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Journal of Clinical Oncology, ISSN 0732-183X, 02/2012, Volume 30, Issue 6, pp. 593 - 599
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2013, Volume 15, Issue 7, pp. 807 - 817
In a significant fraction of breast cancer patients, distant metastases emerge after years or even decades of latency. How disseminated tumour cells (DTCs) are... 
CANCER-CELLS | METASTATIC NICHE | EPITHELIAL-CELLS | HEMATOPOIETIC STEM-CELLS | ENDOTHELIAL-CELLS | SELF-RENEWAL | 3-DIMENSIONAL CULTURE | EXTRACELLULAR-MATRIX | ANGIOCRINE FACTORS | BASEMENT-MEMBRANE | CELL BIOLOGY | Neoplasm, Residual - pathology | Neoplasm, Residual - metabolism | Humans | Lung Neoplasms - metabolism | Neovascularization, Pathologic | Tumor Microenvironment | Neoplasm, Residual - blood supply | Brain Neoplasms - blood supply | Brain Neoplasms - metabolism | Breast Neoplasms - metabolism | Brain Neoplasms - secondary | Lung Neoplasms - secondary | Pericytes - pathology | Female | Tumor Cells, Cultured | Lung Neoplasms - blood supply | Pericytes - metabolism | Breast Neoplasms - blood supply | Cell Adhesion Molecules - metabolism | Zebrafish - growth & development | Bone Marrow Neoplasms - secondary | Animals | Bone Marrow Neoplasms - metabolism | Breast Neoplasms - pathology | Endothelium, Vascular - metabolism | Zebrafish - metabolism | Fluorescent Antibody Technique | Endothelium, Vascular - pathology | Stem Cell Niche - physiology | Mice | Thrombospondin 1 - metabolism | Bone Marrow Neoplasms - blood supply | Transforming Growth Factor beta - metabolism | Physiological aspects | Bone morphogenetic proteins | Genetic aspects | Breast cancer | Research | Transforming growth factors | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2015, Volume 21, Issue 11, pp. 1262 - 1271
Cancer-associated muscle weakness is a poorly understood phenomenon, and there is no effective treatment. Here we find that seven different mouse models of... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER CACHEXIA | CELLS | INTRACELLULAR CALCIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | CELL BIOLOGY | DYSTROPHIC MUSCLE | GROWTH-FACTOR-BETA | HORMONE-RELATED PROTEIN | RYANODINE RECEPTOR | CAMURATI-ENGELMANN-DISEASE | IN-VIVO | Neoplasms - metabolism | Prostatic Neoplasms - metabolism | Up-Regulation | Calcium - metabolism | Humans | Lung Neoplasms - metabolism | NADPH Oxidases - metabolism | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Muscle, Skeletal - metabolism | Osteolysis - etiology | Ryanodine Receptor Calcium Release Channel - metabolism | X-Ray Microtomography | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Neoplasms - complications | MCF-7 Cells | Osteolysis - diagnostic imaging | Muscle Proteins - metabolism | NADPH Oxidases - genetics | Female | Camurati-Engelmann Syndrome - metabolism | Muscle Strength | Calcium Signaling | Disease Models, Animal | Muscle Weakness - etiology | Prostatic Neoplasms - pathology | Oxidation-Reduction | Bone Neoplasms - diagnostic imaging | NADPH Oxidase 4 | Mice, SCID | Multiple Myeloma - metabolism | Absorptiometry, Photon | Osteolysis - metabolism | Multiple Myeloma - pathology | Animals | Muscle Contraction | Breast Neoplasms - pathology | Mice, Nude | Muscle Weakness - metabolism | Cell Line, Tumor | Mice | Neoplasms - pathology | Transforming Growth Factor beta - metabolism | Index Medicus
Journal Article
American Journal of Pathology, ISSN 0002-9440, 2010, Volume 177, Issue 4, pp. 1647 - 1656
Phosphatase and tensin homolog (PTEN) is a key modulator of trastuzumab sensitivity in HER2-overexpressing breast cancer. Because PTEN opposes the downstream... 
ADJUVANT CHEMOTHERAPY | CELLS | INHIBITION | THERAPY | HUMAN-BREAST-CANCER | MUTATIONS | PATHOLOGY | RECEPTORS | TRASTUZUMAB RESISTANCE | EXPRESSION | CARCINOMA | Lung Neoplasms - drug therapy | Receptors, Estrogen - metabolism | Receptor, ErbB-2 - genetics | Lung Neoplasms - mortality | Humans | Middle Aged | Bone Neoplasms - secondary | Antibodies, Monoclonal - therapeutic use | Immunoenzyme Techniques | Receptors, Progesterone - metabolism | Young Adult | Carcinoma, Ductal, Breast - drug therapy | Brain Neoplasms - mortality | Liver Neoplasms - secondary | Proto-Oncogene Proteins c-akt - metabolism | Carcinoma, Ductal, Breast - metabolism | PTEN Phosphohydrolase - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Survival Rate | Lymphatic Metastasis | Brain Neoplasms - drug therapy | Mutation - genetics | Breast Neoplasms - drug therapy | Class I Phosphatidylinositol 3-Kinases | Carcinoma, Lobular - metabolism | Trastuzumab | Bone Neoplasms - mortality | Phosphorylation | Prognosis | Receptor, ErbB-2 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Liver Neoplasms - mortality | Carcinoma, Ductal, Breast - mortality | Carcinoma, Lobular - mortality | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | Brain Neoplasms - secondary | In Situ Hybridization | Lung Neoplasms - secondary | Adult | Female | Bone Neoplasms - drug therapy | Neoplasm Invasiveness | Liver Neoplasms - drug therapy | PTEN Phosphohydrolase - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - mortality | Aged | Carcinoma, Lobular - drug therapy | Index Medicus | Abridged Index Medicus | Regular
Journal Article
Human Pathology, ISSN 0046-8177, 2013, Volume 44, Issue 11, pp. 2563 - 2570
Summary BRAF mutation is seen in a variety of human neoplasms including cutaneous malignant melanoma, papillary thyroid carcinoma, colorectal carcinoma,... 
Pathology | Immunohistochemistry | Anti–B-Raf | BRAF V600E | VE1 | Glioma | Melanoma | Thyroid carcinoma | Anti-B-Raf | PROTEIN | IMPROVED SURVIVAL | PATHOLOGY | CANCER | TUMORS | HAIRY-CELL LEUKEMIA | THERAPY | MEK INHIBITION | GENE | MUTANT BRAF | VEMURAFENIB | Neoplasms - metabolism | Gastrointestinal Neoplasms - genetics | Humans | Lung Neoplasms - metabolism | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Mutation, Missense | Breast Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Ovarian Neoplasms - genetics | Gastrointestinal Neoplasms - pathology | Neoplasms - genetics | DNA Mutational Analysis | Melanoma - genetics | Glioma - pathology | Sensitivity and Specificity | Biomarkers, Tumor - metabolism | Female | Ovarian Neoplasms - metabolism | Carcinoma - pathology | Antibodies, Monoclonal - immunology | Proto-Oncogene Proteins B-raf - metabolism | Gastrointestinal Neoplasms - metabolism | Lung Neoplasms - genetics | Melanoma - metabolism | Mutant Proteins - genetics | Mutant Proteins - metabolism | Melanoma - pathology | Thyroid Neoplasms - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Proto-Oncogene Proteins B-raf - genetics | Carcinoma - genetics | Biomarkers, Tumor - genetics | Carcinoma - metabolism | Neoplasms - pathology | Amino Acid Substitution | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology | Carcinoma | Gene mutations | Gliomas | Thyroid diseases | Monoclonal antibodies | Genetic aspects | Comparative analysis | Lung cancer, Non-small cell | Cancer | Breast cancer | Mutation | Tumors | Skin cancer | Index Medicus
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 03/2008, Volume 26, Issue 8, pp. 1275 - 1281
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 11/2015, Volume 6, Issue 1, pp. 8760 - 8760
Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic... 
HETEROGENEITY | ACTIVATION | VARIANTS | PATHWAY | MULTIDISCIPLINARY SCIENCES | KINASE | ACQUIRED-RESISTANCE | SEQUENCING DATA | Carcinoma, Ductal, Breast - genetics | Receptors, Estrogen - metabolism | Humans | Receptor, ErbB-2 - metabolism | Clonal Evolution - genetics | Tamoxifen - administration & dosage | Case-Control Studies | Breast Neoplasms - metabolism | Brain Neoplasms - secondary | Carcinoma, Ductal, Breast - drug therapy | Neoplasm Metastasis | Lung Neoplasms - secondary | Adult | Carcinoma, Ductal, Breast - pathology | Female | Quinazolines - administration & dosage | Liver Neoplasms - secondary | Carcinoma, Ductal, Breast - metabolism | Lung Neoplasms - genetics | Liver Neoplasms - genetics | Deoxycytidine - administration & dosage | Brain Neoplasms - genetics | Trastuzumab - administration & dosage | Breast Neoplasms - drug therapy | Sequence Analysis, DNA | Spinal Neoplasms - secondary | Breast Neoplasms - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Spinal Neoplasms - genetics | Bayes Theorem | DNA, Neoplasm - genetics | Mutation | Deoxycytidine - analogs & derivatives | Biological evolution | Breast cancer | Genomes | Metastasis | ErbB-2 protein | Patients | Metastases | Heterogeneity | Biopsy | Breast | Evolution | Deoxyribonucleic acid--DNA | Cancer | Tumors | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 247 - 256
MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast... 
ADHESION | STEM-CELLS | INVASION | N-MYC | C-MYC | TUMOR ANGIOGENESIS | HUMAN BREAST-CANCER | MESENCHYMAL TRANSITION | EXPRESSION | MAMMARY EPITHELIAL-CELLS | CELL BIOLOGY | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Protein Binding - genetics | Cell Proliferation | MicroRNAs - antagonists & inhibitors | Cadherins - metabolism | Gene Expression - genetics | Humans | 3' Untranslated Regions - genetics | Vascular Endothelial Growth Factor A - genetics | N-Myc Proto-Oncogene Protein | Cadherins - genetics | Oncogene Proteins - metabolism | Vascular Endothelial Growth Factor A - blood | Epithelial Cells - pathology | DNA - metabolism | Neuroblastoma - diagnosis | beta Catenin - metabolism | Down-Regulation - genetics | Cell Line, Tumor | Mice, Inbred NOD | Mice | Mice, Inbred BALB C | Neovascularization, Pathologic - metabolism | Neuroblastoma - metabolism | Proto-Oncogene Proteins c-myc - genetics | Histones - metabolism | MicroRNAs - physiology | Neoplasms - metabolism | Epithelial Cells - metabolism | Vimentin - metabolism | Lung Neoplasms - pathology | Breast Neoplasms - metabolism | Neovascularization, Pathologic - pathology | Neoplasms - blood | Transfection | Lung Neoplasms - secondary | Neoplasm Invasiveness - pathology | Female | Nuclear Proteins - genetics | Gene Expression Regulation, Neoplastic - physiology | Neuroblastoma - pathology | Cell Line | Neuroblastoma - genetics | Nuclear Proteins - metabolism | Gene Dosage | Mice, SCID | Proto-Oncogene Proteins c-myc - metabolism | beta Catenin - genetics | Neoplasm Metastasis - genetics | Animals | Breast Neoplasms - pathology | Neoplasm Metastasis - pathology | Signal Transduction - physiology | Transplantation, Heterologous - pathology | Neoplasm Invasiveness - genetics | Neoplasms - pathology | MicroRNA | Physiological aspects | Cadherins | Development and progression | Genetic aspects | Metastasis | Research | Oncogenes | Index Medicus
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2008, Volume 60, Issue 3, pp. 379 - 387
Background Previous reports regarding the rates at which various internal tumors metastasize to the skin have been limited and have only included the Caucasian... 
Dermatology | LUNG-CANCER | PROGNOSTIC-FACTORS | ASIAN ETHNICITY | BREAST-CANCER METASTASIS | SKIN-ASSOCIATED CHEMOKINE | BASAL-CELL CARCINOMA | WHITE WOMEN | DRINKING-WATER | AFRICAN-AMERICAN | CHINESE WOMEN | DERMATOLOGY | Immunohistochemistry | Lung Neoplasms - ethnology | Academic Medical Centers - statistics & numerical data | Carcinoma, Squamous Cell - metabolism | Humans | Lung Neoplasms - metabolism | Carcinoma, Transitional Cell - secondary | Lung Neoplasms - pathology | Mouth Neoplasms - metabolism | Carcinoma, Hepatocellular - secondary | Carcinoma, Transitional Cell - ethnology | Breast Neoplasms - metabolism | Carcinoma, Squamous Cell - ethnology | Gastrointestinal Neoplasms - pathology | Mouth Neoplasms - ethnology | Adenocarcinoma - metabolism | Urinary Bladder Neoplasms - pathology | Liver Neoplasms - pathology | Retrospective Studies | Adenocarcinoma - ethnology | Breast Neoplasms - ethnology | Urinary Bladder Neoplasms - metabolism | Carcinoma, Hepatocellular - ethnology | Gastrointestinal Neoplasms - metabolism | Receptors, CCR10 - metabolism | Skin Neoplasms - ethnology | Carcinoma, Transitional Cell - metabolism | Adenocarcinoma - secondary | Receptors, CXCR4 - metabolism | Skin Neoplasms - metabolism | Liver Neoplasms - ethnology | Breast Neoplasms - pathology | Taiwan - epidemiology | Liver Neoplasms - metabolism | Skin Neoplasms - secondary | Mouth Neoplasms - pathology | Carcinoma, Squamous Cell - secondary | Gastrointestinal Neoplasms - ethnology | Asian Continental Ancestry Group - statistics & numerical data | Carcinoma, Hepatocellular - metabolism | Urinary Bladder Neoplasms - ethnology | Medical colleges | Hospitals | Metastasis | Medical centers | Cancer | Index Medicus
Journal Article