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NATURE, ISSN 0028-0836, 05/2009, Volume 459, Issue 7245, pp. 446 - U167
Sodium-potassium ATPase is an ATP-powered ion pump that establishes concentration gradients for Na+ and K+ ions across the plasma membrane in all animal cells... 
PROTEIN STRUCTURES | NA,K-ATPASE BETA-SUBUNIT | ION-TRANSPORT | RECTAL GLANDS | ATPASE | MULTIDISCIPLINARY SCIENCES | CATION-BINDING | NA+,K+-ATPASE | CALCIUM-PUMP | SARCOPLASMIC-RETICULUM | OCCLUSION
Journal Article
Journal Article
Science, ISSN 0036-8075, 01/2016, Volume 351, Issue 6270, pp. 226 - 227
  A growing body of evidence shows that so-called long noncoding RNAs (lncRNAs) often produce short peptides from small open reading frames (s mORFs) . Whether... 
SARCOLIPIN | CALCIUM-PUMP | PHOSPHOLAMBAN | MULTIDISCIPLINARY SCIENCES | Heart | Proteins | Peptides | Ribonucleic acid--RNA
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 01/2013, Volume 110, Issue 5, pp. E358 - E367
Most P-type ATPases pump specific cations or heavy metals across a membrane to form ion gradients. However, the type IV P-type ATPases evolved the ability to... 
ACTIVATION | SODIUM | ATP8A2 | ATP8A1 | SPECIFICITY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | AMINOPHOSPHOLIPID TRANSLOCASE | IDENTIFICATION | PLASMA-MEMBRANE | YEAST | flippase | P4-ATPase | CALCIUM-PUMP
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 502, Issue 7470, pp. 201 - 206
Journal Article
Neuron, ISSN 0896-6273, 07/2004, Volume 43, Issue 2, pp. 169 - 175
Rapid-onset dystonia-parkinsonism (RDP, DYT12) is a distinctive autosomal-dominant movement disorder with variable expressivity and reduced penetrance... 
SYSTEM | DOMAIN | CA2+-ATPASE | NA,K-ATPASE | RESOLUTION | SARCOPLASMIC-RETICULUM | SCANNING MUTAGENESIS | CALCIUM-PUMP | FAMILIAL HEMIPLEGIC MIGRAINE | NEUROSCIENCES | SUBUNIT
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2012, Volume 586, Issue 19, pp. 3172 - 3178
We have identified 15 residues from the surface of sarcoplasmic reticulum Ca -pump ATPase, by mass spectrometry using diethylpyrocarbonate modification. The... 
Calcium pump | Ion transport | Solvent accessibility | ATPase
Journal Article
Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 9, pp. 1055 - 1060
Journal Article
QUARTERLY REVIEWS OF BIOPHYSICS, ISSN 0033-5835, 11/2010, Volume 43, Issue 4, pp. 501 - 566
The sarcoplasmic (SERCA 1a) Ca2+-ATPase is a membrane protein abundantly present in skeletal mucles where it functions as an indispensable component of the... 
CA2+ TRANSPORT ATPASE | ADP-INSENSITIVE PHOSPHOENZYME | BIOPHYSICS | P-TYPE ATPASES | TRANSMEMBRANE SEGMENTS 6 | RETICULUM CALCIUM-PUMP | DEPENDENT ADENOSINE-TRIPHOSPHATASE | NUCLEAR MAGNETIC-RESONANCE | NUCLEOTIDE-BINDING SITE | UNCOUPLED ATP HYDROLYSIS | CATALYZING OXIDATIVE PHOSPHORYLATION
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 08/2019, Volume 166, pp. 1 - 11
Research on flavonoids from plant sources has recently sparked increasing interest because of their beneficial health properties. Different studies have shown... 
Natural flavonoids | Plasma membrane calcium pump | Gossypin | Quercetin | Inhibition mechanism | ACTIVATION | MECHANISM | ACTIN | ATPASE | QUANTITATION | CA2 | CALMODULIN | DYNAMICS | PHARMACOLOGY & PHARMACY | CALCIUM-PUMP
Journal Article
Traffic (Copenhagen, Denmark), ISSN 1398-9219, 4/2017, Volume 18, Issue 4, pp. 232 - 241
Darier’s disease (DD) is an autosomal dominantly inherited skin disorder caused by mutations in SERCA2, a Ca 2+ pump that transports Ca 2+ from the cytosol to... 
ER-to-Golgi blockade | desmosomal cadherins | desmosomal adhesion | keratinocytes | Darier disease | SERCA2 calcium pump
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 05/2006, Volume 103, Issue 19, pp. 7500 - 7505
L-type Ca2+ channels play a critical role in regulating Ca2+-dependent signaling in cardiac myocytes, including excitation-contraction coupling; however, the... 
INDUCED HEART-FAILURE | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | CARDIOMYOCYTE CAVEOLAE | RECEPTOR | VENTRICULAR MYOCYTES | PLASMA-MEMBRANE | electrophysiology | ADENYLYL-CYCLASE | KINASE-C ISOFORMS | LIPID RAFTS | ventricular myocyte | CALCIUM-PUMP | caveolae
Journal Article
Journal of BioScience and Biotechnology, ISSN 1314-6238, 08/2017, Volume 6, Issue 2, pp. 111 - 117
Sickle cell disease is a red blood cells disorder, which affects millions of people in the world. One of its clinical manifestations is cation fluxes. Although... 
Sickle Cell Disease | Calcium Pump | Antisickling agents
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 48, pp. 19656 - 19673
Calcium (Ca2+) is a fundamental regulator of cell signaling and function. Thapsigargin (Tg) blocks the sarco/endoplasmic reticulum (ER) Ca2+-ATPase (SERCA),... 
calcium | CANCER CELLS | CALPAIN | unfolded protein response (UPR) | PROSTATE-SPECIFIC ANTIGEN | INTRACELLULAR CALCIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | SARCOPLASMIC-RETICULUM | INACTIVATION | stromal interaction molecule 1 (STIM1) | PRODRUG | endoplasmic reticulum (ER) | CALCIUM-PUMP | STRESS | Cell Biology
Journal Article
Interdisciplinary Toxicology, ISSN 1337-6853, 03/2013, Volume 6, Issue 1, pp. 3 - 8
Journal Article
Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5996, pp. 1175 - 1180
Recent reports of increased tolerance to artemisinin derivatives—the most recently adopted class of antimalarials— have prompted a need for new treatments. The... 
Malaria | Artemisinins | RESEARCH ARTICLES | Genomics | Adenosine triphosphatases | Antimalarials | Parasites | Inhibitory concentration 50 | Drug resistance | Dosage | Genetic mutation | VIVAX | MULTIDISCIPLINARY SCIENCES | PARASITE PLASMODIUM-FALCIPARUM | ERADICATION | CALCIUM-PUMP | DRUG-RESISTANCE | SARCOPLASMIC-RETICULUM | ANTIMALARIALS | IDENTIFICATION | CHLOROQUINE | ARTEMISININ | Parasitic Sensitivity Tests | Humans | Male | Plasmodium falciparum - drug effects | Indoles - administration & dosage | Plasmodium falciparum - genetics | Protein Synthesis Inhibitors - pharmacology | Mutant Proteins - antagonists & inhibitors | Antimalarials - pharmacokinetics | Adenosine Triphosphatases - metabolism | Models, Molecular | Rats | Spiro Compounds - pharmacokinetics | Adenosine Triphosphatases - antagonists & inhibitors | Antimalarials - administration & dosage | Malaria - parasitology | Adenosine Triphosphatases - genetics | Mice | Mutation | Erythrocytes - parasitology | Plasmodium berghei - drug effects | Plasmodium vivax - growth & development | Protein Synthesis Inhibitors - chemistry | Rats, Wistar | Spiro Compounds - administration & dosage | Genes, Protozoan | Protozoan Proteins - genetics | Protein Synthesis Inhibitors - administration & dosage | Protozoan Proteins - metabolism | Female | Indoles - pharmacology | Protozoan Proteins - chemistry | Drug Resistance | Spiro Compounds - chemistry | Cell Line | Plasmodium vivax - drug effects | Mutant Proteins - metabolism | Drug Discovery | Protozoan Proteins - biosynthesis | Antimalarials - pharmacology | Protein Synthesis Inhibitors - pharmacokinetics | Animals | Mutant Proteins - chemistry | Antimalarials - chemistry | Adenosine Triphosphatases - chemistry | Indoles - pharmacokinetics | Malaria - drug therapy | Plasmodium falciparum - growth & development | Indoles - chemistry | Spiro Compounds - pharmacology | Research | Pharmacology | Inhibitor drugs | Drug therapy | Protein synthesis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2018, Volume 115, Issue 50, pp. 12722 - 12727
Ca2+-ATPase of sarcoplasmic reticulum (SERCA1a) pumps two Ca2+ per ATP hydrolyzed from the cytoplasm and two or three protons in the opposite direction. In the... 
Quantum chemical calculation | SERCA | Ion pump | Deprotonation | quantum chemical calculation | ATPASE | MULTIDISCIPLINARY SCIENCES | INHIBITION | SARCOPLASMIC-RETICULUM CA2+-ATPASE | SITES | SARCOLIPIN | ABSENCE | ion pump | CALCIUM-PUMP | BINDING | deprotonation | Biological Sciences
Journal Article