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Nature Reviews Cancer, ISSN 1474-175X, 01/2012, Volume 12, Issue 1, pp. 23 - 38
Journal Article
Chemical Science, ISSN 2041-6520, 06/2015, Volume 6, Issue 9, pp. 5269 - 5283
Following recent work on heterometallic titanocene-gold complexes as potential chemotherapeutics for renal cancer, we report here on the synthesis,... 
TRANSITION-ELEMENTS | XENOGRAFTED CAKI-1 TUMORS | TRANSFORMED GROWTH | TITANOCENE ANTICANCER DRUGS | THIOREDOXIN REDUCTASE | ANTITUMOR-ACTIVITY | AB-INITIO PSEUDOPOTENTIALS | BIOLOGICAL-PROPERTIES | CHEMISTRY, MULTIDISCIPLINARY | KINASE-C-IOTA | METAL-COMPLEXES
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 12/2013, Volume 11, Issue 12, pp. 1624 - 1635
Protein kinase Ci (PKCi) has oncogenic potential and is an attractive therapeutic target for treatment of lung cancer, particularly those tumors that express... 
OVEREXPRESSION | ONCOGENE | ONCOLOGY | TRANSFORMED GROWTH | CANCER | EXPRESSION | KINASE-C-IOTA | CELL BIOLOGY
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 01/2019, Volume 30, Issue 1, pp. 65 - 71
Protein kinase C-iota (PKC-ι) is an oncogene overexpressed in many cancer cells including prostate, breast, ovarian, melanoma, and glioma. Previous in-vitro... 
Preclinical Reports | kinase inhibitor | PRKCI | prostate cancer | protein kinase C-iota
Journal Article
Chemical Science, ISSN 2041-6520, 08/2015, Volume 6, Issue 9, pp. 5269 - 5283
Following recent work on heterometallic titanocene-gold complexes as potential chemotherapeutics for renal cancer, we report here on the synthesis,... 
Proteins | Surgical implants | Biotechnology | Biocompatibility | Mathematical models | Mice | Kinases | Cancer
Journal Article
ANTI-CANCER DRUGS, ISSN 0959-4973, 01/2019, Volume 30, Issue 1, pp. 65 - 71
Protein kinase C-iota (PKC-iota) is an oncogene overexpressed in many cancer cells including prostate, breast, ovarian, melanoma, and glioma. Previous in-vitro... 
kinase inhibitor | CELLS | PRKCI | prostate cancer | ONCOLOGY | GROWTH | PHARMACOLOGY & PHARMACY | PKC-IOTA | protein kinase C-iota
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2014, Volume 25, Issue 2, pp. 139 - 151
We report that two oncogenes coamplified on chromosome 3q26, and , cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC). Protein... 
INITIATING CELLS | DETECTS FREQUENT | STEM-CELLS | PROTEIN | CANCER CELLS | EPITHELIUM | ONCOLOGY | TRANSFORMED GROWTH | PKC-IOTA | KINASE-C-IOTA | BASAL-CELLS | CELL BIOLOGY | Acyltransferases - antagonists & inhibitors | Protein Kinase C - genetics | RNA, Small Interfering - genetics | Cell Proliferation | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | SOXB1 Transcription Factors - antagonists & inhibitors | Lung Neoplasms - pathology | Acyltransferases - metabolism | Acyltransferases - genetics | Promoter Regions, Genetic - genetics | Immunoenzyme Techniques | SOXB1 Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Cell Transformation, Neoplastic - genetics | Isoenzymes - metabolism | Protein Kinase C - metabolism | Neoplastic Stem Cells - pathology | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Isoenzymes - genetics | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Protein Kinase C - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Animals | High-Throughput Nucleotide Sequencing | Mice | Cell Transformation, Neoplastic - pathology | Isoenzymes - antagonists & inhibitors | Apoptosis | Squamous cell carcinoma | Genetic aspects | Cancer
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 09/2018, Volume 430, Issue 19, pp. 3585 - 3612
Journal Article
CELLULAR SIGNALLING, ISSN 0898-6568, 10/2017, Volume 38, pp. 223 - 229
Platelet activation at sites of vascular injury is crucial for hemostasis, but it may also cause myocardial infarction or ischemic stroke. Upon platelet... 
GLYCOPROTEIN-VI | ACTIVATION | COLLAGEN | RECEPTOR | MECHANISMS | ZETA-PKC | C-IOTA | CELL BIOLOGY | ADHESION | Platelet | Rho GTPases | PKC1/lambda | Spreading | IN-VIVO | Cdc42
Journal Article
ANTICANCER RESEARCH, ISSN 0250-7005, 10/2019, Volume 39, Issue 10, pp. 5715 - 5720
Background/Aim: The PRKCI gene encodes Protein kinase C iota. The overexpression of protein kinase C iota is associated with poor outcomes in patients with... 
CELLS | PRKCI | ACTIVATION | ONCOGENE | ONCOLOGY | PROGNOSIS | GROWTH | PKC-IOTA | Gastric cancer | KINASE-C-IOTA | protein kinase C iota | Proteins | Protein kinase C | Mucosa | Gastrectomy | Gene expression | Kinases | Tissues | Stomach cancer | Cancer
Journal Article
BIOCHEMICAL PHARMACOLOGY, ISSN 0006-2952, 03/2014, Volume 88, Issue 1, pp. 1 - 11
Journal Article
by Lim, TG and Kim, YA and Kim, JE and Baek, S and Lee, SY and Lee, CC and Chen, H and Kim, JR and Kwon, JY and Bode, AM and Lee, CY and Dong, Z and Oh, DK and Park, JS and Lee, KW
EXPERIMENTAL DERMATOLOGY, ISSN 0906-6705, 05/2018, Volume 27, Issue 5, pp. 449 - 452
The soy isoflavone daidzein is bioconverted to 7,8,4-trihydroxyisoflavone (7,8,4-THIF) by microorganisms. Here, we investigated the matrix metalloproteinase... 
Protein kinase C iota | GROWTH-FACTOR RECEPTOR | ISOFLAVONES | CELLS | PROTEIN-KINASE-C | ACTIVATION |