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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2006, Volume 103, Issue 31, pp. 11736 - 11741
We have demonstrated that cytokine thymic stromal lymphopoietin (TSLP), whose expression is rapidly induced upon keratinocyteselective ablation of retinoid X... 
T lymphocytes | Receptors | Ethanol | Vitamin D | Cytokines | Cholecalciferols | Keratinocytes | Skin | Mast cells | Inflammation | Retinoic acid receptor | Retinoid X receptor | Retinoic acid | Vitamin D receptor | retinoid X receptor | ALLERGIC INFLAMMATION | CELLS | MULTIDISCIPLINARY SCIENCES | skin | NUCLEAR RECEPTOR SUPERFAMILY | retinoic acid receptor | retinoic acid | GENE | ASTHMA | ABLATION | vitamin D receptor | 1,25-DIHYDROXYVITAMIN D-3 | MICE | ASSOCIATION | Skin - cytology | Retinoid X Receptor alpha - metabolism | Calcium - metabolism | Dermatologic Agents - administration & dosage | Humans | Calcitriol - adverse effects | Dermatologic Agents - adverse effects | Receptors, Calcitriol - genetics | Receptors, Retinoic Acid - genetics | Calcitriol - administration & dosage | Calcitriol - analogs & derivatives | Dermatitis, Atopic - chemically induced | Vitamins - immunology | Receptors, Retinoic Acid - agonists | Dermatitis, Atopic - immunology | Female | Cytokines - genetics | Dimerization | Skin - pathology | Cytokines - immunology | Retinoid X Receptor beta - metabolism | Vitamins - chemistry | Cells, Cultured | Retinoid X Receptor beta - genetics | Mice, Transgenic | Receptors, Retinoic Acid - metabolism | Keratinocytes - cytology | Receptors, Calcitriol - metabolism | Keratinocytes - immunology | Mice, Knockout | Retinoid X Receptor alpha - agonists | Vitamins - adverse effects | Animals | Retinoid X Receptor alpha - genetics | Mice | Dermatologic Agents - immunology | Administration, Topical | Retinoids - immunology | Skin - drug effects | Vitamins - administration & dosage | Calcitriol - immunology | Retinoid X Receptor beta - agonists | Physiological aspects | Causes of | Vitamin D3 | Atopic dermatitis | Tretinoin | Dermatitis, Atopic | Calcium | Calcitriol | Retinoid X Receptor alpha | Retinoids | Life Sciences | Retinoid X Receptor beta | Receptors, Retinoic Acid | Biochemistry, Molecular Biology | Vitamins | Dermatologic Agents | Receptors, Calcitriol | Molecular biology | Biological Sciences
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 08/2011, Volume 342, Issue 1-2, pp. 32 - 40
Parathyroid hormone-related protein (PTHrP) increases the growth and osteolytic potential of prostate cancer cells, making it important to control PTHrP... 
Calcitriol
Journal Article
Journal Article
Immunology Letters, ISSN 0165-2478, 07/2010, Volume 131, Issue 2, pp. 151 - 158
The active form of vitamin D, 1a,25-dihydroxyvitamin D3 [1a,25(OH)2D3], has been reported to influence the functioning of the immune system by targeting the... 
Calcitriol
Journal Article
Structure, ISSN 0969-2126, 2010, Volume 18, Issue 10, pp. 1332 - 1341
Regulation of nuclear receptor (NR) activity is driven by alterations in the conformational dynamics of the receptor upon ligand binding. Previously, we... 
ENSEMBLE MODEL | MODULATORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | D 25-HYDROXYLASE | IDENTIFICATION | MASS-SPECTROMETRY | NUCLEAR RECEPTOR | HORMONE RECEPTORS | CELL BIOLOGY | BIOPHYSICS | DEUTERIUM-EXCHANGE | LIGAND | HYDROGEN-EXCHANGE | Luciferases - metabolism | Hydroxycholecalciferols - metabolism | Humans | Protein Multimerization | Transcriptional Activation - drug effects | Molecular Sequence Data | Crystallography, X-Ray | Hydrogen - chemistry | Luciferases - genetics | Calcitriol - analogs & derivatives | Transfection | Mass Spectrometry | HEK293 Cells | Calcitriol - metabolism | Retinoid X Receptors - metabolism | Hydrogen - metabolism | Binding, Competitive | Amino Acid Sequence | Deuterium - metabolism | Hydroxycholecalciferols - agonists | Deuterium - chemistry | Models, Molecular | Receptors, Calcitriol - chemistry | Calcitriol - chemistry | Retinoid X Receptors - chemistry | Receptors, Calcitriol - metabolism | Calcitriol - agonists | Deuterium Exchange Measurement - methods | Hydroxycholecalciferols - chemistry | Receptors, Calcitriol - agonists | Retinoid X Receptors - agonists | Calcitriol - pharmacology | Protein Conformation | Vitamin D - analogs & derivatives | Kinetics | Calcifediol | Alfacalcidol | Vitamin D | Structure | Crystals | Estrogen | Deuterium | Binding | Receptors | Dynamics | Ligands | Dimers | Vitamins | Crystal structure
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2013, Volume 123, Issue 11, pp. 4579 - 4594
The TGF-beta superfamily comprises pleiotropic cytokines that regulate SMAD and non-SMAD signaling. TGF-beta-SMAD signal transd.uction is known to be involved... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR-BETA | COMPLEX-FORMATION | TGF-BETA | NUCLEAR RECEPTORS | CRYSTAL-STRUCTURE | INTERSTITIAL FIBROSIS | GENE-EXPRESSION | 1,25-DIHYDROXYVITAMIN D-3 | MICE LACKING SMAD3 | EXPERIMENTAL GLOMERULONEPHRITIS | Kidney - pathology | Humans | Ureteral Obstruction - metabolism | RNA, Messenger - metabolism | Receptors, Calcitriol - genetics | Gene Knockdown Techniques | Calcitriol - analogs & derivatives | Kidney - metabolism | HEK293 Cells | Lactams - pharmacology | Ureteral Obstruction - genetics | Calcitriol - metabolism | Receptors, Calcitriol - antagonists & inhibitors | Promoter Regions, Genetic | Kidney - drug effects | Mice, Inbred C57BL | RNA, Messenger - genetics | Models, Molecular | Receptors, Calcitriol - metabolism | Drug Discovery | Animals | Signal Transduction - drug effects | Calcitriol - pharmacology | Ureteral Obstruction - pathology | Fibrosis | Ligands | Mice | Smad Proteins - metabolism | Transforming Growth Factor beta - metabolism | Care and treatment | Usage | Vitamin D | Physiological aspects | Calcifediol | Genetic aspects | Research | Alfacalcidol | Transforming growth factors | Health aspects | Kidneys | Gene expression | Experiments | Proteins | Studies | Signal transduction | Acids | Metabolites | Rodents | Collagen | Genetic engineering | Laboratory animals | Crystal structure
Journal Article
PLoS ONE, 10/2013, Volume 8, Issue 10
Genome-wide analysis of vitamin D receptor (VDR) binding sites in THP-1 human monocyte-like cells highlighted the interleukin 8 gene, also known as chemokine... 
Calcitriol
Journal Article
Endocrinology, ISSN 0013-7227, 2006, Volume 147, Issue 12, pp. 5542 - 5548
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 3, pp. 1514 - 1528
Muscle weakness and myopathy are observed in vitamin D deficiency and chronic renal failure, where concentrations of the active vitamin D3 metabolite,... 
Mitochondrial Dynamics | Phosphorylation | MicroRNAs - antagonists & inhibitors | Humans | Mitochondria, Muscle - metabolism | MicroRNAs - metabolism | Muscle, Skeletal - metabolism | Gene Expression Profiling | Green Fluorescent Proteins - genetics | Muscle, Skeletal - cytology | Receptors, Calcitriol - genetics | Recombinant Fusion Proteins - metabolism | Calcitriol - analogs & derivatives | RNA Interference | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - metabolism | Calcitriol - metabolism | MicroRNAs - agonists | Protein-Serine-Threonine Kinases - metabolism | Receptors, Calcitriol - antagonists & inhibitors | Green Fluorescent Proteins - metabolism | Muscle, Skeletal - enzymology | Mitochondria, Muscle - enzymology | Signal Transduction | Cells, Cultured | Gene Expression Regulation | Oxidative Phosphorylation | Protein-Serine-Threonine Kinases - genetics | Receptors, Calcitriol - metabolism | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Receptors, Calcitriol - agonists | Protein Processing, Post-Translational | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - genetics | Gene Regulation | 1,25-dihydroxyvitamin D3 | RNA-seq | WTSS | oxygen consumption | mitochondria | vitamin D | cell signaling | skeletal muscle | gene expression
Journal Article
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, ISSN 0960-0760, 07/2017, Volume 171, pp. 144 - 154
As a continuation of our efforts directed to the structure-activity relationship studies of vitamin D compounds, we present in this paper the synthesis of new... 
Secosteroids | D-seco vitamin D | MECHANISM | Vitamin D receptor | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-D-RECEPTOR | Vitamin D analogues | NUCLEAR RECEPTOR | 19-Norvitamin D | LIGANDS | ENDOCRINOLOGY & METABOLISM | 1,25-DIHYDROXYVITAMIN-D | Cellular differentiation | Transcriptional activity | Vitamin D3 24-Hydroxylase - genetics | Stereoisomerism | Weaning | Humans | Molecular Conformation | Vitamin D Deficiency - drug therapy | Male | Structure-Activity Relationship | Calcitriol - therapeutic use | Gastrointestinal Agents - chemistry | Receptors, Calcitriol - genetics | Calcitriol - analogs & derivatives | Drug Design | Vitamin D3 24-Hydroxylase - chemistry | Calcitriol - metabolism | Bone Density Conservation Agents - metabolism | Binding Sites | Vitamin D3 24-Hydroxylase - metabolism | Bone Density Conservation Agents - chemistry | Recombinant Proteins - metabolism | Bone Density Conservation Agents - therapeutic use | Models, Molecular | Recombinant Proteins - chemistry | Calcitriol - chemistry | Receptors, Calcitriol - metabolism | Rats, Sprague-Dawley | Bone Density Conservation Agents - pharmacology | Gastrointestinal Agents - pharmacology | Animals | Cell Differentiation - drug effects | Receptors, Calcitriol - agonists | Calcitriol - pharmacology | Gastrointestinal Agents - therapeutic use | HL-60 Cells | Genes, Reporter - drug effects | Ligands | Molecular Docking Simulation | Gastrointestinal Agents - metabolism
Journal Article