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Journal Article
Reference
Journal Article
Lung Cancer, ISSN 0169-5002, 2013, Volume 82, Issue 3, pp. 390 - 396
Journal Article
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 10/2017, Volume 276, pp. 167 - 173
Carbonyl reduction is an important metabolic pathway for endogenous and xenobiotic substances. The tobacco specific nitrosamine... 
Enzyme inhibition | Sex hormones | 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) | Short-chain dehydrogenases/reductases (SDR) | Carbonyl reduction | Aldo-keto reductases (AKR) | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-HYDROXYSTEROID DEHYDROGENASE | CARCINOGEN NNK | 4-METHYLNITROSAMINO-1-(3-PYRIDYL)-1-BUTANONE NNK | CIGARETTE-SMOKING | PHARMACOLOGY & PHARMACY | HUMAN LIVER | F344 RATS | TOXICOLOGY | LUNG-CANCER RISK | TOBACCO-SPECIFIC NITROSAMINE | N-NITROSAMINES | Inactivation, Metabolic | Aldo-Keto Reductases - genetics | Liver - enzymology | Nitrosamines - metabolism | Humans | Gonadal Hormones - chemistry | Recombinant Proteins - biosynthesis | Carcinogens - metabolism | Recombinant Proteins - isolation & purification | Progesterone - chemistry | Short Chain Dehydrogenase-Reductases - antagonists & inhibitors | Carcinogens - chemistry | Aldo-Keto Reductases - antagonists & inhibitors | Estradiol - metabolism | Tobacco - metabolism | Nitrosamines - chemistry | Recombinant Proteins - chemistry | Short Chain Dehydrogenase-Reductases - genetics | Gonadal Hormones - metabolism | Androstenes - chemistry | Estradiol - chemistry | Aldo-Keto Reductases - metabolism | Progesterone - metabolism | Androstenes - metabolism | Tobacco - chemistry | Short Chain Dehydrogenase-Reductases - metabolism | Testosterone | Enzymes | Analysis | Lung cancer | Physiological aspects | Development and progression | Ethinyl estradiol | Progesterone | Hormones | Oral contraceptives | Nitrosoamines | Estradiol | Index Medicus
Journal Article
Cancer Epidemiology Biomarkers and Prevention, ISSN 1055-9965, 03/2018, Volume 27, Issue 3, pp. 262 - 267
Background: Tobacco-specific nitrosamines (TSNAs) are a class of carcinogens found in tobacco products, whose levels can vary considerably depending on tobacco... 
LUNG-CANCER | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | CIGARETTES | ONCOLOGY | SMOKERS | Creatinine | Mixtures | Nitrosamines | Exposure | Cigarettes | Cigarette smoking | Epidemiology | Pyridyl)-1-butanone | Manufacturing industry | Tobacco | Carcinogens | Biomarkers | Butanol | Bioindicators | Cotinine | Females | Cancer | Index Medicus
Journal Article
Journal Article
Toxicology in Vitro, ISSN 0887-2333, 10/2014, Volume 28, Issue 7, pp. 1329 - 1337
Recent work using purified enzymes demonstrated that nicotine and/or a nicotine metabolite could inhibit CYPs (CYP2A6, 2A13, 2E1) involved in the metabolism of... 
NNK | Cotinine | COMET | Bioactivation | DNA strand break | Nicotine | HUMAN LUNG | METABOLIC-ACTIVATION | IN-VITRO | HUMAN HEPATOCYTES | CYTOCHROME-P450 2A13 | TOBACCO-SPECIFIC CARCINOGEN | 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE NNK | CIGARETTE-SMOKE | TOXICOLOGY | LIVER-MICROSOMES | N-NITROSAMINES
Journal Article