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BBA - Molecular Cell Research, ISSN 0167-4889, 08/2019, Volume 1866, Issue 8, pp. 1249 - 1259
Intact store-operated calcium entry (SOCE) mechanisms ensure the maintenance of Ca homeostasis in cardiomyocytes while their dysregulation promotes the... 
Orai1 | Cavin-4 | STIM1 | MURC | Store-operated calcium entry | Cardiomyocyte
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 06/2018, Volume 217, Issue 6, pp. 1895 - 1897
STIM1 activates store-operated Ca2+ entry when Ca2+ in the endoplasmic reticulum (ER) is depleted. In this issue, Chang et al. (2018. J. Cell Biol.... 
LEAK | CHANNELS | CALCIUM-ENTRY | CELL BIOLOGY | Index Medicus | Commentaries
Journal Article
Cell Calcium, ISSN 0143-4160, 06/2019, Volume 80, pp. 1 - 7
Ca channels play an important role in the development of different types of cancer, and considerable progress has been made to understand the... 
ARC channels | Orai1 | Store-independent calcium entry | Cancer
Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5
The Orai1-STIM1 current undergoes slow Ca2+-dependent inactivation (SCDI) mediated by the binding of SARAF to STIM1. Here we report the use of SCDI by SARAF as... 
DOMAIN | ACTIVATION | FAST CA2+-DEPENDENT INACTIVATION | CALCIUM-ENTRY | STROMAL INTERACTION MOLECULE-1 | MULTIDISCIPLINARY SCIENCES | CRAC CHANNELS | PROTEINS | ER | STIM1-ORAI1 | PHOSPHOINOSITIDES
Journal Article
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 05/2009, Volume 360, Issue 19, pp. 1971 - 1980
A mutation in ORAI1, the gene encoding the pore-forming subunit of the Ca(sup 2+)-release-activated Ca(sup 2+) (CRAC) channel, abrogates the store-operated... 
CA2+ INFLUX | MEDICINE, GENERAL & INTERNAL | ACTIVATION | OPERATED CALCIUM-ENTRY | ORAI1 | T-CELL | STORE DEPLETION | SENSOR STIM1 | OLIGOMERIZATION | CRAC CHANNEL | LYMPHOCYTES
Journal Article
Nature Communications, ISSN 2041-1723, 07/2015, Volume 6, Issue 1, p. 7826
Store-operated Ca2+ entry mediated by STIM1 and ORAI1 constitutes one of the major Ca2+ entry routes in mammalian cells. The molecular choreography of... 
ACTIVATION | OPERATED CALCIUM-ENTRY | PROTEIN | ORAI CHANNELS | MECHANISTIC INSIGHTS | MULTIDISCIPLINARY SCIENCES | TRYPTOPHAN-SCANNING MUTAGENESIS | INTERACTION MOLECULE-1 STIM1 | CRAC CHANNELS | COILED-COIL | PLASMA-MEMBRANE
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 08/2001, Volume 91, Issue 2, pp. 973 - 983
The smooth muscle of arterioles responds to an increase in intraluminal pressure with vasoconstriction and with vasodilation when pressure is decreased. Such... 
Calcium signaling | Calcium entry | Myogenic response | Arterioles
Journal Article
NEURON, ISSN 0896-6273, 06/2008, Volume 58, Issue 6, pp. 871 - 883
Mutations in presenilins (PS) are the major cause of familial Alzheimer's disease (FAD) and have been associated with calcium (Ca2+) signaling abnormalities.... 
CAPACITATIVE CALCIUM-ENTRY | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-TYPE-1 | CORTICAL-NEURONS | LINKED MUTATIONS | IN-VIVO | AMYLOID-BETA-PROTEIN | ENDOPLASMIC-RETICULUM | PC12 CELLS | NEUROSCIENCES | TRANSGENIC MICE | MUTANT PRESENILINS
Journal Article
06/2010
Store-operated calcium entry (SOCE) is the major Ca2+ entry pathway in most non-excitable cells maintaining prolonged elevation of cytosolic Ca2+ levels... 
NMR | 0786 | STIM | 0487 | store-operated calcium entry | sterile alpha-motif | EF hand | structure | Orai | CRAC
Dissertation
11/2011
Optogenetics has emerged as a branch of biotechnology that combines genetic engineering with optics to observe intracellular changes as well as control... 
Store Operated Calcium Entry | 0541 | Protein Engineering | Fusion Proteins | Orai1 | Optogenetics | Stim1 | LOVS1K | Photo-activated | FRET Biosensors | Calcium Signaling
Dissertation
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 06/2006, Volume 103, Issue 24, pp. 9357 - 9362
Journal Article
Cell, ISSN 0092-8674, 06/2016, Volume 165, Issue 6, pp. 1454 - 1466
Maintaining homeostasis of Ca stores in the endoplasmic reticulum (ER) is crucial for proper Ca signaling and key cellular functions. The Ca -release-activated... 
OPERATED CALCIUM-ENTRY | STIM1 | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORAI1 | SENSOR | INOSITOL TRISPHOSPHATE | ENDOPLASMIC-RETICULUM STRESS | STORE DEPLETION | PLASMA-MEMBRANE | CRAC CHANNEL | CELL BIOLOGY
Journal Article
Cell Calcium, ISSN 0143-4160, 03/2019, Volume 78, pp. 66 - 75
Methylglyoxal (MG) is a by-product of glucose metabolism and its accumulation has been linked to the development of diabetic complications such as retinopathy... 
Methylglyoxal | Calcium entry | Calcium release activated calcium (CRAC) channels | Endothelial cells
Journal Article
Cellular Signalling, ISSN 0898-6568, 11/2019, Volume 63, pp. 109358 - 109358
Calcium influx via store-operated calcium entry (SOCE) has an important role for regulation of vast majority of cellular physiological events. MAPK signalling... 
Protease-activated receptor-2 | Tumor necrosis factor | p38 MAPK | Store-operated calcium entry | Muscarinic acetylcholine receptor | Index Medicus
Journal Article
Biochimica et Biophysica Acta - Molecular Cell Research, ISSN 0167-4889, 07/2019, Volume 1866, Issue 7, pp. 1239 - 1248
Skeletal muscle fibres support store-operated Ca -entry (SOCE) across the t-tubular membrane upon exhaustive depletion of Ca from the sarcoplasmic reticulum... 
Calcium | Electrical field stimulation | Excitation-contraction coupling | stim1 | Store-operated calcium entry | orai1 | Confocal microscopy | Skinned fibre | Skeletal muscle
Journal Article
Oncotarget, ISSN 1949-2553, 07/2019, Volume 10, Issue 43, pp. 4466 - 4478
Mantle Cell Lymphoma (MCL) is one of the worst lymphomas with a median overall survival of 3 to 4 years. Even if the use of rituximab was a great step in... 
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 01/2016, Volume 7, p. 10332
The etiology of idiopathic Parkinson's disease (idPD) remains enigmatic despite recent successes in identification of genes (PARKs) that underlie familial PD.... 
CAPACITATIVE CA2 | OPERATED CALCIUM-ENTRY | INDEPENDENT PHOSPHOLIPASE A | PLA2G6 MUTATIONS | CHAPERONE-MEDIATED AUTOPHAGY | MULTIDISCIPLINARY SCIENCES | ALPHA-SYNUCLEIN | DYSTONIA-PARKINSONISM | DOPAMINERGIC-NEURONS | MITOCHONDRIAL OXIDANT STRESS | INFANTILE NEUROAXONAL DYSTROPHY
Journal Article
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