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Chemical Society Reviews, ISSN 0306-0012, 6/2011, Volume 4, Issue 7, pp. 3445 - 3454
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 4, p. e60933
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat... 
CANDIDATE | SQ109 | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | Pyrazoles - therapeutic use | Antitubercular Agents - chemistry | Humans | Drug Resistance, Bacterial | Spiro Compounds - therapeutic use | Tuberculosis - microbiology | Chromatography, Thin Layer | Mycobacterium tuberculosis - drug effects | Microbial Sensitivity Tests | Pyrazoles - chemistry | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Tuberculosis - drug therapy | Pyrazoles - pharmacokinetics | Spiro Compounds - chemistry | Antitubercular Agents - therapeutic use | Disease Models, Animal | Pyrazoles - pharmacology | Bacterial Proteins - antagonists & inhibitors | Cord Factors | Microbial Viability - drug effects | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Antitubercular Agents - pharmacology | Rats | Genotype | Treatment Outcome | Mutation - genetics | Mycobacterium tuberculosis - isolation & purification | Spiro Compounds - pharmacokinetics | Hep G2 Cells | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Antitubercular Agents - pharmacokinetics | Dogs | Bacterial Proteins - metabolism | Mice | Kinetics | Spiro Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics | Mycobacterium tuberculosis - genetics | Pyrimidines | Tuberculosis | Genomics | Nucleotide sequencing | Drug therapy | Patient compliance | DNA sequencing | Trehalose | Medical treatment | Lung diseases | BCG | Cytotoxicity | Genomes | Drug resistance | Mutants | Gene sequencing | Chemistry | Lungs | Resistant mutant | Bacteria | Mutation | Piperidine
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 03/2018, Volume 83, Issue 5, pp. 2892 - 2897
Journal Article
Journal Article
Journal Article
Nature chemical biology, ISSN 1552-4469, 2010, Volume 7, Issue 1, pp. 41 - 50
Bruton's tyrosine kinase (Btk) is a therapeutic target for rheumatoid arthritis, but the cellular and molecular mechanisms by which Btk mediates inflammation... 
RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | BRUTONS TYROSINE KINASE | ACTIVATION | CITRULLINATED PROTEINS | FC-GAMMA RECEPTORS | II COLLAGEN | PHOSPHORYLATION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | Tumor Necrosis Factor-alpha - metabolism | Arthritis, Experimental - drug therapy | Autoantibodies - metabolism | Protein-Tyrosine Kinases - therapeutic use | Arthritis, Experimental - metabolism | Arthritis, Rheumatoid - metabolism | Protein-Tyrosine Kinases - pharmacology | Protein Kinase Inhibitors - chemistry | Benzamides - therapeutic use | Arthritis, Rheumatoid - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Interleukin-1beta - metabolism | Myeloid Cells - immunology | Protein-Tyrosine Kinases - chemistry | Tumor Necrosis Factor-alpha - immunology | Myeloid Cells - drug effects | Benzamides - pharmacology | Phosphorylation - drug effects | Interleukin-6 - metabolism | B-Lymphocytes - metabolism | Benzamides - chemistry | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Interleukin-1beta - immunology | Arthritis, Experimental - immunology | Enzyme Activation - drug effects | B-Lymphocytes - drug effects | Autoantibodies - immunology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | B-Lymphocytes - immunology | Protein Kinase Inhibitors - therapeutic use | Interleukin-6 - immunology | Myeloid Cells - metabolism | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Arthritis, Rheumatoid - immunology | Arthritis | Biochemistry | Inhibitor drugs | Kinases | Binding sites
Journal Article