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Toxicological Sciences, ISSN 1096-6080, 2018, Volume 165, Issue 1, pp. 232 - 243
Journal Article
Cell, ISSN 0092-8674, 02/2010, Volume 140, Issue 4, pp. 517 - 528
Despite its toxicity, H O is produced as a signaling molecule that oxidizes critical cysteine residues of effectors such as protein tyrosine phosphatases in... 
PROTEINS | SIGNALING | NADPH OXIDASE | REACTIVE OXYGEN | TYROSINE PHOSPHORYLATION | C-ABL | REDOX REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH-FACTORS | LIPID RAFTS | CYSTEINE-SULFINIC ACID | HYDROGEN-PEROXIDE | MAMMALIAN PEROXIREDOXIN | CELL BIOLOGY
Journal Article
JOURNAL OF PHYSICAL CHEMISTRY B, ISSN 1520-6106, 07/2019, Volume 123, Issue 26, pp. 5385 - 5394
The aberrant expression of kinases is often associated with pathologies such as cancer and autoimmune diseases. Like other types of enzymes, kinases can adopt... 
MOLECULAR-DYNAMICS | C-ABL | MECHANISM | SRC | TYROSINE KINASE | MUTATION | CHEMISTRY, PHYSICAL | MYELOID-LEUKEMIA | RECEPTOR | INHIBITOR | EXPRESSION
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 11/2016, Volume 76, Issue 22, pp. 6577 - 6587
Existing anticancer strategies focused on disrupting integrin functions in tumor cells or tumor-involved endothelial cells have met limited success. An... 
MIGRATION | INVASION | ACTIVATION | C-ABL | ONCOLOGY | STABILITY | GROWTH | PHENOTYPE | YAP | CELL | CARCINOMA
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 18, pp. 8120 - 8135
Chronic myelogenous leukemia (CML) arises from the constitutive activity of the BCR-ABL1 oncoprotein. Tyrosine kinase inhibitors (TKIs) that target the... 
CHEMISTRY, MEDICINAL | MANAGEMENT | C-ABL | BCR-ABL | DRUG DISCOVERY | IMATINIB | RESISTANCE | BINDING-SITE | PATCH-CLAMP | CHRONIC MYELOID-LEUKEMIA
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 02/2019, Volume 139, Issue 2, pp. 439 - 447
Tyrosine kinase inhibitors have emerged as a therapeutic option for rheumatic diseases such as systemic sclerosis (SSc). Because tyrosine kinases like c-Abl... 
FIBROSIS | C-ABL | TRANSPORTERS | SENSITIVITY | TYROSINE KINASES | MECHANISMS | GROWTH-FACTOR | SKIN | EXPRESSION | CELLULAR UPTAKE | DERMATOLOGY
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2014, Volume 92, Issue 2, pp. 235 - 250
Imatinib mesylate is a tyrosine kinase inhibitor with selectivity for abelson tyrosine-protein kinase 1 (c-Abl), breakpoint cluster region (Bcr)-Abl fusion... 
p27 KIP1 | pRb | Imatinib | CDK2 | c-Abl | Neuroblastoma
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 09/2018, Volume 29, Issue 18, pp. 2228 - 2242
Ionizing radiation (IR) not only activates DNA damage response (DDR) in irradiated cells but also induces bystander effects (BE) in cells not directly targeted... 
RESPONSES | ACTIVATION | C-ABL | TYROSINE KINASE | DNA-DAMAGE | SECRETION | IONIZING-RADIATION | EXPRESSION | CELL BIOLOGY | Index Medicus
Journal Article
HUMAN MOLECULAR GENETICS, ISSN 0964-6906, 08/2013, Volume 22, Issue 16, pp. 3315 - 3328
Parkinsons disease is a movement disorder characterized by death of dopaminergic substantia nigra (SN) neurons and brain accumulation of -synuclein. The... 
CHRONIC MYELOGENOUS LEUKEMIA | MULTIPLE SYSTEM ATROPHY | TAU PHOSPHORYLATION | C-ABL | ABL TYROSINE KINASE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | NITRATED ALPHA-SYNUCLEIN | GENE-TRANSFER MODEL | LEWY BODIES | NEURODEGENERATIVE DISEASES
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2016, Volume 55, Issue 2, pp. 807 - 810
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 11/2004, Volume 114, Issue 9, pp. 1308 - 1316
Idiopathic pulmonary fibrosis is a progressive and fatal fibrotic disease of the lungs with unclear etiology. Prior efforts to treat idiopathic pulmonary... 
PATHOGENESIS | MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR-BETA | THERAPY | C-ABL | TYROSINE KINASE | FAMILY KINASES | MICE | GENE-TRANSFER | IDIOPATHIC PULMONARY-FIBROSIS | EXPRESSION
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2010, Volume 11, Issue 11, pp. 1029 - 1035
Journal Article
BLOOD, ISSN 0006-4971, 11/2017, Volume 130, Issue 21, pp. 2326 - 2338
A number of studies have recently demonstrated that super-enhancers, which are large cluster of enhancers typically marked by a high level of acetylation of... 
APOPTOTIC RESPONSE | HTLV-I | SUPER-ENHANCERS | MULTICENTER PHASE-II | KINASE C-ABL | DNA-DAMAGE | LYMPHOMA | 1ST HUMAN RETROVIRUS | LEUKEMIA/LYMPHOMA | KAPPA-B | HEMATOLOGY
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2014, Volume 16, Issue 4, pp. 376 - 381
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2007, Volume 104, Issue 33, pp. 13283 - 13288
Dasatinib is a small-molecule kinase inhibitor used for the treatment of imatinib-resistant chronic myelogenous leukemia (CML). We have analyzed the kinases... 
leukemia | C-ABL | CHRONIC-PHASE | Tec kinases | MULTIDISCIPLINARY SCIENCES | X-LINKED AGAMMAGLOBULINEMIA | CRYSTAL-STRUCTURES | CHRONIC MYELOID-LEUKEMIA | kinase inhibitor | IN-VITRO | STRUCTURAL BASIS | IMATINIB | SELECTIVE INHIBITORS | STI-571 INHIBITION
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2015, Volume 21, Issue 5, pp. 440 - 448
Journal Article
by Xu, HM and Liu, M and Huang, XD and Min, QH and Zhu, JJ
ANALYTICAL CHEMISTRY, ISSN 0003-2700, 08/2018, Volume 90, Issue 16, pp. 9859 - 9867
Protein kinase is regarded as a potential target for anticancer therapeutics due to its relation to many diseases, in which more than one kinase participates... 
NANOPARTICLES | CHEMISTRY, ANALYTICAL | C-ABL | MOF | BCR-ABL | GROWTH | ENRICHMENT | RESISTANCE | SRC FAMILY KINASES | IMATINIB MESYLATE | CERIUM OXIDE | Index Medicus <