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Journal of Biological Chemistry, ISSN 0021-9258, 04/2009, Volume 284, Issue 16, pp. 10774 - 10782
The innate immune system provides an initial defense system against microbial infections and contributes to the development of adaptive immune response. Type I... 
DOUBLE-STRANDED-RNA | SIGNALING PATHWAYS | IMMUNE-RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | GENE-EXPRESSION | INNATE | TNF-ALPHA | HELICASE ANTIVIRAL PATHWAY | NF-KAPPA-B | ADAPTER PROTEIN | Fibroblasts - physiology | TNF Receptor-Associated Factor 2 - genetics | Immunity, Innate - physiology | p38 Mitogen-Activated Protein Kinases - metabolism | Interferons - genetics | DEAD-box RNA Helicases - metabolism | Virus Activation | Dendritic Cells - metabolism | Sendai virus - physiology | DEAD Box Protein 58 | MAP Kinase Kinase Kinases - genetics | Mice, Inbred C57BL | Cells, Cultured | TNF Receptor-Associated Factor 2 - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Mice, Knockout | DEAD-box RNA Helicases - genetics | Animals | Adaptor Proteins, Signal Transducing - genetics | Interferons - metabolism | Mitogen-Activated Protein Kinases - genetics | Signal Transduction - physiology | Dendritic Cells - cytology | Fibroblasts - cytology | Mice | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | Mitogen-Activated Protein Kinases - metabolism | Pathogens | RNA viruses | Phosphorylation | Dendritic cells | TAK1 protein | MKK3 protein | Interleukin 12 | MAP kinase | a-Interferon | Infection | TRAF2 protein | Cell activation | Enzymatic activity | c-Jun amino-terminal kinase | Protein kinase | Fibroblasts | Replication | Interferon
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2014, Volume 461, Issue 3, pp. 531 - 537
IKK beta {I kappa B [inhibitor of NF-kappa B (nuclear factor kappa B)] kinase beta} is required to activate the transcription factor NF-kappa B, but how IKK... 
Inhibitor of nuclear factor κB kinase (IKK) | Linear ubiquitin chain assembly complex (LUBAC) | Nuclear factor κB(NF-κB) | Transforming growth factor β-activated kinase-1 (TAK1) | Interleukin-1 (IL-1) | nuclear factor kappa B (NF-kappa B) | linear ubiquitin chain assembly complex (LUBAC) | SIGNALING PATHWAYS | PROTEIN | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | interleukin-1 (IL-1) | KINASE COMPLEX | transforming growth factor beta-activated kinase-1 (TAK1) | UBIQUITIN CHAINS | INFLAMMATION | inhibitor of nuclear factor kappa B kinase (IKK) | POLYUBIQUITIN CHAINS | NF-KAPPA-B | NEMO | BINDING | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | I-kappa B Kinase - antagonists & inhibitors | HEK293 Cells | Protein Interaction Domains and Motifs | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Mutant Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cells, Cultured | Mutant Proteins - genetics | Recombinant Proteins - chemistry | Mice, Transgenic | Mutant Proteins - metabolism | MAP Kinase Kinase Kinases - metabolism | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Serine - metabolism | Gene Knock-In Techniques | Animals | Embryo, Mammalian - cytology | Mutant Proteins - chemistry | Mice | Protein Kinase Inhibitors - pharmacology | I-kappa B Kinase - chemistry | Amino Acid Substitution | NEMO, NF-κB essential modulator | TLR, Toll-like receptor | IKK, IκB kinase | TNF, tumour necrosis factor | transforming growth factor β-activated kinase-1 (TAK1) | HEK, human embryonic kidney | IL-1, interleukin-1 | JNK, c-Jun N-terminal kinase | PP1γ, protein phosphatase 1γ | TRAF, TNF receptor-associated factor | inhibitor of nuclear factor κB kinase (IKK) | LUBAC, linear ubiquitin chain assembly complex | HOIP, HOIL1 [haem-oxidized IRP2 (iron regulatory protein 2) ubiquitin ligase 1]-interacting protein | IκB, inhibitor of NF-κB | TAB, TAK1-binding protein | TAK1, transforming growth factor β-activated kinase-1 | BMDM, bone-marrow-derived macrophage | NF-κB, nuclear factor κB | M-CSF, macrophage colony-stimulating factor | MKK, MAPK kinase | Accelerated Publication | E, embryonic day | MEF, mouse embryonic fibroblast | HA, haemaglutinnin | LPS, lipopolysaccharide | nuclear factor κB (NF-κB) | MAPK, mitogen-activated protein kinase
Journal Article
Blood, ISSN 0006-4971, 2016, Volume 127, Issue 14, pp. 1780 - 1789
Journal Article
by Chan, QKY and Lam, HM and Ng, CF and Lee, AYY and Chan, ESY and Ng, HK and Ho, SM and Lau, KM
Cell Death and Differentiation, ISSN 1350-9047, 09/2010, Volume 17, Issue 9, pp. 1511 - 1523
G-protein-coupled receptor-30 (GPR30) shows estrogen-binding affinity and mediates non-genomic signaling of estrogen to regulate cell growth. We here showed... 
COUPLED RECEPTOR GPR30 | ER-BETA | signal transduction | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | G-protein-coupled receptor-30 | G2/M | PROLIFERATION | G-PROTEIN | non-genomic estrogen signaling | ESTROGEN-RECEPTOR | 17-BETA-ESTRADIOL | CELL BIOLOGY | NUCLEAR ACCUMULATION | Y TRANSCRIPTION FACTOR | EXPRESSION | 1-[4-(6-bromobenzo[1,3]dioxol-5yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone | Prostatic Neoplasms - metabolism | RNA, Small Interfering - genetics | Gene Expression - drug effects | Gene Expression - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptors, G-Protein-Coupled - agonists | G2 Phase - drug effects | Quinolines - pharmacology | Cell Nucleus - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Phosphorylation - drug effects | Prostatic Neoplasms - drug therapy | Proto-Oncogene Proteins - metabolism | Prostatic Neoplasms - pathology | Proto-Oncogene Proteins c-jun - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Proto-Oncogene Proteins c-fos - metabolism | Receptors, Estrogen - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Cyclopentanes - pharmacology | Xenograft Model Antitumor Assays | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Mice, Nude | Proto-Oncogene Proteins c-jun - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-fos - genetics | Signal Transduction - physiology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Receptors, G-Protein-Coupled - genetics | Cell Cycle - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 05/1999, Volume 20, Issue 5, pp. 942 - 952
The transcription factor nuclear factor (NF)-kappa B is activated by oxidative stress or cytokines and is critical to the activation of inflammatory genes.... 
TNF RECEPTOR | PULMONARY FIBROSIS | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-BINDING ACTIVITY | FREE-RADICALS | CELL BIOLOGY | EPITHELIAL-CELLS | RESPIRATORY SYSTEM | DIFFERENTIAL ACTIVATION | GENE-EXPRESSION | NITRIC-OXIDE | C-JUN
Journal Article
JOURNAL OF VIROLOGY, ISSN 0022-538X, 05/2018, Volume 92, Issue 9
Maraviroc is a CCR5 antagonist used in the treatment of HIV-1 infection. We and others have suggested that maraviroc could reactivate latent HIV-1. To test the... 
HIV-1 | maraviroc | HISTONE DEACETYLASE INHIBITOR | HIV infected | PROTEIN | latency | TRANSCRIPTION | INTENSIFICATION | AP-1 | VORINOSTAT | NF-kappa B | VIROLOGY | VIRUS-REPLICATION | IN-VIVO | GENE-EXPRESSION | persistence | LRA | reservoir | C-JUN
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