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Journal of clinical oncology, ISSN 0732-183X, 05/2008, Volume 26, Issue 14, pp. 2311 - 2319
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Tumors | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Antibodies, Monoclonal, Humanized | Neoplasm Metastasis | Organoplatinum Compounds - administration & dosage | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Camptothecin - administration & dosage | Female | Cetuximab | Camptothecin - analogs & derivatives | Camptothecin - adverse effects | Receptor, Epidermal Growth Factor - biosynthesis | Camptothecin - therapeutic use | Pyrimidines - administration & dosage | Disease-Free Survival | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pyrimidines - adverse effects | Quality of Life | Aged | Colorectal Neoplasms - pathology | Organoplatinum Compounds - adverse effects | Index Medicus | Camptothecin | Organoplatinum Compounds | Antineoplastic Combined Chemotherapy Protocols | Antibodies, Monoclonal | Life Sciences | Pyrimidines | Immunology | Colorectal Neoplasms | Receptor, Epidermal Growth Factor
Journal Article
The New England journal of medicine, ISSN 0028-4793, 10/2014, Volume 371, Issue 17, pp. 1609 - 1618
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | General aspects | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Immunomodulators | Tumors | Follow-Up Studies | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Bevacizumab | Fluorouracil - therapeutic use | Antibodies, Monoclonal, Humanized - administration & dosage | Leucovorin - adverse effects | Fluorouracil - adverse effects | Neoplasm Metastasis - drug therapy | Colorectal Neoplasms - drug therapy | Adult | Female | Leucovorin - therapeutic use | Liver Neoplasms - secondary | Camptothecin - analogs & derivatives | Colorectal Neoplasms - mortality | Antibodies, Monoclonal, Humanized - adverse effects | Camptothecin - adverse effects | Camptothecin - therapeutic use | Kaplan-Meier Estimate | Liver Neoplasms - drug therapy | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Colorectal Neoplasms - pathology | Organoplatinum Compounds - therapeutic use | Organoplatinum Compounds - adverse effects | Treatment outcome | Care and treatment | Analysis | Colorectal cancer | Dosage and administration | Leucovorin | Fluorouracil | Colorectal carcinoma | Diarrhea | Metastasis | Survival | Patients | Clinical outcomes | Metastases | Irinotecan | Stomatitis | Chemotherapy | Neurotoxicity | Oxaliplatin | Monoclonal antibodies | Vascular endothelial growth factor | Neutropenia | Index Medicus | Abridged Index Medicus
Journal Article
Nature nanotechnology, ISSN 1748-3387, 08/2019, Volume 14, Issue 8, pp. 799 - 809
Science & Technology - Other Topics | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology | Camptothecin - pharmacokinetics | Neoplasms - metabolism | Camptothecin - metabolism | Drug Carriers - metabolism | Camptothecin - therapeutic use | Humans | gamma-Glutamyltransferase - metabolism | Mice, Inbred ICR | Drug Delivery Systems | Neoplasms - drug therapy | Antineoplastic Agents, Phytogenic - administration & dosage | Animals | Cell Line, Tumor | Camptothecin - administration & dosage | Female | Antineoplastic Agents, Phytogenic - metabolism | Mice | Mice, Inbred BALB C | Transcytosis | Antineoplastic Agents, Phytogenic - therapeutic use | Antineoplastic Agents, Phytogenic - pharmacokinetics | Polymers - metabolism | Camptothecin | Conjugates | Animal models | Drug delivery systems | Amines | Gemcitabine | g-Glutamyltransferase | Caveolae | Blood vessels | Drug delivery | Cell membranes | Endothelial cells | Anticancer properties | Endocytosis | Penetration | Diffusion barriers | Solid tumors | Polymers | Pancreas | Tumors | Index Medicus
Journal Article
Science translational medicine, ISSN 1946-6234, 12/2020, Volume 12, Issue 572
Journal Article
ACS nano, ISSN 1936-0851, 09/2017, Volume 11, Issue 9, pp. 8838 - 8848
self-assembly | camptothecin prodrug | drug delivery | nanostructures | albumin | Physical Sciences | Chemistry | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology - Other Topics | Chemistry, Multidisciplinary | Chemistry, Physical | Science & Technology | Prodrugs - administration & dosage | Camptothecin - chemistry | Nanoparticles - chemistry | Humans | Surface-Active Agents - pharmacokinetics | Prodrugs - chemistry | Drug Delivery Systems | Antineoplastic Agents, Phytogenic - administration & dosage | Camptothecin - blood | Camptothecin - administration & dosage | Female | Antineoplastic Agents, Phytogenic - pharmacokinetics | Antineoplastic Agents, Phytogenic - blood | Camptothecin - pharmacokinetics | Oxidation-Reduction | HCT116 Cells | Solubility | Antineoplastic Agents, Phytogenic - chemistry | Nanoconjugates - administration & dosage | Neoplasms - drug therapy | Animals | Prodrugs - pharmacokinetics | Mice, Nude | Mice | Surface-Active Agents - chemistry | Nanoconjugates - chemistry | Index Medicus
Journal Article
ACS nano, ISSN 1936-0851, 02/2016, Volume 10, Issue 2, pp. 2702 - 2715
FOLFIRINOX | pancreatic cancer | toxicity reduction | irinotecan | mesoporous silica nanoparticle | proton gradient | lipid bilayer | Camptothecin - pharmacokinetics | Camptothecin - adverse effects | Nanoparticles - chemistry | Silicon Dioxide - chemistry | Nanoparticles - adverse effects | Adenocarcinoma - drug therapy | Liposomes - adverse effects | Pancreatic Neoplasms - drug therapy | Antineoplastic Agents, Phytogenic - administration & dosage | Liposomes - chemistry | Animals | Cell Line, Tumor | Drug Liberation | Camptothecin - administration & dosage | Female | Mice | Lipid Bilayers - chemistry | Antineoplastic Agents, Phytogenic - pharmacokinetics | Antineoplastic Agents, Phytogenic - adverse effects | Camptothecin - analogs & derivatives | Index Medicus
Journal Article
Investigational new drugs, ISSN 0167-6997, 8/2013, Volume 31, Issue 4, pp. 986 - 1000
Phase 1/2a | Solid tumor | Medicine & Public Health | Nanopharmaceutical | Oncology | Polymer conjugate camptothecin | Pharmacology/Toxicology | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | General aspects | Pharmacology. Drug treatments | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Antineoplastic agents | Tumors | Cellulose - blood | Immunohistochemistry | Cyclodextrins - adverse effects | Demography | Cellulose - therapeutic use | Area Under Curve | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Nanoparticles - adverse effects | Cyclodextrins - therapeutic use | Dose-Response Relationship, Drug | Nanoparticles - therapeutic use | Camptothecin - blood | Cellulose - pharmacokinetics | Adult | Female | Cellulose - adverse effects | Camptothecin - pharmacokinetics | Camptothecin - adverse effects | Camptothecin - therapeutic use | Cyclodextrins - pharmacokinetics | Treatment Outcome | Neoplasms - diagnostic imaging | Neoplasms - drug therapy | Disease-Free Survival | Maximum Tolerated Dose | Cyclodextrins - blood | Biopsy | Aged | Neoplasm Staging | Neoplasms - pathology | Camptothecin | Complications and side effects | Dosage and administration | Drug therapy | Studies | Research | Cancer therapies | Pharmaceutical sciences | Index Medicus | Phase 1 | 2a
Journal Article
Cancer, ISSN 0008-543X, 10/2017, Volume 123, Issue 19, pp. 3843 - 3854
clinical trial | trophoblastic cell‐surface antigen (Trop‐2) | epithelial cancers | antibody‐drug conjugate | IMMU‐132 (sacituzumab govitecan) | SN‐38 | trophoblastic cell-surface antigen (Trop-2) | SN-38 | antibody-drug conjugate | IMMU-132 (sacituzumab govitecan) | Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - metabolism | Humans | Middle Aged | Half-Life | Immunoconjugates - pharmacokinetics | Male | Response Evaluation Criteria in Solid Tumors | Immunoconjugates - administration & dosage | Glucuronosyltransferase - genetics | Antineoplastic Agents, Phytogenic - administration & dosage | Antibodies, Monoclonal, Humanized - administration & dosage | Time Factors | Antibodies, Monoclonal, Humanized - pharmacokinetics | Camptothecin - blood | Aged, 80 and over | Antigens, Neoplasm - metabolism | Adult | Camptothecin - administration & dosage | Female | Neutropenia - chemically induced | Antineoplastic Agents, Phytogenic - pharmacokinetics | Antineoplastic Agents, Phytogenic - adverse effects | Camptothecin - analogs & derivatives | Immunoconjugates - adverse effects | Camptothecin - pharmacokinetics | Antibodies, Monoclonal, Humanized - adverse effects | Camptothecin - adverse effects | Cell Adhesion Molecules - metabolism | Neoplasms - drug therapy | Irinotecan | Aged | Immunoglobulin G - metabolism | Usage | Care and treatment | Safety and security measures | Analysis | Epithelial tumors | Pharmacokinetics | Antibody-drug conjugates | Camptothecin | Antigens | Toxicity | Immunoglobulin G | Breast cancer | Pharmacology | Metastasis | Criteria | Patients | Cell surface | Metastases | Uridine | Safety | Solid tumors | Drug dosages | Cancer | Tumors | Half life | Neutropenia | Glucuronosyltransferase | Index Medicus | Abridged Index Medicus
Journal Article
ACS nano, ISSN 1936-0851, 07/2015, Volume 9, Issue 7, pp. 7195 - 7206
polymeric micelle | 7-ethyl-10-hydroxylcamptothecin | cancer drug delivery | tumor penetration | size effect | Physical Sciences | Chemistry | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology - Other Topics | Chemistry, Multidisciplinary | Chemistry, Physical | Science & Technology | Camptothecin - pharmacokinetics | Camptothecin - therapeutic use | Humans | Mice, Inbred ICR | Antineoplastic Agents, Phytogenic - administration & dosage | Animals | Mice, Nude | Micelles | Cell Line, Tumor | Camptothecin - administration & dosage | Female | Mice | Mice, Inbred BALB C | Antineoplastic Agents, Phytogenic - therapeutic use | Antineoplastic Agents, Phytogenic - pharmacokinetics | Camptothecin - analogs & derivatives | Mammary Neoplasms, Experimental - drug therapy | Index Medicus | Drugs | Penetration | Effectiveness | Nanostructure | Physical properties | Optimization | Tumors
Journal Article
Journal of controlled release, ISSN 0168-3659, 02/2017, Volume 247, pp. 28 - 54
Stimuli-responsive | Clinical trials | Camptothecin nanomedicines | Camptothecin analogues | Structure-activity relationship | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Camptothecin - pharmacokinetics | Topoisomerase I Inhibitors - pharmacokinetics | Camptothecin - adverse effects | Nanoparticles - chemistry | Humans | Topoisomerase I Inhibitors - administration & dosage | Models, Molecular | Antineoplastic Agents, Phytogenic - chemistry | Delayed-Action Preparations - chemistry | Clinical Trials as Topic | Antineoplastic Agents, Phytogenic - administration & dosage | Topoisomerase I Inhibitors - adverse effects | Animals | Drug Liberation | Camptothecin - administration & dosage | Antineoplastic Agents, Phytogenic - pharmacokinetics | Drug Delivery Systems - methods | Nanomedicine | Topoisomerase I Inhibitors - chemistry | Antineoplastic Agents, Phytogenic - adverse effects | Camptothecin - analogs & derivatives | Magnetic fields | Enzymes | Therapeutics | Homeopathy | Materia medica and therapeutics | Index Medicus
Journal Article