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1. Full Text Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses
by Lockridge, Oksana
Pharmacology & therapeutics (Oxford), ISSN 0163-7258, 2015, Volume 148, pp. 34 - 46
Cocaine | Butyrylcholinesterase | Genetic variants | Nerve agent | Clinical use | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Genetic Variation | Amino Acid Sequence | Animals | Butyrylcholinesterase - chemistry | Butyrylcholinesterase - genetics | Butyrylcholinesterase - metabolism | Base Sequence | Humans | Protein Conformation | Cocaine-Related Disorders - drug therapy | Butyrylcholinesterase - therapeutic use | Nerve Agents - toxicity | Genetic vectors | Gene therapy | Health aspects | Index Medicus
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2. Full Text Butyrylcholinesterase-knockout reduces brain deposition of fibrillar β-amyloid in an Alzheimer mouse model
by Reid, G. Andrew and Darvesh, Sultan
Neuroscience, ISSN 0306-4522, 2015, Volume 298, pp. 424 - 435
Neurology | 5XFAD mouse | butyrylcholinesterase | Alzheimer’s disease | butyrylcholinesterase-knockout | cholinergic system | β-amyloid | Cholinergic system | Butyrylcholinesterase-knockout | Butyrylcholinesterase | Alzheimer's disease | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Butyrylcholinesterase - genetics | Age Factors | Gene Expression Regulation - genetics | Humans | Mice, Inbred C57BL | Presenilin-1 - genetics | Male | Mice, Transgenic | Alzheimer Disease - pathology | Brain - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Amyloid - metabolism | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Brain - pathology | Female | Mice | Alzheimer Disease - genetics | Index Medicus
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3. Full Text Enzyme-linked immunosorbent assay for detection of organophosphorylated butyrylcholinesterase: A biomarker of exposure to organophosphate agents
by Wang, Limin and Du, Dan and Lu, Donglai and Lin, Chiann-Tso and Smith, Jordan N and Timchalk, Charles and Liu, Fengquan and Wang, Jun and Lin, Yuehe and Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
Analytica chimica acta, ISSN 0003-2670, 2011, Volume 693, Issue 1, pp. 1 - 6
Butyrylcholinesterase | Organophosphate insecticides and nerve agents | Organophosphorylated butyrylcholinesterase | Sandwich ELISA | Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Analytical chemistry | Miscellaneous | Exact sciences and technology | Butyrylcholinesterase - blood | Enzyme-Linked Immunosorbent Assay - methods | Phosphorylation | Animals | Butyrylcholinesterase - chemistry | Antibodies - immunology | Butyrylcholinesterase - immunology | Rats | Organophosphorus Compounds - analysis | Biomarkers - blood | Insecticides - analysis | Mathematical analysis | Nerves | Antibodies | Insecticides | Assaying | Recognition | Organophosphates | Adducts | Index Medicus | ANTIBODIES | NERVES | SENSITIVITY | ADDUCTS | sandwich ELISA, organophosphorylated butyrylcholinesterase, butyrylcholinesterase, organophosphate insecticides and nerve agents | 60 APPLIED LIFE SCIENCES | PLASMA | IN VITRO | MATRICES | Environmental Molecular Sciences Laboratory | ENZYME IMMUNOASSAY | DETECTION | INSECTICIDES
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4. Full Text Human butyrylcholinesterase produced in insect cells: huprine‐based affinity purification and crystal structure
by Brazzolotto, Xavier and Wandhammer, Marielle and Ronco, Cyril and Trovaslet, Marie and Jean, Ludovic and Lockridge, Oksana and Renard, Pierre‐Yves and Nachon, Florian
The FEBS journal, ISSN 1742-464X, 08/2012, Volume 279, Issue 16, pp. 2905 - 2916
affinity chromatography | butyrylcholinesterase | X‐ray structure | insect cells | huprine | X-ray structure | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Catalytic Domain | Cricetinae | Butyrylcholinesterase - genetics | Cricetulus | Drosophila | Humans | Crystallization | Heterocyclic Compounds, 4 or More Rings - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Glycosylation | Recombinant Proteins - isolation & purification | Animals | Butyrylcholinesterase - chemistry | Butyrylcholinesterase - metabolism | Aminoquinolines - chemistry | Butyrylcholinesterase - isolation & purification | Kinetics | Chromatography, Affinity - methods | CHO Cells | Amino acids | Structure | Cells | Crystals | Enzymes | Cellular biology | Molecular biology | Gene expression | Crystal structure | Index Medicus | Organic chemistry | Chemical Sciences
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5. Full Text The impact of sialylation linkage‐type on the pharmacokinetics of recombinant butyrylcholinesterases
by Chung, Cheng‐Yu and Wang, Qiong and Yang, Shuang and Chough, Sandra and Seo, Younji and Cipollo, John F and Balthasar, Joseph P and Betenbaugh, Michael J
Biotechnology and bioengineering, ISSN 0006-3592, 01/2020, Volume 117, Issue 1, pp. 157 - 166
sialic Acid | α‐2,3 sialylation | butyrylcholinesterase | pharmacokinetic | α‐2,6 sialylation | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Butyrylcholinesterase - blood | Cricetinae | Butyrylcholinesterase - genetics | Butyrylcholinesterase - pharmacokinetics | Cricetulus | Humans | Recombinant Proteins - chemistry | Recombinant Proteins - pharmacokinetics | Recombinant Proteins - genetics | N-Acetylneuraminic Acid - metabolism | Recombinant Proteins - blood | Animals | Butyrylcholinesterase - chemistry | Mice | CHO Cells | Polysaccharides | Animal models | Toxicity | Glycoproteins | Pharmacology | Pharmacokinetics | Sialic acids | Glycan | Index Medicus
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6. Full Text Crystal structures of human cholinesterases in complex with huprine W and tacrine: Elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase
by Nachon, Florian and Carletti, Eugénie and Ronco, Cyril and Trovaslet, Marie and Nicolet, Yvain and Jean, Ludovic and Renard, Pierre-Yves
Biochemical journal, ISSN 0264-6021, 08/2013, Volume 453, Issue 3, pp. 393 - 399
Huprine | Inhibitor | Acetylcholinesterase | Butyrylcholinesterase | Alzheimer's disease | X-ray structure | Tacrine | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | Cholinesterase Inhibitors - chemistry | Acetylcholinesterase - chemistry | Alzheimer Disease - enzymology | Crystallography, X-Ray - methods | Butyrylcholinesterase - chemistry | Cholinesterase Inhibitors - pharmacology | Cholinesterases - chemistry | Butyrylcholinesterase - metabolism | Aminoquinolines - chemistry | Cholinesterases - metabolism | Cholinesterases - pharmacology | Aminoquinolines - pharmacology | Acetylcholinesterase - metabolism | Tacrine - chemistry | Index Medicus | Organic chemistry | Chemical Sciences
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7. Full Text Inhibition of cholinesterases by safranin O: Integration of inhibition kinetics with molecular docking simulations
by Onder, Seda and Sari, Suat and Tacal, Ozden
Archives of biochemistry and biophysics, ISSN 0003-9861, 02/2021, Volume 698, pp. 108728 - 108728
Safranin O | Acetylcholinesterase | Butyrylcholinesterase | Cholinesterase inhibition | Molecular docking | Catalytic Domain | Butyrylcholinesterase - genetics | Humans | Cholinesterase Inhibitors - chemistry | Acetylcholinesterase - chemistry | Butyrylcholinesterase - chemistry | Phenazines - metabolism | Cholinesterase Inhibitors - metabolism | Phenazines - chemistry | Butyrylcholinesterase - metabolism | Protein Binding | Ligands | Molecular Docking Simulation | Erythrocytes - enzymology | Kinetics | Mutation | Acetylcholinesterase - metabolism | Index Medicus
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8. Full Text Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma
by Li, Bin and Sedlacek, Meghan and Manoharan, Indumathi and Boopathy, Rathnam and Duysen, Ellen G and Masson, Patrick and Lockridge, Oksana
Biochemical pharmacology, ISSN 0006-2952, 2005, Volume 70, Issue 11, pp. 1673 - 1684
Irinotecan | Aspirin | Human plasma | Succinylcholine | Cocaine esterase | Albumin | Procaine | Paraoxonase | Acetylcholinesterase | Carboxylesterase | Mivacurium | Butyrylcholinesterase knockout mice | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Hydrolases | Analytical, structural and metabolic biochemistry | Enzymes and enzyme inhibitors | Aryldialkylphosphatase - blood | Butyrylcholinesterase - blood | Acetylcholinesterase - blood | Butyrylcholinesterase - genetics | Carboxylesterase - blood | Albumins - metabolism | Humans | Aryldialkylphosphatase - metabolism | Carboxylesterase - metabolism | Acetylcholinesterase - genetics | Mice, Knockout | Organophosphates - pharmacology | Animals | Cholinesterase Inhibitors - pharmacology | Butyrylcholinesterase - metabolism | Sensitivity and Specificity | Mice | Acetylcholinesterase - metabolism | Hydrolysis | Injections | Enzyme inhibitors | Esterases | Anesthetics | Index Medicus
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9. Full Text Butyrylcholinesterase nanocapsule as a long circulating bioscavenger with reduced immune response
by Zhang, Peng and Jain, Priyesh and Tsao, Caroline and Sinclair, Andrew and Sun, Fang and Hung, Hsiang-Chieh and Bai, Tao and Wu, Kan and Jiang, Shaoyi
Journal of controlled release, ISSN 0168-3659, 05/2016, Volume 230, pp. 73 - 78
Protein delivery | Immune response | Nanogel | Organophosphate | Butyrylcholinesterase | Circulation | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Cell Survival - drug effects | NIH 3T3 Cells | Butyrylcholinesterase - pharmacokinetics | Gels | Nanocapsules - administration & dosage | Cholinesterase Inhibitors - chemistry | Male | Butyrylcholinesterase - administration & dosage | Nanocapsules - chemistry | Rats, Sprague-Dawley | Betaine - analogs & derivatives | Betaine - chemistry | Animals | Butyrylcholinesterase - chemistry | Fluorescein-5-isothiocyanate | Horses | Paraoxon - chemistry | Mice | Paraoxon - analogs & derivatives | Fluorescent Dyes | Surface active agents | Proteins | Poisoning | Denaturation | Index Medicus
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