X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
camp-specific phosphodiesterase (381) 381
animals (243) 243
humans (233) 233
biochemistry & molecular biology (150) 150
index medicus (139) 139
cyclic nucleotide phosphodiesterases, type 4 (111) 111
pharmacology & pharmacy (109) 109
cyclic amp - metabolism (104) 104
3',5'-cyclic-amp phosphodiesterases - metabolism (98) 98
phosphodiesterase inhibitors - pharmacology (92) 92
phosphodiesterase (88) 88
rolipram (84) 84
male (76) 76
phosphorylation (76) 76
expression (74) 74
camp (73) 73
cyclic-nucleotide phosphodiesterases (72) 72
rats (72) 72
dependent protein-kinase (71) 71
cyclic-nucleotide phosphodiesterase (66) 66
cell biology (65) 65
3',5'-cyclic-amp phosphodiesterases - genetics (64) 64
3',5'-cyclic-amp phosphodiesterases - antagonists & inhibitors (62) 62
mice (61) 61
signal transduction (61) 61
molecular sequence data (59) 59
messenger-rna (57) 57
molecular-cloning (57) 57
cyclic nucleotide phosphodiesterases, type 4 - metabolism (56) 56
amino acid sequence (53) 53
activation (52) 52
phosphoric diester hydrolases - metabolism (51) 51
isoenzymes - metabolism (48) 48
neurosciences (48) 48
pde4 (44) 44
camp-specific phosphodiesterases (43) 43
cyclic amp (43) 43
cyclic amp-dependent protein kinases - metabolism (41) 41
phosphodiesterases (40) 40
cells, cultured (39) 39
protein-kinase (39) 39
isoenzymes - genetics (37) 37
protein binding (37) 37
amp-specific phosphodiesterase (36) 36
identification (36) 36
female (33) 33
kinetics (33) 33
base sequence (32) 32
cell line (32) 32
cells (32) 32
inhibitors (32) 32
3',5'-cyclic-amp phosphodiesterases - chemistry (31) 31
gene expression (31) 31
phosphodiesterase inhibitors - therapeutic use (31) 31
protein-kinase-a (31) 31
binding (30) 30
article (28) 28
catalytic domain (28) 28
cyclic nucleotide phosphodiesterases, type 4 - genetics (28) 28
nucleotide phosphodiesterases (28) 28
cloning (27) 27
enzyme inhibitors - pharmacology (27) 27
family (27) 27
gene (27) 27
rolipram - pharmacology (27) 27
brain (26) 26
cgmp (26) 26
cyclic-amp (26) 26
map kinase (26) 26
protein structure, tertiary (26) 26
rats, sprague-dawley (26) 26
analysis (25) 25
biophysics (25) 25
drosophila-melanogaster (25) 25
protein (25) 25
asthma (24) 24
beta-arrestin (24) 24
binding sites (24) 24
chemistry, medicinal (24) 24
cgmp-specific phosphodiesterase (23) 23
cloning, molecular (23) 23
cyclic adenylic acid (23) 23
cyclic nucleotide phosphodiesterases, type 3 (23) 23
in-vitro (23) 23
phosphoric diester hydrolases - genetics (23) 23
splice variants (23) 23
cyclic gmp - metabolism (22) 22
enzymes (22) 22
physiological aspects (22) 22
rat-brain (22) 22
dose-response relationship, drug (21) 21
endocrinology & metabolism (21) 21
sequence homology, amino acid (21) 21
inhibition (20) 20
phosphodiesterase inhibitors - chemistry (20) 20
proteins (20) 20
research (20) 20
reverse transcriptase polymerase chain reaction (20) 20
structure-activity relationship (20) 20
blotting, western (19) 19
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Biotechnology, ISSN 1087-0156, 01/2010, Volume 28, Issue 1, pp. 63 - 70
Phosphodiesterase 4 (PDE4), the primary cAMP-hydrolyzing enzyme in cells, is a promising drug target for a wide range of conditions. Here we present seven... 
CAMP-SPECIFIC PHOSPHODIESTERASE | PHOSPHORYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROTEIN-KINASE | GENE COMPOSER | SUNCUS-MURINUS | AMP-SPECIFIC PHOSPHODIESTERASE | INHIBITORS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | ROLIPRAM BINDING | ANTIDEPRESSANT DRUGS | Phosphodiesterase Inhibitors - therapeutic use | Phosphodiesterase Inhibitors - adverse effects | Humans | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Benzhydryl Compounds - chemistry | Benzhydryl Compounds - adverse effects | Phenylurea Compounds - adverse effects | Phenylurea Compounds - chemistry | Drug Design | Phosphodiesterase 4 Inhibitors | Behavior, Animal - drug effects | Biological Assay | Phosphodiesterase Inhibitors - chemistry | Benzhydryl Compounds - therapeutic use | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Disease Models, Animal | Allosteric Regulation - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Catalytic Domain | Models, Molecular | Phenylurea Compounds - therapeutic use | Phosphodiesterase Inhibitors - pharmacology | Vomiting - drug therapy | Cognition - drug effects | Animals | Benzhydryl Compounds - pharmacology | Mice | Phenylurea Compounds - pharmacology | Kinetics | Care and treatment | Schizophrenia | Physiological aspects | Genetic aspects | Cellular signal transduction | Cyclic adenylic acid | Research | Phosphodiesterases | Enzymes | Biotechnology | Cellular biology | Molecular biology | Cognitive ability | Crystal structure | Index Medicus
Journal Article
Oral Diseases, ISSN 1354-523X, 01/2015, Volume 21, Issue 1, pp. e25 - e50
By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical... 
protein kinase A (PKA) | phosphodiesterase (PDE) | A‐kinase anchoring protein (AKAP) | signalosome | oral and systemic diseases | cancer | cAMP | Phosphodiesterase (PDE) | Signalosome | A-kinase anchoring protein (AKAP) | Protein kinase A (PKA) | Oral and systemic diseases | Cancer | BONE MORPHOGENETIC PROTEIN-2 | MULTIPLE MOLECULAR-FORMS | GLUCOCORTICOID-INDUCED OSTEOPOROSIS | ROD CGMP PHOSPHODIESTERASE | OBSTRUCTIVE PULMONARY-DISEASE | DENTISTRY, ORAL SURGERY & MEDICINE | CHRONIC LYMPHOCYTIC-LEUKEMIA | DUCHENNE MUSCULAR-DYSTROPHY | TYPE-2 DIABETES-MELLITUS | CAMP-SPECIFIC PHOSPHODIESTERASES | STATIONARY NIGHT BLINDNESS | 3',5'-Cyclic-GMP Phosphodiesterases - drug effects | Phosphodiesterase Inhibitors - therapeutic use | Animals | Signal Transduction - drug effects | 3',5'-Cyclic-GMP Phosphodiesterases - physiology | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | 3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors | Humans | Phosphodiesterase Inhibitors - pharmacology | 3',5'-Cyclic-AMP Phosphodiesterases - drug effects | Signal Transduction - physiology | 3',5'-Cyclic-AMP Phosphodiesterases - physiology | Medical research | Enzymes | Oral diseases | Mutation | Rodents | Crystal structure | Protein Kinase A | Phosphodiesterase | A Kinase Anchoring Protein | Oral and Systemic Diseases | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | protein (AKAP) | Clinical Medicine | Endokrinologi och diabetes | A-kinase anchoring | Endocrinology and Diabetes
Journal Article