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Leukemia, ISSN 0887-6924, 10/2017, Volume 31, Issue 10, pp. 2075 - 2084
Although the BTK inhibitor ibrutinib has transformed the management of patients with chronic lymphocytic leukemia (CLL), it does not induce substantial... 
MULTICENTER | CLL CELLS | THERAPY | ONCOLOGY | MCL-1 | IBRUTINIB | RESISTANCE | BTK | LYMPHOMA | OPEN-LABEL | HEMATOLOGY | ABT-199 | Peptide Fragments | Pyrazoles - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - physiology | Apoptosis - drug effects | Humans | Neoplasm Proteins - physiology | Pyrazines - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - agonists | Neoplasm Proteins - antagonists & inhibitors | Pyrazines - therapeutic use | Molecular Targeted Therapy | Benzamides - administration & dosage | Benzamides - therapeutic use | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Sulfonamides - agonists | Benzamides - pharmacology | Proto-Oncogene Proteins | Pyrazoles - pharmacology | Pyrimidines - administration & dosage | Bcl-2-Like Protein 11 - genetics | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Clinical Trials as Topic | Mitochondria - drug effects | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Bcl-2-Like Protein 11 - biosynthesis | Drug Synergism | Protein Kinase Inhibitors - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Pyrazoles - administration & dosage | Sulfonamides - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Agammaglobulinaemia Tyrosine Kinase | Protein Kinase Inhibitors - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Pyrazines - pharmacology | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Protein-Tyrosine Kinases - antagonists & inhibitors | Enzymes | Chronic lymphocytic leukemia | Care and treatment | Development and progression | Genetic aspects | Regulation | Drug resistance | Health aspects | Killing | Tyrosine | Drugs | Medical research | Chronic lymphatic leukemia | Bcl-2 protein | Leukemia | Clinical trials | Priming | Lymphatic leukemia | Patients | Bruton's tyrosine kinase | Mitochondria | Inhibitors | Cell death | Sensitivity enhancement | Inhibition | Pretreatment | Protein-tyrosine kinase | BIM protein | Apoptosis | ibrutinib | BCL-2 | mitochondrial priming | acalabrutinib (ACP-196) | venetoclax | BH3 profiling
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 4, p. e60933
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat... 
CANDIDATE | SQ109 | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | Pyrazoles - therapeutic use | Antitubercular Agents - chemistry | Humans | Drug Resistance, Bacterial | Spiro Compounds - therapeutic use | Tuberculosis - microbiology | Chromatography, Thin Layer | Mycobacterium tuberculosis - drug effects | Microbial Sensitivity Tests | Pyrazoles - chemistry | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Tuberculosis - drug therapy | Pyrazoles - pharmacokinetics | Spiro Compounds - chemistry | Antitubercular Agents - therapeutic use | Disease Models, Animal | Pyrazoles - pharmacology | Bacterial Proteins - antagonists & inhibitors | Cord Factors | Microbial Viability - drug effects | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Antitubercular Agents - pharmacology | Rats | Genotype | Treatment Outcome | Mutation - genetics | Mycobacterium tuberculosis - isolation & purification | Spiro Compounds - pharmacokinetics | Hep G2 Cells | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Antitubercular Agents - pharmacokinetics | Dogs | Bacterial Proteins - metabolism | Mice | Kinetics | Spiro Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics | Mycobacterium tuberculosis - genetics | Pyrimidines | Tuberculosis | Genomics | Nucleotide sequencing | Drug therapy | Patient compliance | DNA sequencing | Trehalose | Medical treatment | Lung diseases | BCG | Cytotoxicity | Genomes | Drug resistance | Mutants | Gene sequencing | Chemistry | Lungs | Resistant mutant | Bacteria | Mutation | Piperidine
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 2017, Volume 35, Issue 8, pp. 826 - 833
Journal Article
Neuron, ISSN 0896-6273, 2005, Volume 46, Issue 4, pp. 595 - 607
Chronic exposure to nicotine elicits upregulation of high-affinity nicotinic receptors in the smoker’s brain. To address the molecular mechanism of... 
CELLS | SH-SY5Y | ACETYLCHOLINE-RECEPTORS | CHRONIC EXPOSURE | FUNCTIONAL-ACTIVITY | ENDOPLASMIC-RETICULUM | BINDING-SITES | EXPRESSION | NEUROSCIENCES | BRAIN | SUBUNIT | Membrane Potentials - genetics | Protein Subunits - immunology | Dihydro-beta-Erythroidine - pharmacology | Humans | Pyridines - pharmacokinetics | Nicotinic Antagonists - pharmacology | Patch-Clamp Techniques - methods | Nicotine - pharmacology | Dose-Response Relationship, Drug | Drug Interactions | Transfection - methods | Time Factors | Protein Binding - drug effects | Nicotinic Agonists - pharmacology | Membrane Potentials - drug effects | Cell Line | Blotting, Western - methods | Receptors, Nicotinic - metabolism | Intracellular Space - drug effects | Immunoprecipitation - methods | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Fluorescent Antibody Technique - methods | Autoradiography - methods | Glycosylation | Antibodies - pharmacology | Binding, Competitive - drug effects | Up-Regulation - drug effects | Carbachol - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Models, Biological | Intracellular Space - physiology | Receptors, Nicotinic - genetics | Tritium - pharmacokinetics | Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics | Physiological aspects | Analysis | Nicotine | Proteins | Carbohydrates | Rodents | Molecular weight | Protein Subunits | Up-Regulation | Immunoprecipitation | Neurons and Cognition | Neurobiology | Antibodies | Tritium | Intracellular Space | Bicyclo Compounds, Heterocyclic | Life Sciences | Transfection | Nicotinic Agonists | Binding, Competitive | Pyridines | Receptors, Nicotinic | Nicotinic Antagonists | Dihydro-beta-Erythroidine | Blotting, Western | Autoradiography | Patch-Clamp Techniques | Membrane Potentials | Carbachol | Fluorescent Antibody Technique | Protein Binding
Journal Article
Journal Article
Blood, ISSN 0006-4971, 03/2013, Volume 121, Issue 12, pp. 2285 - 2288
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 04/2007, Volume 321, Issue 1, pp. 308 - 317
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 8/2010, Volume 107, Issue 32, pp. 14309 - 14314
Journal Article
Nature chemical biology, ISSN 1552-4469, 2010, Volume 7, Issue 1, pp. 41 - 50
Bruton's tyrosine kinase (Btk) is a therapeutic target for rheumatoid arthritis, but the cellular and molecular mechanisms by which Btk mediates inflammation... 
RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | BRUTONS TYROSINE KINASE | ACTIVATION | CITRULLINATED PROTEINS | FC-GAMMA RECEPTORS | II COLLAGEN | PHOSPHORYLATION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | Tumor Necrosis Factor-alpha - metabolism | Arthritis, Experimental - drug therapy | Autoantibodies - metabolism | Protein-Tyrosine Kinases - therapeutic use | Arthritis, Experimental - metabolism | Arthritis, Rheumatoid - metabolism | Protein-Tyrosine Kinases - pharmacology | Protein Kinase Inhibitors - chemistry | Benzamides - therapeutic use | Arthritis, Rheumatoid - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Interleukin-1beta - metabolism | Myeloid Cells - immunology | Protein-Tyrosine Kinases - chemistry | Tumor Necrosis Factor-alpha - immunology | Myeloid Cells - drug effects | Benzamides - pharmacology | Phosphorylation - drug effects | Interleukin-6 - metabolism | B-Lymphocytes - metabolism | Benzamides - chemistry | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Interleukin-1beta - immunology | Arthritis, Experimental - immunology | Enzyme Activation - drug effects | B-Lymphocytes - drug effects | Autoantibodies - immunology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | B-Lymphocytes - immunology | Protein Kinase Inhibitors - therapeutic use | Interleukin-6 - immunology | Myeloid Cells - metabolism | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Arthritis, Rheumatoid - immunology | Arthritis | Biochemistry | Inhibitor drugs | Kinases | Binding sites
Journal Article
Journal Article
The international journal of neuropsychopharmacology, ISSN 1461-1457, 06/2012, Volume 15, Issue 5, pp. 657 - 668
A single non-anaesthetic dose of ketamine, a non-competitive NMDA receptor (NMDAR) antagonist with hallucinogenic properties, induces cognitive impairment and... 
Antipsychotic | schizophrenia | ketamine | gamma power | EEG | NEURONAL-ACTIVITY | NMDA RECEPTOR | GLUTAMATE-RECEPTOR AGONIST | RAT | 40 HZ | SYNCHRONY | PSYCHIATRY | NEUROSCIENCES | PREFRONTAL CORTEX | CLINICAL NEUROLOGY | PHARMACOLOGY & PHARMACY | OSCILLATIONS | 1ST-EPISODE PSYCHOSIS | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Drug Administration Schedule | Rats, Wistar | Clozapine - administration & dosage | Excitatory Amino Acid Antagonists - administration & dosage | Haloperidol - administration & dosage | Rats | Male | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Electrodes, Implanted | Excitatory Amino Acid Antagonists - pharmacology | Amino Acids - administration & dosage | Amino Acids - pharmacology | Ketamine - administration & dosage | Antipsychotic Agents - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Brain Waves - drug effects | Antipsychotic Agents - pharmacology | Cerebral Cortex - drug effects | Ketamine - pharmacology | Haloperidol - pharmacology | Clozapine - pharmacokinetics | Drugs | Animal models | Neuroleptics | Channel gating | Glutamic acid receptors (ionotropic) | Cognitive ability | Cortex | Oscillations | Schizophrenia | Auditory evoked potentials | N-Methyl-D-aspartic acid receptors | Glutamic acid receptors | Haloperidol | Electrodes | Psychosis | Ketamine | Skull | Locomotor activity | Brain Waves | Neurons and Cognition | Receptors, N-Methyl-D-Aspartate | Cerebral Cortex | Clozapine | Amino Acids | Bicyclo Compounds, Heterocyclic | Life Sciences | Antipsychotic Agents | Excitatory Amino Acid Antagonists
Journal Article
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 2013, Volume 52, Issue 4, pp. 1231 - 1234
Journal Article