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FEBS Letters, ISSN 0014-5793, 10/2011, Volume 585, Issue 20, pp. 3289 - 3296
► Linalool is an aromatic monoterpene abundant in teas and essential oils. ► Linalool feeding significantly lowered LDL cholesterol concentrations in mice. ►... 
Ubiquitination | HMG-CoA reductase | Cholesterol | Sterol regulatory element binding protein-2 | SREBP-2 | HFD | SRE | HMGCR | ChIP | chromatin immunoprecipitation | sterol regulatory element binding protein-2 | S1P | site-2 protease | LDL | cAMP responsive element | sterol regulatory element | CYP | 25-HC | cytochrome P450 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | low-density lipoprotein | S2P | 25-hydroxycholesterol | high-fat diet | CRE | P300/CBP-associated factor | site-1 protease | coronary heart disease | PCAF | CHD | RANDOMIZED CONTROLLED-TRIALS | METAANALYSIS | ESSENTIAL OILS | LIPID-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | (-)-LINALOOL | CELL BIOLOGY | CHOLESTEROL-METABOLISM | GREEN TEA | BIOPHYSICS | FEEDBACK-REGULATION | DEGRADATION | MICE | Insecticides - pharmacology | Gene Expression Regulation, Enzymologic - drug effects | Response Elements | Cholesterol - blood | Humans | Ubiquitin - metabolism | Male | Ubiquitin - genetics | Hydroxymethylglutaryl CoA Reductases - biosynthesis | Hep G2 Cells | Monoterpenes - pharmacology | Proteolysis - drug effects | Animals | Gene Expression Regulation, Enzymologic - genetics | Mice | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Hydroxymethylglutaryl CoA Reductases - genetics | Anticholesteremic Agents - pharmacology | Lipoproteins, LDL - blood | Proteases | Proteolysis | Low density lipoproteins | Cytochrome P-450 | Chemical properties | Coronary heart disease | Trans fatty acids | Protein binding
Journal Article
Journal Article
Diabetes, ISSN 0012-1797, 2006, Volume 55, Issue 8, pp. 2220 - 2230
cAMP-responsive element-binding protein (CREB) is required for beta-cell survival by regulating expression of crucial genes such as bcl-2 and IRS-2. Using MIN6... 
Protein kinase A | DMEM | Glucagon-like peptide-1 | CREB | GLP-1 | cAMP-responsive element-binding protein | PKA | Extracellular signal-regulated kinase | Dulbecco's modified Eagle's medium | ERK | siRNA, small interfering RNA | APOPTOSIS | HUMAN ISLETS | ACTIVATION | PATHWAY | LINE | ENDOCRINOLOGY & METABOLISM | MECHANISMS | INSULIN GENE-TRANSCRIPTION | SECRETION | REGULATED KINASES | LANGERHANS | RNA, Small Interfering - genetics | Phosphorylation | Rats, Wistar | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | RNA, Messenger - analysis | Male | CREB-Binding Protein - metabolism | Isoquinolines - pharmacology | Transfection | Mitogen-Activated Protein Kinase 1 - genetics | Proto-Oncogene Proteins c-bcl-2 - analysis | Flavonoids - pharmacology | Islets of Langerhans - ultrastructure | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cell Line | Microscopy, Electron, Transmission | Gene Expression | Islets of Langerhans - physiology | Mitogen-Activated Protein Kinase 1 - physiology | Mitogen-Activated Protein Kinase 3 - genetics | Cell Survival | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Rats | Glucose - pharmacology | Sulfonamides - pharmacology | Genes, bcl-2 - genetics | Mitogen-Activated Protein Kinase 3 - physiology | Cyclic AMP-Dependent Protein Kinases - physiology | Animals | CREB-Binding Protein - analysis | Protein Kinase Inhibitors - pharmacology | Apoptosis | Isoquinolines | Glucose | Life Sciences | Endocrinology and metabolism | Cyclic AMP-Dependent Protein Kinases | CREB-Binding Protein | Genes, bcl-2 | Human health and pathology | Protein Kinase Inhibitors | Flavonoids | Sulfonamides | RNA, Small Interfering | Islets of Langerhans | Proto-Oncogene Proteins c-bcl-2 | Mitogen-Activated Protein Kinase 1 | RNA, Messenger | Mitogen-Activated Protein Kinase 3
Journal Article
Neurochemical Research, ISSN 0364-3190, 8/2017, Volume 42, Issue 8, pp. 2230 - 2245
By taking advantage of a “floxed” conditional CREB mutant mouse (CREB1loxP/loxP), in which postnatal deletion of the Creb gene in the forebrain is driven by... 
Neurochemistry | Biochemistry, general | Neurology | Neurosciences | Biomedicine | Astroglia | cAMP responsive-element binding (CREB) | Neuroinflammation | S100B | Hippocampus | Cell Biology | Microglia | TRANSCRIPTION FACTORS | TRIMETHYLTIN-INDUCED NEURODEGENERATION | LONG-TERM-MEMORY | TEMPORAL-LOBE EPILEPSY | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | QUANTITATIVE-ANALYSIS | NEUROSCIENCES | COGNITIVE FUNCTION | NETWORK OSCILLATIONS | RAT HIPPOCAMPUS | HUNTINGTONS-DISEASE | Inflammation - pathology | Microglia - metabolism | Neurons - pathology | Age Factors | Astrocytes - pathology | Atrophy - pathology | Male | Mice, Transgenic | Hippocampus - pathology | Mice, Knockout | Cyclic AMP Response Element-Binding Protein - genetics | Hippocampus - metabolism | Inflammation - metabolism | Animals | Gene Deletion | Atrophy - genetics | Inflammation Mediators - metabolism | Inflammation - genetics | Microglia - pathology | Mice | Neurons - metabolism | Atrophy - metabolism | Cyclic AMP Response Element-Binding Protein - deficiency | Astrocytes - metabolism | Brain | Cyclic adenylic acid | RNA | Neurons | Calcium | Forebrain | S100b protein | mRNA | Regulatory sequences | Gene deletion | Kinases | Alterations | Pathways | Clonal deletion | Rodents | Calcium-binding protein | Deletion | Microglial cells | Calmodulin | Astrocytes | Glial fibrillary acidic protein | Inflammation | Shrinkage | Cyclic AMP response element-binding protein | Gene expression | Gliosis | Ca2+/calmodulin-dependent protein kinase II
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2012, Volume 32, Issue 11, pp. 2670 - 2677
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 12/2011, Volume 44, Issue 3, pp. 330 - 349
In neurons, the convergence of multiple intracellular signaling cascades leading to cAMP-responsive element-binding protein (CREB) activation suggests that... 
Neurology | Neurosciences | Biomedicine | CREB | Neuronal plasticity | Memory | Neurobiology | Transgenic mice | Virus-mediated expression | Cell Biology | HIPPOCAMPAL SYNAPTIC PLASTICITY | LONG-TERM-MEMORY | ELEMENT-BINDING-PROTEIN | CAMP-RESPONSIVE ELEMENT | CONSTITUTIVELY ACTIVE FORM | NUCLEUS-ACCUMBENS NEURONS | NEUROSCIENCES | CA1 PYRAMIDAL NEURONS | VIRAL-MEDIATED EXPRESSION | FAMILY TRANSCRIPTION FACTORS | OCULAR DOMINANCE PLASTICITY | Amino Acid Sequence | Gene Targeting | Cyclic AMP Response Element-Binding Protein - chemistry | Animals, Genetically Modified | Humans | Gene Expression Regulation | Molecular Sequence Data | Gene Knockdown Techniques | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Neuronal Plasticity - physiology | Cyclic AMP Response Element-Binding Protein - metabolism | Neurons - physiology | Protein Conformation | Transcription, Genetic | Genetic Vectors | Memory - physiology | Genetically modified animals | Embryonic development | Neurons | Genes | Genetic research | Gene expression | Health aspects | Investigations | Genetics | Transgenic animals | Rodents | Brain | Transcription factors | Cell survival | Electrophysiology | Excitability | Intracellular signalling | Nervous system | Cyclic AMP response element-binding protein | Convergence | Plasticity (neural) | Embryogenesis | Plasticity (synaptic) | Reviews | Long term memory | Neurons and Cognition | Life Sciences | Neuronal Plasticity | Cyclic AMP Response Element-Binding Protein
Journal Article
American Journal of Translational Research, ISSN 1943-8141, 2015, Volume 7, Issue 10, pp. 2053 - 2059
Background: MicroRNAs (miRNA) have been documented playing critical roles in cancer progression. Aberrant expression of miR-205 has been reported in several... 
miR-205 | Colorectal cancer | CAMP responsive element binding protein 1 | MEDICINE, RESEARCH & EXPERIMENTAL | METASTASIS | cAMP responsive element binding protein 1 | ONCOLOGY | CELL-GROWTH | EXPRESSION
Journal Article
Neuroscience, ISSN 0306-4522, 2008, Volume 157, Issue 3, pp. 644 - 655
Abstract Histone deacetylase (HDAC) plays an important role in chromatin remodeling in response to a variety of neurochemical signalings and behavioral... 
Neurology | amphetamine | butyric acid | valproic acid | histone deacetylase | cAMP responsive element binding protein | chromatin immunoprecipitation | NERVOUS-SYSTEM | C-FOS | GLYCOGEN-SYNTHASE KINASE-3 | COCAINE REWARD | NEUROSCIENCES | CREB | GENE-EXPRESSION | MOOD STABILIZER | PROMOTER | TRANSCRIPTION FACTOR
Journal Article
MOLECULAR NUTRITION & FOOD RESEARCH, ISSN 1613-4125, 07/2010, Volume 54, Issue 7, pp. 918 - 928
Multidrug resistance (MDR) is a major obstacle in cancer chemotherapy and its inhibition is an effective way to reverse cancer drug resistance. In the present... 
PHOSPHORYLATION | FOOD SCIENCE & TECHNOLOGY | DOWN-REGULATION | P-GLYCOPROTEIN EXPRESSION | AMP-activated protein kinase | Puerarin | Nuclear factor kappa-B | MEDIATED INDUCTION | INHIBITION | cAMP responsive element | LIVER | MULTIPLE-DRUG RESISTANCE | GENE-EXPRESSION | Multidrug resistance 1 | MULTIDRUG-RESISTANCE | BINDING
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2315 - 11
Journal Article