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Vaccine, ISSN 0264-410X, 2014, Volume 32, Issue 49, pp. 6659 - 6666
Highlights • A novel molecular chaperon Dnak from Brucella melitensis elicits a Th1-dominant immune response as well as a strong humoral immune response. •... 
Allergy and Immunology | Molecular chaperon | Vaccine | Recombinant protein | Brucella | CPG OLIGODEOXYNUCLEOTIDES | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | LOW ENDOTOXIN CONTENTS | IMMUNOLOGY | SUBUNIT VACCINE | BALB/C MICE | HEAT-SHOCK PROTEINS | DNA VACCINE | INTERFERON-GAMMA | ABORTUS INFECTION | OUTER-MEMBRANE PROTEIN-31 | Cell Proliferation | Vaccines, Subunit - isolation & purification | Immunoglobulin G - blood | Vaccines, Subunit - genetics | Brucellosis - immunology | Vaccines, Synthetic - immunology | Vaccines, Combined - administration & dosage | Vaccines, Combined - immunology | Vaccines, Synthetic - isolation & purification | Brucella Vaccine - genetics | Heat-Shock Proteins - genetics | Lymphocytes - immunology | Cloning, Molecular | Vaccines, Combined - genetics | Brucella melitensis - immunology | Female | Brucellosis - prevention & control | Antibodies, Bacterial - blood | Molecular Chaperones - immunology | Bacterial Outer Membrane Proteins - genetics | Gene Expression | Bacterial Outer Membrane Proteins - immunology | Brucella Vaccine - isolation & purification | Vaccines, Synthetic - genetics | Cytokines - secretion | Molecular Chaperones - genetics | Vaccines, Combined - isolation & purification | Recombinant Proteins - genetics | Vaccines, Subunit - immunology | Brucella Vaccine - administration & dosage | Heat-Shock Proteins - immunology | Brucella Vaccine - immunology | Brucella melitensis - genetics | Animals | Recombinant Proteins - immunology | Escherichia coli - genetics | Vaccines, Subunit - administration & dosage | Mice, Inbred BALB C | Vaccines, Synthetic - administration & dosage | Monoclonal antibodies | Immunization | Biological products | Health aspects | Public health | Antigens | Bacterial proteins | Recombinant proteins | Immunoglobulin G | Vaccination
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2017, Volume 12, Issue 10, p. e0186484
We previously developed a potent candidate vaccine against bovine brucellosis caused by Brucella abortus using the influenza viral vector expressing Brucella... 
IMMUNE-RESPONSE | OMP16 PROTEINS | VIRUS | EFFICACY | L7/L12 | SAFETY | STRAIN RB51 | MULTIDISCIPLINARY SCIENCES | HEIFERS | FUTURE | LIVE | Goats | Lipoproteins - genetics | Vaccination | Antigens, Bacterial - immunology | Brucellosis - immunology | Interferon-gamma - metabolism | Antigens, Bacterial - genetics | Brucella Vaccine - genetics | T-Lymphocytes - metabolism | Immunoglobulin G - immunology | Superoxide Dismutase-1 - metabolism | Lipoproteins - metabolism | Antibodies - immunology | Female | Bacterial Proteins - immunology | Brucellosis - prevention & control | B-Lymphocytes - metabolism | Bacterial Outer Membrane Proteins - genetics | Superoxide Dismutase-1 - immunology | B-Lymphocytes - cytology | Bacterial Outer Membrane Proteins - immunology | Abortion, Spontaneous - prevention & control | Bacterial Proteins - genetics | Hemagglutinins, Viral - immunology | Brucella Vaccine - immunology | Brucella Vaccine - metabolism | Pregnancy | Brucella melitensis - genetics | Animals | B-Lymphocytes - immunology | Bacterial Outer Membrane Proteins - metabolism | T-Lymphocytes - cytology | Orthomyxoviridae - genetics | Superoxide Dismutase-1 - genetics | Bacterial Proteins - metabolism | Sheep | T-Lymphocytes - immunology | Antigens, Bacterial - metabolism | Lipoproteins - immunology | Brucella melitensis - pathogenicity | Brucellosis | Usage | Research | Vaccines | Influenza | Drug delivery systems | Laboratories | Immunoglobulin G | Antibodies | Lymphocytes T | Infections | Abortion | Proteins | Cattle | Animal tissues | Immunization | Effectiveness | Research & development--R&D | Fetuses | Outer membrane proteins | Vectors (Biology) | Disease prevention | Infectious diseases | Lymphocytes B | γ-Interferon | Interferon | Colonization | Research & development | R&D
Journal Article
Infection, Genetics and Evolution, ISSN 1567-1348, 07/2017, Volume 51, pp. 227 - 234
Current investigations have demonstrated that a multi-epitope peptide vaccine targeting multiple antigens could be considered as an ideal approach for... 
Dnak | BLS | L7–L12 | Brucellosis | Omp31 | BP26 | Multi-epitope vaccine | INFECTIOUS DISEASES | DESIGN | PROTEIN | PROTECTION | MELITENSIS INFECTION | L7-L12 | IN-SILICO APPROACH | BALB/C MICE | SERVER | BINDING | ABORTUS 544 INFECTION | STRUCTURE PREDICTION | Recombinant Fusion Proteins - immunology | Bacterial Vaccines - genetics | Humans | Antigens, Bacterial - immunology | Brucellosis - immunology | Epitopes, T-Lymphocyte - genetics | Ribosomal Proteins - immunology | Acetyltransferases - genetics | Antigens, Bacterial - genetics | Brucella - genetics | Brucella - chemistry | T-Lymphocytes - drug effects | Escherichia coli - metabolism | Brucella - immunology | Cholera Toxin - immunology | Bacterial Vaccines - biosynthesis | Bacterial Vaccines - pharmacology | Epitopes, T-Lymphocyte - immunology | Brucellosis - prevention & control | Bacterial Outer Membrane Proteins - genetics | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Vaccines, Subunit | Antigens, Bacterial - chemistry | Bacterial Outer Membrane Proteins - immunology | HSP70 Heat-Shock Proteins - immunology | Membrane Proteins - genetics | Ribosomal Proteins - genetics | Computational Biology | Models, Molecular | HSP70 Heat-Shock Proteins - genetics | Membrane Proteins - immunology | Recombinant Fusion Proteins - chemistry | Epitopes, T-Lymphocyte - chemistry | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Protein Conformation, beta-Strand | T-Lymphocytes - cytology | Cholera Toxin - genetics | Escherichia coli - genetics | Recombinant Fusion Proteins - genetics | T-Lymphocytes - immunology | Acetyltransferases - immunology | Proteins | Medical research | Usage | Analysis | Medicine, Experimental | Vaccines | Cholera toxin | Tetanus | T cells | Antigenic determinants | Immune response
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2014, Volume 192, Issue 8, pp. 3740 - 3752
Journal Article
Vaccine, ISSN 0264-410X, 2015, Volume 33, Issue 19, pp. 2248 - 2253
Abstract Zoonoses that affect human and animal health have an important economic impact. In the study now presented, a bivalent vaccine has been developed that... 
Allergy and Immunology | Shiga toxin-producing Escherichia coli | Recombinant vaccine | Brucella | MEDICINE, RESEARCH & EXPERIMENTAL | III SECRETED PROTEINS | CATTLE | SHIGA-TOXIN | IMMUNOLOGY | VIRULENCE | GENE | CLONING | O157-H7 | LIPOPOLYSACCHARIDE | CYCLIC BETA-1,2-GLUCAN | POLYSACCHARIDE | Recombinant Fusion Proteins - immunology | Bacterial Vaccines - genetics | Escherichia coli Infections - prevention & control | Brucella abortus - genetics | Brucellosis, Bovine - immunology | Vaccines, Synthetic - immunology | Bacterial Vaccines - isolation & purification | Vaccines, Synthetic - isolation & purification | Brucellosis, Bovine - microbiology | Brucella abortus - immunology | Cattle | Escherichia coli Proteins - immunology | Gene Expression | Escherichia coli O157 - genetics | Vaccines, Synthetic - genetics | Escherichia coli Infections - microbiology | Animals | Bacterial Vaccines - administration & dosage | Bacterial Vaccines - immunology | Immunoglobulin A - immunology | Brucellosis, Bovine - prevention & control | Escherichia coli Proteins - genetics | Recombinant Fusion Proteins - genetics | Antibodies, Bacterial - immunology | Escherichia coli Infections - immunology | Mice | Mice, Inbred BALB C | Vaccines, Synthetic - administration & dosage | Escherichia coli O157 - immunology | Prevention | Vaccines | Health aspects | Escherichia coli | Zoonoses | Antigens | Medical research | Disease transmission | Gastrointestinal diseases | Medicine, Experimental | Shiga toxin | Flagellin | Antibodies | Infections | Glucose | Immunoglobulin A | Regulatory approval | Impact analysis | Proteins | E coli | Intestine | Combined vaccines | Bacteria | Feces | Immune system | Pathogens | Antigen presentation | Immunization | Immune response | Intimin | Animal health | Plasmids | Brucellosis | Economic impact | Colonization
Journal Article
Journal Article
Journal Article
Molecular Immunology, ISSN 0161-5890, 08/2015, Volume 66, Issue 2, pp. 384 - 391
•rL7/L12-TOmp31 DNA priming protein boosting immunizations induces a vigorous humoral response and Th1 cellular response more than a DNA vaccine or protein... 
DNA vaccine | Electroporation | Footpad route | Prime-boost strategy | Brucella | IMMUNE-RESPONSE | CONFERS PROTECTION | MELITENSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNOLOGY | L7/L12 RIBOSOMAL-PROTEIN | BALB/C MICE | IMMUNIZATION | ADJUVANTS | ABORTUS | INFECTION | OUTER-MEMBRANE PROTEIN-31 | Recombinant Fusion Proteins - immunology | Spleen - immunology | Humans | Brucellosis - immunology | DNA, Bacterial - immunology | Vaccines, DNA | Ribosomal Proteins - immunology | Spleen - drug effects | Spleen - microbiology | Brucella Vaccine - genetics | Immunity, Cellular - drug effects | Immunization, Secondary | Antibodies, Bacterial - biosynthesis | Immunoglobulin G - biosynthesis | Brucella abortus - immunology | Plasmids - genetics | Brucella melitensis - chemistry | Brucella melitensis - immunology | Female | DNA, Bacterial - administration & dosage | Brucellosis - prevention & control | Bacterial Outer Membrane Proteins - genetics | Recombinant Fusion Proteins - administration & dosage | Brucellosis - microbiology | Bacterial Outer Membrane Proteins - immunology | Ribosomal Proteins - genetics | Plasmids - immunology | Bacterial Outer Membrane Proteins - administration & dosage | Brucella Vaccine - administration & dosage | Brucella Vaccine - immunology | Animals | DNA, Bacterial - genetics | Ribosomal Proteins - administration & dosage | Immunity, Humoral - drug effects | Recombinant Fusion Proteins - genetics | Mice | Mice, Inbred BALB C | Interferon-gamma - biosynthesis | Plasmids - administration & dosage | Brucella abortus - chemistry | Molecular biology | DNA | Vaccines | Antigens | Medical research | Immunoglobulin G | Vaccination | Medicine, Experimental | Zoonoses
Journal Article
Expert Review of Vaccines, ISSN 1476-0584, 09/2011, Volume 10, Issue 9, pp. 1291 - 1305
Brucellosis is an important zoonotic disease of nearly worldwide distribution. This pathogen causes abortion in domestic animals and undulant fever, arthritis,... 
DNA vaccine | vaccine | Brucella abortus | recombinant protein vaccine | live-attenuated vaccine | brucellosis | PROTEIN CONFERS PROTECTION | POLYMERIC BACTERIAL PROTEIN | IMMUNOLOGY | CD8(+) T-CELLS | BALB/C MICE | TOLL-LIKE RECEPTOR-4 | OUTER-MEMBRANE PROTEIN | O-POLYSACCHARIDE SYNTHESIS | ZN SUPEROXIDE-DISMUTASE | ACTIVATES DENDRITIC CELLS | Vaccines, DNA - chemical synthesis | Vaccines, Attenuated - biosynthesis | Brucella abortus - physiology | Humans | Brucella Vaccine - chemical synthesis | Brucellosis - immunology | Molecular Sequence Data | Vaccines, DNA - administration & dosage | Pregnancy Complications, Infectious - immunology | Cattle | Vaccines, Attenuated - administration & dosage | Pregnancy Complications, Infectious - prevention & control | Brazil | Female | Brucellosis - prevention & control | Brucellosis - microbiology | Amino Acid Sequence | Argentina | Vaccines, Attenuated - chemical synthesis | Vaccines, Subunit - chemical synthesis | Vaccines, Synthetic - biosynthesis | Vaccines, Synthetic - genetics | Brucella Vaccine - biosynthesis | Treatment Outcome | Brucella Vaccine - administration & dosage | Pregnancy | Animals | Vaccines, Subunit - biosynthesis | Vaccines, Subunit - administration & dosage | Brucella abortus - drug effects | Government Regulation | Sheep | Vaccines, DNA - biosynthesis | Mice | Vaccines, Synthetic - administration & dosage | Medical research | DNA | Endocarditis | Medicine, Experimental | Brucellosis | Vaccines | Gene therapy | Abortion | Recombinant proteins | Contamination | Zoonoses | Pathogens | Meningitis | Arthritis | DNA vaccines | Domestic animals | Fever
Journal Article
Vaccine, ISSN 0264-410X, 2010, Volume 28, Issue 34, pp. 5627 - 5634
Journal Article