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06/2011
The Liver X Receptor (LXR) and Pregnane X Receptor (PXR) are members of the nuclear receptor superfamily. Previously, they have been classified as important... 
transcription factor | homeostasis | c-Jun | inflammation | Akt | MKK7
Web Resource
Oncotarget, 2017, Volume 8, Issue 61, pp. 104206 - 104215
Journal Article
Neuroscience, ISSN 0306-4522, 02/2019, Volume 399, pp. 117 - 124
Parkinson’s disease (PD) is a common neurodegenerative disease that is characterized by the progressive loss of dopaminergic neurons in the substantia nigra... 
c-Jun | MPTP | Parkinson’s disease | dopaminergic neurons | Bim
Journal Article
Genes and Cancer, ISSN 1947-6019, 09/2013, Volume 4, Issue 9-10, pp. 397 - 400
c-Jun NH2-terminal kinase (JNK) was discovered almost 20 years ago as the protein kinase responsible for phosphorylating c-Jun at Ser-63 and Ser-73. These... 
c-Jun | cancer | MAPK | MKK | Ras | JNK | Monographs
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 2/2018, Volume 67, Issue 2, pp. 560 - 574
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. It may result in several types of liver problems including impaired... 
c-Jun | Steatohepatitis | Hepatic steatosis | Calcium release channel | Liver regeneration
Journal Article
Current Biology, ISSN 0960-9822, 06/2019, Volume 29, Issue 12, pp. 1954 - 1962.e4
In plants, cryptochromes are photoreceptors that negatively regulate the ubiquitin ligase CRL4 . In mammals, cryptochromes are core components of the circadian... 
c-Jun | glucocorticoid receptor | CRL4 | transrepression | cryptochromes | glucagon | Cul4 | circadian clock | Cop1 | Det1
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2019, Volume 381, p. 114732
Endothelium inflammation has become a major risk factor for pathological development of atherosclerosis. IMM-H007 (H007), a small molecule compound, is... 
Endothelium Inflammation | NF-κB Signaling | H007 | JNK/c-Jun Signaling
Journal Article
FEBS Letters, ISSN 0014-5793, 05/2019, Volume 593, Issue 10, pp. 1040 - 1049
Transcriptional regulation involves a series of sophisticated protein–protein and protein– DNA interactions ( PPI and PDI ). Some transcriptional complexes,... 
c‐Fos/c‐Jun | transcription factor | cDNA | evolution | proximity ligation | display
Journal Article
Life Sciences, ISSN 0024-3205, 10/2019, Volume 235, p. 116831
TRAF6 is an intracellular signal adapter molecule plays a significant role in tumor development. However, the specific mechanism causes and promotes of... 
Nuclear shuttle | TRAF6 | Colorectal cancer | NF-kB/c-jun signaling
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 09/2019, Volume 9
Mechanical compression is a common abnormality of brain tumors that has been shown to be responsible for the severe neurological defects of brain cancer... 
c-Jun | GBM | phosphoproteomic screen | metastasis | midline shift | small GTPases
Journal Article
Medicinal Research Reviews, ISSN 0198-6325, 2019
c-Jun N-terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell... 
c-Jun N-terminal kinase | chemoresistance | cancer | tumor development | cell survival | JNK
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 12, p. e0209544
[This corrects the article DOI: 10.1371/journal.pone.0079573.]. 
Transcription factors | Androgens | Castration | c-Jun protein | Taxane | Prostate cancer | Prostate | Cancer
Journal Article
11/2010
Chronic hyperglycemia, a hallmark of type 2 diabetes, can decrease β-cell function and mass (β-cell glucotoxicity); however, the mechanisms are incompletely... 
Oxidative Stress | Type 2 Diabetes | Endoplasmic Reticulum Stress | 0719 | Glucotoxicity | c-jun N-terminal kinase
Dissertation
Oncotarget, 2016, Volume 7, Issue 37, pp. 59932 - 59944
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 03/2019, Volume 120, Issue 3, pp. 3384 - 3392
Psoriasis, a chronic immune-mediated inflammatory skin disease, is characterized by dysregulated keratinocyte proliferation. The EF-hand calcium binding... 
CRISPR | c-jun activation domain-binding protein-1 (Jab1) | psoriasin | p27 | keratinocyte | psoriasis | CSN5 | S100A7
Journal Article
Journal Article
Anesthesiology, ISSN 0003-3022, 12/2011, Volume 115, Issue 6, pp. 1363 - 1381
Journal Article
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