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Seminars in Immunology, ISSN 1044-5323, 2006, Volume 18, Issue 5, pp. 263 - 275
BAFF, APRIL and their receptors play important immunological roles, especially in the B cell arm of the immune system. A number of splice isoforms have been... 
Signaling | BAFF | B cells | Structure | Splice variants | MATURATION ANTIGEN | signaling | PROTEIN-KINASE | splice variants | COMMON VARIABLE IMMUNODEFICIENCY | LYMPHOCYTE STIMULATOR | T-CELL | IMMUNOLOGY | structure | TNF FAMILY | CELL-ACTIVATING FACTOR | NECROSIS-FACTOR FAMILY | NF-KAPPA-B | AUTOIMMUNE-DISEASE | B-Cell Activating Factor - physiology | Alternative Splicing | Humans | Substrate Specificity | Structure-Activity Relationship | Lymphocyte Subsets - immunology | Immunoglobulin Class Switching - physiology | Protein Kinase C-delta - antagonists & inhibitors | B-Cell Activating Factor - immunology | Tumor Necrosis Factor Ligand Superfamily Member 13 - chemistry | B-Cell Activation Factor Receptor - genetics | B-Cell Activation Factor Receptor - immunology | B-Cell Activation Factor Receptor - chemistry | Tumor Necrosis Factor Ligand Superfamily Member 13 - immunology | B-Lymphocytes - cytology | Transmembrane Activator and CAML Interactor Protein - chemistry | Signal Transduction | B-Cell Maturation Antigen - physiology | Lymphocyte Activation | B-Cell Activating Factor - chemistry | Tumor Necrosis Factor Ligand Superfamily Member 13 - physiology | Models, Molecular | B-Cell Activation Factor Receptor - physiology | Transmembrane Activator and CAML Interactor Protein - physiology | Protein Interaction Mapping | Transmembrane Activator and CAML Interactor Protein - genetics | Animals | B-Lymphocytes - immunology | B-Cell Activating Factor - genetics | NF-kappa B - physiology | Protein Conformation | Tumor Necrosis Factor Ligand Superfamily Member 13 - genetics | Mice | NF-kappa B p50 Subunit - physiology | Apoptosis - physiology | Transmembrane Activator and CAML Interactor Protein - immunology | Antigen Presentation - physiology
Journal Article
Annual Review of Immunology, ISSN 0732-0582, 2009, Volume 27, Issue 1, pp. 199 - 227
Sophisticated genetic tools have made possible the identification of the genes responsible for most well-described immunodeficiencies in the past 15 years.... 
Btk | Common variable immunodeficiency | TACI | X-linked agammaglobulinemia | Hyper-IgM syndrome | DISEASE GENE SH2D1A | INDUCED CYTIDINE DEAMINASE | common variable immunodeficiency | MAJOR HISTOCOMPATIBILITY COMPLEX | IMMUNOLOGY | hyper-IgM syndrome | BRUTONS TYROSINE KINASE | ANTIBODY-DEFICIENCY SYNDROME | CLASS-SWITCH RECOMBINATION | AUTOSOMAL RECESSIVE FORM | Inducible T-Cell Co-Stimulator Protein | CD79 Antigens - immunology | Protein-Tyrosine Kinases - metabolism | Humans | Precursor Cells, B-Lymphoid - metabolism | Precursor Cells, B-Lymphoid - immunology | Antigens, CD19 - genetics | Protein-Tyrosine Kinases - immunology | Transmembrane Activator and CAML Interactor Protein - metabolism | Protein-Tyrosine Kinases - genetics | Adaptor Proteins, Signal Transducing - immunology | Immunologic Deficiency Syndromes - immunology | B-Lymphocytes - metabolism | Antigens, CD19 - immunology | Antigens, Differentiation, T-Lymphocyte - immunology | Antigens, Differentiation, T-Lymphocyte - metabolism | CD79 Antigens - metabolism | Transmembrane Activator and CAML Interactor Protein - genetics | Animals | B-Lymphocytes - immunology | Adaptor Proteins, Signal Transducing - genetics | Antigens, Differentiation, T-Lymphocyte - genetics | Immunologic Deficiency Syndromes - genetics | Antigens, CD19 - metabolism | CD79 Antigens - genetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Transmembrane Activator and CAML Interactor Protein - immunology | Genetic aspects | B cells | Properties | Identification and classification | Immunodeficiency | Immunological research
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 07/2009, Volume 9, Issue 7, pp. 491 - 502
Journal Article
Blood, ISSN 0006-4971, 2015, Volume 125, Issue 11, pp. 1749 - 1758
Subjects with common variable immune deficiency may have mutations in transmembrane activator calcium modulator and cyclophilin ligand interactor (TACI).... 
B-CELLS | BLIMP-1 | TRANSMEMBRANE ACTIVATOR | MARGINAL ZONE | BONE-MARROW | COMMON VARIABLE IMMUNODEFICIENCY | CALCIUM MODULATOR | RECEPTOR | MUTATIONS | LIGAND | HEMATOLOGY | Common Variable Immunodeficiency - immunology | Alternative Splicing | Humans | Precursor Cells, B-Lymphoid - metabolism | B-Lymphocyte Subsets - cytology | Precursor Cells, B-Lymphoid - immunology | RNA, Messenger - metabolism | X-Box Binding Protein 1 | Transmembrane Activator and CAML Interactor Protein - metabolism | Protein Isoforms - metabolism | B-Lymphocyte Subsets - immunology | Plasma Cells - metabolism | Cell Differentiation | Recombinant Proteins - metabolism | Mutagenesis, Site-Directed | Transduction, Genetic | Signal Transduction | RNA, Messenger - genetics | Repressor Proteins - genetics | Common Variable Immunodeficiency - genetics | Recombinant Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Transmembrane Activator and CAML Interactor Protein - genetics | Animals | Common Variable Immunodeficiency - metabolism | B-Lymphocyte Subsets - metabolism | Recombinant Proteins - immunology | Transcription Factor RelA - metabolism | Precursor Cells, B-Lymphoid - cytology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Protein Isoforms - immunology | Myeloid Differentiation Factor 88 - metabolism | Transmembrane Activator and CAML Interactor Protein - immunology | Plasma Cells - cytology | Plasma Cells - immunology | Positive Regulatory Domain I-Binding Factor 1 | Protein Isoforms - genetics | Immunobiology | 102
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2015, Volume 194, Issue 2, pp. 542 - 552
Journal Article
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 07/2016, Volume 291, Issue 29, pp. 15292 - 15306
The GET (guided entry of tail-anchored proteins)/TRC (transmembrane recognition complex) pathway for tail-anchored protein targeting to the endoplasmic... 
ENDOPLASMIC-RETICULUM MEMBRANE | TRANSLOCATION | COMPLEX | CAML | ACTIVATED T-CELLS | TARGETING FACTOR | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODULATING CYCLOPHILIN LIGAND | ER MEMBRANE | PHOSPHOLIPID-BILAYERS
Journal Article
Oncogene, ISSN 0950-9232, 06/2007, Volume 26, Issue 27, pp. 3972 - 3979
ABT-737 is a subnanomolar inhibitor of the antiapoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w. Although ABT-737 triggers extensive cell death in many small-cell... 
ABT-737 | Mcl-1 | siRNA | Off-target | Bcl-X | Seed | Niacinamide - analogs & derivatives | Lung Neoplasms - drug therapy | RNA, Small Interfering - genetics | Carcinoma, Small Cell - genetics | Proto-Oncogene Proteins c-bcl-2 - physiology | Receptor, Fibroblast Growth Factor, Type 2 | Humans | Neoplasm Proteins - physiology | 3' Untranslated Regions - genetics | Cell Survival - genetics | Lung Neoplasms - pathology | Phenylurea Compounds | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Benzenesulfonates - pharmacology | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | bcl-X Protein - antagonists & inhibitors | Base Sequence | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Cell Survival - physiology | Lung Neoplasms - genetics | Cell Survival - drug effects | Purines - pharmacology | Carcinoma, Small Cell - drug therapy | DNA-Binding Proteins - genetics | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Transmembrane Activator and CAML Interactor Protein - genetics | Drug Resistance, Neoplasm - genetics | Myeloid Cell Leukemia Sequence 1 Protein | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Zinc Fingers - genetics | Pyridines - pharmacology | Carcinoma, Small Cell - pathology | Proto-Oncogene Proteins c-bcl-2 - genetics | Drug Resistance, Neoplasm - drug effects | Gene silencing | Genetic aspects | Research | Methods | Cancer | Inhibitor drugs | Ribonucleic acid | Oncology | Drug resistance | Ribonucleic acid--RNA | Apoptosis | Tumors
Journal Article
Blood, ISSN 0006-4971, 04/2007, Volume 109, Issue 7, pp. 2961 - 2967
Journal Article