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1. Full Text Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial
by Jacobs, Ian J, Prof and Menon, Usha, Prof and Ryan, Andy, PhD and Gentry-Maharaj, Aleksandra, PhD and Burnell, Matthew, PhD and Kalsi, Jatinderpal K, PhD and Amso, Nazar N, Prof and Apostolidou, Sophia, PhD and Benjamin, Elizabeth, FRCPath and Cruickshank, Derek, FRCOG and Crump, Danielle N, BSN and Davies, Susan K, RGN and Dawnay, Anne, PhD and Dobbs, Stephen, FRCOG and Fletcher, Gwendolen, DCR(R) and Ford, Jeremy, MSc and Godfrey, Keith, FRCOG and Gunu, Richard, MSc and Habib, Mariam, PhD and Hallett, Rachel, PhD and Herod, Jonathan, MRCOG and Jenkins, Howard, FRCOG and Karpinskyj, Chloe, BSc and Leeson, Simon, FRCOG and Lewis, Sara J, MSc and Liston, William R and Lopes, Alberto, FRCOG and Mould, Tim, FRCOG and Murdoch, John, FRCOG and Oram, David, FRCOG and Rabideau, Dustin J, MSc and Reynolds, Karina, FRCOG and Scott, Ian, FRCOG and Seif, Mourad W, FRCOG and Sharma, Aarti, PhD and Singh, Naveena, FRCPath and Taylor, Julie, MSc and Warburton, Fiona, MSc and Widschwendter, Martin, Prof and Williamson, Karin, FRCOG and Woolas, Robert, MD and Fallowfield, Lesley, Prof and McGuire, Alistair J, Prof and Campbell, Stuart, Prof and Parmar, Mahesh, Prof and Skates, Steven J, PhD
Lancet, The, ISSN 0140-6736, 2016, Volume 387, Issue 10022, pp. 945 - 956
Summary Background Ovarian cancer has a poor prognosis, with just 40% of patients surviving 5 years. We designed this trial to establish the effect of early... 
Internal Medicine | PROPORTIONAL-HAZARDS | PROSTATE | LUNG | MEDICINE, GENERAL & INTERNAL | MULTICENTER | MODELS | ULTRASOUND | ALGORITHM | PREVENTION | RISK | POSTMENOPAUSAL WOMEN | CA-125 Antigen - blood | Outcome Assessment (Health Care) | Early Detection of Cancer | Ovarian Neoplasms - diagnosis | Humans | Middle Aged | Proportional Hazards Models | United Kingdom | Ovarian Neoplasms - mortality | Algorithms | Female | Aged | Membrane Proteins - blood | Women | Medical colleges | Oncology, Experimental | Mortality | Research | Diagnosis | Health aspects | Ovarian cancer | Cancer | Analysis | Australia | Studies | Ultrasonic imaging | Womens health | Health services | Medical prognosis | Medical screening | Primary care | Tumors
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2. Full Text Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts
by Huhtinen, K and Suvitie, P and Hiissa, J and Junnila, J and Huvila, J and Kujari, H and Setälä, M and Härkki, P and Jalkanen, J and Fraser, J and Mäkinen, J and Auranen, A and Poutanen, M and Perheentupa, A
British Journal of Cancer, ISSN 0007-0920, 04/2009, Volume 100, Issue 8, pp. 1315 - 1319
Human epididymal secretory protein E4 (HE4, also known as WAP four-disulphide core domain protein 2) is a new promising biomarker for ovarian cancer but its... 
CA125 | Endometriosis | HE4 | Ovarian cancer | PROTEIN | ovarian cancer | endometriosis | MARKERS | RISK | CANCER | MULTIPLE | BIOMARKERS | ONCOLOGY | CA-125 | CARCINOMA | Diagnosis, Differential | CA-125 Antigen - blood | CA-125 Antigen - genetics | Endometriosis - blood | Humans | RNA, Messenger - genetics | Ovarian Neoplasms - blood | Reference Values | beta-Defensins | Biomarkers, Tumor - blood | Epididymal Secretory Proteins - metabolism | Sensitivity and Specificity | RNA, Neoplasm - genetics | Female | Ovarian Cysts - blood | Endometrial Neoplasms - blood | Epididymal Secretory Proteins - genetics | Molecular Diagnostics
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3. Full Text The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass
by Moore, Richard G and Brown, Amy K and Miller, M. Craig and Skates, Steven and Allard, W. Jeffrey and Verch, Thorsten and Steinhoff, Margaret and Messerlian, Geralyn and DiSilvestro, Paul and Granai, C.O and Bast, Robert C
Gynecologic Oncology, ISSN 0090-8258, 2007, Volume 108, Issue 2, pp. 402 - 408
Abstract Objectives. The CA125 tumor marker is used to help predict the presence of ovarian cancer in patients with an adnexal mass. Because elevated CA125... 
Hematology, Oncology and Palliative Medicine | Obstetrics and Gynecology | CA125 | Tumor markers | Pelvic mass | HE4 | Ovarian cancer | SURVIVAL | DIAGNOSIS | CA72-4 | MANAGEMENT | tumor markers | ovarian cancer | CA 125 | MARKERS | SERUM CA-125 LEVELS | OBSTETRICS & GYNECOLOGY | CANCER-PATIENTS | ONCOLOGY | POSTMENOPAUSAL WOMEN | ULTRASONOGRAPHY | pelvic mass | Prospective Studies | CA-125 Antigen - blood | Humans | Middle Aged | Ovarian Neoplasms - pathology | Ovarian Neoplasms - blood | beta-Defensins | Adnexa Uteri - pathology | CA-125 Antigen - urine | Biomarkers, Tumor - blood | Biomarkers, Tumor - urine | Epididymal Secretory Proteins - metabolism | Sensitivity and Specificity | Pelvic Neoplasms - blood | Female | Aged | Pelvic Neoplasms - urine | Ovarian Neoplasms - urine | Pelvic Neoplasms - pathology | Biological markers | Care and treatment | Tumors
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4. Full Text Characterization of Binding Epitopes of CA125 Monoclonal Antibodies
by Marcos-Silva, Lara and Narimatsu, Yoshiki and Halim, Adnan and Campos, Diana and Yang, Zhang and Tarp, Mads A and Pereira, Pedro J. B and Mandel, Ulla and Bennett, Eric P and Vakhrushev, Sergey Y and Levery, Steven B and David, Leonor and Clausen, Henrik
Journal of Proteome Research, ISSN 1535-3893, 07/2014, Volume 13, Issue 7, pp. 3349 - 3359
The most used cancer serum biomarker is the CA125 immunoassay for ovarian cancer that detects the mucin glycoprotein MUC16. Several monoclonal antibodies... 
mass spectrometry | ETD | cancer vaccine | GALNT | O-GLYCOPROTEOME | MUC16 | MUCIN | BIOCHEMICAL RESEARCH METHODS | GLYCOSYLATION | IDENTIFICATION | RESPONSES | OVARIAN-CANCER ANTIGEN | CA-125 | EXPRESSION | EPITHELIAL OVARIAN | Protein Structure, Tertiary | Epitope Mapping | CA-125 Antigen - immunology | Cricetinae | Cricetulus | Antibodies, Monoclonal, Murine-Derived - chemistry | Membrane Proteins - immunology | Glycosylation | Animals | Membrane Proteins - chemistry | Protein Binding | Membrane Proteins - metabolism | Mice | Protein Processing, Post-Translational | CA-125 Antigen - metabolism | CA-125 Antigen - chemistry | CHO Cells
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5. Full Text Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments
by Das, Srustidhar and Majhi, Prabin D and Al-Mugotir, Mona H and Rachagani, Satyanarayana and Sorgen, Paul and Batra, Surinder K
Scientific Reports, ISSN 2045-2322, 06/2015, Volume 5, p. 9759
MUC16, precursor of the most widely used ovarian cancer biomarker CA125, is up regulated in multiple malignancies and is associated with poor prognosis. While... 
OCULAR SURFACE | PANCREATIC DUCTAL ADENOCARCINOMA | TETHERED MUCINS | MULTIDISCIPLINARY SCIENCES | CA125 | CELL-SURFACE | SEA DOMAIN | EXTRACELLULAR SUPERSTRUCTURE | GAMMA-SECRETASE | EPITHELIAL OVARIAN-CANCER | CA-125 GENE | Leukocyte Elastase - metabolism | Signal Transduction | CA-125 Antigen - genetics | Membrane Proteins - genetics | Humans | Glycosylation | Protein Transport | Ubiquitination | Animals | Matrix Metalloproteinase 7 - metabolism | Membrane Proteins - chemistry | Proteolysis | Intracellular Space - metabolism | Golgi Apparatus - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | Mice | Protein Interaction Domains and Motifs | Protein Stability | CA-125 Antigen - metabolism | CA-125 Antigen - chemistry | Hydrogen-Ion Concentration | Chromatin | Therapeutic applications | Gene expression | pH effects | Nuclei | Ovarian cancer | Metastases | Golgi apparatus
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6. Full Text Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer
by Balachandran, Vinod P and Luksza, Marta and Zhao, Julia N and Makarov, Vladimir and Moral, John Alec and Remark, Romain and Herbst, Brian and Askan, Gokce and Bhanot, Umesh and Senbabaoglu, Yasin and Wells, Daniel K and Cary, Charles Ian Ormsby and Grbovic-Huezo, Olivera and Attiyeh, Marc and Medina, Benjamin and Zhang, Jennifer and Loo, Jennifer and Saglimbeni, Joseph and Abu-Akeel, Mohsen and Zappasodi, Roberta and Riaz, Nadeem and Smoragiewicz, Martin and Kelley, Z. Larkin and Basturk, Olca and Gönen, Mithat and Levine, Arnold J and Allen, Peter J and Fearon, Douglas T and Merad, Miriam and Gnjatic, Sacha and Iacobuzio-Donahue, Christine A and Wolchok, Jedd D and DeMatteo, Ronald P and Chan, Timothy A and Greenbaum, Benjamin D and Merghoub, Taha and Leach, Steven D and Australian Pancreatic Canc Genom and Garvan Institute of Medical Research and Bankstown Hospital and St Vincent’s Hospital and Royal Adelaide Hospital and Royal North Shore Hospital and Envoi Pathology and QIMR Berghofer Medical Research Institute and Prince of Wales Hospital and University of Melbourne, Centre for Cancer Research and University of Queensland, Institute for Molecular Bioscience and Royal Prince Alfred Hospital, Chris O’Brien Lifehouse and Princess Alexandria Hospital and Fremantle Hospital and Liverpool Hospital and Austin Hospital and University of Glasgow and Johns Hopkins Medical Institutes and Flinders Medical Centre and Westmead Hospital and St John of God Healthcare and ARC-Net Centre for Applied Research on Cancer and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 11/2017, Volume 551, Issue 7681, pp. S12 - S16
Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving past 5 years. T-cell immunity has been linked to the exceptional... 
CELLS | MUC16 | LANDSCAPE | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | DYNAMICS | HUMAN-MELANOMA | MICE | TUMORS | ANTIGEN | CA-125 Antigen - immunology | Cancer Survivors | Cross Reactions - genetics | Prognosis | CA-125 Antigen - genetics | Humans | Computer Simulation | Immunotherapy | Adenocarcinoma - genetics | Bacterial Proteins - immunology | T-Lymphocytes, Cytotoxic - immunology | Antigens, Neoplasm - genetics | Pancreatic Neoplasms - blood | Antigens, Neoplasm - immunology | Membrane Proteins - genetics | Adenocarcinoma - blood | Adenocarcinoma - immunology | Bacterial Proteins - genetics | Membrane Proteins - immunology | Pancreatic Neoplasms - genetics | Cross Reactions - immunology | Whole Exome Sequencing | Bacterial Proteins - blood | Pancreatic Neoplasms - immunology | Survival Analysis | T-Lymphocytes, Cytotoxic - cytology | Physiological aspects | Antigens | Health aspects | Pancreatic cancer | Adenocarcinoma | Transcription | Peptides | CD8 antigen | Homology | Lymphocytes T | Genomes | Immunity | Metastases | Cell activation | Microorganisms | Lymphocytes | Bioindicators | Medical research | Cell survival | T cell receptors | Epitopes | Biophysics | Patients | Studies | Chemotherapy | Infectious diseases | Immunogenicity | Biomarkers | Tumors | Cancer
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7. Full Text Pattern of tissue expression of CA-125 and HE4 in primary epithelial ovarian tumours and correlation with serum CA-125 levels
by Devan, Shobana Mukunda and Pailoor, Jayalakshmi and Sthaneshwar, Pavai and Narayanan, Vallikkanu
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2013, Volume 14, Issue 8, pp. 4545 - 4548
Immunohistochemistry | CA-125 | HE4 | Serum CA-125 | Ovarian tumours
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8. Full Text Detection and monitoring of ovarian cancer
by Su, Zengliu and Graybill, Whitney S and Zhu, Yusheng
Clinica Chimica Acta, ISSN 0009-8981, 01/2013, Volume 415, pp. 341 - 345
Ovarian cancer is the fifth leading cause of death among women in the United States and remains the most common cause of death from a gynecologic malignancy.... 
Detection | Treatment monitoring | Ovarian cancer | DIAGNOSIS | CA 125 | HE-4 | RISK | PROTEOMIC BIOMARKERS | MULTIPLE | CA-125 | CA125 | MEDICAL LABORATORY TECHNOLOGY | SERUM MARKERS | PROGRESSION | Predictive Value of Tests | Carcinoma - blood | Gene Expression | CA-125 Antigen - blood | CA-125 Antigen - genetics | Ovarian Neoplasms - diagnosis | Humans | Carcinoma - mortality | Ovarian Neoplasms - blood | Carcinoma - diagnosis | Risk | Ovarian Neoplasms - mortality | Biomarkers, Tumor - blood | Ovarian Neoplasms - genetics | Proteins - genetics | Algorithms | Proteins - metabolism | Survival Analysis | Carcinoma - genetics | Female | Neoplasm Proteins - blood | Biomarkers, Tumor - genetics | Neoplasm Proteins - genetics | Early Diagnosis | Care and treatment | Diagnosis | Cancer
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9. Full Text CA125 expression pattern, prognosis and correlation with serum CA125 in ovarian tumor patients. From The Danish "MALOVA" Ovarian Cancer Study
by Høgdall, Estrid V.S and Christensen, Lise and Kjaer, Susanne K and Blaakaer, Jan and Kjærbye-Thygesen, Anette and Gayther, Simon and Jacobs, Ian J and Høgdall, Claus K
Gynecologic Oncology, ISSN 0090-8258, 03/2007, Volume 104, Issue 3, pp. 508 - 515
Objectives: To determine the CA125 tissue expression levels in borderline and invasive epithelial ovarian tumor tissues. Secondly, to evaluate whether CA125... 
Immunohistochemistry | CA125 | Prognosis | Tissue array | Ovarian cancer | ovarian cancer | CA 125 | TISSUE MICROARRAYS | PATHOLOGY | prognosis | POTENTIAL MARKERS | immunchistochemistry | OBSTETRICS & GYNECOLOGY | tissue array | ONCOLOGY | CA-125 | OREGOVOMAB | CARCINOMA | ANTIGEN | CA-125 Antigen - blood | Humans | Middle Aged | Ovarian Neoplasms - pathology | Ovarian Neoplasms - blood | CA-125 Antigen - biosynthesis | Adult | Female | Aged | Ovarian Neoplasms - metabolism | Neoplasm Staging
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10. Full Text Characterization of the Oligosaccharides Associated with the Human Ovarian Tumor Marker CA125
by Nyet Kui Wong and Richard L. Easton and Maria Panico and Mark Sutton-Smith and Jamie C. Morrison and Frank A. Lattanzio and Howard R. Morris and Gary F. Clark and Anne Dell and Manish S. Patankar
Journal of Biological Chemistry, ISSN 0021-9258, 08/2003, Volume 278, Issue 31, pp. 28619 - 28634
CA125 is a mucin commonly employed as a diagnostic marker for epithelial ovarian cancer. Induction of humoral responses to CA125 leads to increased survival... 
N-LINKED OLIGOSACCHARIDES | C-TYPE LECTIN | GLYCOPHORIN-A | DC-SIGN | IMMUNE-RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER ANTIGEN | CLASS-I | MONOCLONAL-ANTIBODY | EXTRACELLULAR SUPERSTRUCTURE | CA-125 GENE | Fucose - chemistry | CA-125 Antigen - immunology | Gas Chromatography-Mass Spectrometry | Molecular Weight | Fucose - metabolism | Humans | Immune Tolerance | Glycosylation | Polysaccharides - analysis | Mannose - analysis | Spectrometry, Mass, Electrospray Ionization | Oligosaccharides - chemistry | Spectrometry, Mass, Fast Atom Bombardment | beta-Galactosidase - metabolism | Polysaccharides - chemistry | Female | CA-125 Antigen - analysis | Molecular Structure | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Tumor Cells, Cultured | Carbohydrate Conformation | CA-125 Antigen - chemistry | Ovarian Neoplasms - immunology
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11. Full Text Human epididymis protein 4 offers superior specificity in the differentiation of benign and malignant adnexal masses in premenopausal women
by Holcomb, Kevin, MD and Vucetic, Zivjena, MD, PhD and Miller, M. Craig, MS and Knapp, Robert C., MD
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 2011, Volume 205, Issue 4, pp. 358.e1 - 358.e6
Objective We sought to assess the ability of human epididymis protein 4 (HE4) and CA-125 to distinguish among benign, borderline, and malignant pelvic masses... 
Obstetrics and Gynecology | premenopausal | ovarian cancer detection | biomarkers | CA-125 and human epididymis protein 4 | Biomarkers | Premenopausal | Ovarian cancer detection | OVARIAN-CANCER | SERUM CA-125 LEVELS | TUMORS | MULTIPLE | PREDICTION | OBSTETRICS & GYNECOLOGY | DISCRIMINATION | PELVIC MASSES | DISEASE | CARCINOMAS | PREOPERATIVE EVALUATION | Epididymal Secretory Proteins - analysis | Diagnosis, Differential | Prospective Studies | CA-125 Antigen - blood | Premenopause | Ovarian Neoplasms - diagnosis | Adnexal Diseases - diagnosis | Humans | Middle Aged | Ovarian Neoplasms - blood | beta-Defensins | Sensitivity and Specificity | Female | Adnexal Diseases - blood | Menopause
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12. Full Text Mucin 16 is a functional selectin ligand on pancreatic cancer cells
by Chen, Shih-Hsun and Dallas, Matthew R and Balzer, Eric M and Konstantopoulos, Konstantinos
FASEB Journal, ISSN 0892-6638, 03/2012, Volume 26, Issue 3, pp. 1349 - 1359
Selectins promote metastasis by mediating specific interactions between selectin ligands on tumor cells and selectin-expressing host cells in the... 
MUC16 | Shear stress | Metastasis | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-CELLS | EXTRACELLULAR SUPERSTRUCTURE | COLON-CARCINOMA CELLS | CELL BIOLOGY | ADHESION | VARIANT ISOFORMS | shear stress | metastasis | VASCULAR INTERACTIONS | BIOLOGY | P-SELECTIN | CARCINOEMBRYONIC ANTIGEN | CA-125 GENE | Immunoprecipitation | Pancreatic Neoplasms - metabolism | Cricetulus | CA-125 Antigen - genetics | P-Selectin - metabolism | Fucose - metabolism | Humans | L-Selectin - genetics | L-Selectin - metabolism | Tandem Mass Spectrometry | Neoplasm Metastasis | Flow Cytometry | RNA Interference | E-Selectin - genetics | Membrane Proteins - metabolism | CA-125 Antigen - isolation & purification | Binding Sites | CA-125 Antigen - metabolism | CHO Cells | Cell Line | Cricetinae | Membrane Proteins - isolation & purification | Membrane Proteins - genetics | Pancreatic Neoplasms - pathology | E-Selectin - metabolism | Pancreatic Neoplasms - genetics | P-Selectin - genetics | N-Acetylneuraminic Acid - metabolism | Blotting, Western | Polysaccharides - metabolism | Animals | Chromatography, Affinity | Cell Line, Tumor | Protein Binding | Ligands | Research Communications
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13. Full Text Aptamer and 5-fluorouracil dual-loading Ag 2 S quantum dots used as a sensitive label-free probe for near-infrared photoluminescence turn-on detection of CA125 antigen
by Jin, Hui and Gui, Rijun and Gong, Jun and Huang, Wenxue
Biosensors & bioelectronics, ISSN 0956-5663, 06/2017, Volume 92, pp. 378 - 384
In this article, Ag S quantum dots (QDs) were prepared by a facile aqueous synthesis method, using thiourea as a new sulfur precursor. Based on electrostatic... 
Limit of Detection | CA-125 Antigen - blood | Humans | Aptamers, Nucleotide - chemistry | Gastric Juice - chemistry | Luminescent Measurements - methods | CA-125 Antigen - urine | Silver Compounds - chemistry | Quantum Dots - ultrastructure | Quantum Dots - chemistry | Fluorouracil - chemistry | Infrared Rays | Biosensing Techniques - methods | CA-125 Antigen - analysis
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14. Full Text One step biofunctionalized electrospun multiwalled carbon nanotubes embedded zinc oxide nanowire interface for highly sensitive detection of carcinoma antigen-125
by Paul, K. Brince and Singh, Vikrant and Singh, Shiv Govind and Vanjari, Siva Rama Krishna
Biosensors and Bioelectronics, ISSN 0956-5663, 02/2017, Volume 88, pp. 144 - 152
Ovarian cancer is the most leading cause of cancer-related death in women . The carcinoma antigen-125, which is found on the surface of many ovarian cancer... 
Multiwalled carbon nanotubes | Ultrasensitive | Electrospinning | Carcinoma antigen | Immunosensor | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | OVARIAN-CANCER PATIENTS | NANOFIBERS | NANOSCIENCE & NANOTECHNOLOGY | COMPOSITES | FUNCTIONALIZATION | NANOPARTICLES | NANOCOMPOSITES | BIOPHYSICS | PHOTOCATALYTIC ACTIVITY | GLUCOSE BIOSENSOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | lmmunosensor | CA-125 | IMMUNOSENSOR | Limit of Detection | Nanowires - ultrastructure | Reproducibility of Results | CA-125 Antigen - blood | Biomarkers, Tumor - analysis | Ovarian Neoplasms - diagnosis | Humans | Ovarian Neoplasms - blood | Nanotubes, Carbon - ultrastructure | Electrochemical Techniques - instrumentation | Membrane Proteins - analysis | Biomarkers, Tumor - blood | Nanowires - chemistry | Point-of-Care Systems | Nanotubes, Carbon - chemistry | Zinc Oxide - chemistry | Biosensing Techniques - instrumentation | Female | CA-125 Antigen - analysis | Membrane Proteins - blood | Electrical engineering | Antigens | Medical colleges | Carcinoma | Detectors | Nanotubes | Zinc oxide | Diagnosis | Electric properties | Ovarian cancer | Cancer | Platforms | Calcination | Nanowires | Biosensors | Multi wall carbon nanotubes
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