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1. The FOS and JUN families of transcription factors
by Angel, Peter A and Herrlich, Peter
1994, ISBN 0849345731, 310
Jun oncogenes | Fos oncogenes | Transcription factors
Book
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2. Rapamycin pre-treatment abrogates Tumour Necrosis Factor-α down-regulatory effects on LXR-α and PXR mRNA expression via inhibition of c-Jun N-terminal kinase 1 activation in HepG2 cells
by Ng, Di-Lin and Tie, Shin-Wei and Ong, Pei-Chin and Lim, Wyi-Sian and Tengku-Muhammad, Tengku-Sifzizul and Choo, Quok-Cheong and Chew, Choy-Hoong
06/2011
The Liver X Receptor (LXR) and Pregnane X Receptor (PXR) are members of the nuclear receptor superfamily. Previously, they have been classified as important... 
transcription factor | homeostasis | c-Jun | inflammation | Akt | MKK7
Web Resource
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3. Full Text Overexpression of miR-216b sensitizes NSCLC cells to cisplatininduced apoptosis by targeting c-Jun
by Huang, Gang and Pan, Jiongwei and Ye, Zaiting and Fang, Bingmu and Cheng, Wei and Cao, Zhuo
Oncotarget, 2017, Volume 8, Issue 61, pp. 104206 - 104215
NSCLC | C-Jun | MiR-216b | Cisplatin | Apoptosis
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4. Full Text c-Jun/Bim Upregulation in Dopaminergic Neurons Promotes Neurodegeneration in the MPTP Mouse Model of Parkinson’s Disease
by Hu, Kunhua and Huang, Qiaoying and Liu, Chong and Liu, Yueyue and Li, Mingtao and Li, Yongyi and Wang, Hao and Ma, Shanshan
Neuroscience, ISSN 0306-4522, 02/2019, Volume 399, pp. 117 - 124
Parkinson’s disease (PD) is a common neurodegenerative disease that is characterized by the progressive loss of dopaminergic neurons in the substantia nigra... 
c-Jun | MPTP | Parkinson’s disease | dopaminergic neurons | Bim
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5. Full Text The 2 Faces of JNK Signaling in Cancer
by Tournier, Cathy
Genes and Cancer, ISSN 1947-6019, 09/2013, Volume 4, Issue 9-10, pp. 397 - 400
c-Jun NH2-terminal kinase (JNK) was discovered almost 20 years ago as the protein kinase responsible for phosphorylating c-Jun at Ser-63 and Ser-73. These... 
c-Jun | cancer | MAPK | MKK | Ras | JNK | Monographs
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6. Full Text Non-alcoholic fatty liver disease impairs expression of the type II inositol 1,4,5-trisphosphate receptor
by Khamphaya, Tanaporn and Chukijrungroat, Natsasi and Saengsirisuwan, Vitoon and Mitchell-Richards, Kisha A and Robert, Marie E and Mennone, Albert and Nathanson, Michael H and Weerachayaphorn, Jittima
Hepatology (Baltimore, Md.), ISSN 0270-9139, 2/2018, Volume 67, Issue 2, pp. 560 - 574
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. It may result in several types of liver problems including impaired... 
c-Jun | Steatohepatitis | Hepatic steatosis | Calcium release channel | Liver regeneration
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7. Full Text ATF3 and stress responses
by Hai, Tsonwin and Wolfgang, Curt D and Marsee, Derek K and Allen, Amy E and Sivaprasad, Umasundari
Gene Expression, ISSN 1052-2166, 1999, Volume 7, Issue 4-6, pp. 321 - 335
The purpose of this review is to discuss ATF3, a member of the ATF/CREB family of transcription factors, and its roles in stress responses. In the... 
ATF/CREB | Stress responses | Transcription factors | ATF3 | DNA-BINDING | transcription factors | ACTIVATING TRANSCRIPTION FACTOR | ELEMENT-BINDING PROTEIN | EPIDERMAL GROWTH-FACTOR | stress responses | CYCLIC-AMP | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | VIRUS TYPE-I | CAMP-DEPENDENT REGULATION | GENETICS & HEREDITY | LEUCINE-ZIPPER PROTEINS | VASCULAR ENDOTHELIAL-CELLS | C-JUN | Transcription Factors - physiology | Animals | Stress, Physiological - genetics | Humans | Leucine Zippers | Stress, Physiological - metabolism | Activating Transcription Factor 3
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8. Full Text Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism
by Rizzini, Luca and Levine, Daniel C and Perelis, Mark and Bass, Joseph and Peek, Clara B and Pagano, Michele
Current Biology, ISSN 0960-9822, 06/2019, Volume 29, Issue 12, pp. 1954 - 1962.e4
In plants, cryptochromes are photoreceptors that negatively regulate the ubiquitin ligase CRL4 . In mammals, cryptochromes are core components of the circadian... 
c-Jun | glucocorticoid receptor | CRL4 | transrepression | cryptochromes | glucagon | Cul4 | circadian clock | Cop1 | Det1
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9. Full Text IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling
by Yu, Bin and Yu, Jinjin and Ming, Hong and Li, Henry You and Chu, Maoping and Zhu, Xinxing and Zhu, Haibo
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2019, Volume 381, p. 114732
Endothelium inflammation has become a major risk factor for pathological development of atherosclerosis. IMM-H007 (H007), a small molecule compound, is... 
Endothelium Inflammation | NF-κB Signaling | H007 | JNK/c-Jun Signaling
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10. Full Text Why the c‐Fos/c‐Jun complex is extremely conserved: An in vitro evolution exploration by combining cDNA display and proximity ligation
by Kang, Shou‐Kai and Chu, Xin‐Yi and Tian, Tian and Dong, Peng‐Fei and Chen, Bai‐Xue and Zhang, Hong‐Yu
FEBS Letters, ISSN 0014-5793, 05/2019, Volume 593, Issue 10, pp. 1040 - 1049
Transcriptional regulation involves a series of sophisticated protein–protein and protein– DNA interactions ( PPI and PDI ). Some transcriptional complexes,... 
c‐Fos/c‐Jun | transcription factor | cDNA | evolution | proximity ligation | display
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11. Full Text TRAF6 promotes the progression and growth of colorectal cancer through nuclear shuttle regulation NF-kB/c-jun signaling pathway
by Zhu, Guangwei and Cheng, Zhibin and Huang, Yongjian and Zheng, Wei and Yang, Shugang and Lin, Chunlin and Ye, Jianxin
Life Sciences, ISSN 0024-3205, 10/2019, Volume 235, p. 116831
TRAF6 is an intracellular signal adapter molecule plays a significant role in tumor development. However, the specific mechanism causes and promotes of... 
Nuclear shuttle | TRAF6 | Colorectal cancer | NF-kB/c-jun signaling
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12. Full Text Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression
by Kalli, Maria and Voutouri, Chrysovalantis and Minia, Angeliki and Pliaka, Vaia and Fotis, Christos and Alexopoulos, Leonidas G and Stylianopoulos, Triantafyllos
Frontiers in Oncology, ISSN 2234-943X, 09/2019, Volume 9
Mechanical compression is a common abnormality of brain tumors that has been shown to be responsible for the severe neurological defects of brain cancer... 
c-Jun | GBM | phosphoproteomic screen | metastasis | midline shift | small GTPases
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13. Full Text JNK signaling in cancer cell survival
by Wu, Qinghua and Wu, Wenda and Fu, Bishi and Shi, Lei and Wang, Xu and Kuca, Kamil
Medicinal Research Reviews, ISSN 0198-6325, 2019
c-Jun N-terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell... 
c-Jun N-terminal kinase | chemoresistance | cancer | tumor development | cell survival | JNK
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14. Full Text MPB, a novel berberine derivative, enhances lysosomal and bactericidal properties via TGF-b-activated kinase 1-dependent activation of the transcription factor EB
by Liu, Xiaojia and Zhang, Na and Liu, Yang and Liu, Lu and Zeng, Qingxuan and Yin, Mingxiao and Wang, Yanxiang and Song, Danqing and Deng, Hongbin
FASEB Journal, ISSN 0892-6638, 01/2019, Volume 33, Issue 1, pp. 1468 - 1481
C-Jun N-terminal protein kinase | Lysosome | Bacterial eradication | AMP-activated protein kinase
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15. Full Text Correction: Interaction between c-jun and Androgen Receptor Determines the Outcome of Taxane Therapy in Castration Resistant Prostate Cancer
by Tinzl, Martina and Chen, Binshen and Chen, Shao-Yong and Semenas, Julius and Abrahamsson, Per-Anders and Dizeyi, Nishtman
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 12, p. e0209544
[This corrects the article DOI: 10.1371/journal.pone.0079573.]. 
Transcription factors | Androgens | Castration | c-Jun protein | Taxane | Prostate cancer | Prostate | Cancer
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16. Mechanisms of High Glucose-induced Decrease in β-cell Function
by Tang, Christine
11/2010
Chronic hyperglycemia, a hallmark of type 2 diabetes, can decrease β-cell function and mass (β-cell glucotoxicity); however, the mechanisms are incompletely... 
Oxidative Stress | Type 2 Diabetes | Endoplasmic Reticulum Stress | 0719 | Glucotoxicity | c-jun N-terminal kinase
Dissertation
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17. Full Text MicroRNA 10b promotes abnormal expression of the protooncogene c-Jun in metastatic breast cancer cells
by Knirsh, Revital and Ben-Dror, Iris and Modai, Shira and Shomron, Noam and Vardimon, Lily
Oncotarget, 2016, Volume 7, Issue 37, pp. 59932 - 59944
NF1 | c-Jun | Metastatic breast cancer | miR10-b | RhoC
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18. Full Text S100A7, Jab1, and p27 kip1 expression in psoriasis and S100A7 CRISPR-activated human keratinocyte cell line
by Granata, Mariagrazia and Skarmoutsou, Evangelia and Gangemi, Pietro and Mazzarino, Maria C and D’Amico, Fabio
Journal of Cellular Biochemistry, ISSN 0730-2312, 03/2019, Volume 120, Issue 3, pp. 3384 - 3392
Psoriasis, a chronic immune-mediated inflammatory skin disease, is characterized by dysregulated keratinocyte proliferation. The EF-hand calcium binding... 
CRISPR | c-jun activation domain-binding protein-1 (Jab1) | psoriasin | p27 | keratinocyte | psoriasis | CSN5 | S100A7
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19. Full Text Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
by Zanconato, Francesca and Forcato, Mattia and Battilana, Giusy and Azzolin, Luca and Quaranta, Erika and Bodega, Beatrice and Rosato, Antonio and Bicciato, Silvio and Cordenonsi, Michelangelo and Piccolo, Stefano
Nature Cell Biology, ISSN 1465-7392, 09/2015, Volume 17, Issue 9, pp. 1218 - 1227
YAP/TAZ are nuclear effectors of the Hippo pathway regulating organ growth and tumorigenesis. Yet, their function as transcriptional regulators remains... 
COMPLEX | DOMAIN | EPITHELIAL-CELLS | CHROMATIN | HIPPO PATHWAY | TRANSCRIPTIONAL COACTIVATOR | C-JUN | TAZ | REGULATORY ELEMENTS | CANCER | CELL BIOLOGY | Transcription Factor AP-1 - genetics | Humans | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Male | Carcinogenesis - metabolism | HEK293 Cells | Female | Phosphoproteins - physiology | Skin Neoplasms - pathology | DNA-Binding Proteins - physiology | Genome-Wide Association Study | Transcription Factors - physiology | Signal Transduction | Carcinogenesis - genetics | Tumor Burden | Mice, Knockout | Skin Neoplasms - metabolism | Adaptor Proteins, Signal Transducing - physiology | Animals | Enhancer Elements, Genetic | Skin Neoplasms - genetics | Cell Line, Tumor | Protein Binding | Nuclear Proteins - physiology | Genetic aspects | Cellular signal transduction | Research | Carcinogenesis | Risk factors
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20. Full Text Molecular mechanisms of opioid receptor-dependent signaling and behavior
by Al-Hasani, Ream and Bruchas, Michael R
Anesthesiology, ISSN 0003-3022, 12/2011, Volume 115, Issue 6, pp. 1363 - 1381
Opioid receptors have been targeted for the treatment of pain and related disorders for thousands of years and remain the most widely used analgesics in the... 
BETA-ARRESTIN 2 | ACTIVATED PROTEIN-KINASE | CALCIUM-CHANNELS | ADENYLYL-CYCLASE | N-TERMINAL KINASE | P38 MAPK | ANESTHESIOLOGY | CENTRAL-NERVOUS-SYSTEM | SINGLE-NUCLEOTIDE POLYMORPHISM | C-JUN | OPIATE ADDICTION | Animals | Signal Transduction - drug effects | Pain - drug therapy | Humans | Drug Tolerance | Analgesics, Opioid - pharmacology | Mice | Receptors, Opioid - drug effects
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