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bufadienolides (376) 376
index medicus (205) 205
animals (165) 165
pharmacology & pharmacy (158) 158
humans (123) 123
bufadienolide (118) 118
bufanolides - chemistry (101) 101
chemistry, medicinal (101) 101
bufalin (88) 88
plant sciences (85) 85
bufanolides - pharmacology (79) 79
biochemistry & molecular biology (66) 66
cinobufagin (65) 65
apoptosis (62) 62
male (59) 59
cytotoxicity (57) 57
toad venom (57) 57
chemistry, analytical (53) 53
molecular structure (53) 53
bufanolides - isolation & purification (52) 52
skin (52) 52
biotransformation (49) 49
female (48) 48
analysis (47) 47
cells (46) 46
mass spectrometry (46) 46
steroids (43) 43
toxicology (43) 43
bufanolides - metabolism (40) 40
chemistry, multidisciplinary (40) 40
rats (40) 40
antineoplastic agents - pharmacology (39) 39
cell line, tumor (39) 39
cancer (38) 38
chromatography, high pressure liquid (37) 37
resibufogenin (37) 37
mass-spectrometry (36) 36
venom (36) 36
chan-su (34) 34
magnetic resonance spectroscopy (34) 34
bufonidae (33) 33
cardiac-glycosides (32) 32
cytotoxic bufadienolides (32) 32
chemistry, applied (29) 29
crassulaceae (29) 29
mice (28) 28
performance liquid-chromatography (28) 28
biochemical research methods (27) 27
inhibition (27) 27
integrative & complementary medicine (27) 27
plant (27) 27
toads (27) 27
toxicity (27) 27
atpase (26) 26
bufanolides - analysis (26) 26
cell proliferation - drug effects (26) 26
chromatography (26) 26
chansu (25) 25
identification (25) 25
liquid chromatography (25) 25
traditional chinese medicine (25) 25
alkaloids (24) 24
ecology (24) 24
glycosides (24) 24
ouabain (24) 24
amphibian venoms - chemistry (23) 23
amphibians (23) 23
cell survival - drug effects (23) 23
drug screening assays, antitumor (23) 23
hydroxylation (23) 23
oncology (23) 23
cardenolides (22) 22
chemistry, organic (22) 22
medicine (22) 22
na+/k+-atpase (22) 22
proteins (22) 22
research (22) 22
antineoplastic agents - chemistry (21) 21
food science & technology (21) 21
human leukemia-cells (21) 21
medicine, chinese traditional (21) 21
bufanolides - toxicity (20) 20
chemistry (20) 20
dose-response relationship, drug (20) 20
cardiac glycosides (19) 19
chinese medicine (19) 19
flavonoids (19) 19
leaves (19) 19
life sciences (19) 19
organic chemistry (19) 19
apoptosis - drug effects (18) 18
arenobufagin (18) 18
bufanolides - pharmacokinetics (18) 18
liquid-chromatography (18) 18
purification (18) 18
rats, sprague-dawley (18) 18
secretions (18) 18
amphibian skin (17) 17
bufo bufo gargarizans (17) 17
bufo-bufo-gargarizans (17) 17
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Organic and Biomolecular Chemistry, ISSN 1477-0520, 08/2015, Volume 13, Issue 29, pp. 7911 - 7914
A synthesis of putative bufopyramide has shown the structure assigned to the natural product to be incorrect. The spectroscopic data for the natural product... 
CHEMISTRY, ORGANIC | BUFADIENOLIDES
Journal Article
Bioscience, Biotechnology, and Biochemistry, ISSN 0916-8451, 06/2000, Volume 64, Issue 6, pp. 1310 - 1312
Two insecticidal bufadienolides (1 and 2) were isolated from a methanol extract of the leaves of Kalanchoe pinnata by bioassay-guided fractionation. Compound 1... 
bufadienolides
Journal Article
Steroids, ISSN 0039-128X, 2010, Volume 75, Issue 12, pp. 884 - 890
Six new bufadienolides ( – ) and two new C steroids ( and ), together with three known compounds ( – ) were isolated from the venom of . Their structures were... 
Cytotoxicity | Bufo bufo gargarizans | Bufadienolide | Toad venom | CELLS | TOAD POISON BUFADIENOLIDES | BUFALIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOTOXIC BUFADIENOLIDES | ENDOCRINOLOGY & METABOLISM | TRADITIONAL CHINESE MEDICINE | CHAN-SU
Journal Article
Studies in Natural Products Chemistry, ISSN 1572-5995, 01/2018, Volume 61, pp. 49 - 84
Cancer incidence has increased exponentially worldwide in the last decades despite greater efforts being made in the field of cancer research alongside... 
Antioxidants | Bryophyllum | Bufadienolides | Cancer prevention | Flavonoids
Journal Article
JOURNAL OF NATURAL PRODUCTS, ISSN 0163-3864, 10/2013, Volume 76, Issue 10, pp. 1842 - 1847
Five new C-23 steroids (1-5) together with five known bufadienolides (6-10) were isolated from the venom of Bufo bufo gargarizans (ChanSu in Chinese). The... 
APOPTOSIS | CELLS | BUFADIENOLIDES | CHEMISTRY, MEDICINAL | PHARMACOLOGY & PHARMACY | PLANT SCIENCES
Journal Article
Biochemical Systematics and Ecology, ISSN 0305-1978, 2010, Volume 38, Issue 4, pp. 759 - 763
Two new bufadienolide glycosides with an A/B trans ring structure, 14 ,16 -dihydroxy-3 -( - -glucopyranosyloxy)-5 -bufa-20,22-dienolide ( ), and 14 ,16... 
Bufadienolides | Phytoecdystones | Helleborus | Helleborus thibetanus | Ranunculaceae | 5 α-Bufadienolides | 5α-Bufadienolides | GLYCOSIDES | EVOLUTIONARY BIOLOGY | 5 alpha Bufadienolides | SAPONINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG CHAN-SU | ECOLOGY | Analysis | Ecdysone
Journal Article
Journal of Natural Products, ISSN 0163-3864, 11/2018, Volume 81, Issue 11, pp. 2576 - 2581
Cyanobufalins A-C (1-3), a new series of cardiotoxic steroids, have been discovered from cyanobacterial blooms in Buckeye Lake and Grand Lake St. Marys in... 
IPSC-DERIVED CARDIOMYOCYTES | BUFADIENOLIDES | CHEMISTRY, MEDICINAL | PHARMACOLOGY & PHARMACY | HALOGENATION | INSIGHTS | PLANT SCIENCES | Index Medicus
Journal Article
Phytochemistry Letters, ISSN 1874-3900, 06/2019, Volume 31, pp. 73 - 77
Three new bufadienolides, (2 ,5 ,14 )-2,5,14-trihydroxy-bufa-20,22-dienolide ( ), (3 ,16 )-3,16-dihydroxy-bufa-14,20,22-trienolide ( ) and (3 ,5 ,16... 
Bufadienolides | Skins of B. Melanosticus | Aqueous extracts | Cytotoxic activity
Journal Article
Zhongguo Zhongyao Zazhi, ISSN 1001-5302, 03/2017, Volume 42, Issue 5, pp. 863 - 869
Journal Article
Journal Article
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, ISSN 1570-0232, 07/2016, Volume 1026, pp. 67 - 74
Bufadienolides possess various bioactivities especially antitumor. Due to the high structural diversity, the separation of bufadienolides often suffers from... 
CHEMISTRY, ANALYTICAL | HPLC-DAD | STEROIDS | BIOCHEMICAL RESEARCH METHODS | CHAN-SU | CELL-GROWTH | MS/MS | IDENTIFICATION | CANCER | ACTIVE BUFADIENOLIDES | Toad skin | CARDIAC-GLYCOSIDES | Bufadienolides | Normal-phase liquid chromatography | EFFICIENT PURIFICATION | Two-dimensional liquid chromatography | BUFO-GARGARIZANS CANTOR | Mass spectrometry | Skin | Liquid chromatography
Journal Article
International Journal of Mass Spectrometry, ISSN 1387-3806, 11/2017, Volume 422, pp. 88 - 93
Journal Article
by Wei, WL and Yu, Y and Wang, X and Yang, LH and Zhang, H and Ji, HJ and Li, ZW and Hou, JJ and Wu, WY and Guo, D
MOLECULES, ISSN 1420-3049, 05/2019, Volume 24, Issue 9, p. 1662
Characterization and determination of metabolites to monitor metabolic pathways play a paramount role in evaluating the efficacy and safety of medicines.... 
PERFORMANCE LIQUID-CHROMATOGRAPHY | APOPTOSIS | BUFADIENOLIDES | metabolite | quantification | MICROSOMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | bufalin | pharmacokinetics | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 09/2014, Volume 155, Issue 2, pp. 1076 - 1085
Toads known as “cururú” ( ) have been used in the Brazilian Pantanal and Paraguayan Chaco wetlands to treat erysipelas and cancer. The aim of the study was to... 
Rhinella schneideri | Argininyl bufadienolides | Bufo | Antiproliferative activity | Brazilian pantanal
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 12/2002, Volume 45, Issue 25, pp. 5440 - 5447
QSAR analysis has been used to identify the essential structural requirements for increasing the inhibitory activities of selected bufadienolides from the... 
CHEMISTRY, MEDICINAL | BUFALIN | TOAD-POISON BUFADIENOLIDES | GROWTH
Journal Article
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