X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
science & technology (1282) 1282
life sciences & biomedicine (1138) 1138
humans (1102) 1102
animals (786) 786
card signaling adaptor proteins (574) 574
mice (545) 545
card signaling adaptor proteins - genetics (523) 523
immunology (443) 443
card signaling adaptor proteins - metabolism (431) 431
male (373) 373
female (370) 370
signal transduction (312) 312
inflammasomes - metabolism (279) 279
mice, knockout (269) 269
nlr family, pyrin domain-containing 3 protein (269) 269
biochemistry & molecular biology (262) 262
caspase 1 - metabolism (259) 259
inflammation (257) 257
mice, inbred c57bl (241) 241
cell biology (240) 240
apoptosis (237) 237
nf-kappa b - metabolism (225) 225
proteins (224) 224
cytoskeletal proteins - metabolism (222) 222
carrier proteins - metabolism (191) 191
cytoskeletal proteins - genetics (190) 190
adult (188) 188
inflammasome (186) 186
middle aged (183) 183
mutation (178) 178
apoptosis regulatory proteins (175) 175
carrier proteins - genetics (169) 169
guanylate cyclase - genetics (168) 168
interleukin-1beta - metabolism (166) 166
cell line (160) 160
apoptosis regulatory proteins - metabolism (155) 155
adaptor proteins, signal transducing - metabolism (152) 152
abridged index medicus (150) 150
card signaling adaptor proteins - immunology (150) 150
cells, cultured (150) 150
science & technology - other topics (147) 147
multidisciplinary sciences (144) 144
gene expression (143) 143
research (138) 138
inflammasomes - immunology (137) 137
caspase-1 (136) 136
cytokines (136) 136
genetic aspects (134) 134
guanylate cyclase - metabolism (124) 124
oncology (122) 122
b-cell cll-lymphoma 10 protein (121) 121
protein binding (121) 121
aged (117) 117
apoptosis regulatory proteins - genetics (117) 117
caspase (117) 117
immunity, innate (117) 117
adaptor proteins, signal transducing - genetics (114) 114
neoplasm proteins - genetics (114) 114
analysis (112) 112
cell line, tumor (111) 111
macrophages - metabolism (109) 109
caspase 1 - genetics (104) 104
caspases - metabolism (104) 104
macrophages - immunology (102) 102
research article (102) 102
disease models, animal (101) 101
health aspects (100) 100
innate immunity (100) 100
neoplasm proteins - metabolism (98) 98
inflammasomes - genetics (97) 97
hek293 cells (95) 95
macrophages (92) 92
protein structure, tertiary (92) 92
membrane proteins - genetics (91) 91
asc (90) 90
genetic predisposition to disease (90) 90
signal transduction - immunology (87) 87
immune system (86) 86
enzyme activation (84) 84
molecular sequence data (84) 84
mucosa-associated lymphoid tissue lymphoma translocation 1 protein (83) 83
il-1β (82) 82
immune response (82) 82
kinases (82) 82
polymorphism, single nucleotide (81) 81
cytokines - metabolism (80) 80
blotting, western (79) 79
microbiology (79) 79
phosphorylation (79) 79
amino acid sequence (78) 78
calcium-binding proteins - metabolism (78) 78
infectious diseases (77) 77
nlr family, pyrin domain-containing 3 protein - metabolism (76) 76
biology (75) 75
case-control studies (75) 75
dermatology (73) 73
interleukin-1beta - immunology (73) 73
physiological aspects (73) 73
calcium-binding proteins - genetics (72) 72
interleukin-1beta - genetics (72) 72
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1508) 1508
Chinese (12) 12
Japanese (10) 10
French (5) 5
Korean (2) 2
Norwegian (1) 1
Portuguese (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases | Index Medicus
Journal Article
Molecular cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 236 - 250
Caspase-8 activation can be triggered by death receptor-mediated formation of the death-inducing signaling complex (DISC... 
caspase-8 | DED | MC159 | cFLIP | DISC | Fas | death domain | FADD | vFLIP | filament | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Death Domain Receptor Signaling Adaptor Proteins - chemistry | Apoptosis - drug effects | Cytoskeletal Proteins - genetics | Humans | Caspase 8 - metabolism | Caspase 8 - chemistry | CASP8 and FADD-Like Apoptosis Regulating Protein - chemistry | Death Domain Receptor Signaling Adaptor Proteins - genetics | Recombinant Fusion Proteins - metabolism | Viral Proteins - metabolism | Caspase 8 - genetics | Transfection | Cytoskeletal Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Death Effector Domain | Fas-Associated Death Domain Protein - genetics | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Jurkat Cells | Viral Proteins - chemistry | Fas-Associated Death Domain Protein - metabolism | Viral Proteins - genetics | fas Receptor - pharmacology | Cytoskeletal Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Plasmids - metabolism | Fas-Associated Death Domain Protein - chemistry | Cryoelectron Microscopy | Sequence Homology, Amino Acid | Sequence Alignment | Protein Conformation, beta-Strand | CARD Signaling Adaptor Proteins | Plasmids - chemistry | Protein Binding | Recombinant Fusion Proteins - genetics | Death Domain Receptor Signaling Adaptor Proteins - metabolism | Autoimmunity | Medical colleges | Skin diseases | Molecular biology | Analysis | Index Medicus
Journal Article
Nature immunology, ISSN 1529-2916, 06/2014, Volume 15, Issue 8, pp. 727 - 737
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 08/2009, Volume 206, Issue 9, pp. 2037 - 2051
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 04/2010, Volume 207, Issue 4, pp. 777 - 792
...), which mobilize downstream signaling cascades. We investigated the role of the cytosolic adaptor caspase recruitment domain family, member 9 (CARD9) in tuberculosis... 
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Lung - microbiology | Chemokines - blood | Pneumonia - therapy | Gene Expression - genetics | Protein-Tyrosine Kinases - metabolism | Immunity, Innate - genetics | Radiation Chimera - microbiology | Apoptosis - genetics | Male | Intracellular Signaling Peptides and Proteins - metabolism | Hypersensitivity, Delayed - immunology | Granulocyte Colony-Stimulating Factor - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - immunology | Neutrophils - metabolism | Syk Kinase | Tuberculosis - pathology | Hypersensitivity, Delayed - genetics | Radiation Chimera - immunology | Antigen-Presenting Cells - metabolism | Macrophage Activation - immunology | Antigen-Presenting Cells - drug effects | Lectins, C-Type | Neutrophils - drug effects | Mice, Knockout | Membrane Proteins - antagonists & inhibitors | Lung - drug effects | Survival Analysis | Chemokines - metabolism | Mice | Protein-Tyrosine Kinases - antagonists & inhibitors | T-Lymphocyte Subsets - immunology | Macrophage Activation - genetics | Pneumonia - pathology | Tuberculosis - microbiology | Antigen-Presenting Cells - microbiology | Leukocyte Reduction Procedures | Tuberculosis - drug therapy | Interleukin-10 - metabolism | Female | Lung - metabolism | Membrane Proteins - metabolism | Antitubercular Agents - therapeutic use | Cytokines - blood | Neutrophils - pathology | Polysaccharides, Bacterial - pharmacology | Nerve Tissue Proteins - antagonists & inhibitors | Genetic Predisposition to Disease - genetics | Lung - pathology | Cytokines - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Neutrophils - immunology | Antigen-Presenting Cells - immunology | Nerve Tissue Proteins - metabolism | Tuberculosis - immunology | Immunity, Innate - immunology | Animals | T-Lymphocyte Subsets - metabolism | CARD Signaling Adaptor Proteins | Adaptor Proteins, Signal Transducing - genetics | Macrophage Activation - drug effects | Lung - immunology | Index Medicus
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 04/2019, Volume 364, Issue 6435, p. eaau1330
Inflammasomes are multiprotein platforms that initiate innate immunity by recruitment and activation of caspase-1. The NLRP1B inflammasome is activated upon... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Subunits | Death Domain Receptor Signaling Adaptor Proteins - chemistry | Humans | Shigella flexneri - pathogenicity | Caspase 1 - metabolism | Neoplasm Proteins - metabolism | Bacillus anthracis - enzymology | Host-Pathogen Interactions - immunology | CARD Signaling Adaptor Proteins - metabolism | Proteolysis | HEK293 Cells | Protein Domains | Shigella flexneri - enzymology | Peptide Hydrolases - metabolism | Mice, Inbred C57BL | Ubiquitin-Protein Ligases - metabolism | Neoplasm Proteins - chemistry | Immunity, Innate | Apoptosis Regulatory Proteins - metabolism | Bacterial Toxins - metabolism | Animals | Inflammasomes - immunology | CARD Signaling Adaptor Proteins - chemistry | Bacterial Proteins - metabolism | RAW 264.7 Cells | Mice | Enzyme Activation | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Antigens, Bacterial - metabolism | Death Domain Receptor Signaling Adaptor Proteins - metabolism | Ubiquitin | Proteinase | Innate immunity | Genomes | Leucine | Macrophages | Lethal factor | Immunity | Recruitment | Fragmentation | Caspase-1 | Degradation | Proteins | Receptors | Cell activation | Enzymatic activity | Protease | Cleavage | Ubiquitin-protein ligase | Immune system | Biodegradation | Antigens | Pathogens | Immune response | Polypeptides | Caspase | Proteinase inhibitors | Inflammation | Anthrax lethal toxin | Screens | Proteasome inhibitors | Domains | Protease inhibitors | Cell death | Anthrax | Proteasomes | Ligands | Destabilization | Apoptosis | Index Medicus
Journal Article