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1. Full Text Deaths attributable to carbapenem-resistant enterobacteriaceae infections
by Falagas, Matthew E and Tansarli, Giannoula S and Karageorgopoulos, Drosos E and Vardakas, Konstantinos Z
Emerging Infectious Diseases, ISSN 1080-6040, 2014, Volume 20, Issue 7, pp. 1170 - 1175
We evaluated the number of deaths attributable to carbapenem-resistant Enterobacteriaceae by using studies from around the world published before April 9,... 
MORTALITY | INFECTIOUS DISEASES | IMPACT | RISK-FACTORS | METAANALYSIS | BETA-LACTAMASE | PREDICTORS | BACTEREMIA | ESCHERICHIA-COLI | KLEBSIELLA-PNEUMONIAE STRAINS | IMMUNOLOGY | BLOOD-STREAM INFECTIONS | Prospective Studies | Enterobacteriaceae - pathogenicity | Humans | Enterobacteriaceae Infections - mortality | Bacteremia - mortality | Case-Control Studies | Anti-Bacterial Agents - therapeutic use | Carbapenems - therapeutic use | Klebsiella pneumoniae - pathogenicity | Drug Resistance, Bacterial - physiology | Enterobacteriaceae - drug effects | Klebsiella Infections - mortality | Retrospective Studies | Infection | Health aspects | Online databases | metaanalysis | bacteria | meta-analysis | bloodstream infection | Research | carbapenemases | systematic review | carbapenem-resistant Enterobacteriaceae | Klebsiella pneumoniae carbapenemase | carbapenem resistance | attributable mortality | carbapenemase-producing | infections | mortality | attributable deaths | Klebsiella pneumoniae | deaths | outcome | Enterobacteriaceae | KPC | bacteremia
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2. Full Text Carbapenem‐resistant Enterobacteriaceae: biology, epidemiology, and management
by Temkin, Elizabeth and Adler, Amos and Lerner, Anat and Carmeli, Yehuda
Annals of the New York Academy of Sciences, ISSN 0077-8923, 09/2014, Volume 1323, Issue 1, pp. 22 - 42
Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug‐resistant Gram‐negative organisms. Over the last... 
molecular genetics | treatment | infection control | carbapenemases | antimicrobial resistance | carbapenem‐resistant Enterobacteriaceae | Carbapenem-resistant Enterobacteriaceae | Treatment | Antimicrobial resistance | Molecular genetics | Carbapenemases | Infection control | INFECTIOUS DISEASES | RISK-FACTORS | ESCHERICHIA-COLI | SEQUENCE TYPE 258 | SELECTIVE DIGESTIVE DECONTAMINATION | MICROBIOLOGY | carbapenem-resistant Enterobacteriaceae | GRAM-NEGATIVE BACTERIA | METALLO-BETA-LACTAMASE | INTENSIVE-CARE-UNIT | KLEBSIELLA-PNEUMONIAE STRAINS | PHARMACOLOGY & PHARMACY | CRITICALLY-ILL PATIENTS | BLOOD-STREAM INFECTIONS | Enterobacteriaceae Infections - epidemiology | Promoter Regions, Genetic | Enterobacteriaceae Infections - diagnosis | Carbapenems - pharmacology | Enterobacteriaceae Infections - microbiology | Alleles | Enterobacteriaceae - drug effects | Drug Resistance, Microbial - genetics | Enterobacteriaceae Infections - drug therapy | Epidemiology | CRE bacteria | Antibiotics | Genetics | Organisms | Biology | Management | Public health
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3. Full Text The rapid spread of carbapenem-resistant Enterobacteriaceae
by Potter, Robert F and D’souza, Alaric W and Dantas, Gautam
Drug Resistance Updates, ISSN 1368-7646, 2016, Volume 29, pp. 30 - 46
Abstract Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now threatened by widespread dissemination of... 
Infectious Disease | Hematology, Oncology and Palliative Medicine | Carbapenem Resistant Enterobacteriaceae | Antibiotic resistance | Horizontal gene transfer | NDM-PRODUCING ENTEROBACTERIACEAE | CLASS-A CARBAPENEMASE | MODIFIED HODGE TEST | ESCHERICHIA-COLI | METALLO-BETA-LACTAMASE | NEW-YORK-CITY | PHARMACOLOGY & PHARMACY | INCFII-TYPE PLASMIDS | RIBOSOMAL-RNA METHYLASE | IN-VITRO ACTIVITY | KLEBSIELLA-PNEUMONIAE INFECTION | Humans | Isoenzymes - classification | Enterobacteriaceae Infections - epidemiology | Carbapenem-Resistant Enterobacteriaceae - enzymology | Carbapenem-Resistant Enterobacteriaceae - genetics | Carbapenems - pharmacology | beta-Lactamases - genetics | Isoenzymes - metabolism | Enterobacteriaceae Infections - transmission | beta-Lactamases - metabolism | Drug Therapy, Combination | Gene Expression | Isoenzymes - genetics | Enterobacteriaceae Infections - microbiology | Bacterial Proteins - genetics | beta-Lactamase Inhibitors - pharmacology | Plasmids - metabolism | beta-Lactamases - classification | Epidemiological Monitoring | Carbapenem-Resistant Enterobacteriaceae - pathogenicity | Plasmids - chemistry | Bacterial Proteins - metabolism | Bacterial Proteins - classification | beta-Lactam Resistance - genetics | Drug Resistance, Multiple, Bacterial - genetics | Carbapenem-Resistant Enterobacteriaceae - drug effects | Enterobacteriaceae Infections - drug therapy | Replicon | Medical colleges | Drug resistance in microorganisms | Bacterial infections | Mortality | Genomics | Beta lactamases | Nucleotide sequencing | Chromosomes | Antibacterial agents | Biomedical engineering | DNA sequencing | Anopheles | Genes
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4. Full Text Carbapenem-Resistant Enterobacteriaceae Infections in Children: An Italian Retrospective Multicenter Study
by Montagnani, Carlotta and Prato, Manuela and Scolfaro, Carlo and Colombo, Sara and Esposito, Susanna and Tagliabue, Claudia and Lo Vecchio, Andrea and Bruzzese, Eugenia and Loy, Anna and Cursi, Laura and Vuerich, Marco and de Martino, Maurizio and Galli, Luisa and Italian Soc Pediat Infect Dis and Italian Society of Pediatric Infectious Diseases
The Pediatric Infectious Disease Journal, ISSN 0891-3668, 04/2016, Volume 35, Issue 8, pp. 862 - 868
BACKGROUND:The spread of carbapenem-resistant Enterobacteriaceae (CRE) is a health problem of major concern. CRE related-infections have significant morbidity... 
children | carbapenem-resistant | Enterobacteriaceae | MORTALITY | INFECTIOUS DISEASES | COMBINATION THERAPY | RISK | IMMUNOLOGY | INTENSIVE-CARE-UNIT | BETA-LACTAMASE | PREDICTORS | COLISTIN | PEDIATRICS | KLEBSIELLA-PNEUMONIAE | Enterobacteriaceae Infections - microbiology | Humans | Child, Preschool | Infant | Male | Enterobacteriaceae Infections - epidemiology | Carbapenems - pharmacology | Enterobacteriaceae - drug effects | Female | Italy - epidemiology | Anti-Bacterial Agents - pharmacology | Retrospective Studies | Child
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5. Full Text Treatment options for carbapenem-resistant Enterobacteriaceae infections
by Morrill, Haley J and Pogue, Jason M and Kaye, Keith S and LaPlante, Kerry L
Open Forum Infectious Diseases, ISSN 2328-8957, 2015, Volume 2, Issue 2, pp. ofv050 - ofv050
This article provides a comprehensive review of currently available treatment options for infections due to carbapenem- resistant Enterobacteriaceae (CRE).... 
Carbapenem-resistant Enterobacteriaceae | Resistant infections | Treatment | Carbapenems | Carbapenemases | treatment | INFECTIOUS DISEASES | MULTIDRUG-RESISTANT | COMBINATION THERAPY | carbapenems | carbapenemases | POLYMYXIN-B | carbapenem-resistant Enterobacteriaceae | GRAM-NEGATIVE BACTERIA | METALLO-BETA-LACTAMASE | INTENSIVE-CARE-UNIT | resistant infections | CRITICALLY-ILL PATIENTS | BLOOD-STREAM INFECTIONS | IN-VITRO ACTIVITY | KLEBSIELLA-PNEUMONIAE
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6. Full Text The global distribution and spread of the mobilized colistin resistance gene mcr-1
by Wang, Ruobing and Van Dorp, Lucy and Shaw, Liam P and Bradley, Phelim and Wang, Qi and Wang, Xiaojuan and Jin, Longyang and Zhang, Qing and Liu, Yuqing and Rieux, Adrien and Dorai-Schneiders, Thamarai and Weinert, Lucy Anne and Iqbal, Zamin and Didelot, Xavier and Wang, Hui and Balloux, Francois
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1179 - 9
Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent... 
PLASMIDS | GRAM-NEGATIVE BACTERIA | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | DISSEMINATION | SPECTRUM BETA-LACTAMASE | CARBAPENEM-RESISTANT | IDENTIFICATION | KLEBSIELLA-PNEUMONIAE | MOLECULAR-MECHANISMS | ENTEROBACTERIACEAE | Humans | Enterobacteriaceae - isolation & purification | Americas - epidemiology | Enterobacteriaceae Infections - epidemiology | Carbapenems - pharmacology | Colistin - pharmacology | Enterobacteriaceae Infections - transmission | Enterobacteriaceae - classification | Gene Expression | Genome, Bacterial | Enterobacteriaceae Infections - microbiology | Enterobacteriaceae - genetics | Europe - epidemiology | Escherichia coli Proteins - metabolism | Gene Transfer, Horizontal | Plasmids - metabolism | DNA Transposable Elements | Asia - epidemiology | Enterobacteriaceae - drug effects | Plasmids - chemistry | Escherichia coli Proteins - genetics | Anti-Bacterial Agents - pharmacology | Drug Resistance, Multiple, Bacterial - genetics | Evolution, Molecular | Population Dynamics | Demographics | Antibiotics | Colistin | Antibiotic resistance | Health risks | Current distribution | Phylogeny | Public health
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7. Full Text Managing Transmission of Carbapenem-Resistant Enterobacteriaceae in Healthcare Settings: A View From the Trenches
by Tara N. Palmore and David K. Henderson
Clinical Infectious Diseases, ISSN 1058-4838, 12/2013, Volume 57, Issue 11, pp. 1593 - 1599
In 2011, the National Institutes of Health Clinical Center experienced a cluster of infection and colonization caused by carbapenem-resistant Klebsiella... 
Intensive care units | Disease transmission | Hydrogen | Health care industry | Infections | HEALTHCARE EPIDEMIOLOGY | Patient surveillance | Epidemiology | Sequencing | Klebsiella pneumoniae | Enterobacteriaceae | Isolation | Whole genome sequencing | Carbapenem-resistant enterobacteriaceae | Multidrug resistance | Transmission | multidrug resistance | INFECTIOUS DISEASES | BACTERIA | UNIT PATIENTS | MICROBIOLOGY | isolation | IMMUNOLOGY | whole genome sequencing | ACINETOBACTER-BAUMANNII | transmission | carbapenem-resistant enterobacteriaceae | HYDROGEN-PEROXIDE VAPOR | HANDWASHING SINKS | DISINFECTION | K. PNEUMONIAE | OUTBREAK | KLEBSIELLA-PNEUMONIAE | EPIDEMIOLOGY | Genome, Bacterial | beta-Lactam Resistance | Enterobacteriaceae Infections - prevention & control | Cross Infection - prevention & control | Enterobacteriaceae Infections - microbiology | Humans | Infection Control | Enterobacteriaceae - genetics | Enterobacteriaceae - isolation & purification | Cross Infection - drug therapy | Disease Transmission, Infectious - prevention & control | Cross Infection - transmission | Carbapenems - pharmacology | Disease Outbreaks | Cross Infection - microbiology | Drug Resistance, Multiple, Bacterial | Enterobacteriaceae - drug effects | Enterobacteriaceae Infections - transmission | Anti-Bacterial Agents - pharmacology | Enterobacteriaceae Infections - drug therapy | Drug resistance in microorganisms | Reports | Enterobacteriaceae infections | Care and treatment | multi-drug resistance | Invited
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8. Full Text Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae – Identification of LYS228
by Reck, Folkert and Bermingham, Alun and Blais, Johanne and Capka, Vladimir and Cariaga, Taryn and Casarez, Anthony and Colvin, Richard and Dean, Charles R and Fekete, Alex and Gong, Wanben and Growcott, Ellie and Guo, Hongqiu and Jones, Adriana K and Li, Cindy and Li, Fengxia and Lin, Xiaodong and Lindvall, Mika and Lopez, Sara and McKenney, David and Metzger, Louis and Moser, Heinz E and Prathapam, Ramadevi and Rasper, Dita and Rudewicz, Patrick and Sethuraman, Vijay and Shen, Xiaoyu and Shaul, Jacob and Simmons, Robert L and Tashiro, Kyuto and Tang, Dazhi and Tjandra, Meiliana and Turner, Nancy and Uehara, Tsuyoshi and Vitt, Charles and Whitebread, Steven and Yifru, Aregahegn and Zang, Xu and Zhu, Qingming
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2018, Volume 28, Issue 4, pp. 748 - 755
Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers... 
NDM-1 | PBP-3 | β-Lactamases | Antibiotic | Monobactam | CRE | Metallo-β-lactamases | β-Lactam | KPC | Metallo-beta-lactamases | ANTIBIOTICS | CHEMISTRY, MEDICINAL | STABILITY | beta-Lactam | ESCHERICHIA-COLI | CHEMISTRY, ORGANIC | SIDEROPHORE-CONJUGATED MONOCARBAM | PARAMETERS | PARENTERAL CEPHALOSPORINS | ANTIBACTERIAL ACTIVITY | PSEUDOMONAS-AERUGINOSA | beta-Lactamases | SPECTRUM BETA-LACTAMASES | DORIPENEM | Cricetulus | Escherichia coli - drug effects | Humans | Monobactams - adverse effects | Structure-Activity Relationship | Aztreonam - pharmacology | Seizures - chemically induced | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Monobactams - metabolism | Female | Anti-Bacterial Agents - adverse effects | Molecular Structure | Monobactams - chemistry | beta-Lactamases - metabolism | CHO Cells | Drug Stability | Anti-Bacterial Agents - metabolism | Pseudomonas aeruginosa - drug effects | Thienamycins - pharmacology | Animals | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Mice | Receptors, GABA-A - metabolism | Monobactams - pharmacology | Carbapenem-Resistant Enterobacteriaceae - drug effects | beta-Lactam Resistance - drug effects | Beta lactam antibiotics | Medicine, Experimental | Medical research | Drug resistance in microorganisms | Bacteria | Beta lactamases
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9. Full Text Carbapenemase-producing Enterobacteriaceae in Mexico: Report of seven non-clonal cases in a pediatric hospital
by Aquino-Andrade, Alejandra and Merida-Vieyra, Jocelin and Arias De La Garza, Eduardo and Arzate-Barbosa, Patricia and De Colsa Ranero, Agustín
BMC Microbiology, ISSN 1471-2180, 04/2018, Volume 18, Issue 1, pp. 38 - 8
Background: Carbapenemases-producing Enterobacteriaceae (CPE) are a worldwide public health emergency. In Mexico, reports of CPE are limited, particularly in... 
NDM-1 | Pediatrics | OXA-232 | KPC-2 | Carbapenemase-producing Enterobacteriaceae | Mexico | OXA-48 | RESISTANT ENTEROBACTERIACEAE | INFECTIONS | ESCHERICHIA-COLI | GLOBAL DISSEMINATION | MICROBIOLOGY | TREATMENT OPTIONS | METALLO-BETA-LACTAMASE | ANTIMICROBIAL SURVEILLANCE PROGRAM | SPREAD | KLEBSIELLA-PNEUMONIAE | Klebsiella pneumoniae - isolation & purification | Carbapenem-Resistant Enterobacteriaceae - isolation & purification | Klebsiella oxytoca - genetics | Enterobacter cloacae - enzymology | Humans | Child, Preschool | Hospitals, Pediatric | Infant | Male | Microbial Sensitivity Tests | Enterobacteriaceae Infections - epidemiology | Klebsiella oxytoca - pathogenicity | Carbapenem-Resistant Enterobacteriaceae - enzymology | Carbapenem-Resistant Enterobacteriaceae - genetics | Escherichia coli - pathogenicity | Klebsiella pneumoniae - genetics | Female | beta-Lactamases - metabolism | Child | Latin America - epidemiology | Enterobacter cloacae - genetics | Escherichia coli - enzymology | Mexico - epidemiology | Enterobacteriaceae Infections - microbiology | Enterobacteriaceae Infections - mortality | Genotype | Klebsiella oxytoca - isolation & purification | Enterobacteriaceae Infections - physiopathology | Enterobacter cloacae - pathogenicity | Molecular Epidemiology | Escherichia coli - genetics | Escherichia coli - isolation & purification | Klebsiella oxytoca - enzymology | Klebsiella pneumoniae - pathogenicity | Carbapenem-Resistant Enterobacteriaceae - pathogenicity | Adolescent | Klebsiella pneumoniae - enzymology | Enterobacter cloacae - isolation & purification | Enterobacteriaceae infections | Colistin | Escherichia coli | Beta lactamases | Dosage and administration | Research | Drug therapy
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10. Full Text Colistin Versus Ceftazidime-Avibactam in the Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae
by Van Duin, David and Lok, Judith J and Earley, Michelle and Cober, Eric and Richter, Sandra S and Perez, Federico and Salata, Robert A and Kalayjian, Robert C and Watkins, Richard R and Doi, Yohei and Kaye, Keith S and Fowler, Vance G and Paterson, David L and Bonomo, Robert A and Evans, Scott and Antibacterial Resistance Leadership Group
Clinical Infectious Diseases, ISSN 1058-4838, 01/2018, Volume 66, Issue 2, pp. 163 - 171
Background. The efficacy of ceftazidime-avibactam-a cephalosporin-beta-lactamase inhibitor combination with in vitro activity against Klebsiella pneumoniae... 
carbapenem-resistant Enterobacteriaceae | ceftazidime-Avibactam | colistin | Klebsiella pneumoniae | benefit-risk | MORTALITY | INFECTIOUS DISEASES | MARGINAL STRUCTURAL MODELS | MICROBIOLOGY | IMMUNOLOGY | ceftazidime-avibactam | LACTAMASE | PNEUMONIAE CARBAPENEMASE | THERAPY | DISSEMINATION | OUTCOMES | EPIDEMIOLOGY | Clinical trials | Enterobacteriaceae infections | Care and treatment | Dosage and administration | Analysis | Ceftazidime | and Commentaries
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11. Full Text Within-a-day detection and rapid characterization of carbapenemase by use of a new carbapenem inactivation method-based test, CIMplus
by Caméléna, François and Cointe, Aurélie and Mathy, Vincent and Hobson, Claire and Doit, Catherine and Bercot, Béatrice and Decré, Dominique and Podglajen, Isabelle and Dortet, Laurent and Monjault, Audrey and Bidet, Philippe and Bonacorsi, Stéphane and Birgy, André
Journal of Clinical Microbiology, ISSN 0095-1137, 09/2018, Volume 56, Issue 9
The dissemination of carbapenemase-producing Enterobacterfaceae (CPE) is a major threat to public health. Rapid and accurate detection of CPE is essential for... 
Carbapenemase inactivation method | Phenotypic detection | Phenylboronic acid | NDM | carbapenemase | EDTA | OXA-48 | MCIM | Enterobacteriaceae | Phenotypic characterization | RESISTANT ENTEROBACTERIACEAE | carbapenemase inactivation method | mCIM | MICROBIOLOGY | phenylboronic acid | PSEUDOMONAS | phenotypic characterization | ASSAYS | phenotypic detection | BETA-LACTAMASES | MODIFIED-HODGE TEST | Carbapenems - metabolism | Enterobacteriaceae - enzymology | Enterobacteriaceae Infections - diagnosis | Carbapenem-Resistant Enterobacteriaceae - isolation & purification | Enterobacteriaceae Infections - microbiology | Humans | Anti-Bacterial Agents - metabolism | Enterobacteriaceae - isolation & purification | Bacterial Proteins - analysis | Carbapenem-Resistant Enterobacteriaceae - enzymology | Carbapenems - pharmacology | beta-Lactamases - classification | Time Factors | beta-Lactamases - analysis | Sensitivity and Specificity | Enterobacteriaceae - drug effects | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Bacterial Proteins - classification | beta-Lactamases - metabolism | Carbapenem-Resistant Enterobacteriaceae - drug effects | Microbial Sensitivity Tests - methods
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