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1. Full Text Branched Chain Amino Acids
by Neinast, Michael and Murashige, Danielle and Arany, Zoltan
Annual Review of Physiology, ISSN 0066-4278, 2/2019, Volume 81, Issue 1, pp. 139 - 164
Branched chain amino acids (BCAAs) are building blocks for all life-forms. We review here the fundamentals of BCAA metabolism in mammalian physiology. Decades... 
cancer | branched chain amino acids | catabolism | diabetes | heart disease | PHYSIOLOGY | LEUCINE METABOLISM | PROMOTES CELL-PROLIFERATION | FATTY-ACIDS | SKELETAL-MUSCLE | TRANSFER-RNA SYNTHETASE | BETA-AMINOISOBUTYRIC ACID | INSULIN-RESISTANCE | WHOLE-BODY | ALPHA-KETOACID DEHYDROGENASE | CORONARY-ARTERY-DISEASE | Medical colleges | Protein biosynthesis | Branched chain amino acids | Heart diseases | Physiological aspects | Inborn errors of metabolism | Secretion | Diabetes mellitus | Chain branching | Amino acids | Chains | Metabolism | Insulin | Proteins | Protein synthesis | Physiology | Catabolism | Chemical synthesis | Cancer
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2. Branched-chain amino acids
: Part B
by Harris, Robert A. 1939- (Robert Allison) and Sokatch, J. R. 1928-2006. (John Robert)
2000, Methods in enzymology, ISBN 9780121822255, Volume 324, xxxv, 550
Volume 324 of Methods in Enzymology supplements Volume 166. It includes genetic information (cloning, gene expression) and information on human genetic... 
metabolism | genetics | Branched chain amino acids | Keto Acids | Amino Acids, Branched-Chain | Ketonic acids | Biology, life sciences
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3. Branched-chain amino acids
by Harris, Robert A. 1939- (Robert Allison) and Sokatch, J. R. 1928-2006. (John Robert)
1988, Methods in enzymology, ISBN 012182067X, Volume 166, xxxi, 534
Metabolism | Branched chain amino acids
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4. Full Text Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure
by Sun, Haipeng and Olson, Kristine C and Gao, Chen and Prosdocimo, Domenick A and Zhou, Meiyi and Wang, Zhihua and Jeyaraj, Darwin and Youn, Ji-Youn and Ren, Shuxun and Liu, Yunxia and Rau, Christoph D and Shah, Svati and Ilkayeva, Olga and Gui, Wen-Jun and William, Noelle S and Wynn, R Max and Newgard, Christopher B and Cai, Hua and Xiao, Xinshu and Chuang, David T and Schulze, Paul Christian and Lynch, Christopher and Jain, Mukesh K and Wang, Yibin
Circulation, ISSN 0009-7322, 05/2016, Volume 133, Issue 21, pp. 2038 - 2049
BACKGROUND—Although metabolic reprogramming is critical in the pathogenesis of heart failure, studies to date have focused principally on fatty acid and... 
heart failure | pathogenesis | oxidant stress | remodeling | metabolism | amino acids | CARDIAC & CARDIOVASCULAR SYSTEMS | ALLOSTERIC INHIBITORS | KETOACID DEHYDROGENASE KINASE | SKELETAL-MUSCLE | FAILING HEART | INSULIN-RESISTANCE | CARDIAC-HYPERTROPHY | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | PROTEIN PHOSPHATASE 2CM | CORONARY-ARTERY-DISEASE | NUTRIENT REGULATION | Metabolomics | Amino Acids, Branched-Chain - metabolism | Humans | Transcriptome | Heart Failure - genetics | Male | Heart Failure - metabolism | Metabolism - physiology | Heart Failure - pathology | Mice, Knockout | Animals | Amino Acids, Branched-Chain - genetics | Mice | Heart failure | Oxidative stress | Amino acids | Influence | Care and treatment | Research | Index Medicus | Abridged Index Medicus | Heart Failure | Catabolic Remodeling | Mitochondrial Defect | Branched-Chain Amino Acid | Branched-Chain Keto Acid
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5. Full Text Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
by Mayers, Jared R and Wu, Chen and Clish, Clary B and Kraft, Peter and Torrence, Margaret E and Fiske, Brian P and Yuan, Chen and Bao, Ying and Townsend, Mary K and Tworoger, Shelley S and Davidson, Shawn M and Papagiannakopoulos, Thales and Yang, Annan and Dayton, Talya L and Ogino, Shuji and Stampfer, Meir J and Giovannucci, Edward L and Qian, Zhi Rong and Rubinson, Douglas A and Ma, Jing and Sesso, Howard D and Gaziano, John M and Cochrane, Barbara B and Liu, Simin and Wactawski-Wende, Jean and Manson, Joann E and Pollak, Michael N and Kimmelman, Alec C and Souza, Amanda and Pierce, Kerry and Wang, Thomas J and Gerszten, Robert E and Fuchs, Charles S and Vander Heiden, Matthew G and Wolpin, Brian M
Nature Medicine, ISSN 1078-8956, 09/2014, Volume 20, Issue 10, pp. 1193 - 1198
Most patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed with advanced disease and survive less than 12 months(1). PDAC has been linked with... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER CACHEXIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | WEIGHT-LOSS | ROC CURVE | RISK | CELL BIOLOGY | LUNG-CANCER | METABOLOMICS | K-RAS | INSULIN-RESISTANCE | POOLED ANALYSIS | Prospective Studies | Pancreatic Neoplasms - etiology | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Middle Aged | Male | Mice, 129 Strain | Case-Control Studies | Time Factors | Aged, 80 and over | Adult | Female | Carcinoma, Pancreatic Ductal - etiology | Disease Models, Animal | Pancreatic Neoplasms - blood | Mice, Inbred C57BL | Risk Factors | Disease Progression | Mice, Knockout | Carcinoma, Pancreatic Ductal - blood | Animals | Aged | Mice | Amino Acids, Branched-Chain - blood | Cohort Studies | Measurement | Development and progression | Research | Branched chain amino acids | Pancreatic cancer | Analysis | Biomarkers | Amino acids | Metabolism | Index Medicus
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6. Full Text Branched-chain amino acids in disease
by White, Phillip J and Newgard, Christopher B
Science, ISSN 0036-8075, 02/2019, Volume 363, Issue 6427, pp. 582 - 583
Human proteins are assembled from 20 amino acids, nine of which are considered “essential” because they cannot be synthesized from other metabolites in the... 
MULTIDISCIPLINARY SCIENCES | TOR protein | Dairy products | Food sources | Muscles | Chain branching | Amino acids | Chains | Protein biosynthesis | Rapamycin | Cachexia | Leucine | Aliphatic compounds | Eggs | Meat | Proteins | Metabolites | Food chains | Protein synthesis | Valine | Aging | Isoleucine
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7. Full Text Immunomodulatory role of branched-chain amino acids
by Bonvini, Andrea and Bonvini, Andrea and Coqueiro, Audrey Y and Tirapegui, Julio and Calder, Philip C and Calder, Philip C and Rogero, Marcelo M
Nutrition reviews, ISSN 0029-6643, 2018, Volume 76, Issue 11, pp. 840 - 856
Branched-chain amino acids (BCAAs) have been associated with immunomodulation since the mid-1970s and 1980s and have been used in the nutritional therapy of... 
Mammalian target of rapamycin (mTOR) | Branched-chain amino acids | Leucine | Immunomodulation | Nutritional therapy | leucine | MAMMALIAN TARGET | immunomodulation | mammalian target of rapamycin (mTOR) | KAPPA-B | branched-chain amino acids | PROTEIN-SYNTHESIS | SKELETAL-MUSCLE | nutritional therapy | MTOR SIGNALING PATHWAY | HEPATOCELLULAR-CARCINOMA | NUTRITION & DIETETICS | HYDROXY-BETA-METHYLBUTYRATE | DOUBLE-BLIND TRIAL | LEUCINE SUPPLEMENTATION | PARENTERAL-NUTRITION | Physiological aspects | Branched chain amino acids | Immunity
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8. Full Text Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health
by Fontana, Luigi and Cummings, Nicole E and Arriola Apelo, Sebastian I and Neuman, Joshua C and Kasza, Ildiko and Schmidt, Brian A and Cava, Edda and Spelta, Francesco and Tosti, Valeria and Syed, Faizan A and Baar, Emma L and Veronese, Nicola and Cottrell, Sara E and Fenske, Rachel J and Bertozzi, Beatrice and Brar, Harpreet K and Pietka, Terri and Bullock, Arnold D and Figenshau, Robert S and Andriole, Gerald L and Merrins, Matthew J and Alexander, Caroline M and Kimple, Michelle E and Lamming, Dudley W
Cell Reports, ISSN 2211-1247, 07/2016, Volume 16, Issue 2, pp. 520 - 530
Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects... 
MORTALITY | LIFE-SPAN | METHIONINE RESTRICTION | LONGEVITY | DIETARY-PROTEIN | GLUCOSE | CALORIC RESTRICTION | MECHANISMS | OSCILLATIONS | INSULIN SENSITIVITY | CELL BIOLOGY | Obesity - diet therapy | Adipose Tissue, White - pathology | Dietary Proteins - administration & dosage | Amino Acids, Branched-Chain - metabolism | Humans | Mice, Inbred C57BL | Middle Aged | Stress, Physiological | Organ Size | Blood Glucose | Male | Glucose Intolerance | Obesity - blood | Fibroblast Growth Factors - metabolism | Amino Acids, Branched-Chain - administration & dosage | Insulin-Secreting Cells - metabolism | Animals | Gluconeogenesis | Index Medicus
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9. Problems and potential of branched-chain amino acids in physiology and medicine
by Odessey, Richard
1986, ISBN 9780444807755, xvi, 342
metabolism | Physiological effect | Amino acids, Branched chain | Amino Acids, Branched-Chain
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10. Full Text A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance
by Jang, Cholsoon and Oh, Sungwhan F and Wada, Shogo and Rowe, Glenn C and Liu, Laura and Chan, Mun Chun and Rhee, James and Hoshino, Atsushi and Kim, Boa and Ibrahim, Ayon and Baca, Luisa G and Kim, Esl and Ghosh, Chandra C and Parikh, Samir M and Jiang, Aihua and Chu, Qingwei and Forman, Daniel E and Lecker, Stewart H and Krishnaiah, Saikumari and Rabinowitz, Joshua D and Weljie, Aalim M and Baur, Joseph A and Kasper, Dennis L and Arany, Zoltan
Nature Medicine, ISSN 1078-8956, 04/2016, Volume 22, Issue 4, pp. 421 - 426
Epidemiological and experimental data implicate branched-chain amino acids (BCAAs) in the development of insulin resistance, but the mechanisms that underlie... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKELETAL-MUSCLE | CAPACITY | FIBERS | TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA | PLASMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | DISEASE | RISK | EXPRESSION | CELL BIOLOGY | Amino Acids, Branched-Chain - metabolism | Humans | Muscle, Skeletal - metabolism | Transcription Factors - biosynthesis | Transcription Factors - genetics | Obesity - genetics | Obesity - metabolism | Obesity - pathology | Insulin - metabolism | Animals | Fatty Acids - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Insulin Resistance - genetics | Mice, Inbred NOD | Mice | Muscle, Skeletal - pathology | Hydroxybutyrates - metabolism | Insulin - genetics | Fatty Acids - metabolism | Transcription factors | Biological transport | Insulin resistance | Development and progression | Genetic aspects | Properties | Health aspects | Amino acids | Diabetes | Pathogenesis | Fatty acids | Index Medicus
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11. Full Text Restoration of metabolic health by decreased consumption of branched-chain amino acids
by Cummings, Nicole E and Williams, Elizabeth M and Kasza, Ildiko and Konon, Elizabeth N and Schaid, Michael D and Schmidt, Brian A and Poudel, Chetan and Sherman, Dawn S and Yu, Deyang and Arriola Apelo, Sebastian I and Cottrell, Sara E and Geiger, Gabriella and Barnes, Macy E and Wisinski, Jaclyn A and Fenske, Rachel J and Matkowskyj, Kristina A and Kimple, Michelle E and Alexander, Caroline M and Merrins, Matthew J and Lamming, Dudley W
Journal of Physiology, ISSN 0022-3751, 02/2018, Volume 596, Issue 4, pp. 623 - 645
Obesity and diabetes are increasing problems around the world, and although even moderate weight loss can improve metabolic health, reduced calorie diets are... 
protein restriction | branched-chain amino acids | diabetes | obesity | DIETARY METHIONINE RESTRICTION | PHYSIOLOGY | WEIGHT-LOSS | LEUCINE RESTRICTION | NEUROSCIENCES | ENERGY-EXPENDITURE | INSULIN-RESISTANCE | HIGH-PROTEIN-DIET | HEPATIC STEATOSIS | GROWTH-FACTOR 21 | GLUCOSE-TOLERANCE | ADIPOSE-TISSUE | Blood Glucose - analysis | Caloric Restriction | Diet - adverse effects | Amino Acids, Branched-Chain - metabolism | Mice, Inbred C57BL | Diabetes Mellitus, Type 2 - prevention & control | Insulin Resistance | Male | Diabetes Mellitus, Type 2 - metabolism | Obesity - metabolism | Fibroblast Growth Factors - metabolism | Amino Acids, Branched-Chain - administration & dosage | Animals | Energy Metabolism | Weight Loss | Obesity - prevention & control | Diabetes Mellitus, Type 2 - etiology | Obesity - etiology | Mice | Insulin resistance | Fibroblast growth factors | Blood sugar | Branched chain amino acids | Reducing diets | Fibroblast growth factor | Adipose tissue | Body fat | Amino acids | Body weight loss | Leucine | Glucose | High fat diet | Proteins | Dietary restrictions | Protein composition | Rodents | Fibroblasts | Growth factors | Low protein diet | Sugar | Isoleucine | Obesity | Nutrient deficiency | Diabetes mellitus | Energy expenditure | Metabolism | Insulin | Feeding | Glucose tolerance | Energy balance | Weight control | Diet | Hypocaloric diet | Valine | Low fat diet | High protein diet | Metabolic disorders | Index Medicus | Research Paper | Endocrine, Nutrition and Metabolism | branched‐chain amino acids
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12. Herbicides inhibiting branched-chain amino acid biosynthesis
: recent developments
by Stetter, J. (Jörg) and Brown, H. M
1994, Chemistry of plant protection, ISBN 3540581812, Volume 10, viii, 219
Herbicides | Synthesis | Inhibitors | Branched chain amino acids
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13. Full Text Regulation of stringent factor by branched-chain amino acids
by Fang, Mingxu and Bauer, Carl E
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2018, Volume 115, Issue 25, pp. 6446 - 6451
When faced with amino acid starvation, prokaryotic cells induce a stringent response that modulates their physiology. The stringent response is manifested by... 
Rhodobacter capsulatus | Branched-chain amino acids | Stringent response | (p)ppGpp alarmone hydrolase | RelA/SpoT homolog | RHODOPSEUDOMONAS-CAPSULATA | SITE | (P)PPGPP | MULTIDISCIPLINARY SCIENCES | stringent response | ESCHERICHIA-COLI | HOMOLOG | branched-chain amino acids | METABOLISM | GENE | CODY | Hydrolases - metabolism | Amino Acid Sequence | Rhodobacter capsulatus - metabolism | Amino Acids, Branched-Chain - metabolism | Ligases - metabolism | Bacterial Proteins - metabolism | Guanosine Triphosphate - metabolism | Guanosine Diphosphate - metabolism | Enzymes | Microbiological research | Prokaryotes | Physiological aspects | Amino acids | Hydrolases | Genetic aspects | Research | Biological control systems | Binding | Starvation | Enzyme activity | Hydrolase | Guanosine | Amino acid starvation | Chain branching | Chains | Metabolism | Cells | Proteins | Domains | Microorganisms | Enzymatic activity | Valine | Isoleucine | Index Medicus | Biological Sciences | SpoT homolog | RelA
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