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cak (31) 31
biochemistry & molecular biology (26) 26
phosphorylation (26) 26
cell biology (24) 24
humans (23) 23
ring finger protein (23) 23
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cyclin-dependent kinases - metabolism (19) 19
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cdk-activating kinase (15) 15
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tfiih (9) 9
transcription (9) 9
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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal Article
Journal Article
Journal Article
Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 06/2003, Volume 13, Issue 6, pp. 925 - 927
The Vertex application discloses an indeterminate number of indolizine and related heterocyclic derivatives that are claimed to be inhibitors of cyclindependent kinase (CDK... 
indolizines | cyclin-dependent kinase (CDK) | antifungal | kinase inhibitors | cyclin-dependent kinase-activating kinase (CAK) | CHEMISTRY, MEDICINAL | PHARMACOLOGY & PHARMACY
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 10/2006, Volume 20, Issue 12, pp. 2142 - 2142
...), an assembly factor and targeting subunit of cyclin-dependent kinase (CDK)-activating kinase (CAK) that regulates G(1) exit. We report here that CAK binds to and phosphorylates PML/RAR alpha in actively proliferating APL cells... 
cell cycle | MAT1 degradation | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR TFIIH | T(15-17) TRANSLOCATION | RAR-ALPHA | CELL BIOLOGY | proliferation/differentiation transition | CAK ACTIVITY | SUBSTRATE-SPECIFICITY | ASSEMBLY FACTOR | UBIQUITIN PROTEIN LIGASE | BIOLOGY | S-PHASE | MOLECULAR-CLONING
Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 02/2012, Volume 11, Issue 2, pp. 267 - 276
...) by the cyclin-dependent kinase-activating kinase (CAK) complex, a key cell-cycle regulator. In this article, we report that, by suppressing CAK phosphorylation of RAR alpha... 
ACID RECEPTOR-ALPHA | KINASE-ACTIVATING KINASE | ARREST | ONCOLOGY | PHOSPHORYLATION | HEMATOPOIETIC STEM-CELLS | FIBROBLAST-GROWTH-FACTOR | RAR-ALPHA | CANCER | EXPRESSION | ACUTE PROMYELOCYTIC LEUKEMIA | Cyclin-Dependent Kinases - metabolism | Humans | Leukemia, Myeloid - genetics | Culture Media, Conditioned - pharmacology | Receptors, Retinoic Acid - genetics | Leukemia, Myeloid - pathology | Granulocytes - drug effects | Granulocytes - pathology | Granulocytes - metabolism | Phosphorylation - drug effects | Fibroblast Growth Factor 8 - genetics | Fibroblast Growth Factor 8 - pharmacology | Hematopoietic Stem Cells - drug effects | Osteoblasts - drug effects | Cells, Cultured | Receptors, Retinoic Acid - metabolism | Hematopoietic Stem Cells - metabolism | Mice, SCID | Blotting, Western | Animals | Cell Differentiation - drug effects | Leukemia, Myeloid - metabolism | Mice, Nude | Cell Line, Tumor | HL-60 Cells | Protein Isoforms - secretion | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | Stem Cell Niche - drug effects | Fibroblast Growth Factor 8 - secretion | Mutation | Osteoblasts - metabolism | Retinoic Acid Receptor alpha | Retinoids - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Protein Isoforms - genetics | MAPK pathway | Osteoblast-formed HSC niche | Leukemic myeloblasts differentiation | RA-induced CAK-RARα signaling | Normal human primitive CD34+ cells
Journal Article
Current opinion in cell biology, ISSN 0955-0674, 1996, Volume 8, Issue 6, pp. 788 - 794
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 11/2002, Volume 277, Issue 45, pp. 43369 - 43376
...) exit are presently unclear. We previously showed that MAT1 (menage a trois 1), an assembly factor and targeting subunit of the cyclin-dependent kinase (CDK)-activating kinase (CAK... 
INHIBITOR P27(KIP1) | SUBSTRATE-SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GRANULOCYTIC DIFFERENTIATION | TRANSCRIPTION FACTOR TFIIH | CELL-CYCLE | FUNCTIONS AF-1 | CAK ASSEMBLY FACTOR | RAR-ALPHA | ACUTE PROMYELOCYTIC LEUKEMIA | DOMINANT-NEGATIVE ACTIVITY
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 05/2004, Volume 64, Issue 9, pp. 2977 - 2983
Cyclin-dependent kinase-activating kinase (CAK) regulates cell cycle G(1) exit, where cells commonly commit either to proliferate or to differentiate. CAK activity in G(1... 
RING FINGER PROTEIN | INDUCED DIFFERENTIATION | IN-VITRO | MAT1 | 9-CIS RETINOIC ACID | ONCOLOGY | PHOSPHORYLATION | TFIIH | PROLIFERATION | RAR-ALPHA | CAK
Journal Article
Journal Article
FEBS letters, ISSN 0014-5793, 10/2000, Volume 484, Issue 1, pp. 17 - 21
MAT1 (ménage à trois1) functions as an assembly/targeting factor of CAK (cyclin-dependent kinase-activating kinase... 
Minichromosome maintenance 7 | Yeast two-hybrid system | Licensing factor | Protein–protein interaction | Ménage à trois1 | Cell cycle control | CAK, cyclin-dependent kinase-activating kinase | MAT1, ménage à trois1 | CDK, cyclin-dependent kinase | CTD, carboxyl-terminal domain | MCM, minichromosome maintenance | Menage a trois1 | Protein-protein interaction | RING FINGER PROTEIN | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR TFIIH | cell cycle control | CDK | COILED COILS | CELL BIOLOGY | ASSEMBLY FACTOR | SUBSTRATE-SPECIFICITY | IN-VITRO | REPLICATION | BIOPHYSICS | minichromosome maintenance 7 | yeast two-hybrid system | licensing factor | protein-protein interaction | menage a troisl | SUBUNIT | Protein Structure, Tertiary | Humans | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Nuclear Proteins - metabolism | Minichromosome Maintenance Complex Component 7 | DNA-Binding Proteins - genetics | Precipitin Tests | Amino Acid Motifs | Macromolecular Substances | DNA-Binding Proteins - metabolism | Two-Hybrid System Techniques | Cyclins - metabolism | Cell Cycle Proteins - genetics | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Cyclin-Dependent Kinases | Tumor Cells, Cultured | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cyclin H
Journal Article