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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2015, Volume 112, Issue 40, pp. 12516 - 12521
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce the number of drug failures in clinical trials and... 
Organoid | Toxicology | Differentiation | Tissue engineering | Machine learning | toxicology | tissue engineering | DEVELOPMENTAL NEUROTOXICITY | differentiation | MULTIDISCIPLINARY SCIENCES | INVOLVEMENT | CLASSIFICATION | NEURODEGENERATION | machine learning | CANCER | organoid | IN-VITRO | MICROGLIA | GENE-EXPRESSION | SYSTEMS | BRAIN | Embryonic Stem Cells - metabolism | Microglia - metabolism | Embryonic Stem Cells - cytology | Humans | Brain - growth & development | Support Vector Machine | Neural Stem Cells - cytology | Xenobiotics - pharmacology | Brain - metabolism | Neurogenesis - genetics | Mesenchymal Stromal Cells - cytology | Xenobiotics - classification | Gene Expression Regulation, Developmental | Cell Differentiation | Neurogenesis - drug effects | Culture Media, Serum-Free - pharmacology | Gene Ontology | Polyethylene Glycols - pharmacology | Microglia - cytology | Mesenchymal Stromal Cells - drug effects | Brain - cytology | Pluripotent Stem Cells - cytology | Tissue Engineering - methods | Microglia - drug effects | Endothelial Cells - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Mesenchymal Stromal Cells - metabolism | Cell Communication - genetics | Macrophages - cytology | Pluripotent Stem Cells - metabolism | Macrophages - metabolism | Embryonic Stem Cells - drug effects | Endothelial Cells - cytology | Models, Biological | Pluripotent Stem Cells - drug effects | Cell Communication - drug effects | Macrophages - drug effects | Hydrogels - pharmacology | Neural Stem Cells - metabolism | Endothelial Cells - drug effects | Neurotoxicity | Stem cells | Gene expression | Biological assays | Bioinformatics | Artificial intelligence | Index Medicus | Biological Sciences
Journal Article
Cell Reports, ISSN 2211-1247, 09/2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Index Medicus | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, pp. e109305 - e109305
We have investigated and compared the neurotrophic activity of human dental pulp stem cells (hDPSC), human bone marrow-derived mesenchymal stem cells (hBMSC)... 
SURVIVAL | OPTIC-NERVE | IN-VITRO | NEUROTROPHIC FACTOR | MULTIDISCIPLINARY SCIENCES | AXON REGENERATION | RATS | SPINAL-CORD | EXPERIMENTAL GLAUCOMA | BRAIN | TRANSPLANTATION | Nerve Growth Factor - secretion | Brain-Derived Neurotrophic Factor - secretion | Cell- and Tissue-Based Therapy - methods | Neuroprotection | Vascular Endothelial Growth Factor A - biosynthesis | Nerve Growth Factor - biosynthesis | Neurites - physiology | Coculture Techniques | Humans | Adipose Tissue - cytology | Male | Dental Pulp - metabolism | Retinal Ganglion Cells - metabolism | Vascular Endothelial Growth Factor A - secretion | Adipose Tissue - metabolism | Paracrine Communication - physiology | Retinal Ganglion Cells - cytology | Axotomy | Mesenchymal Stromal Cells - cytology | Brain-Derived Neurotrophic Factor - biosynthesis | Bone Marrow Cells - cytology | Dental Pulp - cytology | Mesenchymal Stromal Cells - metabolism | Rats | Rats, Sprague-Dawley | Animals | Primary Cell Culture | Bone Marrow Cells - metabolism | Fc receptors | Platelet-derived growth factor | Stem cells | Nerve growth factor | Comparative analysis | Ganglion | Vascular endothelial growth factor | Health aspects | Enzyme-linked immunosorbent assay | Neurosciences | Spinal cord | Mesenchyme | Neurobiology | Paracrine signalling | Stem cell transplantation | Retina | Nervous system | Neurotrophin 3 | Pulp | Receptors | Rodents | Bone marrow | Conditioning | Ganglion cells | Growth factors | Glial cell line-derived neurotrophic factor | Optic nerve | Cytokines | Axonogenesis | Dentistry | Gene expression | Survival | Medicine | Retinal ganglion cells | Brain research | Brain-derived neurotrophic factor | Inhibitors | Apoptosis | Dental pulp | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 3, pp. e17540 - e17540
Background: Neural induction of human pluripotent stem cells often yields heterogeneous cell populations that can hamper quantitative and comparative analyses.... 
PROGENITOR CELLS | NERVOUS-SYSTEM | HUMAN ES | MULTIDISCIPLINARY SCIENCES | SPINAL-CORD | SELF-RENEWAL | FLOW-CYTOMETRIC ANALYSIS | DOPAMINERGIC-NEURONS | DIFFERENTIATION | FETAL | HUMAN BLASTOCYSTS | Cell Proliferation | Antibodies - metabolism | Humans | Neurons - cytology | Neural Stem Cells - cytology | Antigens, CD - metabolism | Neuroglia - cytology | Spinal Cord - pathology | Neural Stem Cells - transplantation | Cell Differentiation | Cell Membrane - metabolism | Neurons - metabolism | Biomarkers - metabolism | Pluripotent Stem Cells - cytology | Cell Survival | Cells, Cultured | Rats | Cell Separation - methods | Rats, Sprague-Dawley | Pluripotent Stem Cells - metabolism | Phenotype | Animals | Models, Biological | Neuroglia - metabolism | Mice | Neural Stem Cells - metabolism | Viral antibodies | Antibodies | Comparative analysis | Cell differentiation | Embryonic stem cells | Neurons | Flow cytometry | Neurosciences | Populations | Transplants & implants | Image processing | Laboratories | Embryo cells | Fluorescence | Cell surface | Neuronal-glial interactions | CD44 antigen | Rodents | Paralysis | Signatures | Drug dosages | Astrocytes | Glial fibrillary acidic protein | Markers | Cultures | Embryos | Screens | Medicine | Studies | Brain research | Stem cells | Neural stem cells | CD18 antigen | Spinal cord injuries | Anesthesiology | Differentiation | Surface markers | Pluripotency | Cell culture | Mixed culture | Action potential | Glia | Index Medicus
Journal Article