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carbacyclin (57) 57
index medicus (27) 27
prostacyclin (23) 23
humans (17) 17
animals (16) 16
pharmacology & pharmacy (16) 16
epoprostenol - pharmacology (13) 13
chemistry, multidisciplinary (12) 12
chemistry, organic (11) 11
epoprostenol - analogs & derivatives (10) 10
epoprostenol - chemical synthesis (9) 9
prostaglandin (9) 9
chemistry, medicinal (8) 8
in vitro techniques (8) 8
platelets (8) 8
isocarbacyclin (7) 7
male (7) 7
platelet aggregation - drug effects (7) 7
platelet aggregation inhibitors - pharmacology (7) 7
platelet-aggregation (7) 7
route (7) 7
biochemistry & molecular biology (6) 6
cell biology (6) 6
iloprost (6) 6
stereospecific synthesis (6) 6
arachidonic acid (5) 5
carbacyclins (5) 5
claisen rearrangement (5) 5
exocyclic olefin (5) 5
female (5) 5
mice (5) 5
prostaglandin analogs (5) 5
rat (5) 5
rats (5) 5
stable prostacyclin analog (5) 5
1,4-hydrogenation (4) 4
adenylate cyclase (4) 4
asymmetric-synthesis (4) 4
blood pressure - drug effects (4) 4
iloprost - pharmacology (4) 4
inhibition (4) 4
isomerization (4) 4
prostaglandins, synthetic - chemical synthesis (4) 4
rabbits (4) 4
stereoisomerism (4) 4
adenylyl cyclases - metabolism (3) 3
adhesion (3) 3
blood platelets - drug effects (3) 3
blood platelets - metabolism (3) 3
cell line (3) 3
chemical phenomena (3) 3
chemistry (3) 3
chemotaxis (3) 3
chirality transfer (3) 3
cytochrome p450 (3) 3
endothelial cells (3) 3
epoprostenol - administration & dosage (3) 3
epoprostenol - physiology (3) 3
highly efficient synthesis (3) 3
human (3) 3
ketones (3) 3
miconazole (3) 3
muscle, smooth, vascular - drug effects (3) 3
oral activity (3) 3
pgi (3) 3
pgi2 (3) 3
platelet aggregation inhibitors - chemical synthesis (3) 3
polymorphonuclear cells (3) 3
prostacyclin analog (3) 3
prostaglandin-e1 (3) 3
prostaglandins (3) 3
reduction (3) 3
smooth muscle cells (3) 3
stereocontrol (3) 3
wittig rearrangement (3) 3
zincate complex (3) 3
1, 4-hydrogenation (2) 2
1,3-diene (2) 2
6a-carbaprostaglandin-i2 (2) 2
[3 + 2]-cycloaddition (2) 2
adenosine diphosphate - pharmacology (2) 2
alkene insertion (2) 2
alpha (2) 2
alprostadil (2) 2
alprostadil - pharmacology (2) 2
aluminum-hydride reagents (2) 2
analog (2) 2
anticoagulant (2) 2
antiulcer drug (2) 2
arachidonic acid cascade (2) 2
arene tricarbonyl chromium complex (2) 2
asymmetric synthesis (2) 2
axially dissymmetric molecules (2) 2
biology (2) 2
carbacyclin analog (2) 2
carbacyclin derivative (2) 2
cardiac & cardiovascular systems (2) 2
cats (2) 2
cattle (2) 2
cdna (2) 2
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Journal Article
Chemical Communications, ISSN 1359-7345, 1996, Issue 15, pp. 1775 - 1776
The chiral mono-thiol diester, 1 or 2, is converted to the corresponding enantiomeric cyclised products, (-)-7 and (+)-7 or (-)-9 and (+)-9, depending on... 
(+)-CARBACYCLIN | CHEMISTRY
Journal Article
Hypertension, ISSN 0194-911X, 05/2013, Volume 61, Issue 5, pp. 1036 - 1043
Journal Article
Journal Article
Journal Article
Prostaglandins and Other Lipid Mediators, ISSN 1098-8823, 2006, Volume 80, Issue 1, pp. 28 - 34
Miconazole is widely used clinically as an anti-fungal agent and experimentally as a cytochrome P450 (CYP) inhibitor. In rat coronary arteries that produce PGI... 
Cytochrome P450 | Carbacyclin | PGI 2 | Miconazole | Arachidonic acid | Smooth muscle cells
Journal Article
by Zhou, W and Lu, T and Spector, AA and Lee, HC
PROSTAGLANDINS & OTHER LIPID MEDIATORS, ISSN 1098-8823, 07/2006, Volume 80, Issue 1-2, pp. 28 - 34
Miconazole is widely used clinically as an anti-fungal agent and experimentally as a cytochrome P450 (CYP) inhibitor. In rat coronary arteries that produce... 
arachidonic acid | carbacyclin | BIOCHEMISTRY & MOLECULAR BIOLOGY | miconazole | cytochrome P450 | ARACHIDONIC-ACID | DILATION | CELL BIOLOGY | smooth muscle cells | PGI | METABOLISM | ANTIFUNGAL AGENTS | HEALTH | EPOXYEICOSATRIENOIC ACIDS | DIABETIC FATTY RATS
Journal Article
TETRAHEDRON LETTERS, ISSN 0040-4039, 03/1995, Volume 36, Issue 13, pp. 2255 - 2256
Both enantiomers of C-2-symmetric dimethyl 3,7-dioxo-cis-bicyclo[3.3.0]octane-2,6-dicarboxylate (3) were prepared in enantiomerically pure form by the... 
ESTER | REDUCTION | HYDROLYSIS | CHEMISTRY, ORGANIC | CARBACYCLIN
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 05/1995, Volume 60, Issue 9, pp. 2692 - 2703
The synthesis of symchiral 1-azatricyclo[6.3.0.0(2,6)]undeca-5-enyl prostaglandin I-2 analog 34 is reported. Construction of the tricyclic skeleton of 34 was... 
THIOCARBOXAMIDES | REAGENTS | CONVERSION | ACIDS | CHEMISTRY, ORGANIC | PROTON | THIOAMIDES | EXCHANGE | CLAISEN REARRANGEMENT | CARBACYCLIN | SULFIDE
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 1992, Volume 27, Issue 2, pp. 155 - 159
Novel stable bicyclo[3.3.0]octanic and bicyclo[4.2.0]octanic 13,14-didehydrocarbacyclins 1a-c, 2a bearing an achiral cyclohexanoic group at C-14 were... 
ω-achiral carbacyclins | inhibitor of platelet aggregation | 13C NMR spectra of ω-achiral carbacyclins | tissue selectivity of carbacyclins | contractive activity | C NMR spectra of ω-achiral carbacyclins
Journal Article
Tetrahedron: Asymmetry, ISSN 0957-4166, 1998, Volume 9, Issue 1, pp. 157 - 167
Both enantiomers of C -symmetric dimethyl 3,7-dihydroxybicyclo[3.3.0]- octa-2,6-diene-2,6-dicarboxylate 3 were prepared in enantiomerically pure form from... 
ROUTE | DELTA-9-CAPNELLENE-3-BETA,8-BETA,10-ALPHA,14-TETROL | ACID | KEY INTERMEDIATE | HYDROLYSIS | CHEMISTRY, ORGANIC | CHEMISTRY, PHYSICAL | CHEMISTRY, INORGANIC & NUCLEAR | REDUCTION | HETEROYOHIMBINE ALKALOIDS | HECK REACTION | (+/-)-DELTA-9-CAPNELLENE | CARBACYCLIN
Journal Article
Bulletin of the Korean Chemical Society, ISSN 0253-2964, 01/2002, Volume 23, Issue 1, pp. 86 - 92
Journal Article
Angewandte Chemie - International Edition in English, ISSN 0570-0833, 1982, Volume 21, Issue 10, pp. 751 - 764
Journal Article
Prostaglandins and Other Lipid Mediators, ISSN 0090-6980, 02/1998, Volume 55, Issue 2-3, pp. 95 - 107
The effects of prostaglandin E (PGE ) on adhesion of activated human polymorphonuclear cells (HPMNs) to human umbilical vein endothelial cells (HUVECs) and on... 
Human | Polymorphonuclear cells | Carbacyclin | Prostacyclin | Prostaglandin E | Adhesion | Chemotaxis | Endothelial cells
Journal Article
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