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Science translational medicine, ISSN 1946-6242, 2019, Volume 11, Issue 484, p. eaar5012
Inhibiting MYC has long been considered unfeasible, although its key role in human cancers makes it a desirable target for therapeutic intervention. One reason... 
MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | DNA-BINDING | INHIBITION | PEPTIDES | PROTEIN | MAX | C-MYC | N-MYC | EXPRESSION | TUMOR INITIATION | CELL BIOLOGY | Lung Neoplasms - drug therapy | Basic-Leucine Zipper Transcription Factors - metabolism | Proto-Oncogene Proteins c-myc - therapeutic use | Adenocarcinoma of Lung - pathology | Humans | Cell-Penetrating Peptides - pharmacokinetics | Lung Neoplasms - pathology | Peptide Fragments - pharmacology | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-myc - administration & dosage | Cell-Penetrating Peptides - pharmacology | Cell-Penetrating Peptides - therapeutic use | Protein Binding - drug effects | Adenocarcinoma of Lung - drug therapy | Female | Proto-Oncogene Proteins c-myc - pharmacology | Disease Models, Animal | Carcinoma, Non-Small-Cell Lung - pathology | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Peptide Fragments - pharmacokinetics | DNA - metabolism | E-Box Elements - genetics | Proto-Oncogene Proteins c-myc - metabolism | Proto-Oncogene Proteins c-myc - pharmacokinetics | Animals | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Cell Line, Tumor | Peptide Fragments - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Protein Multimerization - drug effects | Cell culture | Animal models | Side effects | Myc protein | Small cell lung carcinoma | Transcription
Journal Article
Journal of cancer research and clinical oncology, ISSN 1432-1335, 2012, Volume 139, Issue 3, pp. 437 - 445
Journal Article
Oncogene, ISSN 1476-5594, 2018, Volume 38, Issue 1, pp. 140 - 150
Overexpression of MYC oncogene is highly prevalent in many malignancies such as aggressive triple-negative breast cancers (TNBCs) and it is associated with... 
ACTIVATION | PROTEIN | EFFICACY | MAX | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-MYC | CHEMOTHERAPY | CELL BIOLOGY | ONCOLOGY | OMOMYC | GENETICS & HEREDITY | RESISTANCE | BET BROMODOMAIN INHIBITORS | TRANSCRIPTION FACTOR | Proto-Oncogene Proteins c-myc - therapeutic use | Humans | Recombinant Fusion Proteins - therapeutic use | Neoplasm Proteins - antagonists & inhibitors | Genes, myc | Peptide Library | Triple Negative Breast Neoplasms - drug therapy | Proto-Oncogene Proteins c-myc - administration & dosage | Cell-Penetrating Peptides - pharmacology | Cell-Penetrating Peptides - therapeutic use | Protein Engineering | Inhibitory Concentration 50 | Female | Peptide Fragments - genetics | Molecular Targeted Therapy - methods | Recombinant Fusion Proteins - administration & dosage | Amino Acid Sequence | Peptide Fragments - administration & dosage | Peptide Fragments - pharmacokinetics | Models, Molecular | Proto-Oncogene Proteins c-myc - pharmacokinetics | Leucine Zippers - genetics | Drug Synergism | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Recombinant Fusion Proteins - pharmacokinetics | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Mice | Peptide Fragments - therapeutic use | Proto-Oncogene Proteins c-myc - genetics | Cell-Penetrating Peptides - administration & dosage | Mutation | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Gene expression | Health aspects | Oncogenes | Bone grafts | Chemotherapy | Peptides | Transcription | Breast cancer | Myc protein | Fusion protein | Protein structure | Apoptosis | Brief Communication
Journal Article
Cell death and differentiation, ISSN 1476-5403, 2011, Volume 19, Issue 6, pp. 968 - 979
Forkhead transcription factors of the O class (FOXOs) are important targets of the phosphatidylinositol 3-kinase/Akt pathway, and are key regulators of the... 
C-Myc | FOXO | Reactive oxygen species | HIF-1a | Mitochondrial biogenesis | TRANSFORMATION | HIF-1 alpha | c-Myc | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | HYPOXIA | mitochondrial biogenesis | CELL BIOLOGY | COMPLEX-III | reactive oxygen species | ROS | DEGRADATION | TRANSCRIPTION FACTOR | CONTRIBUTES | Reactive Oxygen Species - metabolism | DNA, Mitochondrial - metabolism | Oxidative Stress | Signal Transduction | Humans | Gene Expression Regulation | Mitochondria - metabolism | Forkhead Transcription Factors - genetics | Proto-Oncogene Proteins c-myc - metabolism | Cell Hypoxia | Mitochondria - genetics | RNA Interference | Forkhead Transcription Factors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Cell Line, Tumor | Forkhead Box Protein O1 | Proto-Oncogene Proteins c-myc - genetics | Forkhead Transcription Factors - antagonists & inhibitors | Forkhead Box Protein O3 | Superoxide Dismutase - metabolism | Apoptosis | RNA, Small Interfering - metabolism | Oxidative stress | Transcription factors | Hypoxia-inducible factor 1 alpha | Detoxification | c-Myc protein | AKT protein | Data processing | Superoxide dismutase | Mitochondrial DNA | Gene expression | Metabolism | Gene silencing | Mitochondria | Cell cycle | Forkhead protein | copy number | FOXO3 protein | Original Paper | HIF-1α
Journal Article
Cell Cycle, ISSN 1551-4005, 2014, Volume 7, Issue 15, pp. 2392 - 2400
To identify C-MYC targets rate-limiting for proliferation of malignant melanoma, we stably inhibited C-MYC in several human metastatic melanoma lines via... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | C-MYC | Nucleotide metabolism | Melanoma | TRANSFORMATION | INSTABILITY | melanoma | nucleotide metabolism | CELL BIOLOGY | TARGET GENES | IN-VITRO | INHIBITION | COLORECTAL-CANCER | DNA | TRANSCRIPTIONAL REGULATION | THYMIDYLATE-SYNTHASE | PROGRESSION
Journal Article
Cell death and differentiation, ISSN 1350-9047, 2013, Volume 20, Issue 3, pp. 503 - 514
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 31, pp. 31569 - 31592
The c-Myc gene codes for a basic-helix-loop-helix-leucine zipper transcription factor protein and is reported to be frequently over-expressed in human cancers.... 
Gene reporter assays | c-Myc transgenic mouse model of papillary lung adenocarcinomas | C-Myc regulatory gene networks | C-Myc regulated cell cycle and apoptotic genes | Whole genome scans | PROTEIN | DNA-DAMAGE | PUTATIVE TUMOR-SUPPRESSOR | EARLY-STAGE | EXPRESSION PROFILES | CANCER | GENOMIC TARGETS | P53 | CELL BIOLOGY | whole genome scans | c-Myc regulated cell cycle and apoptotic genes | c-Myc regulatory gene networks | EPIDERMAL-GROWTH-FACTOR | TRANSCRIPTION FACTOR | gene reporter assays | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Humans | Lung Neoplasms - metabolism | Adenocarcinoma, Papillary - genetics | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Gene Regulatory Networks | Adenocarcinoma - metabolism | Transfection | Chromatin Immunoprecipitation | Adenocarcinoma, Papillary - metabolism | Apoptosis Regulatory Proteins - genetics | Cell Cycle Proteins - genetics | Adenocarcinoma - genetics | Electrophoretic Mobility Shift Assay | Binding Sites | Genes, Reporter | Adenocarcinoma, Papillary - pathology | Lung Neoplasms - genetics | Promoter Regions, Genetic | Genetic Predisposition to Disease | Signal Transduction | Cell Cycle Proteins - metabolism | Computational Biology | Gene Expression Profiling - methods | Mice, Transgenic | Proto-Oncogene Proteins c-myc - metabolism | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Phenotype | Animals | Cell Cycle | Cell Line, Tumor | Proto-Oncogene Proteins c-myc - genetics | Apoptosis | Index Medicus
Journal Article
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2012, Volume 209, Issue 4, pp. 679 - 696
Journal Article