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Journal Article
LANCET NEUROLOGY, ISSN 1474-4422, 02/2016, Volume 15, Issue 2, pp. 136 - 137
Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2015, Volume 14, Issue 5, pp. 469 - 477
Journal Article
Circulation: Heart Failure, ISSN 1941-3289, 01/2016, Volume 9, Issue 1, pp. e002370 - e002370
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2015, Volume 746, pp. 167 - 173
Bumetanide is increasingly being used for experimental treatment of brain disorders, including neonatal seizures, epilepsy, and autism, because the neuronal... 
Neonatal seizures | Drug transport | Cation chloride cotransporters | Epilepsy | Blood–brain barrier | Blood-brain barrier | ACID | CATION-CHLORIDE COTRANSPORTERS | RENAL TRANSPORT | MRP4 | NEONATAL SEIZURES | Epilepsy Neonatal seizures | P-GLYCOPROTEIN | DRUG TRANSPORTERS | DISEASE | RESISTANCE | PHARMACOLOGY & PHARMACY | EPILEPSY | Bumetanide - metabolism | Diuretics - pharmacokinetics | Sodium Potassium Chloride Symporter Inhibitors - pharmacology | Humans | Sodium Potassium Chloride Symporter Inhibitors - pharmacokinetics | Half-Life | Organic Anion Transporters - metabolism | Brain - metabolism | Kidney - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Membrane Transport Modulators - pharmacology | Female | Animals, Outbred Strains | Biological Transport - drug effects | Neurons - metabolism | Neurons - drug effects | Diuretics - blood | Diuretics - metabolism | Recombinant Proteins - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Anticonvulsants - blood | Anticonvulsants - pharmacokinetics | Organic Anion Transporters - antagonists & inhibitors | Kidney - drug effects | Probenecid - pharmacology | Anticonvulsants - metabolism | Bumetanide - blood | Recombinant Proteins - chemistry | Bumetanide - pharmacokinetics | Blood-Brain Barrier - drug effects | Nerve Tissue Proteins - genetics | Bumetanide - pharmacology | Blood-Brain Barrier - metabolism | Brain - drug effects | Nerve Tissue Proteins - metabolism | Animals | Dogs | Sodium Potassium Chloride Symporter Inhibitors - metabolism | Mice | Sodium Potassium Chloride Symporter Inhibitors - blood | Diuretics | Seizures (Medicine) | Ionization | Probenecid | Protein binding | Index Medicus
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 03/2018, Volume 20, Issue 3, pp. 479 - 487
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2015, Volume 21, Issue 12, pp. 1436 - 1444
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2016, Volume 770, pp. 117 - 125
Recently, it has been suggested that bumetanide, an inhibitor of the Na–K–2Cl co-transporter (NKCC1), may be useful in the treatment of central nervous system... 
Neonatal seizures | Bidirectional permeability assay | Efflux transport | Bumetanide | Pharmacokinetics | Blood–brain barrier | Abbreviations A→B apical to basolateral | MDCKII-WT wildtype MDCKII cells | NKCC1 Na-K-2Cl transporter | HEK human embryonic kidney | hOAT3 human organic anion transporter 3 | MDCKII Madin-Darby canine kidney cell line | P | B→A basolateral to apical | GAPDH glyceraldehyde 3-phosphate dehydrogenase | CNS central nervous system | BBB blood-brain barrier | V | brain volume of distribution in brain | OAT3 organic anion transporter 3 | FBS foetal bovine serum | eGFP enhanced green fluorescent protein | HPLC high-performance liquid chromatography | brain fraction unbound in brain | FACS fluorescence-activated cell sorting | f | P passage | NEAA non-essential amino acids | plasma albumin fraction unbound in plasma albumin | DMEM Dulbecco's modified Eagle medium | lv lentiviral | apparent permeability | ORGANIC ANION TRANSPORTER | DRUG-DELIVERY | SPECIES-DIFFERENCE | BLOOD-BRAIN-BARRIER | P-GLYCOPROTEIN | PERFORMANCE LIQUID-CHROMATOGRAPHY | Blood-brain barrier | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | RAT-BRAIN | CANCER RESISTANCE PROTEIN | Solute Carrier Family 12, Member 2 - metabolism | Bumetanide - metabolism | Organic Anion Transporters, Sodium-Independent - genetics | Organic Anion Transporters, Sodium-Independent - metabolism | Humans | HEK293 Cells | Bumetanide - pharmacokinetics | Permeability | Bumetanide - pharmacology | Blood-Brain Barrier - metabolism | Pharmacy | Protein binding | Index Medicus
Journal Article
Annals of Neurology, ISSN 0364-5134, 04/2014, Volume 75, Issue 4, pp. 550 - 562
Journal Article
Journal Article