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Cell, ISSN 0092-8674, 01/2018, Volume 172, Issue 1-2, pp. 81 - 89.e10
The multidrug resistance protein MRP1 is an ATP-driven pump that confers resistance to chemotherapy. Previously, we have shown that intracellular substrates... 
outward facing | multidrug resistance | MRP1 | ABCC1 | ABC transporter | cryo-EM | ABC TRANSPORTER | MALTOSE TRANSPORTER | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALTERNATING ACCESS | EM STRUCTURE DETERMINATION | CRYO-EM | ELECTRON-MICROSCOPY | P-GLYCOPROTEIN | CATALYTIC CYCLE | CELL BIOLOGY | Hydrolysis | Drug resistance in microorganisms | Chemotherapy | Cancer | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2011, Volume 19, Issue 6, pp. 2090 - 2102
Journal Article
Plos One, ISSN 1932-6203, 2011, Volume 6, Issue 4, pp. e18438 - e18438
During chronic kidney disease (CKD), there is a progressive accumulation of toxic solutes due to inadequate renal clearance. Here, the interaction between... 
INDOXYL SULFATE | ORGANIC ANION TRANSPORTER | EFFLUX PUMP | ACID | MEMBRANE | MRP4/ABCC4 | BIOLOGY | RENAL-FAILURE | KIDNEY | EXPRESSION | ABCG2 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Methotrexate - metabolism | Toxins, Biological - blood | Toxins, Biological - toxicity | Humans | Substrate Specificity | Uremia - metabolism | Neoplasm Proteins - metabolism | Dose-Response Relationship, Drug | Gene Expression Regulation - drug effects | Estrone - analogs & derivatives | Kidney Failure, Chronic - blood | Estrone - metabolism | HEK293 Cells | ATP-Binding Cassette Transporters - metabolism | Biological Transport - drug effects | Cell Membrane - metabolism | Multidrug Resistance-Associated Proteins - metabolism | Cell Membrane - drug effects | Drug resistance in microorganisms | Auxin | Phenylacetic acid | Chronic kidney failure | Oxalic acid | Breast cancer | Oxalates | Acetic acid | Sulfates | High performance liquid chromatography | Organic acids | Pediatrics | Active transport | Hippuric acid | Indole | Solutes | Putrescine | Peritoneal dialysis | Proteins | Cresol | p-Cresol | Toxicology | Mathematical analysis | Rodents | Physiology | Life sciences | Kynurenic acid | Quinolinic acid | Methotrexate | Urine | Efflux | Multidrug resistance | Glycerol | Membrane vesicles | Mass spectroscopy | Glycoproteins | Pharmacology | Liquid chromatography | High-performance liquid chromatography | Patients | Membrane proteins | Acids | Estrone | Toxins | Sulfate | Transport | Mass spectrometry | Kidney transplantation | Cancer | Index Medicus
Journal Article
11/2012
Mother's milk provides multiple benefits to the offspring. However, xenobiotics transferred into breast milk may pose a risk to the nursing infant. The breast... 
Toxicology | Lactation | Cimetidine | 0383 | Riboflavin | 0419 | Pharmacology | Breast cancer resistance protein (BCRP) | Mammary Gland | Riboflavin transporters | Breast milk
Dissertation
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 12/2015, Volume 56, Issue 12, pp. 1930 - 1936
C-11-erlotinib is a PET tracer to distinguish responders from nonresponders to epidermal growth factor receptor-targeted tyrosine kinase inhibitors and may... 
breast cancer resistance protein | nonlinear pharmacokinetics | TRANSPORTERS | PENETRATION | BLOOD-BRAIN-BARRIER | P-glycoprotein | TYROSINE KINASE INHIBITORS | LUNG-CANCER | POSITRON-EMISSION-TOMOGRAPHY | C-11-erlotinib | MICE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | ERLOTINIB
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2012, Volume 20, Issue 1, pp. 346 - 355
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 03/2019, Volume 47, Issue 3, pp. 203 - 214
Esculetin (ET)-7-O-glucuronide (ET-G) and 4-methylesculetin (4-ME)-7-O-glucuronide (4-ME-G) are the main glucuronide of ET and 4-ME, respectively. The... 
ESCULETIN | CELLS | EFFLUX TRANSPORTERS | IN-VITRO | PHARMACOKINETICS | CACO-2 | PHARMACOLOGY & PHARMACY | KNOCKOUT | ABSORPTION | EXPRESSION | BIOAVAILABILITY | Propionates - pharmacology | Intestinal Mucosa - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism | Area Under Curve | Humans | Male | Neoplasm Proteins - antagonists & inhibitors | Umbelliferones - pharmacokinetics | Neoplasm Proteins - metabolism | Heterocyclic Compounds, 4 or More Rings - pharmacology | Intestinal Absorption | Quinolines - pharmacology | Umbelliferones - metabolism | Glucuronides - metabolism | Multidrug Resistance-Associated Proteins - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 2 - antagonists & inhibitors | Caco-2 Cells | ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Diketopiperazines - pharmacology | Mice, Knockout | Animals | Glucuronosyltransferase - metabolism | Perfusion | Hepatobiliary Elimination - drug effects | Metabolic Clearance Rate - drug effects | Mice | Multidrug Resistance-Associated Proteins - metabolism | Efflux | Excretion | Data points | Intestines | Duodenum | Multidrug resistance | Breast cancer | Pharmacology | Permeability | Proteins | Inhibitors | Intestine | Bioactive compounds | Rodents | Monolayers | Transporter | Cancer | Bile
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2004, Volume 317, Issue 1, pp. 269 - 275
Journal Article