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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2013, Volume 110, Issue 10, pp. 3806 - 3811
Prostaglandin E-2 (PGE(2)) is a key mediator in inflammatory response. The main source of inducible PGE(2), microsomal PGE(2) synthase-1 (mPGES-1), has emerged... 
SITE | PROTEIN | MULTIDISCIPLINARY SCIENCES | LEUKOTRIENE C-4 SYNTHASE | INHIBITOR BINDING | X-ray crystallography | PROJECTION | MODELS | GLUTATHIONE | membrane protein | ARGININE | enzyme mechanism | TRANSFERASE
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2015, Volume 290, Issue 8, pp. 5015 - 5027
Leukotriene-C-4 synthase (LTC4S) generates LTC4 from arachidonic acid metabolism. LTC4 is a proinflammatory factor that acts on plasma membrane cysteinyl... 
SMOOTH-MUSCLE | CRAC CURRENTS | OPERATED CALCIUM-ENTRY | STIM1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE-CELL PROLIFERATION | PROMOTER POLYMORPHISM | ORAI1 | CYSTEINYL-LEUKOTRIENES | I-CRAC | C-4 SYNTHASE
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, ISSN 1388-1981, 11/2016, Volume 1861, Issue 11, pp. 1605 - 1613
Cysteinyl leukotrienes (cys-LTs) cause bronchoconstriction in anaphylaxis and asthma. They are formed by 5-lipoxygenase (5-LOX) from arachidonic acid (AA)... 
CYSLT RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | 5-LIPOXYGENASE-ACTIVATING PROTEIN | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | Leukotriene C-4 | GLUTATHIONE METABOLISM | CELL BIOLOGY | Assay | BIOPHYSICS | HEK293 cells | BIOSYNTHESIS | PHARMACOLOGY | BIOCHEMISTRY | SUPERFAMILY | Inhibitor | LTC4 synthase | MEMBRANE-ASSOCIATED PROTEINS | IN-SITU
Journal Article
Clinical & Experimental Allergy, ISSN 0954-7894, 08/2011, Volume 41, Issue 8, pp. 1133 - 1142
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 2002, Volume 109, Issue 6, pp. 936 - 942
Background: The A to C transversion in the promoter region of the gene encoding leukotriene C-4 synthase (LTC4S) is proposed to be associated with the... 
ANTAGONIST | INTOLERANT ASTHMA | URINARY LEUKOTRIENE-E4 | EOSINOPHILS | TRANSCRIPTION | polymorphism | IMMUNOLOGY | 11-DEHYDROTHROMBOXANE B-2 | EXCRETION | GENE | ALLERGY | leukotriene C-4 synthase | aspirin-induced asthma | cysteinyl leukotrienes | 5-lipoxygenase | EXPRESSION | SENSITIVE ASTHMA
Journal Article
Current Drug Targets, ISSN 1389-4501, 07/2012, Volume 13, Issue 8, pp. 1107 - 1118
Journal Article
Clinical & Experimental Allergy, ISSN 0954-7894, 10/2007, Volume 37, Issue 10, pp. 1487 - 1493
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 02/1998, Volume 101, Issue 4, pp. 834 - 846
Aspirin causes bronchoconstriction in aspirin-intolerant asthma (AIA) patients by triggering cysteinyl-leukotriene (cys-LT) production, probably by removing... 
MEDICINE, RESEARCH & EXPERIMENTAL | HUMAN-LEUKOCYTES | MAST-CELL ACTIVATION | URINARY LEUKOTRIENE-E4 | NASAL SECRETIONS | cyclooxygenase | INHALED LYSINE-ASPIRIN | AIRWAY-OBSTRUCTION | BRONCHOALVEOLAR LAVAGE | HUMAN EOSINOPHILS | leukotriene C-4 synthase | aspirin | MOLECULAR-CLONING | 5-lipoxygenase | SENSITIVE ASTHMATICS
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2009, Volume 603, Issue 1, pp. 98 - 107
Asiatic acid is a triterpenoid component possessing antioxidative, anti-inflammatory and hepatoprotective activity. In this issue, we explored the protective... 
Redox | Asiatic acid | D-galactosamine/lipopolysaccharide | Leukotriene C 4 synthase | Hepatotoxicity | ACUTE LIVER-FAILURE | OXIDATIVE STRESS | ANTIINFLAMMATORY ACTIVITY | RAT HEPATOCYTES | Leukotriene C-4 synthase | KAPPA-B | SYNTHESIS ENZYMES | IN-VIVO | TRITERPENE ACIDS | PHARMACOLOGY & PHARMACY | FULMINANT HEPATIC-FAILURE | CYSTEINYL-LEUKOTRIENES
Journal Article
FEBS Letters, ISSN 0014-5793, 04/2000, Volume 471, Issue 1, pp. 78 - 82
Journal Article
Journal Article