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Cell reports (Cambridge), ISSN 2211-1247, 2016, Volume 16, Issue 10, pp. 2576 - 2592
.... Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroepithelial stem (NES... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Bioimpacts, ISSN 2228-5660, 12/2018, Volume 8, Issue Suppl 1, pp. S1 - S129
Journal Article
Cell stem cell, ISSN 1934-5909, 2017, Volume 20, Issue 2, pp. 233 - 246.e7
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 489, Issue 7414, pp. 150 - 154
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 40, pp. 12516 - 12521
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce the number of drug failures in clinical trials and offer a cost-effective approach... 
Organoid | Toxicology | Differentiation | Tissue engineering | Machine learning | toxicology | HUMAN NEOCORTEX | tissue engineering | DEVELOPMENTAL NEUROTOXICITY | differentiation | HUMAN BRAIN | MULTIDISCIPLINARY SCIENCES | CLASSIFICATION | FATTY-ACIDS | machine learning | CANCER | organoid | IN-VITRO | HUMAN CEREBRAL-CORTEX | MICROGLIA | GENE-EXPRESSION | Embryonic Stem Cells - metabolism | Microglia - metabolism | Embryonic Stem Cells - cytology | Humans | Brain - growth & development | Support Vector Machine | Neural Stem Cells - cytology | Xenobiotics - pharmacology | Brain - metabolism | Neurogenesis - genetics | Mesenchymal Stromal Cells - cytology | Xenobiotics - classification | Gene Expression Regulation, Developmental | Cell Differentiation | Neurogenesis - drug effects | Culture Media, Serum-Free - pharmacology | Gene Ontology | Polyethylene Glycols - pharmacology | Microglia - cytology | Mesenchymal Stromal Cells - drug effects | Brain - cytology | Pluripotent Stem Cells - cytology | Tissue Engineering - methods | Microglia - drug effects | Endothelial Cells - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Mesenchymal Stromal Cells - metabolism | Cell Communication - genetics | Macrophages - cytology | Pluripotent Stem Cells - metabolism | Macrophages - metabolism | Embryonic Stem Cells - drug effects | Endothelial Cells - cytology | Models, Biological | Pluripotent Stem Cells - drug effects | Cell Communication - drug effects | Macrophages - drug effects | Hydrogels - pharmacology | Neural Stem Cells - metabolism | Endothelial Cells - drug effects | Biological Sciences
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 522, Issue 7555, pp. 216 - 220
.... Oligodendrocyte progenitor cells are stem cells in the central nervous system and the principal source of myelinating oligodendrocytes(1... 
MYELIN BASIC-PROTEIN | TRANSCRIPTS | GLUCOCORTICOIDS | MULTIPLE-SCLEROSIS | LYSOLECITHIN | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | SPINAL-CORD | CENTRAL-NERVOUS-SYSTEM | DIFFERENTIATION | OLIGODENDROCYTE PROGENITOR CELLS | Oligodendroglia - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Cerebellum - drug effects | Myelin Sheath - drug effects | Male | Receptors, Glucocorticoid - metabolism | Demyelinating Diseases - metabolism | MAP Kinase Signaling System | Myelin Sheath - metabolism | Oligodendroglia - drug effects | Female | Oligodendroglia - cytology | Demyelinating Diseases - pathology | Demyelinating Diseases - drug therapy | Disease Models, Animal | Multiple Sclerosis - metabolism | Germ Layers - drug effects | Germ Layers - pathology | Encephalomyelitis, Autoimmune, Experimental - pathology | Lysophosphatidylcholines | Pluripotent Stem Cells - cytology | Germ Layers - metabolism | Tissue Culture Techniques | Cerebellum - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Cerebellum - pathology | Pluripotent Stem Cells - metabolism | Phenotype | Regeneration - drug effects | Animals | Cell Differentiation - drug effects | Miconazole - pharmacology | Pluripotent Stem Cells - drug effects | Multiple Sclerosis - pathology | Mice | Clobetasol - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Multiple Sclerosis - drug therapy | Medical research | Myelination | Multiple sclerosis | Stem cells | Physiological aspects | Medicine, Experimental | Research | Drugs | Proteins | Blood-brain barrier | Laboratories | Rodents | Clinical trials | FDA approval | Gene expression
Journal Article
International journal of nanomedicine, ISSN 1178-2013, 2018, Volume 13, pp. 5231 - 5248
Background: Mesenchymal stem cells (MSCs) possess inherent tropism towards tumor cells, and so have attracted increased attention as targeted-therapy vehicles for glioma treatment. Purpose... 
C6 cells | Drug targeting | Orthotopic glioma | Bmscs | Contralateral injection | EXOCYTOSIS | LUNG MELANOMA METASTASES | DRUG-DELIVERY | orthotopic glioma | NANOSCIENCE & NANOTECHNOLOGY | POLY(D,L-LACTIDE-CO-GLYCOLIDE) | PACLITAXEL | TEMOZOLOMIDE | drug targeting | MALIGNANT GLIOMA | PHARMACOLOGY & PHARMACY | GENE-THERAPY | contralateral injection | STROMAL CELLS | BMSCs | BRAIN | Paclitaxel - pharmacology | Nanoparticles - chemistry | Polylactic Acid-Polyglycolic Acid Copolymer | Adipogenesis - drug effects | Humans | Male | Drug Carriers | Drug Delivery Systems | Tissue Distribution | Endocytosis | Mesenchymal Stem Cells - cytology | Mesenchymal Stem Cells - drug effects | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Mesenchymal Stem Cells - metabolism | Lactic Acid - chemistry | Osteogenesis - drug effects | Nanoparticles - ultrastructure | Paclitaxel - therapeutic use | Rats, Sprague-Dawley | Cell Movement - drug effects | Animals | Polyglycolic Acid - chemistry | Cell Line, Tumor | Nanoparticles - administration & dosage | Kinetics | Cell Cycle - drug effects | Glioma - drug therapy | Nanoparticles | Chemotherapy | Gliomas | Cell death | Stem cells | Transplantation | Health aspects | Cancer | Quantum dots | Brain cancer | Radiation therapy | Artificial chromosomes | Cancer therapies | Molecular weight | Microscopy | Medical prognosis | Cell cycle | Polyvinyl alcohol | Gene therapy | Laboratory animals | Drug dosages | Tumors
Journal Article
Journal Article
Nature Neuroscience, ISSN 1097-6256, 03/2006, Volume 9, Issue 3, pp. 331 - 339
Adult stem cells are characterized by self-renewal and multilineage differentiation, and these properties seem to be regulated by signals from adjacent differentiated cell types and by extracellular... 
STIMULATES NEUROGENESIS | FACTOR PEDF | MOUSE BRAIN | IN-VIVO | ENDOTHELIAL-CELLS | NEUROTROPHIC ACTIVITY | NEURONS | SELF-RENEWAL | ADULT MAMMALIAN BRAIN | GROWTH-FACTOR | NEUROSCIENCES | Humans | Injections, Intraventricular | Cercopithecus aethiops | Neuronal Plasticity - drug effects | Lateral Ventricles - metabolism | Neurons - cytology | Nerve Growth Factors - metabolism | Lateral Ventricles - cytology | Stem Cells - metabolism | Nerve Growth Factors - pharmacology | Neuronal Plasticity - physiology | Ependyma - cytology | Telencephalon - drug effects | Neurons - metabolism | Cell Differentiation - physiology | Telencephalon - metabolism | Serpins - metabolism | Telencephalon - cytology | Cells, Cultured | Ependyma - metabolism | Ependyma - drug effects | Hippocampus - cytology | Serpins - pharmacology | Cell Division - drug effects | Cell Division - physiology | Hippocampus - metabolism | Animals | Eye Proteins - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Endothelium, Vascular - metabolism | Endothelium, Vascular - secretion | Cell Cycle - physiology | Stem Cells - drug effects | Signal Transduction - physiology | Cell Proliferation - drug effects | Mice | Cell Cycle - drug effects | COS Cells | Eye Proteins - pharmacology | Physiological aspects | Cellular signal transduction | Research | Epithelium | Stem cells
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2014, Volume 344, Issue 6184, pp. 630 - 634
Journal Article