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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2014, Volume 57, Issue 3, pp. 836 - 848
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2009, Volume 52, Issue 21, pp. 6768 - 6781
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 01/2017, Volume 8, Issue 1, pp. 115 - 127
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2010, Volume 53, Issue 12, pp. 4731 - 4748
To create potentially superior aids to smoking cessation and/or antidepressants and to elucidate bupropion's possible mechanisms of action(s), 23 analogues... 
SYSTEM | NICOTINIC RECEPTORS | METABOLITES | CHEMISTRY, MEDICINAL | DRUG-INTERACTIONS | TRANSPORTERS | NEURONS | TARGETS | ALPHA 6 | BRAIN | BUPROPION HYDROXYLATION | Analgesics - pharmacology | Body Temperature - drug effects | Stereoisomerism | Humans | Bupropion - analogs & derivatives | Motor Activity - drug effects | Male | Nicotinic Antagonists - pharmacology | Structure-Activity Relationship | Serotonin Uptake Inhibitors - chemical synthesis | Nicotine - pharmacology | Adrenergic Uptake Inhibitors - chemistry | Nicotinic Antagonists - chemical synthesis | Analgesics - chemical synthesis | Dopamine Uptake Inhibitors - chemical synthesis | Adrenergic Uptake Inhibitors - chemical synthesis | Nicotinic Agonists - pharmacology | Cell Line | Dopamine Uptake Inhibitors - pharmacology | Bupropion - chemical synthesis | Serotonin Uptake Inhibitors - chemistry | Mice, Inbred ICR | Animals | Bupropion - chemistry | Nicotinic Antagonists - chemistry | Receptors, Nicotinic - physiology | Analgesics - chemistry | Dopamine Uptake Inhibitors - chemistry | Adrenergic Uptake Inhibitors - pharmacology | Bupropion - pharmacology | Mice | Serotonin Uptake Inhibitors - pharmacology | Smoking Cessation | hydroxybupropion | antinociception | hypothermia | nAChR antagonism | norepinephrine uptake | locomotor activity | structure activity relationship | dopamine uptake | bupropion | Nicotine
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2007, Volume 48, Issue 27, pp. 4695 - 4697
Analogous structures in phosphinate series of hydroxybupropion , that is, (±)-2-aryl-3,3,5,5-tetramethyl-[1,4,2]-oxazaphosphinanes , are prepared according to... 
Oxazaphosphinane | Oxazolidine | Hydroxybupropion | Arylmorpholinol | arylmorpholinol | BUPROPION | 2-HYDROGENO-2-OXO-1,4,2-OXAZAPHOSPHINANES | oxazaphosphinane | ANTI-TETRABENAZINE ACTIVITY | STEREOCHEMISTRY | CHEMISTRY, ORGANIC | hydroxylhupropion | oxazolidine | Organic chemistry | Chemical Sciences
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2011, Volume 54, Issue 5, pp. 1441 - 1448
Toward development of smoking cessation aids superior to bupropion (2), we describe synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues... 
SMOKING-CESSATION | PARTIAL AGONISTS | CHEMISTRY, MEDICINAL | EFFICACY | BUPROPION | TRANSPORTERS | PHARMACOLOGY | ADDICTION | DEPENDENCE | Body Temperature - drug effects | Stereoisomerism | Humans | Bupropion - analogs & derivatives | Motor Activity - drug effects | Male | Nicotinic Antagonists - pharmacology | Structure-Activity Relationship | Nicotine - pharmacology | Adrenergic Uptake Inhibitors - chemistry | Nicotinic Antagonists - chemical synthesis | HEK293 Cells | Dopamine Uptake Inhibitors - chemical synthesis | Behavior, Animal - drug effects | Adrenergic Uptake Inhibitors - chemical synthesis | Dopamine - metabolism | Morpholines - chemical synthesis | Receptors, Nicotinic - metabolism | Dopamine Uptake Inhibitors - pharmacology | Conditioning (Psychology) - drug effects | Morpholines - pharmacology | Mice, Inbred ICR | Morpholines - chemistry | Animals | Bupropion - chemistry | Norepinephrine - metabolism | Nicotinic Antagonists - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Adrenergic Uptake Inhibitors - pharmacology | Bupropion - pharmacology | Mice | Biogenic Monoamines - metabolism | Smoking Cessation | hydroxybupropion | antinociception | hypothermia | nAChR antagonism | norepinephrine uptake | locomotor activity | structure activity relationship | dopamine uptake | bupropion | Nicotine
Journal Article
NEUROCHEMISTRY INTERNATIONAL, ISSN 0197-0186, 11/2016, Volume 100, pp. 67 - 77
The interaction of (+/-)-bupropion [(+/-)-BP] with the human (h) alpha 4 beta 2 nicotinic acetylcholine receptor (AChR) was compared to that for its... 
Bupropion | (+/-)-SADU-3-72 | INHIBITION | Ca2+ influx | BIOCHEMISTRY & MOLECULAR BIOLOGY | DYNAMICS | TRANSMEMBRANE DOMAIN | Luminal and non-luminal sites | NEUROSCIENCES | Molecular docking | Human alpha 4 beta 2 nicotinic acetylcholine receptor
Journal Article
Neurochemistry International, ISSN 0197-0186, 11/2016, Volume 100, p. 67
The interaction of ([+ or -])-bupropion [([+ or -])-BP] with the human (h) [alpha]4[beta]2 nicotinic acetylcholine receptor (AChR) was compared to that for its... 
Medical colleges | Bupropion | Analysis
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 06/2005, Volume 15, Issue 12, pp. 2974 - 2979
The preparation and biological activity of analogs of (-)-cytisine, an alpha 4 beta 2 nicotinic receptor partial agonist, are discussed. All-carbon-containing... 
CHEMISTRY, MEDICINAL | CYTISINE | MALE BRITISH DOCTORS | CHEMISTRY, ORGANIC | alkaloid | ADDICTION | alpha 4 beta 2 nicotinic receptor | partial agonist | ACETYLCHOLINE-RECEPTORS | MECAMYLAMINE | BUPROPION | nAChR | smoking | cessation | BETA-2 SUBUNIT | RAT-BRAIN | (+/-)-CYTISINE | DERIVATIVES
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 09/2014, Volume 96, Issue 3, pp. 349 - 359
The suitability of the capillary dried blood spot (DBS) sampling method was assessed for simultaneous phenotyping of cytochrome P450 (CYP) enzymes and... 
P4502B6 ACTIVITY | VORICONAZOLE | LC-MS/MS | SINGLE-POINT | ORAL MIDAZOLAM | VOLUNTEERS | IN-VIVO | PHARMACOLOGY & PHARMACY | DRUG-METABOLIZING-ENZYMES | KAROLINSKA COCKTAIL | BUPROPION HYDROXYLATION | Predictive Value of Tests | Pharmaceutical Preparations - blood | Caffeine - administration & dosage | Cytochrome P-450 Enzyme Inhibitors | Dried Blood Spot Testing | Humans | Omeprazole - blood | Bupropion - blood | Midazolam - administration & dosage | Substrate Specificity | Male | Chromatography, High Pressure Liquid | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Coffee | Terfenadine - administration & dosage | Caffeine - pharmacokinetics | Feasibility Studies | Enzyme Inhibitors - administration & dosage | Young Adult | Chromatography, Reverse-Phase | Tandem Mass Spectrometry | Capsules | Spectrometry, Mass, Electrospray Ionization | Flurbiprofen - administration & dosage | Adult | Dextromethorphan - pharmacokinetics | Terfenadine - blood | ATP-Binding Cassette, Sub-Family B, Member 1 - blood | Pharmaceutical Preparations - administration & dosage | Terfenadine - pharmacokinetics | Bupropion - pharmacokinetics | Flurbiprofen - pharmacokinetics | Cytochrome P-450 Enzyme System - blood | Administration, Oral | Isoenzymes | Caffeine - blood | Omeprazole - administration & dosage | Terfenadine - analogs & derivatives | Omeprazole - pharmacokinetics | Carbonated Beverages | Midazolam - pharmacokinetics | Bupropion - administration & dosage | Dextromethorphan - blood | Flurbiprofen - blood | Phenotype | Pilot Projects | Midazolam - blood | Dextromethorphan - administration & dosage | Usage | Glycoproteins | Liquid chromatography | Research | Pharmacokinetics | Cytochrome P-450 | Index Medicus | Abridged Index Medicus
Journal Article
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 09/2016, Volume 2016, Issue 9, p. CD003384
Journal Article