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Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 07/2016, Volume 26, Issue 13, pp. 2980 - 2983
Journal Article
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 08/2017, Volume 18, Issue 16, pp. 1583 - 1588
Journal Article
Journal Article
CNS & neurological disorders drug targets, ISSN 1871-5273, 02/2016, Volume 15, Issue 1, pp. 102 - 107
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 2, pp. e30550 - e30550
Despite advances in radical surgery and chemotherapy delivery, ovarian cancer is the most lethal gynecologic malignancy. Standard therapy includes treatment... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Predictive Value of Tests | Bridged-Ring Compounds - therapeutic use | Paclitaxel - pharmacology | Taxoids - pharmacology | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents | Gene Expression Profiling | Cisplatin - pharmacology | Ovarian Neoplasms - mortality | Paclitaxel - therapeutic use | Platinum Compounds - therapeutic use | Taxoids - therapeutic use | Drug Resistance, Neoplasm - genetics | Carboplatin - therapeutic use | Cisplatin - therapeutic use | Bridged-Ring Compounds - pharmacology | Female | Chemotherapy, Adjuvant | Carboplatin - pharmacology | Ovarian Neoplasms - drug therapy | Platinum Compounds - pharmacology | Antimitotic agents | Genes | Genomics | Adjuvant treatment | Development and progression | Genetic aspects | Genomes | Drug therapy, Combination | Antineoplastic agents | Gene expression | Ovarian cancer | Cancer | Drugs | Health sciences | Ovarian carcinoma | Lung cancer | Malignancy | Taxane | Epidemiology | Cancer therapies | Clinical outcomes | Platinum | Surgery | Classification | Paclitaxel | Public health | Taxol | Gynecology | Breast cancer | Patients | Survival | Obstetrics | Studies | Chemotherapy | DNA microarrays | Response rates | Biomarkers | Carboplatin | Tumors | Index Medicus
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 05/2017, Volume 19, Issue 8, pp. 1669 - 1684
Although non-small cell lung cancer (NSCLC) patients benefit from standard taxane-platin chemotherapy, many relapse, developing drug resistance. We established... 
lung cancer | histone methylation | taxane-platin chemotherapy | JIB-04 | GSK-J4 | KDM | histone demethylases | demethylase inhibitors | Jumonji demethylases | drug resistance | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - drug therapy | Transcription, Genetic - drug effects | Taxoids - pharmacology | Benzazepines - adverse effects | Humans | Aminopyridines - adverse effects | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Taxoids - therapeutic use | Hydrazones - adverse effects | Aminopyridines - therapeutic use | Carboplatin - therapeutic use | Hydrazones - therapeutic use | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Bridged-Ring Compounds - pharmacology | Neoadjuvant Therapy | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Bridged-Ring Compounds - therapeutic use | Carcinoma, Non-Small-Cell Lung - genetics | Enzyme Inhibitors - pharmacology | Benzazepines - pharmacology | Pyrimidines - pharmacology | Enzyme Inhibitors - therapeutic use | Hydrazones - pharmacology | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | Animals | Benzazepines - therapeutic use | Pyrimidines - therapeutic use | Aminopyridines - pharmacology | Pyrimidines - adverse effects | Cell Line, Tumor | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Histones - metabolism | Carboplatin - pharmacology | Methylation | Jumonji Domain-Containing Histone Demethylases - metabolism | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
The Journal of physiology, ISSN 0022-3751, 07/2010, Volume 588, Issue 14, pp. 2605 - 2619
In vertebrate retina, melatonin regulates various physiological functions. In this work we investigated the mechanisms underlying melatonin‐induced... 
Neurosciences | Physiology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Cyclic GMP - pharmacology | Receptor, Melatonin, MT2 - antagonists & inhibitors | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Male | Calcium - analysis | Melatonin - physiology | Type C Phospholipases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - physiology | Isoquinolines - pharmacology | Cyclic GMP - analogs & derivatives | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Bridged-Ring Compounds - pharmacology | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Guanosine Diphosphate - pharmacology | Pertussis Toxin - pharmacology | Retinal Ganglion Cells - physiology | Protein Kinase C - physiology | Retinal Ganglion Cells - enzymology | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Rats | Protein Kinase C - antagonists & inhibitors | Receptor, Melatonin, MT2 - physiology | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Animals | Egtazic Acid - pharmacology | Glycine - physiology | Guanosine Diphosphate - analogs & derivatives | Signal Transduction - drug effects | Tetrahydronaphthalenes - pharmacology | Thiones - pharmacology | Carbazoles - pharmacology | Type C Phospholipases - physiology | Melatonin | Phospholipids | Glycine | Ganglion | Gross domestic product | Protein kinases | Kinases | Retina | Index Medicus | Neuroscience
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2007, Volume 133, Issue 4, pp. 1219 - 1228
Background & Aims: We previously showed that intestinal inflammation is reduced by electrical stimulation of the efferent vagus nerve, which prevents... 
Gastroenterology and Hepatology | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Intestines - drug effects | Ileus - metabolism | Transcription, Genetic - drug effects | Postoperative Complications - metabolism | Postoperative Complications - prevention & control | NF-kappa B - metabolism | Spiro Compounds - therapeutic use | Nicotine - pharmacology | Dose-Response Relationship, Drug | Bridged-Ring Compounds - pharmacology | Anti-Inflammatory Agents - therapeutic use | Female | Nicotinic Agonists - toxicity | Macrophages, Peritoneal - drug effects | Nicotinic Agonists - pharmacology | Disease Models, Animal | Bridged-Ring Compounds - therapeutic use | Receptors, Nicotinic - drug effects | Receptors, Nicotinic - metabolism | Postoperative Complications - physiopathology | Cytokines - metabolism | Anti-Inflammatory Agents - pharmacology | Anti-Inflammatory Agents - toxicity | Ileus - physiopathology | Intestines - innervation | Intestines - surgery | Cells, Cultured | Vagus Nerve - surgery | Electric Stimulation Therapy | Gastroenteritis - prevention & control | Nicotine - toxicity | Nicotinic Agonists - therapeutic use | Vagotomy | Animals | Gastric Emptying - drug effects | Gastroenteritis - metabolism | Ileus - prevention & control | Mice | Mice, Inbred BALB C | Intestines - physiopathology | Macrophages, Peritoneal - metabolism | Gastroenteritis - physiopathology | Spiro Compounds - pharmacology | alpha7 Nicotinic Acetylcholine Receptor | Intestines | Obstructions | Cytokines | Anti-inflammatory drugs | Index Medicus | Abridged Index Medicus
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 01/2014, Volume 58, Issue 1, pp. 325 - 332
...), we extended the set of tested compounds from our laboratories to 59. On the basis of this extended data set, further enriched by literature data for 10 compounds tested under the same conditions, our quantitative structure-activity relationship (QSAR... 
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Trypanocidal Agents - pharmacology | Heterocyclic Compounds, 3-Ring - pharmacology | Furans - pharmacology | Bridged-Ring Compounds - pharmacology | Inhibitory Concentration 50 | Molecular Structure | Trypanosoma brucei rhodesiense - drug effects | Sesquiterpenes - pharmacology | Lactones - pharmacology | Quantitative Structure-Activity Relationship | Index Medicus | Experimental Therapeutics
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 05/2014, Volume 111, Issue 23, pp. 8607 - 8612
Journal Article