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Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2011, Volume 54, Issue 24, pp. 8251 - 8270
Journal Article
Journal Article
Lipids in Health and Disease, ISSN 1476-511X, 11/2015, Volume 14, Issue 1, p. 141
Background: Cholinesterase inhibition is a vital target for the development of novel and mechanism based inhibitors, owing to their role in the breakdown of... 
GC-MS | Essential oils | Polygonum hydropiper | Anticholinesterase and antioxidant | BIOCHEMISTRY & MOLECULAR BIOLOGY | BERBERINE | SUBSEQUENT FRACTIONS | NUTRITION & DIETETICS | CRUDE SAPONINS | ANTIOXIDANT POTENTIALS | CLINICAL-TRIALS | DISEASE | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | ACETYLCHOLINESTERASE INHIBITORS | METHANOLIC EXTRACT | Plant Extracts - chemistry | Gas Chromatography-Mass Spectrometry | Oils, Volatile - chemistry | Free Radical Scavengers - chemistry | Cholinesterase Inhibitors - chemistry | Flowers - chemistry | Hydrogen Peroxide - chemistry | Sulfonic Acids - chemistry | Butyrylcholinesterase - chemistry | Biphenyl Compounds - antagonists & inhibitors | Picrates - chemistry | Benzothiazoles - antagonists & inhibitors | Cholinesterase Inhibitors - isolation & purification | Biphenyl Compounds - chemistry | Plant Leaves - chemistry | Electrophorus | Enzyme Assays | Acetylcholinesterase - chemistry | Oils, Volatile - isolation & purification | Free Radical Scavengers - isolation & purification | Polygonum - chemistry | Sulfonic Acids - antagonists & inhibitors | Picrates - antagonists & inhibitors | Animals | Acetylcholinesterase - isolation & purification | Benzothiazoles - chemistry | Butyrylcholinesterase - isolation & purification | Horses | Antioxidants | Care and treatment | Hydrogen peroxide | Development and progression | Research | Health aspects | Alzheimer's disease
Journal Article
Journal of Biochemical and Molecular Toxicology, ISSN 1095-6670, 09/2018, Volume 32, Issue 9, pp. e22197 - n/a
[Ni(C 11 H 9 N 2 O 5 ) 2 (H 2 O) 2 ]•3(C 3 H 7 NO) ( 1 ) and [Co(C 11 H 9 N 2 O 5 ) 2 (H 2 O) 2 ]•3(C 3 H 7 NO) ( 2 ) are synthesized and characterized by... 
synthesis | crystal structure | magnetic properties | enzyme inhibition | N‐salicyloil‐N’‐maleoil‐hydrazine | N-salicyloil-N’-maleoil-hydrazine | BIOACTIVITY | BUTYRYLCHOLINESTERASE | N-salicyloil-N'-maleoil-hydrazine | PROFILES | CARBONIC-ANHYDRASE ISOENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | II INHIBITION | ACETYLCHOLINESTERASE | ALPHA-GLUCOSIDASE INHIBITORS | TOXICOLOGY | DERIVATIVES | BROMOPHENOLS | MANNICH-BASES | Cholinergic Antagonists - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrase II - metabolism | Crystallography, X-Ray | Cholinesterase Inhibitors - chemical synthesis | Carbonic Anhydrase I - metabolism | Enzyme Inhibitors - chemical synthesis | Spectroscopy, Fourier Transform Infrared | Carbonic Anhydrase II - antagonists & inhibitors | Cholinergic Antagonists - pharmacology | Hydrazines - chemistry | Hydrazines - chemical synthesis | Butyrylcholinesterase - chemistry | Cobalt - pharmacology | Proton Magnetic Resonance Spectroscopy | Butyrylcholinesterase - metabolism | Magnetic Phenomena | Enzyme Inhibitors - chemistry | Carbon-13 Magnetic Resonance Spectroscopy | Coordination Complexes - pharmacology | Molecular Structure | Nickel - pharmacology | Glycoside Hydrolases - antagonists & inhibitors | Hydrazines - pharmacology | Nickel - chemistry | Enzyme Inhibitors - pharmacology | Hypoglycemic Agents - chemistry | Acetylcholinesterase - chemistry | Carbonic Anhydrase I - chemistry | Coordination Complexes - chemistry | Hypoglycemic Agents - pharmacology | Animals | Cholinesterase Inhibitors - pharmacology | Carbonic Anhydrase I - antagonists & inhibitors | Cholinergic Antagonists - chemistry | Hypoglycemic Agents - chemical synthesis | Glycoside Hydrolases - metabolism | Acetylcholinesterase - metabolism | Cobalt - chemistry | Infrared spectroscopy | Hydrazines | Water chemistry | Oxygen | Diabetes mellitus | Nitrogen atoms | Acetylcholinesterase | Magnetic susceptibility | Oxygen atoms | Carbonic anhydrase | Magnetic permeability | Isoforms | Acetylcholine receptors | Nickel | Thermal analysis | Hydrazine | Crystal structure | Metal ions
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 10/2015, Volume 23, Issue 19, pp. 6389 - 6403
A series of novel Diallyl disulfide (DADS) derivatives were designed, synthesized and evaluated as chemical agents, which target and modulate multiple facets... 
Diallyl disulfide derivatives Alzheimer's disease Aβ aggregation AChE inhibitors Antioxidant Metal chelator Molecular docking | A beta aggregation | ACETYLCHOLINESTERASE ACTIVITY | TORPEDO-CALIFORNICA | CHEMISTRY, MEDICINAL | Diallyl disulfide derivatives | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CHOLINESTERASE-INHIBITORS | DIRECTED LIGANDS | Antioxidant | Molecular docking | NEURODEGENERATIVE DISEASES | SCAVENGER RECEPTOR | AGED GARLIC EXTRACT | AChE inhibitors | Metal chelator | Alzheimer's disease | PHARMACOLOGICAL EVALUATION | AGGREGATION | Disulfides - metabolism | Antioxidants - chemistry | Anhydrides - therapeutic use | Antioxidants - metabolism | Humans | Allyl Compounds - chemistry | Cholinesterase Inhibitors - chemistry | Structure-Activity Relationship | Anhydrides - chemistry | Disulfides - therapeutic use | Butyrylcholinesterase - chemistry | Copper - chemistry | Anhydrides - metabolism | Cholinesterase Inhibitors - metabolism | Butyrylcholinesterase - metabolism | Disulfides - chemistry | Amyloid beta-Peptides - metabolism | Binding Sites | Chelating Agents - therapeutic use | Catalytic Domain | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Acetylcholinesterase - chemistry | Allyl Compounds - therapeutic use | Allyl Compounds - metabolism | Molecular Docking Simulation | Amyloid beta-Peptides - chemistry | Chelating Agents - metabolism | Cholinesterase Inhibitors - therapeutic use | Acetylcholinesterase - metabolism | Index Medicus
Journal Article
ChemBioChem, ISSN 1439-4227, 08/2017, Volume 18, Issue 16, pp. 1583 - 1588
We measured the affinity of five molecular container compounds (calabadions 1 and 2 , CB[7], sulfocalix[4]arene, and HP‐β‐CD) toward seven drugs of abuse in... 
drugs of abuse | reversal agent | methamphetamine | molecular container | calabadion | BUTYRYLCHOLINESTERASE | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | OVERDOSE | VACCINE | COCAINE | HOST | SOLUBILIZING EXCIPIENTS | NEUROMUSCULAR-BLOCKING-AGENTS | AFFINITY | SYSTEMS | 2-Hydroxypropyl-beta-cyclodextrin - pharmacology | Sequestering Agents - pharmacology | Methamphetamine - toxicity | Imidazoles - chemistry | Crystallography, X-Ray | Male | Methamphetamine - chemistry | Heterocyclic Compounds, 4 or More Rings - pharmacology | Sulfonic Acids - chemistry | Calixarenes - chemistry | Bridged-Ring Compounds - chemistry | Fentanyl - chemistry | Bridged-Ring Compounds - pharmacology | Sequestering Agents - chemistry | Locomotion - drug effects | Phenols - pharmacology | Calixarenes - pharmacology | Heterocyclic Compounds, 4 or More Rings - chemistry | Imidazoles - pharmacology | Sulfonic Acids - pharmacology | Rats, Sprague-Dawley | Animals | 2-Hydroxypropyl-beta-cyclodextrin - chemistry | Phenols - chemistry | Street Drugs - toxicity | Street Drugs - chemistry | Illegal drugs | Containers | Drug abuse | Structure | Crystals | Methamphetamine | Drugs | Rats | Titration calorimetry | In vitro testing | Bioavailability | Heat measurement | pH effects | Optimization | Calorimetry | Titration | Intoxication | Crystal structure | cucurbituril
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3126 - 3134
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 7, p. 1509
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, distinctively characterized by senile plaques, neurofibrillary tangles, and synaptic... 
BACE1 | Citrus flavanones | In silico docking | Alzheimer’s disease | Hesperidin | Cholinesterases | OXIDATIVE STRESS | citrus flavanones | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HESPERETIN | CHEMISTRY, MULTIDISCIPLINARY | hesperidin | IMPAIRMENT | in silico docking | LIQUID-CHROMATOGRAPHY | cholinesterases | ANTIOXIDANT | NARINGENIN | Alzheimer's disease | BRAIN | RAT PLASMA | Flavanones - isolation & purification | Humans | Cholinesterase Inhibitors - chemistry | Citrus - chemistry | Hesperidin - isolation & purification | Thermodynamics | Butyrylcholinesterase - chemistry | Flavanones - chemistry | Cholinesterase Inhibitors - isolation & purification | Protein Interaction Domains and Motifs | GPI-Linked Proteins - antagonists & inhibitors | Binding Sites | Aspartic Acid Endopeptidases - chemistry | Protein Conformation, alpha-Helical | Neuroprotective Agents - chemistry | Aspartic Acid Endopeptidases - antagonists & inhibitors | Nootropic Agents - isolation & purification | Enzyme Assays | Acetylcholinesterase - chemistry | Nootropic Agents - chemistry | Amyloid Precursor Protein Secretases - chemistry | GPI-Linked Proteins - chemistry | Neuroprotective Agents - isolation & purification | Protein Conformation, beta-Strand | Hesperidin - chemistry | Protein Binding | Molecular Docking Simulation | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Kinetics | Enzymes | b-Site APP cleaving enzyme 1 | Hesperetin | Target recognition | Naringenin | Therapeutic applications | Acetylcholinesterase | Amyloid precursor protein | Molecular docking | Proteins | Neurofibrillary tangles | Inhibitors | Senile plaques | Enzyme kinetics
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2012, Volume 55, Issue 3, pp. 1303 - 1317
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 250 - 262
Multi-target drug discovery is one of the most followed approaches in the active central nervous system (CNS) therapeutic area, especially in the search for... 
Neuroinflammation | Amyloid | Acetylcholinesterase | Alzheimer's disease | Multitarget compounds | DESIGN | CHEMISTRY, MEDICINAL | MULTITARGET DRUG DISCOVERY | NATURAL-PRODUCTS | NEURODEGENERATIVE DISEASES | POLYPHARMACOLOGY | BIOLOGICAL EVALUATION | AGENTS | ACETYLCHOLINESTERASE INHIBITORS | DERIVATIVES | AGGREGATION | Neuroprotective Agents - therapeutic use | Antioxidants - chemistry | Antioxidants - metabolism | Humans | Cholinesterase Inhibitors - chemistry | Stilbenes - chemistry | Molecular Targeted Therapy | Tacrine - therapeutic use | Tacrine - pharmacology | Neuroprotective Agents - pharmacology | Cholinesterase Inhibitors - metabolism | Liver - drug effects | Butyrylcholinesterase - metabolism | Drug Design | Tacrine - chemistry | Protein Aggregates - drug effects | Tacrine - metabolism | Neuroprotective Agents - chemistry | Alzheimer Disease - drug therapy | Rats | Antioxidants - pharmacology | Blood-Brain Barrier - metabolism | Antioxidants - therapeutic use | Peptide Fragments - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Alzheimer Disease - metabolism | Ligands | Amyloid beta-Peptides - chemistry | Cholinesterase Inhibitors - therapeutic use | Acetylcholinesterase - metabolism | Antioxidants | Analysis | Pharmacy | Resveratrol | Drugstores | Drug discovery | Permeability | Health aspects | Target marketing | Index Medicus
Journal Article