adenocarcinoma - secondary | Melanoma - secondary | Head and Neck Neoplasms - pathology | Disease-Free Survival | B7-H1 Antigen - antagonists & inhibitors | Adenocarcinoma - therapy | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Urinary Bladder Neoplasms - therapy | Brain Neoplasms - therapy | Radiotherapy, Conformal | Aged | Small Cell Lung Carcinoma - therapy | Melanoma - therapy | Biochemistry | Apoptosis
Journal Article
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 2013, Volume 131, Issue 1, pp. 36 - 41
Abstract Objective We evaluated the clinical outcome and prognostic factors for post-relapse survival (PRS) in a large retrospective series of ovarian cancer... 
Hematology, Oncology and Palliative Medicine | Obstetrics and Gynecology | Anatomic site of disease | Favourable prognosis | Recurrent ovarian cancer | Localized relapse | Secondary debulking surgery | SURVIVAL | METASTASIS | SECONDARY CYTOREDUCTIVE SURGERY | IDENTIFICATION | CHEMOTHERAPY | OBSTETRICS & GYNECOLOGY | 2ND-LINE | THERAPY | CISPLATIN | ONCOLOGY | RECURRENT | CARCINOMA | Lymph Nodes - pathology | Follow-Up Studies | Lymph Nodes - surgery | Humans | Middle Aged | Brain Neoplasms - pathology | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Brain Neoplasms - surgery | Neoplasm Recurrence, Local - pathology | Platinum Compounds - therapeutic use | Young Adult | Brain Neoplasms - secondary | Lung Neoplasms - secondary | Aged, 80 and over | Adult | Female | Liver Neoplasms - pathology | Retrospective Studies | Liver Neoplasms - secondary | Carcinoma - secondary | Peritoneal Neoplasms - secondary | Carcinoma - drug therapy | Peritoneal Neoplasms - pathology | Neoplasms, Glandular and Epithelial - pathology | Neoplasm Recurrence, Local - therapy | Peritoneal Neoplasms - surgery | Neoplasms, Glandular and Epithelial - therapy | Liver Neoplasms - surgery | Lymphatic Metastasis | Splenic Neoplasms - surgery | Splenic Neoplasms - pathology | Carcinoma, Ovarian Epithelial | Ovarian Neoplasms - therapy | Carcinoma - therapy | Aged | Neoplasm Staging | Splenic Neoplasms - secondary | Care and treatment | Cancer patients | Prognosis | Patient outcomes | Ovarian cancer
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 03/2013, Volume 8, Issue 3, pp. 346 - 351
Journal Article
Nature cell biology, ISSN 1476-4679, 2013, Volume 15, Issue 7, pp. 807 - 817
Journal Article
Nature communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, p. 8760
Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic... 
HETEROGENEITY | ACTIVATION | VARIANTS | PATHWAY | MULTIDISCIPLINARY SCIENCES | KINASE | ACQUIRED-RESISTANCE | SEQUENCING DATA | Carcinoma, Ductal, Breast - genetics | Receptors, Estrogen - metabolism | Humans | Receptor, ErbB-2 - metabolism | Clonal Evolution - genetics | Tamoxifen - administration & dosage | Case-Control Studies | Breast Neoplasms - metabolism | Brain Neoplasms - secondary | Carcinoma, Ductal, Breast - drug therapy | Neoplasm Metastasis | Lung Neoplasms - secondary | Adult | Carcinoma, Ductal, Breast - pathology | Female | Quinazolines - administration & dosage | Lapatinib | Liver Neoplasms - secondary | Carcinoma, Ductal, Breast - metabolism | Lung Neoplasms - genetics | Liver Neoplasms - genetics | Deoxycytidine - administration & dosage | Brain Neoplasms - genetics | Trastuzumab - administration & dosage | Breast Neoplasms - drug therapy | Sequence Analysis, DNA | Spinal Neoplasms - secondary | Breast Neoplasms - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Spinal Neoplasms - genetics | Bayes Theorem | DNA, Neoplasm - genetics | Mutation | Deoxycytidine - analogs & derivatives | Biological evolution | Breast cancer | Genomes | Metastasis | ErbB-2 protein | Patients | Metastases | Heterogeneity | Biopsy | Evolution | Deoxyribonucleic acid--DNA | Cancer | Tumors
Journal Article
American Journal of Pathology, ISSN 0002-9440, 2010, Volume 177, Issue 4, pp. 1647 - 1656
Phosphatase and tensin homolog (PTEN) is a key modulator of trastuzumab sensitivity in HER2-overexpressing breast cancer. Because PTEN opposes the downstream... 
ADJUVANT CHEMOTHERAPY | INHIBITION | THERAPY | PROTEIN | HUMAN-BREAST-CANCER | PATHWAY | MUTATIONS | PATHOLOGY | RECEPTORS | TRASTUZUMAB RESISTANCE | EXPRESSION | Lung Neoplasms - drug therapy | Receptors, Estrogen - metabolism | Receptor, ErbB-2 - genetics | Lung Neoplasms - mortality | Humans | Middle Aged | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Immunoenzyme Techniques | Receptors, Progesterone - metabolism | Young Adult | Carcinoma, Ductal, Breast - drug therapy | Brain Neoplasms - mortality | Liver Neoplasms - secondary | Proto-Oncogene Proteins c-akt - metabolism | Carcinoma, Ductal, Breast - metabolism | PTEN Phosphohydrolase - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Survival Rate | Lymphatic Metastasis | Brain Neoplasms - drug therapy | Mutation - genetics | Breast Neoplasms - drug therapy | Class I Phosphatidylinositol 3-Kinases | Carcinoma, Lobular - metabolism | Trastuzumab | Bone Neoplasms - mortality | Phosphorylation | Prognosis | Receptor, ErbB-2 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Liver Neoplasms - mortality | Carcinoma, Ductal, Breast - mortality | Carcinoma, Lobular - mortality | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | Brain Neoplasms - secondary | In Situ Hybridization | Lung Neoplasms - secondary | Adult | Female | Bone Neoplasms - drug therapy | Neoplasm Invasiveness | Liver Neoplasms - drug therapy | PTEN Phosphohydrolase - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - mortality | Aged | Carcinoma, Lobular - drug therapy | Regular
Journal Article
Clinical Lung Cancer, ISSN 1525-7304, 2011, Volume 12, Issue 6, pp. 380 - 386
Micro-Abstract We evaluated EGFR and KRAS mutations between 37 paired primary tumors and corresponding metastases in lung adenocarcinoma. A substantial... 
Hematology, Oncology and Palliative Medicine | Pulmonary/Respiratory | Lung adenocarcinoma | Metastasis | Mutation | Epidermal growth factor receptor | Pleura | GENE-MUTATIONS | PRIMARY TUMORS | GEFITINIB | GROWTH-FACTOR-RECEPTOR | KRAS MUTATION | TREATED PATIENTS | CANCER | LYMPH-NODE METASTASIS | ONCOLOGY | BRAIN METASTASES | PROGRESSION | Adrenal Gland Neoplasms - drug therapy | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Pleural Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Adenocarcinoma - pathology | Prognosis | Humans | Middle Aged | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Pleural Neoplasms - drug therapy | Brain Neoplasms - secondary | Carcinoma, Non-Small-Cell Lung - secondary | Polymerase Chain Reaction | Aged, 80 and over | Adrenal Gland Neoplasms - secondary | Adult | Female | Adenocarcinoma - genetics | Bone Neoplasms - genetics | Bone Neoplasms - drug therapy | Liver Neoplasms - secondary | Lung Neoplasms - genetics | Pleural Neoplasms - secondary | Liver Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Liver Neoplasms - drug therapy | Brain Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Brain Neoplasms - drug therapy | Mutation - genetics | Adenocarcinoma - drug therapy | Aged | Biomarkers, Tumor - genetics | Carcinoma, Non-Small-Cell Lung - drug therapy | DNA, Neoplasm - genetics | Neoplasm Staging | Adrenal Gland Neoplasms - genetics
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2014, Volume 89, Issue 4, pp. 880 - 887
Purpose Although palliative chemotherapy is the standard of care for patients with diagnoses of stage IV non-small cell lung cancer (NSCLC), patients with a... 
Radiology | Hematology, Oncology and Palliative Medicine | ADRENAL METASTASES | SURVIVAL | RADICAL TREATMENT | PHASE-II-TRIAL | MANAGEMENT | PROGNOSTIC-FACTORS | BRAIN METASTASIS | ONCOLOGY | RESECTION | SURGICAL-TREATMENT | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | RADIATION-THERAPY | Bone Neoplasms - mortality | Bone Neoplasms - therapy | Lung Neoplasms - mortality | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Carcinoma, Squamous Cell - diagnostic imaging | Adrenal Gland Neoplasms - mortality | Brain Neoplasms - secondary | Carcinoma, Non-Small-Cell Lung - secondary | Carcinoma, Squamous Cell - mortality | Adrenal Gland Neoplasms - secondary | Female | Retrospective Studies | Brain Neoplasms - mortality | Databases, Factual | Carcinoma, Non-Small-Cell Lung - pathology | Severity of Illness Index | Carcinoma, Squamous Cell - therapy | Lung Neoplasms - therapy | Carcinoma, Non-Small-Cell Lung - mortality | Radiography | Propensity Score | Carcinoma, Non-Small-Cell Lung - therapy | Analysis of Variance | Brain Neoplasms - therapy | Carcinoma, Squamous Cell - secondary | Lung Neoplasms - diagnostic imaging | Aged | Carcinoma, Non-Small-Cell Lung - diagnostic imaging | Neoplasm Staging | Adrenal Gland Neoplasms - therapy | Lung cancer, Small cell | Chemotherapy | Lung cancer, Non-small cell | Cancer | DIAGNOSIS | PATIENTS | NEOPLASMS | LUNGS | METASTASES | RADIOLOGY AND NUCLEAR MEDICINE | HISTOLOGY | CHEMOTHERAPY | HAZARDS
Journal Article
BMC cancer, ISSN 1471-2407, 2006, Volume 6, Issue 1, pp. 225 - 225
Background: HER2/neu overexpression is linked to promotion of angiogenesis in breast cancer. We therefore tested the activity of the combination of Trastuzumab... 
PROTEIN | ANGIOGENESIS | ONCOLOGY | NEU ONCOGENE | EPIDERMAL-GROWTH-FACTOR | IN-VIVO | PHASE-II | MONOCLONAL-ANTIBODY | ANTITUMOR-ACTIVITY | FACTOR RECEPTOR | PLUS | Lung Neoplasms - drug therapy | Cyclophosphamide - administration & dosage | Humans | Middle Aged | Neoplasm Proteins - immunology | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Neoplasm Proteins - antagonists & inhibitors | Cyclophosphamide - adverse effects | Bone Neoplasms - blood supply | Leukopenia - chemically induced | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Liver Neoplasms - secondary | Combined Modality Therapy | Lung Neoplasms - therapy | Lymphatic Metastasis | Breast Neoplasms - blood supply | Brain Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Remission Induction | Methotrexate - adverse effects | Breast Neoplasms - genetics | Brain Neoplasms - therapy | Immunization, Passive | Methotrexate - administration & dosage | Trastuzumab | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Bone Neoplasms - therapy | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Brain Neoplasms - blood supply | Liver Neoplasms - therapy | Ventricular Dysfunction, Left - chemically induced | Breast Neoplasms - therapy | Antibodies, Monoclonal, Humanized | Brain Neoplasms - secondary | Lung Neoplasms - secondary | Angiogenesis Inhibitors - therapeutic use | Adult | Female | Bone Neoplasms - drug therapy | Neutropenia - chemically induced | Lung Neoplasms - blood supply | Drug Administration Schedule | Liver Neoplasms - drug therapy | Treatment Outcome | Gene Amplification | Liver Neoplasms - blood supply | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Genes, erbB-2 | Aged
Journal Article