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ORGANIC LETTERS, ISSN 1523-7060, 03/2017, Volume 19, Issue 5, pp. 1180 - 1183
An efficient synthesis of the C1-C9 and the C11-C25 fragments of amphidinolides C, C2, C3, and F from a common intermediate is reported. The construction of... 
ALCOHOLS | C-C FRAGMENT | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | ABSOLUTE STEREOCHEMISTRY | POLYKETIDES | BIOACTIVE MACROLIDES | DIMETHYL-SULFOXIDE | DINOFLAGELLATE AMPHIDINIUM SP
Journal Article
Organic Letters, ISSN 1523-7060, 06/2018, Volume 20, Issue 11, pp. 3192 - 3196
A new and efficient convergent approach toward the synthesis of amphidinolide F is described through the assembly of three fragments. The two... 
CARBON BOND FORMATION | TRANSITION-METAL CATALYSIS | KETONES | ACID | C-C FRAGMENT | NATURAL-PRODUCTS | SIDE-CHAIN | CHEMISTRY, ORGANIC | ABSOLUTE STEREOCHEMISTRY | BIOACTIVE MACROLIDES | C1-C9 FRAGMENT
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2013, Volume 52, Issue 36, pp. 9534 - 9538
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2017, Volume 15, Issue 13, pp. 2740 - 2767
Two approaches to the synthesis of compounds corresponding to the C17-C27 fragment of the 20-deoxybryostatins are described. The first approach is based on the... 
INDUCED CELL-DEATH | BUGULA-NERITINA | ALCOHOLS | PROTEIN-KINASE-C | DESIGN | BOND-FORMING HYDROGENATION | BRYOSTATIN ANALOGS | C-C FRAGMENT | CHEMISTRY, ORGANIC | B-RING | STEREOCONTROLLED SYNTHESIS
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 06/2019, Volume 10, Issue 1, pp. 2869 - 10
Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader... 
BACILLUS-THURINGIENSIS | C-FRAGMENT | GENE | SEROTYPE | TETANUS | TOXIN | MULTIDISCIPLINARY SCIENCES | BOTULINUM NEUROTOXIN | BINDING-SITE | IDENTIFICATION | BIFERMENTANS SUBSP MALAYSIA | Vector-borne diseases | Neurotoxins | Malaria | Nervous system | SNAP receptors | Exocytosis | Aquatic insects | Syntaxin | Vertebrates | Mosquitoes | Evolution | Toxins | Tetanus | Strains (organisms)
Journal Article
Chemical Communications, ISSN 1359-7345, 11/2011, Volume 47, Issue 44, pp. 12191 - 12193
Quintuply bonded [(LCr)-L-H-Cr-iPr](2) reacts with alkynes RC CR (R = Me, Et, Ph, CF3) to form exclusively 1 : 1 adducts [(LCr)-L-H-Cr-iPr](2)(RCCR). All... 
METAL-METAL DISTANCES | N=C FRAGMENT | C=X-M FRAGMENT | FE-O=C FRAGMENT | 1,3-DIPOLAR CYCLOADDITION | COMPLEXES | NATURAL RESONANCE THEORY | REACTIVITY | CHEMISTRY, MULTIDISCIPLINARY | DIMETHYL ACETYLENEDICARBOXYLATE | ELECTRONIC-STRUCTURE | Carbon-carbon composites | Chromium | Hydrocarbons | Ligands | Bonding | Elongation | Adducts | Alkynes
Journal Article
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, ISSN 1434-193X, 02/2013, Issue 4, pp. 756 - 760
The generation of a new Lewis acid (BF2OBn center dot OEt2) has been reported, and its usefulness has been demonstrated in the regio- and stereoselective... 
Regioselectivity | Cyclization | Natural products | C-C FRAGMENT | STEREOCHEMISTRY | Lewis acids | Epoxidation | ASYMMETRIC EPOXIDATION | CHEMISTRY, ORGANIC | Asymmetric catalysis
Journal Article
Journal of Molecular Endocrinology, ISSN 0952-5041, 05/2016, Volume 56, Issue 4, pp. T13 - T25
Many important fields of research had a humble origin. In the distant past, A J P Martin's discovery that amino acids could be separated by paper... 
POMC | Neurotransmitters | Beta-endorphin | Lipotropin | beta-endorphin | PORCINE PITUITARY | ANALGESIC ACTIVITY | COMMON PRECURSOR | RAT PITUITARY | INACTIVE FORMS | lipotropin | OPIOID PEPTIDE | C-FRAGMENT | neurotransmitters | SHEEP PITUITARY-GLANDS | ENDOCRINOLOGY & METABOLISM | OPIATE RECEPTORS | BRAIN
Journal Article
BIOSENSORS & BIOELECTRONICS, ISSN 0956-5663, 10/2011, Volume 28, Issue 1, pp. 97 - 104
Journal Article
Organic Letters, ISSN 1523-7060, 04/2013, Volume 15, Issue 7, pp. 1464 - 1467
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2008, Volume 49, Issue 44, pp. 6352 - 6355
The modified Julia olefination is used to prepare advanced intermediates for convergent syntheses of bryostatins. Modified Julia olefination reactions using... 
CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | ASYMMETRIC-SYNTHESIS | ANALOGS | C-C FRAGMENT | STRATEGY
Journal Article
Organic Letters, ISSN 1523-7060, 04/2013, Volume 15, Issue 7, pp. 1460 - 1463
The C-1-C-17 fragment of amphidinolides C, C2, C3, and F has been constructed from a trans-2,5-disubstituted dihydrofuranone prepared by diastereoselective... 
REARRANGEMENT | CONCISE | CARBENOIDS | C-C FRAGMENT | NATURAL-PRODUCTS | CHEMISTRY, ORGANIC | ABSOLUTE STEREOCHEMISTRY | STEREOSELECTIVE-SYNTHESIS | BIOACTIVE MACROLIDES | OXONIUM YLIDES | DINOFLAGELLATE AMPHIDINIUM SP | Molecular Structure | Macrolides - chemistry | Dinoflagellida - chemistry | Macrolides - chemical synthesis | Stereoisomerism | Index Medicus
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2017, Volume 8, Issue 7, pp. 701 - 704
An approach to: the validation of a linker strategy for the epothilone family of microtubule-stabilizing agents is reported. An analogue of epothilone B in... 
linker | methyl extension | microtubules | antibody-drug conjugates | Epothilones | FLUDELONE | CHEMISTRY, MEDICINAL | MECHANISM | C-C FRAGMENT | AGENTS | EFFICIENT | DISCOVERY
Journal Article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 2013, Volume 52, Issue 12, pp. 3446 - 3449
Journal Article
Proceedings of SPIE, ISSN 0277-786X, 02/2010, Volume 7576, Issue 1, pp. 75761N - 75761N-7
We have developed a fluorescent ruthenium metalloglycocluster as a powerful molecular probe for evaluating a binding event between carbohydrates and lectins by... 
Metalloglycocluster | Fluorescence polarization | Lectin | Tetanus toxin c-fragment | Carbohydrate
Conference Proceeding