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Molecular Pharmaceutics, ISSN 1543-8384, 04/2019, Volume 16, Issue 4, pp. 1489 - 1497
Carbonic anhydrase IX (CA-IX) is regarded as a favorable target for in vivo imaging because of its specific expression in hypoxic regions of tumors. Hypoxia... 
hydroxamamide | carbonic anhydrase IX | imaging | technetium-99m
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1832 - 1832
Sensitive detection of altered proteins expression in plasma membranes is of fundamental importance, for both diagnostic and prognostic purposes.... 
PROTEIN | SPECTROSCOPY | CARBONIC-ANHYDRASE IX | MULTIDISCIPLINARY SCIENCES
Journal Article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 10/2014, Volume 53, Issue 44, pp. 11876 - 11880
A new zwitterionic organotrifluoroborate is appended to three radiosynthons that afford undergo facile bioconjugation to several clinically relevant peptides... 
PET imaging | STABILITY | F-18-labeling | click chemistry | peptides | CHEMISTRY, MULTIDISCIPLINARY | bioconjugation | CYCLOADDITION | THERAPY | RADIOSYNTHESIS | CARBONIC-ANHYDRASE IX | EXCHANGE | EXPRESSION | PET
Journal Article
Journal of Cell Science, ISSN 0021-9533, 04/2011, Volume 124, Issue 7, pp. 1077 - 1087
Journal Article
Chemical Science, ISSN 2041-6520, 3/2013, Volume 4, Issue 4, pp. 141 - 1419
Metal complexes are increasingly being used to inhibit enzymes. The reasons for this increased interest arise from the special features that metal complexes... 
CARBONIC-ANHYDRASE-IX | POST-GENOMIC ERA | ANTICANCER AGENTS | RUTHENIUM COMPLEXES | HALF-SANDWICH COMPLEXES | HISTONE DEACETYLASE INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | PROTEIN-KINASE INHIBITORS | ANTITUMOR DRUGS | CYSTEINE PROTEASES | RATIONAL DESIGN
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 06/2017, Volume 139, Issue 22, pp. 7595 - 7602
Journal Article
Theranostics, 2018, Volume 8, Issue 11, pp. 2992 - 3006
Hypoxic cells dynamically translocate during tumor growth and after radiotherapy. The most desirable direction for therapy targeting hypoxic cells is combining... 
Radiotheranostics | Hypoxia | Carbonic anhydrase-IX | Radiometallic ureidosulfonamide scaffold
Journal Article
NATURE PROTOCOLS, ISSN 1754-2189, 09/2015, Volume 10, Issue 9, pp. 1423 - 1432
Herein we present a general protocol for the functionalization of biomolecules with an organotrifluoroborate moiety so that they can be radiolabeled with... 
TARGET | POSITRON-EMISSION-TOMOGRAPHY | PEPTIDES | AZIDES | RADIOSYNTHESIS | CARBONIC-ANHYDRASE IX | KIT | BIOCHEMICAL RESEARCH METHODS | IN-VIVO EVALUATION | PET | CHELATION
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2018, Volume 61, Issue 3, pp. 1031 - 1044
Quinazolinone-based anticancer agents were designed, decorated with functional groups from a 2-methoxyestradiol-based microtubule disruptor series,... 
STEROID SULFATASE INHIBITORS | CANCER THERAPEUTICS | BREAST-CANCER | CHEMISTRY, MEDICINAL | ESTRONE SULFATASE | COLCHICINE SITE | MECHANISM | ANALOGS | CARBONIC-ANHYDRASE IX | IN-VIVO | CHIMERIC MICROTUBULE DISRUPTORS | Index Medicus
Journal Article
CELL CYCLE, ISSN 1538-4101, 06/2013, Volume 12, Issue 11, pp. 1791 - 1801
Extracellular acidification, a mandatory feature of several malignancies, has been mainly correlated with metabolic reprogramming of tumor cells toward Warburg... 
TUMOR-STROMA | SURVIVAL | OXIDATIVE STRESS | METASTASIS | FIBROBLASTS | CELL BIOLOGY | cancer-associated fibroblasts | prostate cancer | INVASION | carbonic anhydrase IX | acidity | METABOLISM | GROWTH | epithelial-mesenchymal transition | EXPRESSION
Journal Article
EUROPEAN UROLOGY, ISSN 0302-2838, 09/2018, Volume 74, Issue 3, pp. 257 - 260
Based on the high expression of carbonic anhydrase IX (CAIX) in 95% of clear cell renal cell carcinoma (ccRCC), the anti-CAIX monoclonal antibody girentuximab... 
Zirconium-89 | Positron emission tomography/computed tomography imaging | Renal cell carcinoma | CARBONIC-ANHYDRASE IX | CG250 | UROLOGY & NEPHROLOGY | Girentuximab
Journal Article
ISSN 0007-0920, 2018
Background Tumour Carbonic Anhydrase IX (CAIX), a hypoxia-inducible tumour-associated cell surface enzyme, is thought to acidify the tumour microenvironment by... 
ISUCA | carbonic anhydrase IX | Magnetic Resonance Spectroscopy | extracellular pH | tumour pH | intracellular pH | pH-stat | MRS
Journal Article
Molecules, ISSN 1420-3049, 12/2018, Volume 24, Issue 1, p. 23
We herein describe a flexible synthesis of a small library of 68Ga-labeled CAIX-targeted molecules via an orthogonal 2-cyanobenzothiazole (CBT)/1,2-aminothiol... 
Index Medicus | carbonic anhydrase IX | click reaction | compound library | 68Ga-labeling
Journal Article
ACS applied materials & interfaces, ISSN 1944-8244, 5/2018, Volume 10, Issue 21, pp. 17792 - 17808
Hypoxia is a common feature of solid tumors contributing to resistance to chemotherapy. Selective delivery of chemotherapeutic drugs to hypoxic tumor niche... 
hypoxia | chemoresistance | carbonic anhydrase IX | inhibitor | gold nanoparticles | doxorubicin delivery | tumor spheroids
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2011, Volume 17, Issue 20, pp. 6389 - 6397
Journal Article
Cancer Research, ISSN 0008-5472, 05/2011, Volume 71, Issue 9, pp. 3364 - 3376
Journal Article
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