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1. Full Text Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets
by Ji-chun Zhang and Wei Yao and Kenji Hashimoto
Current Neuropharmacology, ISSN 1570-159X, 10/2016, Volume 14, Issue 7, pp. 721 - 731
Depression is the most prevalent and among the most debilitating of psychiatric disorders. The precise neurobiology of this illness is unknown. Several lines... 
Nucleus accumbens | TrkB | Brain-derived neurotrophic factor (BDNF) | Depression | Inflammation | Prefrontal cortex | Hippocampus | OXIDATIVE STRESS | MINOCYCLINE | SUICIDAL IDEATION | D-ASPARTATE ANTAGONIST | NEUROSCIENCES | TRKB AGONIST | SOCIAL DEFEAT | SERUM-LEVELS | DOUBLE-BLIND | INDUCED SICKNESS BEHAVIOR | PHARMACOLOGY & PHARMACY | ANTIDEPRESSANT ACTIONS | Inflammation - psychology | Anti-Inflammatory Agents - pharmacology | Humans | Receptor, trkB - immunology | Depressive Disorder - immunology | Depressive Disorder - drug therapy | Brain-Derived Neurotrophic Factor - immunology | Antidepressive Agents - therapeutic use | Brain - drug effects | Animals | Inflammation - drug therapy | Anti-Inflammatory Agents - therapeutic use | Antidepressive Agents - pharmacology | Brain - immunology | Inflammation - physiopathology
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2. Full Text Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β- hydroxybutyrate
by Sleiman, Sama F and Henry, Jeffrey and Al-Haddad, Rami and El Hayek, Lauretta and Haidar, Edwina Abou and Stringer, Thomas and Ulja, Devyani and Karuppagounder, Saravanan S and Holson, Edward B and Ratan, Rajiv R and Ninan, Ipe and Chao, Moses V
eLife, ISSN 2050-084X, 06/2016, Volume 5, Issue 2016
Exercise induces beneficial responses in the brain, which is accompanied by an increase in BDNF, a trophic factor associated with cognitive improvement and the... 
HISTONE DEACETYLASES | CORTICAL-NEURONS | MEMORY | MESSENGER-RNA EXPRESSION | BIOLOGY | PHYSICAL-EXERCISE | RAT HIPPOCAMPUS | ENHANCED NEUROTRANSMITTER RELEASE | SYNAPTIC PLASTICITY | CULTURED HIPPOCAMPAL-NEURONS | NEURODEGENERATIVE DISEASES | Brain-Derived Neurotrophic Factor - genetics | Histone Deacetylase 2 - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Histone Deacetylases - chemistry | Neurotransmitter Agents - metabolism | Male | Neurons - cytology | Hippocampus - drug effects | Gene Expression Regulation - drug effects | Hippocampus - metabolism | Animals | 3-Hydroxybutyric Acid - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Mice | Neurons - metabolism | Acetylation | Histones - metabolism | Neurons - drug effects | Receptor, trkB - metabolism | Physical Conditioning, Animal | Histone deacetylase | Neurotransmitter release | Transcription | Memory | Cognitive ability | Nervous system | Mental depression | Gene expression | Promoters | Proteins | Physical fitness | Hypotheses | Exercise | Brain research | Brain-derived neurotrophic factor | Rodents | Epigenetics | TrkB receptors | Anxiety | Ventricle | HDAC2 protein | Hippocampus | Animal cognition
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3. Full Text Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression
by Haile, C.N and Murrough, J.W and Iosifescu, D.V and Chang, L.C and Al Jurdi, R.K and Foulkes, A and Iqbal, S and Mahoney, J.J and De La Garza, R and Charney, D.S and Newton, T.F and Mathew, S.J
International Journal of Neuropsychopharmacology, ISSN 1461-1457, 02/2014, Volume 17, Issue 2, pp. 331 - 336
Ketamine produces rapid antidepressant effects in treatment-resistant depression (TRD), but the magnitude of response varies considerably between individual... 
depression | biomarker | BDNF | ketamine | MAMMALIAN TARGET | RAPAMYCIN | ABNORMALITIES | PSYCHIATRY | DISORDERS | MAJOR DEPRESSION | NEUROSCIENCES | CLINICAL NEUROLOGY | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | Depressive Disorder, Treatment-Resistant - diagnosis | Double-Blind Method | Depressive Disorder, Treatment-Resistant - blood | Humans | Middle Aged | Male | Treatment Outcome | Brain-Derived Neurotrophic Factor - blood | Biomarkers - blood | Depressive Disorder, Treatment-Resistant - drug therapy | Young Adult | Midazolam - therapeutic use | Aged, 80 and over | Adult | Female | Aged | Ketamine - therapeutic use
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4. Full Text The Effect of exercise training on resting concentrations of peripheral brain-derived neurotrophic factor (BDNF): A meta-analysis
by Dinoff, Adam and Herrmann, Nathan and Swardfager, Walter and Liu, Celina S and Sherman, Chelsea and Chan, Sarah and Lanctôt, Krista L
PLoS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, pp. e0163037 - e0163037
Background The mechanisms through which physical activity supports healthy brain function remain to be elucidated. One hypothesis suggests that increased... 
CIRCULATING LEVELS | RESISTANCE EXERCISE | MULTIDISCIPLINARY SCIENCES | COGNITIVE IMPAIRMENT | AEROBIC EXERCISE | PHYSICAL-ACTIVITY | METABOLIC RISK-FACTORS | GROWTH-FACTOR | PLASMA BDNF | HIPPOCAMPAL FUNCTION | BIPOLAR DISORDER | Brain | Physical training | Physical activity | Bias | Cognitive ability | Systematic review | Males | Blood | Subgroups | Sports medicine | Training | Studies | Brain-derived neurotrophic factor | Mood | Rodents | Resistance training | Peripheral blood | Rehabilitation | Females
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5. Full Text Brain-derived neurotrophic factor (BDNF) and type 2 diabetes
by Krabbe, K S and Krabbe, K S and Nielsen, A R and Nielsen, A R and Krogh-Madsen, R and Krogh-Madsen, R and Plomgaard, P and Plomgaard, P and Rasmussen, P and Rasmussen, P and Erikstrup, C and Erikstrup, C and Fischer, C P and Fischer, C P and Lindegaard, B and Lindegaard, B and Petersen, A M. W and Petersen, A M. W and Taudorf, S and Taudorf, S and Secher, N H and Secher, N H and Pilegaard, H and Pilegaard, H and Bruunsgaard, H and Bruunsgaard, H and Pedersen, B K and Pedersen, B K
Diabetologia, ISSN 0012-186X, 2/2007, Volume 50, Issue 2, pp. 431 - 438
Decreased levels of brain-derived neurotrophic factor (BDNF) have been implicated in the pathogenesis of Alzheimer’s disease and depression. These disorders... 
Neurotrophin | Brain | Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | Glucose | Insulin | Polymorphism | C-REACTIVE PROTEIN | glucose | insulin | ALZHEIMERS-DISEASE | RISK | polymorphism | MAJOR DEPRESSION | brain | VAL66MET POLYMORPHISM | COGNITIVE DYSFUNCTION | INSULIN-RESISTANCE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | MICE | neurotrophin | GLUCOSE-TOLERANCE | Brain-Derived Neurotrophic Factor - genetics | Insulin - pharmacology | Glucose Tolerance Test | Cross-Sectional Studies | Diabetes Mellitus, Type 2 - genetics | Humans | Insulin Resistance | Male | Reference Values | Brain-Derived Neurotrophic Factor - blood | Diabetic Angiopathies - blood | Diabetes Mellitus, Type 2 - epidemiology | Blood Glucose - drug effects | DNA - genetics | DNA - isolation & purification | Diabetes Mellitus, Type 2 - blood | C-Reactive Protein - metabolism | Brain-Derived Neurotrophic Factor - physiology | Polymerase Chain Reaction | Cardiovascular Diseases - blood | Adult | Polymorphism, Single Nucleotide | Glucose Clamp Technique | Blood Glucose - metabolism | Type 2 diabetes | Glucose metabolism | Blood sugar | Analysis | Depression, Mental | Amyloid beta-protein | Physiological aspects | Insulin resistance | Universities and colleges | Alzheimer's disease
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6. Full Text Pharmacological Profile of Brain-derived Neurotrophic Factor (BDNF) Splice Variant Translation Using a Novel Drug Screening Assay A "QUANTITATIVE CODE"
by Vaghi, V and Polacchini, A and Baj, G and Pinheiro, VLM and Vicario, A and Tongiorgi, E
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2014, Volume 289, Issue 40, pp. 27702 - 27713
Background: Brain-derived neurotrophic factor is encoded by multiple transcripts with specific brain localization. Results: BDNF transcripts display a... 
CELLS | Translation | PROTEIN | TOTAL NUMBER | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | In Vitro Assay | FACTOR MESSENGER-RNA | Brain-derived Neurotrophic Factor (BDNF) | BAC TRANSGENIC MICE | Signaling | Splice Variants | IN-VIVO | Neurotransmitter | GENE-EXPRESSION | NEURONS | Drug Screening | RAT HIPPOCAMPUS | Brain-Derived Neurotrophic Factor - antagonists & inhibitors | Brain-Derived Neurotrophic Factor - genetics | Peptide Chain Elongation, Translational | Alternative Splicing | Humans | RNA, Messenger - genetics | RNA, Messenger - metabolism | 5' Untranslated Regions | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - metabolism | 3' Untranslated Regions | Drug Evaluation, Preclinical | Genes, Reporter | Neurobiology
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7. Full Text DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression
by Fuchikami, Manabu and Morinobu, Shigeru and Segawa, Masahiro and Okamoto, Yasumasa and Yamawaki, Shigeto and Ozaki, Norio and Inoue, Takeshi and Kusumi, Ichiro and Koyama, Tsukasa and Tsuchiyama, Kounosuke and Terao, Takeshi
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23881
Major depression, because of its recurring and life-threatening nature, is one of the top 10 diseases for global disease burden. Major depression is still... 
LABORATORY TEST | MINI | MULTIDISCIPLINARY SCIENCES | VALIDATION | PREVALENCE | BURDEN | CANCER | Biomarkers - metabolism | Brain-Derived Neurotrophic Factor - genetics | Humans | Middle Aged | Exons - genetics | Male | Promoter Regions, Genetic - genetics | Case-Control Studies | DNA Methylation | Depressive Disorder, Major - genetics | Epigenesis, Genetic - genetics | CpG Islands - genetics | Adult | Female | Depressive Disorder, Major - diagnosis | Epigenetic inheritance | Medical colleges | Analysis | Genes | DNA | Methylation | Major depressive disorder | Cluster analysis | Brain | Mental depression | Clustering | Patients | Psychotropic drugs | Brain-derived neurotrophic factor | Classification | Peripheral blood | DNA methylation | Biomarkers | Diagnostic systems | Diagnosis | Two dimensional analysis | Deoxyribonucleic acid--DNA | CpG islands | Deoxyribonucleic acid
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8. Full Text Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants
by Shimizu, Eiji and Hashimoto, Kenji and Okamura, Naoe and Koike, Kaori and Komatsu, Naoya and Kumakiri, Chikara and Nakazato, Michiko and Watanabe, Hiroyuki and Shinoda, Naoyuki and Okada, Sin-ichi and Iyo, Masaomi
Biological Psychiatry, ISSN 0006-3223, 2003, Volume 54, Issue 1, pp. 70 - 75
Background: Because researchers have reported that antidepressants increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus,... 
mood disorder | biological marker | Antidepressants | major depression | brain-derived neurotrophic factor (BDNF) | Mood disorder | Biological marker | Brain-derived neurotrophic factor (BDNF) | Major depression | POSTTRAUMATIC-STRESS-DISORDER | INDUCED ATROPHY | GLUCOCORTICOIDS | PSYCHIATRY | HIPPOCAMPAL CA3C NEURONS | VOLUME | HUMAN PLATELETS | antidepressants | BIPOLAR DISORDER | FAMILY-BASED ASSOCIATION | NEUROSCIENCES | APICAL DENDRITES | RAT HIPPOCAMPUS | Depressive Disorder, Major - blood | Enzyme-Linked Immunosorbent Assay | Humans | Middle Aged | Male | Brain-Derived Neurotrophic Factor - blood | Biomarkers - blood | Case-Control Studies | Antidepressive Agents - therapeutic use | Brain-Derived Neurotrophic Factor - drug effects | Adult | Female | Aged | Antidepressive Agents - pharmacology | Depressive Disorder, Major - drug therapy
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9. Full Text Brain-derived neurotrophic factor (BDNF)-induced mitochondrial motility arrest and presynaptic docking contribute to BDNF-enhanced synaptic transmission
by Su, Bo and Ji, Yun-Song and Sun, Xu-Lu and Liu, Xiang-Hua and Chen, Zhe-Yu
Journal of Biological Chemistry, ISSN 0021-9258, 01/2014, Volume 289, Issue 3, pp. 1213 - 1226
Background: Appropriate mitochondrial transport and localization are highly associated with neuronal activities. Results: BDNF induces mitochondrial motility... 
DENDRITIC GROWTH | Signal Transduction | Synaptic Plasticity | NEUROTRANSMITTER RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNAPTOSOMES | INCREASES | Brain-derived Neurotrophic Factor (BDNF) | AXONAL-TRANSPORT | HIPPOCAMPAL-NEURONS | TRPC CHANNELS | CORTICAL-NEURONS | Mitochondrial Transport | TRP Channels | EXCITATORY SYNAPSES | KINESIN HEAVY-CHAIN | Brain-Derived Neurotrophic Factor - genetics | Synaptic Transmission - physiology | Calcium - metabolism | Mitochondrial Proteins - genetics | Phosphatidylinositol 3-Kinases - metabolism | Receptor, trkB - genetics | Mitochondria - genetics | Biological Transport, Active - physiology | Mitochondrial Proteins - metabolism | Brain-Derived Neurotrophic Factor - metabolism | TRPC Cation Channels - genetics | rho GTP-Binding Proteins - genetics | Cells, Cultured | Axons - metabolism | Rats | Mitochondria - metabolism | Hippocampus - cytology | Rats, Sprague-Dawley | Phosphatidylinositol 3-Kinases - genetics | Hippocampus - metabolism | Animals | rho GTP-Binding Proteins - metabolism | TRPC Cation Channels - metabolism | Mutation | Enzyme Activation - physiology | Receptor, trkB - metabolism | Neurobiology
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10. Full Text Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in bipolar disorder: A meta-analysis of 52 studies
by Fernandes, Brisa S and Molendijk, Marc L and Köhler, Cristiano A and Soares, Jair C and Leite, Cláudio Manuel G.S and Machado-Vieira, Rodrigo and Ribeiro, Thamara L and Silva, Jéssica C and Sales, Paulo M.G and Quevedo, João and Oertel-Knöchel, Viola and Vieta, Eduard and González-Pinto, Ana and Berk, Michael and Carvalho, André F
BMC Medicine, ISSN 1741-7015, 11/2015, Volume 13, Issue 1, p. 289
Background: The neurotrophic hypothesis postulates that mood disorders such as bipolar disorder (BD) are associated with a lower expression of brain-derived... 
Bipolar disorder | Biomarker | Brain-derived neurotrophic factor | Meta-analysis | SEROTONIN TRANSPORTER | SYSTEMATIC REVIEWS | VS. LATE-STAGE | INTERNATIONAL SOCIETY | PLASMA BDNF | MOOD EPISODES | VAL66MET POLYMORPHISM | COGNITIVE FUNCTION | MEDICINE, GENERAL & INTERNAL | FACTOR SERUM-LEVELS | DECREASED LEVELS | Brain-Derived Neurotrophic Factor - genetics | Humans | Middle Aged | Depression | Female | Male | Brain-Derived Neurotrophic Factor - metabolism | Biomarkers - blood | Bipolar Disorder - drug therapy | Bipolar Disorder - blood | Medicine, Experimental | Medical research | Care and treatment | Analysis | Blood proteins | Case studies | Trastorn bipolar | Neurotransmitters | Manic-depressive illness | Neurotransmissors | Estudi de casos | Marcadors bioquímics | Biochemical markers
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11. Full Text Population genetic study of the brain-derived neurotrophic factor ( ) gene
by Petryshen, T.L and Sabeti, P.C and Aldinger, K.A and Fry, B and Fan, J.B and Schaffner, S.F and Waggoner, S.G and Tahl, A.R and Sklar, P
Molecular Psychiatry, ISSN 1359-4184, 08/2010, Volume 15, Issue 8, pp. 810 - 815
Genetic variants in the brain-derived neurotrophic factor (BDNF) gene, predominantly the functional Val66Met polymorphism, have been associated with risk of... 
diversity | gene association | haplotype | susceptibility locus | selection | single-nucleotide polymorphism | EUROPEAN POPULATIONS | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCHIZOPHRENIA | VAL66MET POLYMORPHISM | BIPOLAR DISORDER | FAMILY-BASED ASSOCIATION | NEUROSCIENCES | ACTIVITY-DEPENDENT SECRETION | OBSESSIVE-COMPULSIVE DISORDER | EPISODIC MEMORY | ANOREXIA-NERVOSA | HUMAN GENOME | Brain-Derived Neurotrophic Factor - genetics | Genetics, Population - methods | Gene Frequency | Humans | Polymorphism, Single Nucleotide - genetics | Genotype | Valine - genetics | Methionine - genetics | Linkage Disequilibrium | Brain-derived neurotrophic factor | Genetic susceptibility | Genetic variation | Genetic aspects | Research | Health aspects | Mental illness | Risk factors
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