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INFECTION AND IMMUNITY, ISSN 0019-9567, 11/2017, Volume 85, Issue 11
The spleen is known as an important filter for blood-borne pathogens that are trapped by specialized macrophages in the marginal zone (MZ): the CD209(+) MZ... 
MOUSE SPLEEN | INFECTIOUS DISEASES | low-grade Th1 inflammation | infection | DENDRITIC CELLS | spleen | MELITENSIS INFECTION | marginal zone macrophages | CD4(+) TH1 CELLS | IMMUNOLOGY | ADAPTIVE IMMUNITY | CRUCIAL ROLE | ABORTUS INFECTION | brucellosis | MEDIATES UPTAKE | CD169(+) MACROPHAGES | Brucella melitensis | T-CELLS | RNA, Messenger - immunology | Spleen - immunology | Receptors, Tumor Necrosis Factor, Type I - immunology | Brucellosis - immunology | Spleen - microbiology | Chemokine CCL21 - immunology | Receptors, Tumor Necrosis Factor, Type I - deficiency | Brucella abortus - immunology | Brucella suis - immunology | Brucella melitensis - immunology | Brucella abortus - pathogenicity | Interferon-gamma - genetics | Chemokine CCL19 - immunology | Chemokine CXCL13 - immunology | Receptors, Interferon - genetics | Macrophages - immunology | Macrophages - microbiology | Brucellosis - microbiology | Brucellosis - genetics | B-Lymphocytes - microbiology | Brucella suis - drug effects | T-Lymphocytes - microbiology | Chemokine CXCL13 - genetics | Brucella melitensis - drug effects | Signal Transduction | Streptomycin - pharmacology | Receptors, Interferon - deficiency | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Brucellosis - drug therapy | Receptors, Tumor Necrosis Factor, Type I - genetics | Chemokine CCL21 - genetics | Mice, Knockout | Host-Pathogen Interactions | Animals | B-Lymphocytes - immunology | Chemokine CCL19 - genetics | Receptors, Interferon - immunology | Interferon-gamma - immunology | Brucella abortus - drug effects | T-Lymphocytes - immunology | Anti-Bacterial Agents - pharmacology | Mice | Rifampin - pharmacology | Brucella suis - pathogenicity | Chronic Disease | Brucella melitensis - pathogenicity
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2014, Volume 192, Issue 8, pp. 3740 - 3752
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 7/2012, Volume 206, Issue 1, pp. 91 - 98
Background. Brucella spp. are intracellular bacteria that establish lifelong infections whose mechanisms of chronicity are poorly understood. Notably, B cells... 
Phagocytes | Antiserum | B lymphocytes | Brucella | Colony forming units assay | Antibodies | Bacteria | Infections | Brucella abortus | Macrophages | MYCOBACTERIUM-TUBERCULOSIS | INFECTIOUS DISEASES | DENDRITIC CELLS | CELL-DEFICIENT MICE | MURINE MACROPHAGES | MICROBIOLOGY | SUIS | VIRB | IMMUNOLOGY | GROWTH-FACTOR-BETA | IMMUNE-RESPONSES | ENDOPLASMIC-RETICULUM | PARTICULATE ANTIGENS | Endosomes - immunology | Stem Cells - immunology | Endosomes - microbiology | Brucella abortus - genetics | Lysosomes - genetics | Transforming Growth Factor beta1 - metabolism | Brucellosis - immunology | Complement System Proteins - immunology | Monocytes - metabolism | Monocytes - immunology | Phagocytosis - genetics | Stem Cells - metabolism | Immunoglobulin M - immunology | Endosomes - metabolism | Complement System Proteins - metabolism | Immunoglobulin M - metabolism | Transforming Growth Factor beta1 - immunology | Lysosomes - metabolism | Brucella abortus - immunology | Stem Cells - microbiology | Antibodies, Bacterial - metabolism | Brucellosis - metabolism | B-Lymphocytes - metabolism | Macrophages - immunology | Macrophages - microbiology | Brucellosis - microbiology | Brucellosis - genetics | Monocytes - microbiology | B-Lymphocytes - microbiology | Endosomes - genetics | Phagocytosis - immunology | Brucella abortus - growth & development | Survival | Macrophages - metabolism | Animals | B-Lymphocytes - immunology | Lysosomes - microbiology | DNA Replication - immunology | DNA Replication - genetics | Antibodies, Bacterial - immunology | Mice | Mice, Inbred BALB C | Lysosomes - immunology | Brucella abortus - metabolism | Physiological aspects | B cells | Research | Major and Brief Reports
Journal Article
Infection and Immunity, ISSN 0019-9567, 2015, Volume 83, Issue 12, pp. 4861 - 4870
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2017, Volume 12, Issue 10, p. e0186484
We previously developed a potent candidate vaccine against bovine brucellosis caused by Brucella abortus using the influenza viral vector expressing Brucella... 
IMMUNE-RESPONSE | OMP16 PROTEINS | VIRUS | EFFICACY | L7/L12 | SAFETY | STRAIN RB51 | MULTIDISCIPLINARY SCIENCES | HEIFERS | FUTURE | LIVE | Goats | Lipoproteins - genetics | Vaccination | Antigens, Bacterial - immunology | Brucellosis - immunology | Interferon-gamma - metabolism | Antigens, Bacterial - genetics | Brucella Vaccine - genetics | T-Lymphocytes - metabolism | Immunoglobulin G - immunology | Superoxide Dismutase-1 - metabolism | Lipoproteins - metabolism | Antibodies - immunology | Female | Bacterial Proteins - immunology | Brucellosis - prevention & control | B-Lymphocytes - metabolism | Bacterial Outer Membrane Proteins - genetics | Superoxide Dismutase-1 - immunology | B-Lymphocytes - cytology | Bacterial Outer Membrane Proteins - immunology | Abortion, Spontaneous - prevention & control | Bacterial Proteins - genetics | Hemagglutinins, Viral - immunology | Brucella Vaccine - immunology | Brucella Vaccine - metabolism | Pregnancy | Brucella melitensis - genetics | Animals | B-Lymphocytes - immunology | Bacterial Outer Membrane Proteins - metabolism | T-Lymphocytes - cytology | Orthomyxoviridae - genetics | Superoxide Dismutase-1 - genetics | Bacterial Proteins - metabolism | Sheep | T-Lymphocytes - immunology | Antigens, Bacterial - metabolism | Lipoproteins - immunology | Brucella melitensis - pathogenicity | Brucellosis | Usage | Research | Vaccines | Influenza | Drug delivery systems | Laboratories | Immunoglobulin G | Antibodies | Lymphocytes T | Infections | Abortion | Proteins | Cattle | Animal tissues | Immunization | Effectiveness | Research & development--R&D | Fetuses | Outer membrane proteins | Vectors (Biology) | Disease prevention | Infectious diseases | Lymphocytes B | γ-Interferon | Interferon | Colonization | Research & development | R&D
Journal Article
Microbial Pathogenesis, ISSN 0882-4010, 09/2017, Volume 110, pp. 7 - 13
Brucellosis is an important zoonotic disease caused by species. The disease is difficult to control due to the intracellular survival of the bacterium and the... 
Antigens | Brucella abortus | Immune responses | Th2 | BOVINE BRUCELLOSIS | MELITENSIS INFECTION | CLINICAL-DIAGNOSIS | CU/ZN SUPEROXIDE-DISMUTASE | MICROBIOLOGY | IMMUNOLOGY | IDENTIFICATION | B-ABORTUS | OUTER-MEMBRANE-PROTEIN | VACCINE DEVELOPMENT | RECOMBINANT PROTEINS | MICE | Immunoglobulin M | Genes, Bacterial - genetics | Brucella abortus - genetics | Immunoglobulin G | Antigens, Bacterial - immunology | Brucellosis - immunology | B-Lymphocytes | Peptide Elongation Factors - immunology | Th1 Cells - immunology | Antigens, Bacterial - genetics | DNA, Bacterial | Malate Dehydrogenase - genetics | Th2 Cells - microbiology | Recombinant Proteins - isolation & purification | Arginase - immunology | Malate Dehydrogenase - immunology | Brucella abortus - immunology | Tumor Necrosis Factor-alpha - immunology | Female | Bacterial Proteins - immunology | Peptide Elongation Factors - genetics | Cytokines - immunology | Brucellosis - microbiology | Immunization | Enzyme-Linked Immunosorbent Assay | Interferon-gamma - secretion | Tumor Necrosis Factor-alpha - secretion | Bacterial Proteins - genetics | Cytokines - secretion | Arginase - genetics | RAW 264.7 Cells - immunology | Animals | Recombinant Proteins - immunology | Antibodies, Bacterial - immunology | Mice | Mice, Inbred BALB C | Gene Expression Regulation, Bacterial | Genetic Vectors | Nitric Oxide - metabolism | Immunity, Cellular | Interleukin-2 - secretion | Brucella abortus - chemistry | Immune response | Bacterial infections | Analysis | Recombinant proteins | Zoonoses
Journal Article
Vaccine, ISSN 0264-410X, 2009, Volume 27, Issue 48, pp. 6704 - 6711
Journal Article
Vaccine, ISSN 0264-410X, 2014, Volume 32, Issue 49, pp. 6659 - 6666
Highlights • A novel molecular chaperon Dnak from Brucella melitensis elicits a Th1-dominant immune response as well as a strong humoral immune response. •... 
Allergy and Immunology | Molecular chaperon | Vaccine | Recombinant protein | Brucella | CPG OLIGODEOXYNUCLEOTIDES | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE-RESPONSE | LOW ENDOTOXIN CONTENTS | IMMUNOLOGY | SUBUNIT VACCINE | BALB/C MICE | HEAT-SHOCK PROTEINS | DNA VACCINE | INTERFERON-GAMMA | ABORTUS INFECTION | OUTER-MEMBRANE PROTEIN-31 | Cell Proliferation | Vaccines, Subunit - isolation & purification | Immunoglobulin G - blood | Vaccines, Subunit - genetics | Brucellosis - immunology | Vaccines, Synthetic - immunology | Vaccines, Combined - administration & dosage | Vaccines, Combined - immunology | Vaccines, Synthetic - isolation & purification | Brucella Vaccine - genetics | Heat-Shock Proteins - genetics | Lymphocytes - immunology | Cloning, Molecular | Vaccines, Combined - genetics | Brucella melitensis - immunology | Female | Brucellosis - prevention & control | Antibodies, Bacterial - blood | Molecular Chaperones - immunology | Bacterial Outer Membrane Proteins - genetics | Gene Expression | Bacterial Outer Membrane Proteins - immunology | Brucella Vaccine - isolation & purification | Vaccines, Synthetic - genetics | Cytokines - secretion | Molecular Chaperones - genetics | Vaccines, Combined - isolation & purification | Recombinant Proteins - genetics | Vaccines, Subunit - immunology | Brucella Vaccine - administration & dosage | Heat-Shock Proteins - immunology | Brucella Vaccine - immunology | Brucella melitensis - genetics | Animals | Recombinant Proteins - immunology | Escherichia coli - genetics | Vaccines, Subunit - administration & dosage | Mice, Inbred BALB C | Vaccines, Synthetic - administration & dosage | Monoclonal antibodies | Immunization | Biological products | Health aspects | Public health | Antigens | Bacterial proteins | Recombinant proteins | Immunoglobulin G | Vaccination
Journal Article
Vaccine, ISSN 0264-410X, 2007, Volume 25, Issue 37, pp. 6721 - 6729
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 7, p. e21978
Journal Article