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Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2017, Volume 60, Issue 7, pp. 2819 - 2839
We previously reported the design of spirooxindoles with two identical substituents at the carbon-2 of the pyrrolidine core as potent MDM2 inhibitors. In this... 
TRIALS | ACTIVATION | DESIGN | CHEMISTRY, MEDICINAL | MECHANISM | DOCKING | PROTEIN-PROTEIN INTERACTION | FLUORINE | P53 PATHWAY | HIGHLY POTENT | RG7112 | Neoplasms - metabolism | Osteosarcoma - drug therapy | Bone and Bones - pathology | Leukemia - pathology | Humans | Antineoplastic Agents - therapeutic use | Leukemia - metabolism | Structure-Activity Relationship | Bone Neoplasms - pathology | Bone Neoplasms - metabolism | Bone and Bones - drug effects | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Bridged Bicyclo Compounds - chemistry | Bone and Bones - metabolism | Bridged Bicyclo Compounds - therapeutic use | Indoles - pharmacology | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Bone Neoplasms - drug therapy | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Osteosarcoma - metabolism | Bridged Bicyclo Compounds - pharmacology | Pyrrolidines - pharmacokinetics | Leukemia - drug therapy | Rats | Antineoplastic Agents - chemistry | Drug Discovery | Pyrrolidines - chemistry | Neoplasms - drug therapy | Animals | Halogenation | Cell Line, Tumor | Indoles - pharmacokinetics | Indoles - therapeutic use | Mice | Molecular Docking Simulation | Bridged Bicyclo Compounds - pharmacokinetics | Neoplasms - pathology | Indoles - chemistry | Osteosarcoma - pathology | Index Medicus
Journal Article
Chemical Communications, ISSN 1359-7345, 08/2014, Volume 50, Issue 66, pp. 9376 - 9378
New sydnone derivatives have been synthesized and screened for their capacity to undergo fast copper-free cycloaddition reaction with bicyclo-[6.1.0]-nonyne.... 
ANTIINFLAMMATORY SYDNONES | CYCLOOCTYNES | COPPER-FREE | FREE CLICK CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | LIVING CELLS | Bridged Bicyclo Compounds - chemistry | Halogens - chemistry | Proton Magnetic Resonance Spectroscopy | Cycloaddition Reaction | Index Medicus
Journal Article
Chemical Communications, ISSN 1359-7345, 2009, Issue 45, pp. 6988 - 6990
Journal Article
Journal Article
Journal Article
Organic Letters, ISSN 1523-7060, 08/2005, Volume 7, Issue 16, pp. 3473 - 3475
[GRAPHICS] Microwave irradiation of alkynyl allenes affords an intramolecular [2 + 2] cycloaddition reaction. This cycloaddition provides an efficient route to... 
ORGANIC-SYNTHESIS | ALKENES | HIGH-PRESSURE | OVENS | CHEMISTRY, ORGANIC | ALKYNES | CYCLO-ADDITION | Alkenes - chemistry | Bridged Bicyclo Compounds - chemical synthesis | Bridged Bicyclo Compounds - chemistry | Cyclization | Molecular Structure | Alkenes - chemical synthesis | Microwaves | Index Medicus
Journal Article